CN104490943A - Poria cocos injection and preparation method thereof - Google Patents
Poria cocos injection and preparation method thereof Download PDFInfo
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- CN104490943A CN104490943A CN201410703513.9A CN201410703513A CN104490943A CN 104490943 A CN104490943 A CN 104490943A CN 201410703513 A CN201410703513 A CN 201410703513A CN 104490943 A CN104490943 A CN 104490943A
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- poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention relates to a poria cocos injection and a preparation method thereof. The poria cocos injection is prepared from the following raw materials in parts by weight: 80-120 parts of poria cocos, 0.5-30 parts of cosolvent, 0.1-0.5 part of antioxidant and 0.4-0.8 part of preservative. The poria cocos injection disclosed by the invention is simple in preparation process and easy to realize. The invention discloses an injection which is administrated by means of intramuscular injection, and capable of rapidly alleviating the pathological symptoms of an animal and improving the immunocompetence of the animal and the bioavailability of medicines in the body.
Description
Technical field
The invention belongs to technical field of medicine, be specifically related to a kind of Poria injection and preparation method thereof.
Background technology
Poria be On Polyporaceae Poria [
p oria COCOS (Schw .) W o1f] dry sclerotia.Its sweet in the mouth, light, flat, return lung, stomach, kidney channel.There is promoting diuresis to eliminate damp pathogen, effect of spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia III.In Poria, pachyman (Pach ym ose) is main component, cuts off the effects such as the pachymaran of side chain has antitumor, improves immunity of organisms, protects the liver, hypnosis, defying age, antiinflammatory.The physiologically active of pachyman and health care have caused the great interest of medical circle and region of chemistry, therefore the health product of pachyman are on the field seen everywhere.The Indian bread polysaccharide formulation occurred in the market mostly is oral formulations, has no its ejection preparation.
Summary of the invention
The invention provides a kind of Poria injection, add the route of administration of pachyman, improve the bioavailability of pachyman, can be used for treatment animal viral disease, and improve the immunocompetence of animal.
In order to achieve the above object, the present invention is by the following technical solutions:
The invention provides a kind of Poria injection, be made up of the raw material of following weight portion: Poria 80 ~ 120, cosolvent 0.5 ~ 30, antioxidant 0.1 ~ 0.5 and antiseptic 0.4 ~ 0.8.
Described Poria injection, is made up of the raw material of following weight portion: Poria 90 ~ 110, cosolvent 15 ~ 25, antioxidant 0.2 ~ 0.4 and antiseptic 0.5 ~ 0.6.
Described Poria injection, is made up of the raw material of following weight portion: Poria 100, cosolvent 20, antioxidant 0.2 and antiseptic 0.5.
Described cosolvent is one or more in sodium salicylate, acetamide, tween 80, ethanol, propylene glycol.
Described antioxidant is sodium sulfite, sodium pyrosulfite or ascorbic acid.
Described antiseptic is sodium benzoate, potassium sorbate or benzyl alcohol.
The preparation method concrete steps of described Poria injection are as follows:
(1) Poria is dry, pulverizing, excessively 40 ~ 60 mesh sieves obtain Indian Bread;
(2) purified water being added 1mol/L sodium hydroxide solution regulates purified water pH value to be 9 ~ 11 obtain alkaline purified water;
(3) step (1) formula ratio Indian Bread is taken, add 8 ~ 10 times of alkaline purified water of step (2), extract 3 times, each 1 ~ 2h, merge three extracting solution, filtering and concentrating obtains mixture a to Poria formula ratio 0.5 ~ 1.5 times, dehydrated alcohol is added to alcohol content 55%(V/V) in mixture a, leave standstill, elimination supernatant, obtains mixture b by precipitate purified water standardize solution;
(4) in step (3) mixture b, adding formula ratio cosolvent, antioxidant and antiseptic, boil dissolving, then cool, is 5.5 ~ 7.0 with 0.1mol/L hydrochloric acid solution adjust ph after cooling, standardize solution, filtration, fill, sterilizing and get final product.
compared with prior art, the present invention has following technique effect:
Pachyman is the principle active component of Chinese herbal medicine Poria, energy invigorating the spleen and benefiting QI, and immunity moderation function regulating YIN and YANG balances, and maintains the good body constitution of body.Pachyman product commercially available at present mainly contains oral liquid, pulvis and granule, is oral formulations, and wherein pulvis and granule are mainly based on compound product, and the pachyman injection product of folk prescription not yet occurs.The present invention adopts single prescription Poria to prepare Poria injection, and preparation technology is simple, is easy to realize.The present invention is injection, intramuscular administration, and the pathological symptom of energy rapid recovery animal, improves immunocompetence and the bioavailability of medicine in body of animal.
