CN104490920A - Paste film for treating oral ulcer and preparation method thereof - Google Patents
Paste film for treating oral ulcer and preparation method thereof Download PDFInfo
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- CN104490920A CN104490920A CN201410698378.3A CN201410698378A CN104490920A CN 104490920 A CN104490920 A CN 104490920A CN 201410698378 A CN201410698378 A CN 201410698378A CN 104490920 A CN104490920 A CN 104490920A
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- hydrochloride
- ethanol
- sodium alginate
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- paste film
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a paste film for treating oral ulcer and a preparation method thereof. The paste film comprises 5-8g of dyclonine hydrochloride, 5-10g of chlortetracycline hydrochloride, 3-5g of metronidazole, 0.1-0.3g of dexamethasone sodium phosphate, 30-60g of sodium alginate, 100-150ml of ethanol, 30-80ml of glycerin and the balance purified water, wherein the total volume of the above ingredients is 1000ml. The invention also provides a preparation method of the paste film. The preparation method comprises the following steps of 1, taking sodium alginate, soaking the sodium alginate in ethanol and grinding the moistened sodium alginate in a mortar, 2, taking dyclonine hydrochloride, dissolving the dyclonine hydrochloride by ethanol, and slowly adding the solution into the ground sodium alginate obtained by the step 1, 3, dissolving metronidazole and dexamethasone sodium phosphate in water, slowly adding the solution into the mixed solution obtained by the steps 1 and 2 and carrying out continuous grinding, 4, taking chlortetracycline hydrochloride, adding glycerinum into the chlortetracycline hydrochloride for moistening, slowly adding the mixture into the mixed solution obtained by the step 3 and carrying out continuous stirring to obtain a uniform mixture, and 5, preparing a film, carrying out drying and carrying out split charging. The paste film can be used for treating oral ulcer or oral inflammation and has effects of diminishing inflammation and relieving pain. The paste film can be pasted to an affected part. The preparation method has simple processes and substantial curative effects.
Description
Technical field
The present invention relates to a kind of pad pasting for the treatment of oral ulcer and preparation method thereof, belong to technical field of medicine preparation.
Background technology
Oral ulcer, also known as aphtha, is the disease that in diseases of oral mucosa, sickness rate is the highest, is apt to occur in adolescent, but old people to suffer from this patient also non-rare.Being a kind of with the repeatedly painful ulcer of the recurrent exerbation chronic inflammatory disease that is feature on oral mucosa, because having the rule of cycle recurrence, therefore often representing its special performance titled with " recurrent ".Be apt to occur in inside lip, the position such as the tip of the tongue, lingual margin, tongue abdomen, buccal mucosa and soft palate, less generation on gingiva and hard palate face.Small-sized ulcer from the beginning of time be thin small red dot, have scorching hot sense of discomfort, expand as less shallow table ulcer subsequently gradually, ulcer surface caves in, and there are yellow-white or canescence pseudomembrane in surface, and that wipes does not come off, and edge is red and swollen, in burning sample pain.To have an intense pain sense during oral ulcer outbreak, impact feed and speaking, bring huge misery and inconvenience to patient, when particularly meeting acid, salty, peppery food, pain is more severe, though be the little trouble in oral cavity, painful unbearably., due to the stimulation of often being chewed, speaking, with the passing of time also likely can there is canceration in the prolonged ulcer do not healed in oral cavity.
In order to alleviate the pain that in diet processes, aphtha occurs, clinician commonly uses 10% silver nitrate aqueous solution calcination local woanded surface, or 0.1% potassium permanganate liquid, boronic acid compound liquid etc. are gargled, to accelerate healing, but collutory dosage form is difficult to stop at oral cavity partial, has little effect.Chinese traditional treatment oral ulcer mostly then is powder, as BINGPENG SAN, respond well, but powder covers cloth inconvenience, and is not easy to accomplish slowly to distribute to strengthen drug effect.Owing to not having suitable dosage form, causing each dental ulcer treatment not thorough, is also a reason of this sick high relapse rate.Make a general survey of the various medicines being used for the treatment of oral ulcer at present, various in style, all there is good curative effect for all kinds of oral ulcer, can the intermission be extended to relapsing aphtha, reduce recurrence, but not yet reach radical cure object.
Summary of the invention
It is good that technical problem to be solved by this invention is to provide a kind of therapeutic effect, and cure rate is high, the pad pasting type stomatocace medicine do not recurred.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
Treat a pad pasting for oral ulcer, comprise the component of following content:
Dyclonine hydrochloride 5-8g,
Chlortetracycline hydrochloride 5-10g,
Metronidazole 3-5g,
Dexamethasone sodium phosphate 0.1-0.3g,
Sodium alginate 30-60g,
Ethanol 100-150ml,
Glycerol 50ml,
Purified water adds to 1000ml.
