CN103919786A - Dental medicinal membrane and preparation method thereof - Google Patents
Dental medicinal membrane and preparation method thereof Download PDFInfo
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- CN103919786A CN103919786A CN201410185919.2A CN201410185919A CN103919786A CN 103919786 A CN103919786 A CN 103919786A CN 201410185919 A CN201410185919 A CN 201410185919A CN 103919786 A CN103919786 A CN 103919786A
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Abstract
The invention discloses a dental medicinal membrane. The dental medicinal membrane comprises the following components by weight: 3-8g of clotrimazole, 3-8g of dyclonine, 1-3g of metronidazole, 0.3-0.6g of dexamethasone, 10-18g of CMC-Na (sodium carboxymethylcellulose), 40-60g of sodium alginate, 12-18g of tragacanth, 100-150g of ethanol and 1,000-1,500g of purified water. The invention also provides preparation of the dental medicinal membrane, which comprises the following steps: (1) soaking the sodium alginate with ethanol, and grinding in a mortar for later use; (2) naturally peptizing the tragacanth and CMC-Na in the purified water; (3) dissolving the clotrimazole and metronidazole in ethanol, and slowly adding the solution into the mortar in the step (1); dissolving the dexamethasone and metronidazole in the purified water, mixing with the solution in the step (2), slowly adding the mixture into the mortar in the step (1), and constantly grinding to obtain a colloidal liquid; and (4) preparing a membrane from the colloidal liquid, drying and subpackaging. The dental medicinal membrane is low in cost, simple in preparation method and remarkable in treatment effect, and has the effects of inhibiting bacteria and diminishing inflammation; and the dental medicinal membrane is an external application, and is applied to an affected part.
Description
Technical field
The present invention relates to a kind of medicine membrane of oral cavity and preparation method thereof, belong to field of medicine preparing technology.
Background technology
Oral ulcer is called again " aphtha ", is a kind of disease of the department of stomatology, large I from the grain of rice to Semen Glycines size, circular or oval, ulcer surface is recessed, congested around.Ulcer has the features such as periodicity, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc.Many patients are along with the prolongation of the course of disease, and ulcer area increases, and number increases, and pain increases the weight of, and healing stage extends, and shorten interval etc., affect food and speak.The various external pulvis curative effects of selling are in the market slow, the ulcer of can not fully recovering fast and effectively.
The factor that causes oral ulcer is a lot, as caused oral ulcer after overtired; The intrinsic factor such as endocrine disturbance, autoimmunity reduction; Inherited genetic factors, stress are large, work is too tired, the frequent extrinsic factor such as insomnia; Also someone thinks, oral ulcer and heredity, hormone etc. are because have direct relation, as having, oral ulcer before women's menstrual phase worsens tendency, climacteric women is more easily suffered from oral ulcer, but pregnancy women is just not easy to suffer from oral ulcer, these phenomenons all show that the hormonal readiness in generation and the body of ulcer changes and has direct relation; Although the method for many treatment oral ulcer has many good qualities, but some shortcomings that exist can cause clinical Difficulty, as apply in rhG-GSF brine treatment caused by chemotherapeutic medicines oral ulcer, although curative effect is obvious, but due to rhG-CSF drug price costliness, for poor family, expense for disease chemotherapy is very difficult, they remove to buy separately rhG-CSF and are used for gargling the expensive price of can not deflorating again, and therefore the high cost in Therapeutic Method is also the restriction factor of clinical expansion.
Summary of the invention
Technical problem to be solved by this invention is to provide and a kind ofly treats that oral ulcer cost is low, therapeutic effect significantly, there is the medicine membrane of oral cavity of antimicrobial and anti-inflammation efficacy.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of medicine membrane of oral cavity, comprises the component of following content:
Clotrimazole 3-8g; Dyclonine 3-8g; Metronidazole 1-3g; Dexamethasone 0.3-0.6g; CMC-Na10-18g; Sodium alginate 40-60g; Tragakanta 12-18g; Ethanol 100-150g; Purified water 1000-1500g.
Preferably, the content of above-mentioned each component is:
Clotrimazole 5g; Dyclonine 5g; Metronidazole 2g; Dexamethasone 0.5g; CMC-Na15g; Sodium alginate 50g; Tragakanta 15g; Ethanol 120g; Purified water 1300g.