Usage and dosage: intramuscular injection, dosage is 0.1 ml/kg, 1 ~ 3 time/d, within 3rd ~ 7, is a course for the treatment of.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described, but do not limit content of the present invention.
embodiment 1
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 80 ~ 120, cosolvent 0.5 ~ 30, antioxidant 0.1 ~ 0.5 and antiseptic 0.4 ~ 0.8.
Described cosolvent is one or more in sodium salicylate, acetamide, tween 80, ethanol, propylene glycol.
Described antioxidant is sodium sulfite, sodium pyrosulfite or ascorbic acid.
Described antiseptic is sodium benzoate, potassium sorbate or benzyl alcohol.
The preparation method concrete steps of described Poria injection are as follows:
(1) Poria is dry, pulverizing, excessively 40 ~ 60 mesh sieves obtain Indian Bread;
(2) purified water being added 1mol/L sodium hydroxide solution regulates purified water pH value to be 9 ~ 11 obtain alkaline purified water;
(3) step (1) formula ratio Indian Bread is taken, add 8 ~ 10 times of alkaline purified water of step (2), extract 3 times, each 1 ~ 2h, merge three extracting solution, filtering and concentrating obtains mixture a to Poria formula ratio 0.5 ~ 1.5 times, dehydrated alcohol is added to alcohol content 55%(V/V) in mixture a, leave standstill, elimination supernatant, obtains mixture b by precipitate purified water standardize solution;
(4) in step (3) mixture b, adding formula ratio cosolvent, antioxidant and antiseptic, boil dissolving, then cool, is 5.5 ~ 7.0 with 0.1mol/L hydrochloric acid solution adjust ph after cooling, standardize solution, filtration, fill, sterilizing and get final product.
embodiment 2
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 100g, sodium salicylate 5g, sulfurous acid acid sodium 0.1g and benzyl alcohol 0.4g.
The preparation method of the present embodiment is identical with the preparation method of embodiment 1.
embodiment 3
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 80g, sodium salicylate 5g, tween 80 5g, sodium pyrosulfite 0.1g and benzyl alcohol 0.7g.
The preparation method of the present embodiment is identical with the preparation method of embodiment 1.
embodiment 4
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 90g, acetamide 6g, propylene glycol 10g, sodium sulfite 0.15g and potassium sorbate 0.6g.
The preparation method of the present embodiment is identical with the preparation method of embodiment 1.
embodiment 5
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 110g, acetamide 2g, propylene glycol 15g, sodium pyrosulfite 0.2g and sodium benzoate 0.5g.
The preparation method of the present embodiment is identical with the preparation method of embodiment 1.
embodiment 6
A kind of Poria injection, is made up of the raw material of following weight portion: Poria 120g, ethanol 5g, propylene glycol 15g, ascorbic acid 0.4g and benzyl alcohol 0.5g.
The preparation method of the present embodiment is identical with the preparation method of embodiment 1.
experimental example
Choose health, ablactational baby pig 42 (25 age in days) that body weight is consistent, be divided into 6 groups at random, often organize 7, public, ratio is consistent, weaning pig feeding standard of feeding daily ration, separated raising, each feedstuff addition with in pit of having enough slightly clout for degree, freely drink water.Matched group: conventional raising; Test 1 group: Poria injection prepared by intramuscular injection embodiment 2, dosage is 0.1 ml/kg, 1 time/d; Test 2 groups: Poria injection prepared by intramuscular injection embodiment 3, dosage is 0.1 ml/kg, 1 time/d; Test 3 groups: Poria injection prepared by intramuscular injection embodiment 4, dosage is 0.1 ml/kg, 1 time/d; Test 4 groups: Poria injection prepared by intramuscular injection embodiment 5, dosage is 0.1 ml/kg, 1 time/d; Test 5 groups: Poria injection prepared by intramuscular injection embodiment 6, dosage is 0.1 ml/kg, 1 time/d.
Raise after 7 days, test pig adopts vena cava anterior blood sampling, blood serum sample is obtained from 15m in through 3000r/m in,-20 DEG C save backup, for detecting the content (immunoturbidimetry of serum immunoglobulin IgG and IgM, measuring test kit is Beijing Leadman Biochemistry Technology Co., Ltd.'s product), the results are shown in Table 1.
As shown in Table 1, ablactational baby pig injection Poria injection is after 1 week, and the content of the immunoglobulin in its blood is significantly higher than the test pig not using pachyman injection.Visible, the present invention prepares the immunity that pachyman injection can improve animal, reduces Animal diseases and occurs.
