CN104491035B - A kind of removing toxic substances processing procedure of the high rhizome of Chinese monkshood - Google Patents
A kind of removing toxic substances processing procedure of the high rhizome of Chinese monkshood Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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Abstract
It is that high monkshood medicinal material is cleaned, softened the invention discloses a kind of processing detoxification technique of high monkshood medicinal material, shreds section, dry in the shade, obtain health product medicine materical crude slice；Mixed again with succus liquiritiae, then in 3 ~ 5h of steaming under 115 ~ 127 DEG C, 0.10 ~ 0.15MPa；Take out, dry, produce.Experiment shows, the high rhizome of Chinese monkshood that the present invention is processed, and the content of total alkaloid is 4.98% ~ 7.75%, and the content of lappaconitine is 1.17 ~ 1.48%.Relative to high monkshood medicinal material, the content of total alkaloid adds 130.65 ~ 141.75%, the content of lappaconitine reduces 46.62 ~ 55.56%, high rhizome of Chinese monkshood total alkaloid is significantly increased, while keeping its drug effect, having the content of lappaconitine in high monkshood medicinal material significantly reduces, so as to substantially reduce its toxicity, be really achieved the purpose of " attenuation synergistic ", it is ensured that its clinical application it is safe and effective.
Description
Technical field
The present invention relates to Chinese medicine preparation field, and in particular to the removing toxic substances processing procedure of the high rhizome of Chinese monkshood.
Background technology
The high rhizome of Chinese monkshood of high rhizome of Chinese monkshood system Ranunculaceae aconitum plantAconitum sinomontanum Nakai root, You Mingma
Cloth seven, pocket seven, plait seven, straw rain cape seven, are the too white area in Gansu, Sichuan, Shaanxi, Shennongjia in Hubei and Yunnan, Guizhou
Etc. one of ground rare rare " seven medicines ", there is dispelling wind and eliminating dampness, regulating qi-flowing for relieving pain, promoting blood circulation to remove blood stasis, damaged for treating bruise
Wound, internal lesion caused by overexertion, bone fracture, rheumatalgia pain, arthralgia, extremity numbness, the therapeutic effect such as desinsection are good.But the health product toxicity of the high rhizome of Chinese monkshood compared with
Greatly, the medical works of multi-section records " the high rhizome of Chinese monkshood, acrid, bitter, warm is poisonous ", such as now record in《Gansu Province's Chinese medicine standard》（2009
Year version）.Due to the high rhizome of Chinese monkshood " hot very toxic ", it is impossible to used as clinic allotment, it is used only as extracting the raw material of lappaconitine, and
Substantial amounts of other alkaloid activity compositions are underused, and waste limited medicine resource.Therefore, the removing toxic substances of the high rhizome of Chinese monkshood is strengthened
Research is processed, makes it while toxicity is reduced, preserves the drug effect of the high rhizome of Chinese monkshood, is clinical to ensure clinical practice safely and effectively
A kind of analgesia Chinese medicine of high-efficiency low-toxicity is provided, with significant social benefit and development prospect.
Though the high rhizome of Chinese monkshood with the rhizome of Chinese monkshood is equal belongs to together, all contain Diterpenoid Alkaloids, its structure parent nucleus is consistent with aconitine, 8
It is different with 14 bit substituents, therefore its toxic component is different from the rhizome of Chinese monkshood, is substantially free of extremely toxic diester-type alkaloids.Lappaconitine
（Also lappaconitine is, handkerchief aconitine, Lappaconitine is drawn）Being that main C18- in the high rhizome of Chinese monkshood is double goes first Diterpenes biological
Alkali, is one of major toxicity composition of the high rhizome of Chinese monkshood.Therefore, the processing removing toxic substances of the high rhizome of Chinese monkshood is actually to reduce high Wu Jia in the high rhizome of Chinese monkshood
The content of element is to reduce its toxicity.
The content of the invention
The purpose of the present invention is larger for high rhizome of Chinese monkshood toxicity, and there is provided a kind of high rhizome of Chinese monkshood for the problem of being limited using scope
Detoxify processing procedure, to reduce the toxicity of the high rhizome of Chinese monkshood, and preserves drug effect, it is ensured that clinical practice safety.
Because its toxic component of many Chinese medicines and active component are consistent, the complexity of attenuation is just determined, it is possible to
During attenuation, the curative effect of medicine is reduced.Therefore it is also comprehensive while concocting method and balance processing degree is chosen
Consider its clinical practice, it is ensured that the medicinal material can rationally and effectively be processed on the premise of its medical advantages is retained.It is high
Total alkaloid in the rhizome of Chinese monkshood is the material base that it plays drug effect, and lappaconitine is both the effective component and toxicity of antalgic and inflammation relieving
Composition, therefore total alkaloid amount " height " should be selected, and the parameter of lappaconitine amount " moderate " is its optimal processing procedure.
The present invention passes through substantial amounts of experiment, it is determined that the technique of high rhizome of Chinese monkshood removing toxic substances processing, be high monkshood medicinal material is cleaned, it is soft
Change, shred section, dry in the shade, obtain health product medicine materical crude slice；Mixed thoroughly again with succus liquiritiae（The quality of succus liquiritiae is the 5% ~ 25% of health product prepared slice quality）,
In 3 ~ 5h of steaming under 115 ~ 127 DEG C, 0.105 ~ 0.15MPa；Take out, dry, produce.
In order to reduce the loss of total alkaloid, but profit method loss is minimum, therefore selection profit method is used as optimal softening method.Specifically
Softening process：After high monkshood medicinal material is cleaned with " robbing water " method, appropriate vessel splendid attire is put, is covered with wet thing, or continue to spray suitable
Clear water is measured, moisture state is kept, and often stirred, the moisture outside medicinal material is slowly penetrated into inside drug entities, so that " medicine is saturating
Water is use up " it is defined, inside and outside humidity is finally reached always, beneficial to cutting.