The present invention also provides the preparation of above-mentioned medicine membrane of oral cavity, comprises the following steps:
(1) sodium alginate is added to ethanol and infiltrate, in mortar, grind for subsequent use;
(2) get tragakanta and CMC-Na, add purified water nature peptization;
(3) get clotrimazole and dyclonine adds dissolve with ethanol, and lysate is slowly joined in the mortar of step (1), separately get dexamethasone and metronidazole is dissolved in purified water, after mixing with the solution in step (2), slowly join in the mortar of step (1), do not stop to grind, obtain sol solution;
(4) by sol solution masking, dry, splitting and get final product.
The invention has the beneficial effects as follows:
Medicine membrane of oral cavity cost of the present invention is low, preparation method is simple, and therapeutic effect is remarkable, has the effect of antimicrobial and anti-inflammation efficacy simultaneously.Usage of the present invention is external, is affixed on affected part.
Detailed description of the invention
embodiment 1
A kind of medicine membrane of oral cavity, comprises the component of following content:
Clotrimazole 5g; Dyclonine 5g; Metronidazole 2g; Dexamethasone 0.5g; CMC-Na15g; Sodium alginate 50g; Tragakanta 15g; Ethanol 120g; Purified water 1300g.
The preparation of above-mentioned medicine membrane of oral cavity, comprises the following steps:
(1) sodium alginate is added to ethanol and infiltrate, in mortar, grind for subsequent use;
(2) get tragakanta and CMC-Na, add purified water nature peptization;
(3) get clotrimazole and dyclonine adds dissolve with ethanol, and lysate is slowly joined in the mortar of step (1), separately get dexamethasone and metronidazole is dissolved in purified water, after mixing with the solution in step (2), slowly join in the mortar of step (1), do not stop to grind, obtain sol solution;
(4) by sol solution masking, dry, splitting and get final product.
embodiment 2
A kind of medicine membrane of oral cavity, comprises the component of following content:
Clotrimazole 8g; Dyclonine 8g; Metronidazole 3g; Dexamethasone 0.6g; CMC-Na18g; Sodium alginate 60g; Tragakanta 18g; Ethanol 150g; Purified water 1500g.
Above-mentioned medicine membrane of oral cavity prepare the following step:
(1) sodium alginate is added to ethanol and infiltrate, in mortar, grind for subsequent use;
(2) get tragakanta and CMC-Na, add purified water nature peptization;
(3) get clotrimazole and dyclonine adds dissolve with ethanol, and lysate is slowly joined in the mortar of step (1), separately get dexamethasone and metronidazole is dissolved in purified water, after mixing with the solution in step (2), slowly join in the mortar of step (1), do not stop to grind, obtain sol solution;
(4) by sol solution masking, dry, splitting and get final product.
embodiment 3
A kind of medicine membrane of oral cavity, comprises the component of following content:
Clotrimazole 3g; Dyclonine 3g; Metronidazole 1g; Dexamethasone 0.3-g; CMC-Na10g; Sodium alginate 40g; Tragakanta 12g; Ethanol 100g; Purified water 1000g.
The preparation of above-mentioned medicine membrane of oral cavity, comprises the following steps:
(1) sodium alginate is added to ethanol and infiltrate, in mortar, grind for subsequent use;
(2) get tragakanta and CMC-Na, add purified water nature peptization;
(3) get clotrimazole and dyclonine adds dissolve with ethanol, and lysate is slowly joined in the mortar of step (1), separately get dexamethasone and metronidazole is dissolved in purified water, after mixing with the solution in step (2), slowly join in the mortar of step (1), do not stop to grind, obtain sol solution;
(4) by sol solution masking, dry, splitting and get final product.
embodiment 4 clinical verifications
Case 1: Liu xx, female, 33 years old, No. 2117, Jinsui River road, Licang District, Qingdao City, on June 30th, 2007 is medical, and readme is lip pain before 3 days, when feed, increases the weight of, check and find that in upper lip, surveying mucosa has 0.2*0.4 ulcer surface, use medicine membrane of oral cavity to be affixed on ulcer surface, healing afterwards in 3 days.