Claims (7)
1. a Poria injection, is characterized in that: be made up of the raw material of following weight portion: Poria 80 ~ 120, cosolvent 0.5 ~ 30, antioxidant 0.1 ~ 0.5 and antiseptic 0.4 ~ 0.8.
2. Poria injection according to claim 1, is characterized in that: be made up of the raw material of following weight portion: Poria 90 ~ 110, cosolvent 15 ~ 25, antioxidant 0.2 ~ 0.4 and antiseptic 0.5 ~ 0.6.
3. Poria injection according to claim 1, is characterized in that: be made up of the raw material of following weight portion: Poria 100, cosolvent 20, antioxidant 0.2 and antiseptic 0.5.
4. Poria injection according to any one of claims 1 to 3, is characterized in that: described cosolvent is one or more in sodium salicylate, acetamide, tween 80, ethanol, propylene glycol.
5. Poria injection according to any one of claims 1 to 3, is characterized in that: described antioxidant is sodium sulfite, sodium pyrosulfite or ascorbic acid.
6. Poria injection according to any one of claims 1 to 3, is characterized in that: described antiseptic is sodium benzoate, potassium sorbate or benzyl alcohol.
7. the preparation method of Poria injection according to any one of claims 1 to 3, is characterized in that: concrete steps are as follows:
(1) Poria is dry, pulverizing, excessively 40 ~ 60 mesh sieves obtain Indian Bread;
(2) purified water being added 1mol/L sodium hydroxide solution regulates purified water pH value to be 9 ~ 11 obtain alkaline purified water;
(3) step (1) formula ratio Indian Bread is taken, add 8 ~ 10 times of alkaline purified water of step (2), extract 3 times, each 1 ~ 2h, merge three extracting solution, filtering and concentrating obtains mixture a to Poria formula ratio 0.5 ~ 1.5 times, dehydrated alcohol is added to alcohol content 55%(V/V) in mixture a, leave standstill, elimination supernatant, obtains mixture b by precipitate purified water standardize solution;
(4) in step (3) mixture b, adding formula ratio cosolvent, antioxidant and antiseptic, boil dissolving, then cool, is 5.5 ~ 7.0 with 0.1mol/L hydrochloric acid solution adjust ph after cooling, standardize solution, filtration, fill, sterilizing and get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410703513.9A CN104490943A (en) | 2014-11-30 | 2014-11-30 | Poria cocos injection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410703513.9A CN104490943A (en) | 2014-11-30 | 2014-11-30 | Poria cocos injection and preparation method thereof |
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| CN104490943A true CN104490943A (en) | 2015-04-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419886A (en) * | 2020-04-20 | 2020-07-17 | 劲牌持正堂药业有限公司 | Preparation method of poria cocos formula granules |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124249A (en) * | 1994-12-09 | 1996-06-12 | 沈阳药科大学 | Antineoplastic new poria polysaccharide water soluble derivative |
| CN1554667A (en) * | 2003-12-26 | 2004-12-15 | 三明市真菌研究所 | Process for producing carboxymethyl pachyman |
| CN1762378A (en) * | 2005-10-10 | 2006-04-26 | 戴甲木 | Indian bread polysaccharide formulation and its preparation method |
| CN101392030A (en) * | 2008-07-05 | 2009-03-25 | 陈勇 | Middle substitution degree carboxymethyl pachyman, preparation method thereof and use thereof |
-
2014
- 2014-11-30 CN CN201410703513.9A patent/CN104490943A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124249A (en) * | 1994-12-09 | 1996-06-12 | 沈阳药科大学 | Antineoplastic new poria polysaccharide water soluble derivative |
| CN1554667A (en) * | 2003-12-26 | 2004-12-15 | 三明市真菌研究所 | Process for producing carboxymethyl pachyman |
| CN1762378A (en) * | 2005-10-10 | 2006-04-26 | 戴甲木 | Indian bread polysaccharide formulation and its preparation method |
| CN101392030A (en) * | 2008-07-05 | 2009-03-25 | 陈勇 | Middle substitution degree carboxymethyl pachyman, preparation method thereof and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 陈春霞: ""羧甲基茯苓多糖及其注射液的稳定性试验"", 《福建中医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419886A (en) * | 2020-04-20 | 2020-07-17 | 劲牌持正堂药业有限公司 | Preparation method of poria cocos formula granules |
| CN111419886B (en) * | 2020-04-20 | 2022-09-30 | 劲牌持正堂药业有限公司 | Preparation method of poria cocos formula granules |
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Application publication date: 20150408 |