CN104436164B - Foot powder containing biologic peptide composition, as well as preparation thereof - Google Patents
Foot powder containing biologic peptide composition, as well as preparation thereof Download PDFInfo
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- CN104436164B CN104436164B CN201410759445.8A CN201410759445A CN104436164B CN 104436164 B CN104436164 B CN 104436164B CN 201410759445 A CN201410759445 A CN 201410759445A CN 104436164 B CN104436164 B CN 104436164B
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Abstract
The invention discloses foot powder containing a biologic peptide composition, as well as preparation thereof. The foot powder containing the biologic peptide composition is prepared from the following components in parts by weight: 30-40 parts of starch component, 0.05-5 parts of biologic peptide composition, 0.03-0.5 part of menthol, 20-30 parts of kaolin, 0.03-3 parts of salicylic acid and the balance of magnesium carbonate. The foot powder containing the biologic peptide composition adopts the biologic peptide composition as the antibacterial component, and the growth of foot pathogenic bacteria can be effectively inhibited by utilizing the broad-spectrum antibacterial characteristic of the biologic peptide; in addition, the hidden safety hazard during use of talcum powder foot powder can be avoided by replacing talcum powder with safe and reliable components,namelycorn starch and denatured starch. The foot powder is safe and reliable, convenient to use and sweat-absorbing, maintains the comfortable and cool feet and has good efficacy of antibacterial characteristic and the like, the demand on daily foot care of people can be met, and the foot powder can also serve as daily foot health products of common people.
Description
Technical field
The present invention relates to commodity, and in particular to a kind of foot-powder containing biological peptide combinations, the preparation of the foot-powder is further related to
Method.
Background technology
Tinea pedis is common foot dermatosis, is caused by pathogenic fungus, and with infectiousness, in China, tinea pedis is sent out
Sick rate is at a relatively high.Research shows：Without sebaceous glands between the vola of people and toe, so as to lack the fat for suppressing skin filamentous fungi
Acid, physiological defense function is poor, and the sweat gland of skin at these positions is very abundant, perspire it is relatively more, in addition air circulation it is poor,
Local damp warm, is conducive to the growth of filamentous fungi.Additionally, vola position keratoderma is thicker, the angle egg in cuticula
It is in vain the abundant nutrition material of fungi, is conducive to the growth of fungi.It is, in general, that gravid woman, overweight people, diabetic is
The group of people at high risk of tinea pedis, while the morbidity of tinea pedis is also relevant with habits and customs.Some people do not note foot sanitation and hygiene and footgear
Situation, provide for fungi and good grow place.Containing chemicals the tinea pedis medicine of existing market, its antibacterial components more
There is side effect in usually antibiotic or steroids, Long-Time Service, the problems such as easily cause the drug resistance of fungi therefore and right
In tinea pedis Susceptible population, daily foodcare and health care is particularly important,
Biological peptide former refers to that the class that Jing is induced and produced in insect body has the basic polypeptide material of antibacterial activity, molecular weight
2000～7000 or so, it is made up of 20～60 amino acid residues.Initially, immunologic mechanism of the people in research North America giant silkworm
When, its diapause pupae is found Jing after environmental stimuli induction, the peptide material with bacteriostasis is generated in its hemolymph, it is this kind of anti-
Bacterium polypeptide is named as cecropin (Cecropins).Later, from other insects and amphibian animal, mammal, also divide
From to the similar antibacterial polypeptide of structure, there is the structure of more than 70 kinds of antibacterial polypeptide determined.Between the several years after 1980, people are successive
Find and separate to obtain with antibacterial activity from bacterium, fungi, amphibian animal, insect, higher plant, mammal or even the mankind
Polypeptide.The features such as active peptides majority has strong basicity, heat endurance and broad-spectrum antiseptic, and it is considered as having wide answering
Use prospect.