The preparation technology of above-mentioned auxiliary material succus liquiritiae：The rhizome and root of glycyrrhizic legume are cleaned, infiltrate, cut into slices, added water
Decoct 2 ~ 3 times, 30 minutes every time, filtering, collecting decoction obtained yellowish-brown liquid；Per 100kg Radix Glycyrrhizaes, 300 ~ 600kg of succus liquiritiae processed.
Determined through high performance liquid chromatograph（Chromatographic condition： ZORBAX SB-C18Chromatographic column（4.6mm×250mm,5μm)；
With methanol -0.05mol/L NaH2PO4Solution (45:55) it is mobile phase；Volume flow is 1.0mL/min；The μ L of sample size 10；Inspection
Survey wavelength 252nm；Column temperature is 30 DEG C.）：The high rhizome of Chinese monkshood processed through present invention process, the content of total alkaloid for 4.98% ~
7.75%, the content of lappaconitine is 1.17% ~ 1.48%.Relative to high monkshood medicinal material, the content of total alkaloid is added
130.65% ~ 141.75%, the content of lappaconitine reduces 46.62 ~ 55.56 %, and high rhizome of Chinese monkshood total alkaloid is significantly increased,
While keeping its drug effect, having the content of lappaconitine in high monkshood medicinal material significantly reduces, so as to drop significantly
Its low toxicity, is really achieved the purpose of " attenuation synergistic ", it is ensured that its clinical application it is safe and effective.
Embodiment
The removing toxic substances processing procedure of the high rhizome of Chinese monkshood of the invention and deciphering effect are described further below by specific embodiment
Embodiment 1
（1）The preparation of succus liquiritiae：The rhizome and root of glycyrrhizic legume are cleaned, infiltrate, cut into slices, add water to cook 2 ~ 3
Secondary, 30 minutes every time, filtering, collecting decoction obtained yellowish-brown liquid；Per 100kg Radix Glycyrrhizaes, succus liquiritiae 300kg processed；
（2）The processing of the high rhizome of Chinese monkshood：The high g of monkshood medicinal material 150 is weighed, water law is robbed and cleans, using profit method softening, is cut after the saturating heart
Broken section（About 5mm）, dry in the shade, then add 15ml succus liquiritiaes, mix thoroughly, vexed profit after succus liquiritiae is sucked completely, is placed in vertical pressure
In power steam sterilizer, 5h is steamed under 115 DEG C, 0.15MPa, is taken out, is dried, the high rhizome of Chinese monkshood must be made.
The total alkaloid content for making the high rhizome of Chinese monkshood is 7.78%, and the amount of lappaconitine is 0.601%.
Embodiment 2
（1）The preparation of succus liquiritiae：Be the same as Example 1；
（2）The processing of the high rhizome of Chinese monkshood：The high g of monkshood medicinal material 150 is weighed, water law is robbed and cleans, using profit method softening, is cut after the saturating heart
Broken section（About 5mm）, dry in the shade, then add 8ml succus liquiritiaes, mix thoroughly, vexed profit after succus liquiritiae is sucked completely, is placed in vertical pressure
In power steam sterilizer, 4h is steamed under 122 DEG C, 0.12MPa, is taken out, is dried, the high rhizome of Chinese monkshood must be made.
The total alkaloid content for making the high rhizome of Chinese monkshood is 7.76%；The amount of lappaconitine is 0.599%.
Embodiment 3
（1）The preparation of succus liquiritiae：Be the same as Example 1；
（2）The processing of the high rhizome of Chinese monkshood：The high g of monkshood medicinal material 150 is weighed, water law is robbed and cleans, using profit method softening, is cut after the saturating heart
Broken section（About 5mm）, dry in the shade, then add 40ml succus liquiritiaes, mix thoroughly, vexed profit after succus liquiritiae is sucked completely, is placed in vertical
In pressure steam sterilizer, 3h is steamed under 127 DEG C, 0.10MPa, is taken out, is dried, the high rhizome of Chinese monkshood must be made.
The total alkaloid content for making the high rhizome of Chinese monkshood is 7.71%；The amount of lappaconitine is 0.589%.
Claims (2)
1. a kind of removing toxic substances processing procedure of the high rhizome of Chinese monkshood, be high monkshood medicinal material is cleaned, the softening of profit method, segment, dry in the shade, obtain health product drink
Piece；It will be mixed thoroughly again with succus liquiritiae, then in 3 ~ 5h of steaming under 115 ~ 127 DEG C, 0.10 ~ 0.15MPa；Take out, dry, produce；
Profit method softening process is：After high monkshood medicinal material is cleaned with " robbing water " method, appropriate vessel splendid attire is put, is covered with wet thing, or
Continue to spray proper amount of clear water, keep moisture state, and often stir, the moisture outside medicinal material is slowly penetrated into drug entities
Portion, is defined by " medicine is permeable to the greatest extent ", inside and outside humidity is finally reached unanimously, beneficial to cutting；
The consumption of succus liquiritiae is the 5 ~ 25% of health product prepared slice quality.
2. the removing toxic substances processing procedure of the high rhizome of Chinese monkshood as claimed in claim 1, it is characterised in that：The preparation technology of the succus liquiritiae：Will
The rhizome and root of glycyrrhizic legume are cleaned, infiltrated, cutting into slices, adding water to cook 2 ~ 3 times, and 30 minutes every time, filtering, collecting decoction were obtained
Yellowish-brown liquid；Per 100kg Radix Glycyrrhizaes, 300 ~ 600kg of succus liquiritiae processed.
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| CN104491035B true CN104491035B (en) | 2017-07-18 |
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