Case 2: horse xx, female, 61 years old, Zhao Jia ridge community, river bend street, Chengyang District, Qingdao City, in JIUYUE, 2007 is gone to a doctor for No. 30, checks the ulcer surface of finding tongue 0.1*0.3, and the white secretions in ulcer surface surface uses medicine membrane of oral cavity to heal afterwards for 5 days.
Case 3: Lee xx, man, 57 years old, Xiao Wang community, Laoshan District Wang Ge village street of Qingdao City, on October 7th, 2007 is medical, checks and finds that there is a 0.3*0.4 ulcer surface buccal, left side, above has faint yellow secretions, gives medicine membrane of oral cavity and pastes affected part treatment, healing afterwards in 5 days.
Claims (3)
1. a medicine membrane of oral cavity, is characterized in that, comprises the component of following content:
Clotrimazole 3-8g; Dyclonine 3-8g; Metronidazole 1-3g; Dexamethasone 0.3-0.6g; CMC-Na10-18g; Sodium alginate 40-60g; Tragakanta 12-18g; Ethanol 100-150g; Purified water 1000-1500g.
2. medicine membrane of oral cavity according to claim 1, is characterized in that, the content of each component is:
Clotrimazole 5g; Dyclonine 5g; Metronidazole 2g; Dexamethasone 0.5g; CMC-Na15g; Sodium alginate 50g; Tragakanta 15g; Ethanol 120g; Purified water 1300g.
3. a method of preparing medicine membrane of oral cavity claimed in claim 1, is characterized in that, comprises the following steps:
(1) sodium alginate is added to ethanol and infiltrate, in mortar, grind for subsequent use;
(2) get tragakanta and CMC-Na, add purified water nature peptization;
(3) get clotrimazole and dyclonine adds dissolve with ethanol, and lysate is slowly joined in the mortar of step (1), separately get dexamethasone and metronidazole is dissolved in purified water, after mixing with the solution in step (2), slowly join in the mortar of step (1), do not stop to grind, obtain sol solution;
(4) by sol solution masking, dry, splitting and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410185919.2A CN103919786A (en) | 2014-05-06 | 2014-05-06 | Dental medicinal membrane and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410185919.2A CN103919786A (en) | 2014-05-06 | 2014-05-06 | Dental medicinal membrane and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103919786A true CN103919786A (en) | 2014-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410185919.2A Pending CN103919786A (en) | 2014-05-06 | 2014-05-06 | Dental medicinal membrane and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490920A (en) * | 2014-11-28 | 2015-04-08 | 青岛市市立医院 | Paste film for treating oral ulcer and preparation method thereof |
| CN107519152A (en) * | 2017-09-07 | 2017-12-29 | 卢恕来 | A kind of stomatocace film and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528460A (en) * | 2003-09-29 | 2004-09-15 | 中国医学科学院皮肤病研究所 | Complex local medicine for mainly treating oral ulcer |
| CN101444555A (en) * | 2008-11-08 | 2009-06-03 | 青岛市市立医院 | Purely Chinese traditional medical film for curing oral ulcer and method for preparing same |
-
2014
- 2014-05-06 CN CN201410185919.2A patent/CN103919786A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528460A (en) * | 2003-09-29 | 2004-09-15 | 中国医学科学院皮肤病研究所 | Complex local medicine for mainly treating oral ulcer |
| CN101444555A (en) * | 2008-11-08 | 2009-06-03 | 青岛市市立医院 | Purely Chinese traditional medical film for curing oral ulcer and method for preparing same |
Non-Patent Citations (3)
| Title |
|---|
| 余学如等: "甲硝唑外用制剂研究进展及临床应用", 《中国药业》 * |
| 朱国军等: "滋阴降炎消溃汤治疗口腔溃疡126例疗效观察", 《甘肃中医学院学报》 * |
| 许格等: "复方溃疡膜治疗口腔溃疡临床疗效观察", 《药物与临床》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490920A (en) * | 2014-11-28 | 2015-04-08 | 青岛市市立医院 | Paste film for treating oral ulcer and preparation method thereof |
| CN107519152A (en) * | 2017-09-07 | 2017-12-29 | 卢恕来 | A kind of stomatocace film and preparation method thereof |
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Application publication date: 20140716 |