At present, on market foot-powder is more based on the foot bath class product such as foot bath salt, lavipeditum powder, and other kinds of foot-powder one
As also simply with absorbing sweat, the dry and comfortable function of foot is kept, without antibacterial components, single function, it is impossible to suppress foot harmful true
The growth of bacterium, has little effect to the daily foodcare of tinea pedis patient, and the talcum powder with ability of sweat absorption in foot-powder, studies table
The bright harm certain to human body, therefore we should try one's best and avoid using containing talcous foot-powder.
The content of the invention
The first object of the present invention is to provide a kind of foot-powder containing biological peptide combinations, and it can effectively suppress foot to cause a disease
Bacterium simultaneously avoids harm of the talcum powder to human body.
Foot-powder containing biological peptide combinations of the present invention, is prepared from by following each component by weight：
Foot-powder containing biological peptide combinations of the present invention, wherein, the starch component is converted starch and/or jade
Rice starch.
Converted starch used in the present invention is existing known arbitrarily converted starch (such as modified corn starch, potato
Converted starch, cassava modified starch, rice modified starch, wheat converted starch) in one or more, when for multiple combination
When, can as needed limit specific proportioning.
Foot-powder containing biological peptide combinations of the present invention, wherein, the biological peptide be combined as Xenopus laevis element, cecropin,
In alexin and bacteriocin at least two.
Institute of the present invention, the foot-powder containing biological peptide combinations stated, the biological peptide combination is preferably cecropin and defence
The mixture of element.
The Xenopus laevis element of the present invention, cecropin, alexin and bacteriocin are known substance, can be obtained by existing technology or
By commercially available.Optional Xenopus laevis element 2 of Xenopus laevis element etc., cecropin can select cecropin A etc., and alexin can select α-defence
Element, beta-alexin and θ-alexin etc., bacteriocin can select colicin, nisin and pyo etc..
Used as preferred scheme, the foot-powder containing biological peptide combinations of the present invention is following each by by weight
Component is prepared from：
It is 1 that the biological peptide combinations are weight ratio:The cecropin of 1-3 and alexinic mixture.
Used as preferred scheme, the foot-powder containing biological peptide combinations of the present invention is as follows by by weight
Each component is prepared from：
It is a further object to provide the preparation method of the described foot-powder containing biological peptide combinations, comprising following
Step:
(1) by the carbon of the starch component of proportional quantity, menthol, kaolin, salicylic acid and 20-80% (w/w) proportional quantity
The mixing of sour magnesium；
(2) the biological peptide combinations and remaining magnesium carbonate of proportional quantity are added in the mixture for obtaining step (1), stirring is equal
Even rear freeze-drying；
(3) the dried mixture grinding of step (2) is sieved, obtains final product the foot-powder containing biological peptide combinations.
Prior art is compared, and the foot-powder containing biological peptide combinations of the present invention has advantages below：Using biological peptide group
Compound has the characteristic of broad spectrum antibacterial as antibacterial components using biological peptide, can effectively suppress the growth of foot pathogenic bacteria, together
When, the present invention also substitutes talcum powder using safe and reliable component (cornstarch and converted starch), it is to avoid use talcum powder
The potential safety hazard that foot-powder brings.The foot-powder of the present invention is safe and reliable, easy to use, energy absorbing sweat, and anti-chap keeps foot pleasant simultaneously
The effects such as with good antibacterial characteristics, the demand of the daily foodcare of people can be met, also can be used as the daily foot of general personage
Portion's health treatment.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1：A kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, it is prepared from by the following each component of weight：Cornstarch
35g, cecropin 0.1g, alexin 0.25g, menthol 0.05g, kaolin 25g, salicylic acid 0.1g, magnesium carbonate adds to 100g.
The preparation method of the foot-powder containing biological peptide combinations described in the present embodiment, comprises the steps of：
(1) by the mixing of the magnesium carbonate of cornstarch, menthol, kaolin, salicylic acid and 50% (w/w)；
(2) cecropin, alexin and remaining magnesium carbonate are added in the mixture for obtaining step (1), it is cold after stirring
It is lyophilized dry；
(3) the dried mixture grinding of step (2) is sieved, obtains final product the foot-powder containing biological peptide combinations.