Preferably, the pad pasting for the treatment of oral ulcer of the present invention, comprises the component of following content:
Dyclonine hydrochloride 5g,
Chlortetracycline hydrochloride 8g,
Metronidazole 3g,
Dexamethasone sodium phosphate 0.2g,
Sodium alginate 30g,
Ethanol 100ml,
Glycerol 50ml,
Purified water adds to 1000ml.
Present invention also offers the preparation method of above-mentioned pad pasting, comprise the following steps:
(1) get sodium alginate, infiltrate with ethanol, be placed in mortar and grind;
(2) get dyclonine hydrochloride, add dissolve with ethanol, slowly add in step (1);
(3) metronidazole, dexamethasone sodium phosphate are water-soluble, slowly add step (1) (2) mixed liquor, do not stop grinding;
(4) get chlortetracycline hydrochloride and add glycerol grinding, make it moistening, slowly add with the mixed liquor in step (3), be constantly stirred to evenly;
(5) masking, drying, subpackage.
The invention has the beneficial effects as follows:
The present invention is used for the treatment of oral ulcer or oral inflammation, has the effect of anti-inflammatory analgetic.Usage is for being affixed on affected part.Preparation method of the present invention is simple, evident in efficacy.
Detailed description of the invention
Embodiment 1
Treat a pad pasting for oral ulcer, comprise the component of following content:
Dyclonine hydrochloride 5g,
Chlortetracycline hydrochloride 5g,
Metronidazole 3g,
Dexamethasone sodium phosphate 0.1g,
Sodium alginate 30g,
Ethanol 100ml,
Glycerol 50ml,
Purified water adds to 1000ml.
Present invention also offers the preparation method of above-mentioned pad pasting, comprise the following steps:
(1) get sodium alginate, infiltrate with ethanol, be placed in mortar and grind;
(2) get dyclonine hydrochloride, add dissolve with ethanol, slowly add in step (1);
(3) metronidazole, dexamethasone sodium phosphate are water-soluble, slowly add step (1) (2) mixed liquor, do not stop grinding;
(4) get chlortetracycline hydrochloride and add glycerol grinding, make it moistening, slowly add with the mixed liquor in step (3), be constantly stirred to evenly;
(5) masking, drying, subpackage.
Embodiment 2
Treat a pad pasting for oral ulcer, comprise the component of following content:
Dyclonine hydrochloride 8g,
Chlortetracycline hydrochloride 10g,
Metronidazole 5g,
Dexamethasone sodium phosphate 0.3g,
Sodium alginate 60g,
Ethanol 150ml,
Glycerol 50ml,
Purified water adds to 1000ml.
Present invention also offers the preparation method of above-mentioned pad pasting, comprise the following steps:
(1) get sodium alginate, infiltrate with ethanol, be placed in mortar and grind;
(2) get dyclonine hydrochloride, add dissolve with ethanol, slowly add in step (1);
(3) metronidazole, dexamethasone sodium phosphate are water-soluble, slowly add step (1) (2) mixed liquor, do not stop grinding;
(4) get chlortetracycline hydrochloride and add glycerol grinding, make it moistening, slowly add with the mixed liquor in step (3), be constantly stirred to evenly;
(5) masking, drying, subpackage.
Embodiment 3
Dyclonine hydrochloride 5g,
Chlortetracycline hydrochloride 8g,
Metronidazole 3g,
Dexamethasone sodium phosphate 0.2g,
Sodium alginate 30g,
Ethanol 100ml,
Glycerol 50ml,
Purified water adds to 1000ml.
Present invention also offers the preparation method of above-mentioned pad pasting, comprise the following steps:
(1) get sodium alginate, infiltrate with ethanol, be placed in mortar and grind;
(2) get dyclonine hydrochloride, add dissolve with ethanol, slowly add in step (1);
(3) metronidazole, dexamethasone sodium phosphate are water-soluble, slowly add step (1) (2) mixed liquor, do not stop grinding;
(4) get chlortetracycline hydrochloride and add glycerol grinding, make it moistening, slowly add with the mixed liquor in step (3), be constantly stirred to evenly;
(5) masking, drying, subpackage.
Embodiment 4
Case 1: Liu xx, female, 28 years old, No. 10, Yun Xi road, Qingdao City, on March 6th, 2008 went to a doctor, and readme is lip pain before 2 days, increases the weight of during feed, checks and finds that surveying mucosa in upper lip has 0.1*0.3 ulcer surface, uses pad pasting to be affixed on ulcer surface, heals after 3 days.