Embodiment 2：A kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, it is prepared from by the following each component of weight：Cornstarch
32g, cecropin 0.05g, alexin 0.05g, menthol 0.04g, kaolin 23g, salicylic acid 0.05g, magnesium carbonate adds to 100g.
Preparation method containing biological peptide combinations foot-powder described in the present embodiment is with embodiment 1.
Embodiment 3：A kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, it is prepared from by the following each component of weight：Cornstarch
38g, cecropin 0.125g, alexin 0.375g, menthol 0.06g, kaolin 27g, salicylic acid 0.15g, magnesium carbonate is added to
100g。
The preparation method of the foot-powder containing biological peptide combinations described in the present embodiment is with embodiment 1.Embodiment 4：One kind is containing life
The foot-powder of thing peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, it is prepared from by the following each component of weight：Converted starch
30g, cecropin 0.05g, menthol 0.03g, kaolin 20g, salicylic acid 0.03g, magnesium carbonate adds to 100g.
The preparation method of the foot-powder containing biological peptide combinations described in the present embodiment, comprises the following steps：
(1) magnesium carbonate of converted starch, menthol, kaolin, salicylic acid and 20% (w/w) is mixed；
(2) cecropin and remaining magnesium carbonate, freeze-drying after stirring are added in the mixture for obtaining step (1)；
(3) the dried mixture grinding of step (2) is sieved, obtains final product the foot-powder containing biological peptide combinations.
Embodiment 5：A kind of foot-powder containing biological peptide combinations
Containing biological peptide combinations foot-powder described in the present embodiment, it is prepared from by the following each component of weight：Cornstarch
40g, Xenopus laevis element 0.09g, alexin 0.10g, bacteriocin 0.15g, menthol 0.05g, kaolin 30g, salicylic acid 0.1g, carbonic acid
Magnesium adds to 100g.
The preparation method of the foot-powder containing biological peptide combinations described in the present embodiment, comprises the following steps：
(1) cornstarch, menthol, kaolin, salicylic acid and 80% (w/w) magnesium carbonate are mixed；
(2) Xenopus laevis element, alexin, bacteriocin and remaining magnesium carbonate are added in the mixture for obtaining step (1), stirring is equal
Even rear freeze-drying；
(3) the dried mixture grinding of step (2) is sieved, must both contains the foot-powder of biological peptide combinations.
Embodiment 6：A kind of foot-powder containing biological peptide combinations
Containing the foot-powder of biological peptide combinations described in the present embodiment, it is prepared from by the following each component of weight：Cornstarch
30g, converted starch 5g, Xenopus laevis element 1g, cecropin 1g, alexin 1g, bacteriocin 2g, menthol 0.5g, kaolin 25g, bigcatkin willow
Sour 3g, magnesium carbonate adds to 100g.
The preparation method of the foot-powder containing biological peptide combinations described in the present embodiment is with embodiment 5.
Further to verify the excellent properties of foot-powder of the present invention, inventor has further spread out a large amount of performance inspections to it
Test is tested, and length is limited, and the part test of part most convincingness is only exemplified by herein.
Experimental example 1：External antimycotic experiment
1st, laboratory sample
Sample 1-5 is the foot-powder of embodiment 1-5, and reference substance 1-3 is the composition and preparation method of reference implementation example 3, wherein：
Reference substance 1：It is to delete cecropin with the difference of embodiment 3, adjustment alexin is 0.5g, remaining component and weight
It is constant；
Reference substance 2：It is to delete alexin with the difference of embodiment 3, adjustment cecropin is 0.5g, remaining component and weight
It is constant；
Reference substance 3：It is to delete cecropin and alexin with the difference of embodiment 3, using the activity in CN102652717
Composition (golden cypress, Pogostemon cablin, radix jurineae, cassia twig and the tuber of stemona) common 0.5g, remaining component and weight it is constant.
2nd, experimental technique
(1) by sample 1-5 and reference substance 1-3, respectively deionized water is configured to the solution that concentration is 1mg/mL；
(2) the Candida albicans second generation fresh cultured thing of 20-25 DEG C of culture 24h, is diluted with sodium chloride injection；Wadding
Shape Epidermophyton, ulotrichy pityrosporion ovale, trichophyton gypseum and Trichophyton rubrum are with the 20-25 DEG C of culture inclined-plane culture of 7 days
Thing, is washed down culture with sodium chloride injection, shaking, filtration, microscopy meter spore count, dilution, make bacterium solution ultimate density for 1 ×
105CFU/mL, using test tube doubling dilution minimal inhibitory concentration (MIC) and MBC (MBC) are determined.
3rd, experimental result
External antimycotic experiment measures minimal inhibitory concentration (MIC) and MBC (MBC), is shown in Table 1.
Table 1：Minimal inhibitory concentration (MIC) and MBC (MBC) (μ g/mL)
It can be seen from table 1, compared with reference substance 1-3, sample 1-5 shows significant fungistatic effect, wherein sample 1-3 compared with
It is prominent, it is optimal with sample 1.
The foot-powder of the present invention has obvious antibacterial and bactericidal action to the susceptible fungi of foot, is using little amount
Antibacterial and sterilized effect is can reach, the foot-powder with embodiment 1 is optimal.
Experimental example 2：In Vitro Bacteriostasis stability test
1st, test specimen：It is identical with experimental example 1.
2nd, test method
By sample 1-5 and reference substance 1-3, respectively deionized water is configured to the solution that concentration is 1mg/mL；
Trichophyton rubrum, acrothesium floccosum and trichophyton gypseum potato dextrose agar solid medium are entered
Row activation.3 bacterial classifications distinguish 1 single bacterium colony of picking, are ground after 15min with 10mL Sterile Salines respectively, use flat-plate bacterial colony meter
Number method is determined containing after bacterium number, and regulation bacteria suspension is containing bacterium number to 1 × 105～1 × 106Cfu/mL, it is standby；
Diluted 3 kinds of bacterium solutions are respectively taken into 100 μ L, in being added to potato dextrose agar solid medium, is smeared
It is even.Then 4 filter papers (diameter 5mm) are added in each flat board, and flattens filter paper.4 wherein on each flat board
Filter paper contains respectively testing sample, blank, anphotericin (positive control), Sterile Saline (negative control).The consumption of testing sample
For 10 μ L, 3 repetitions are set to each bacterial classification.Each testing sample is carried out successively aforesaid operations to 3 kinds for examination bacterium, and carries out area
Minute mark is remembered.After testing sample is fully absorbed by filter paper, it is in microbiological incubator 7 to overturn and be put into 28 DEG C culture dish
Observation and determination experiment result after it, the experimental result of each testing sample takes the mean value of 3 repetitions.
Detection time is 0 month, 3 months, 6 months, 12 months, and preservation condition is：Sealed with vial, indoor shady place
It is conventional to place, it is not placed in direct projection under sunlight.
3rd, In Vitro Bacteriostasis stability test result
3.1 Bactericidal test criterions：
Antibacterial circle diameter is more than 20mm：It is extremely quick；15～20mm：Gao Min；10～15mm：In it is quick；7～10mm：Muting sensitive；It is less than
7mm：It is insensitive.
3.2nd, the average inhibition zone of 0 month extracorporeal bacteria inhibitor test, is shown in Table 2.
Table 2：The average inhibition zone (mm) of 0 month extracorporeal bacteria inhibitor test
It can be seen from table 2, compared with reference substance 1-3, the fungistatic effect of sample 1-5 significantly, is extremely quick to three bacterial classifications.
The inhibition of sample 1-3 is projected, optimal with sample 1.