Case 2: Lu xx, female, 31 years old, No. 1, Yucheng road, Qingdao City, on June 9th, 2008 went to a doctor, and checks the ulcer surface finding right side buccal 0.2*0.4, ulcer surface superficial white secretions, uses pad pasting to heal after 5 days.
Case 3: Zhao x, man, 47 years old, No. 2, Qingdao City's Siping Road, on July 10th, 2008 went to a doctor, and checks and finds that tongue has a 0.2*0.3 ulcer surface, above have faint yellow secretions, gives pad pasting and pastes affected part treatment, heal after 5 days.
Claims (3)
1. treat a pad pasting for oral ulcer, it is characterized in that, comprise the component of following content:
Dyclonine hydrochloride 5-8g,
Chlortetracycline hydrochloride 5-10g,
Metronidazole 3-5g,
Dexamethasone sodium phosphate 0.1-0.3g,
Sodium alginate 30-60g,
Ethanol 100-150ml,
Glycerol 30-80ml,
Purified water adds to 1000ml.
2. the pad pasting for the treatment of oral ulcer according to claim 1, is characterized in that, comprises the component of following content:
Dyclonine hydrochloride 5g,
Chlortetracycline hydrochloride 8g,
Metronidazole 3g,
Dexamethasone sodium phosphate 0.2g,
Sodium alginate 30g,
Ethanol 100ml,
Glycerol 50ml,
Purified water adds to 1000ml.
3. the method for the treatment film for treating oral ulcer of preparation described in claim 1 or 2, is characterized in that, comprise the following steps:
(1) get sodium alginate, infiltrate with ethanol, be placed in mortar and grind;
(2) get dyclonine hydrochloride, add dissolve with ethanol, slowly add in step (1);
(3) metronidazole, dexamethasone sodium phosphate are water-soluble, slowly add step (1) (2) mixed liquor, do not stop grinding;
(4) get chlortetracycline hydrochloride and add glycerol grinding, make it moistening, slowly add with the mixed liquor in step (3), be constantly stirred to evenly;
(5) masking, drying, subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410698378.3A CN104490920A (en) | 2014-11-28 | 2014-11-28 | Paste film for treating oral ulcer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410698378.3A CN104490920A (en) | 2014-11-28 | 2014-11-28 | Paste film for treating oral ulcer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104490920A true CN104490920A (en) | 2015-04-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410698378.3A Pending CN104490920A (en) | 2014-11-28 | 2014-11-28 | Paste film for treating oral ulcer and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN104490920A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN106511441A (en) * | 2016-12-21 | 2017-03-22 | 青岛琛蓝海洋生物工程有限公司 | Oral ulcer membrane and preparation method thereof |
| CN107519152A (en) * | 2017-09-07 | 2017-12-29 | 卢恕来 | A kind of stomatocace film and preparation method thereof |
| CN115025125A (en) * | 2022-06-24 | 2022-09-09 | 四川大学 | A pharmaceutical composition for treating oral ulcer and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528460A (en) * | 2003-09-29 | 2004-09-15 | 中国医学科学院皮肤病研究所 | Complex local medicine for mainly treating oral ulcer |
| CN103919786A (en) * | 2014-05-06 | 2014-07-16 | 青岛市市立医院 | Dental medicinal membrane and preparation method thereof |
-
2014
- 2014-11-28 CN CN201410698378.3A patent/CN104490920A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528460A (en) * | 2003-09-29 | 2004-09-15 | 中国医学科学院皮肤病研究所 | Complex local medicine for mainly treating oral ulcer |
| CN103919786A (en) * | 2014-05-06 | 2014-07-16 | 青岛市市立医院 | Dental medicinal membrane and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 汪波等: "甲硝哇-金霉素复合剂体外药效学的研究", 《现代应用药学》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN106511441A (en) * | 2016-12-21 | 2017-03-22 | 青岛琛蓝海洋生物工程有限公司 | Oral ulcer membrane and preparation method thereof |
| CN107519152A (en) * | 2017-09-07 | 2017-12-29 | 卢恕来 | A kind of stomatocace film and preparation method thereof |
| CN115025125A (en) * | 2022-06-24 | 2022-09-09 | 四川大学 | A pharmaceutical composition for treating oral ulcer and preparation method thereof |
| CN115025125B (en) * | 2022-06-24 | 2023-09-29 | 四川大学 | Pharmaceutical composition for treating dental ulcer and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150408 |