3.3rd, the average inhibition zone of 6 months extracorporeal bacteria inhibitor tests, is shown in Table 3.
Table 3：The average inhibition zone (mm) of 6 months extracorporeal bacteria inhibitor tests
It can be seen from table 3, compared with reference substance 1-3, the fungistatic effect of sample 1-5 is good, is partly pole to three bacterial classifications
Quick, remaining is Gao Min.The inhibition of sample 1-3 is projected, optimal with sample 1.
3.4th, the average inhibition zone of 12 months extracorporeal bacteria inhibitor tests, is shown in Table 4.
Table 4：The average inhibition zone (mm) of 12 months extracorporeal bacteria inhibitor tests
It can be seen from table 4, compared with reference substance 1-3, sample 1-5 with certain fungistatic effect, partly to three bacterium
It is extremely quick to plant, and remaining is Gao Min.The inhibition of sample 1-3 is projected, optimal with sample 1.
3.5th, the average inhibition zone of 18 months extracorporeal bacteria inhibitor tests, is shown in Table 5.
Table 5：The average inhibition zone (mm) of 18 months extracorporeal bacteria inhibitor tests
It can be seen from table 5, compared with reference substance 1-3, sample 1-5 with certain fungistatic effect, the suppression of sample 1-3
Effect is projected, optimal with sample 1, is extremely quick to 3 bacterial classifications.
To sum up analysis understands that the foot-powder of the present invention is notable to the fungistatic effect of 3 bacterial classifications, and the foot-powder of wherein embodiment 1 exists
The fungistatic effect of 0-18 month preferably, and is stablized.
Experimental example 3：Clinical testing
1st, clinical data
198 tinea pedis and dermatitis patients are selected, men and women is each 99, average age is 29 years old, max age 75 years old, minimal ages
22 years old.It is randomly divided into 9 experimental groups.
2nd, test specimen：With experimental example 1.
2nd, treatment method
Each experimental group uses a kind of different testing sample, soaking therapy.Daily immersion 1 time, treats test sample with 5g every time
Product are dissolved in 37～40 DEG C of water, are soaked half an hour every time, and two weeks is a course for the treatment of.
3rd, treatment results
3.1st, standard is treated：
Clinical recovery：Mycology examination is negative at skin damaged, and skin lesion disappears；
It is effective：Fungus examination is turned out cloudy at skin damaged, skin lesion regression 80%；
Effectively：Fungus examination is turned out cloudy at skin damaged, skin lesion regression 60%；
It is invalid：Fungus examination is positive at skin damaged, skin lesion regression less than 30% or it is counter see increase.Treatment fore-and-aft observing note
Various skin damaged situation and bad reaction are recorded, coating position should discontinue medication if any burning sensation, itch, redness etc..
3.2nd, treatment results, are shown in Table 6.
Table 6:Clinical treatment outcome (%)
It can be seen from table 6, compared with reference substance 1-3, significantly, sample 1-3's clinical therapeutic efficacy of sample 1-5 relatively dashes forward
Go out, it is optimal with sample 1.The foot-powder of the present invention is treated, and embodiment 1 is optimal.
Although above with a general description of the specific embodiments the present invention is described in detail,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, without departing from theon the basis of the spirit of the present invention these modifications or improvements, belong to the scope of protection of present invention.
Claims (3)
1. a kind of foot-powder containing biological peptide combinations, it is characterised in that：It is prepared from by following each component by weight：
It is 1 that the biological peptide combinations are weight ratio:The cecropin of 1-3 and alexinic mixture.
2. the foot-powder containing biological peptide combinations according to claim 1, it is characterised in that following each by by weight
Component is prepared from：
3. the preparation method of the foot-powder containing biological peptide combinations any one of claim 1 to 2, it is characterised in that bag
Containing following steps:
(1) magnesium carbonate of the starch component of proportional quantity, menthol, kaolin, salicylic acid and 20-80% proportional quantities is mixed
With；
(2) the biological peptide combinations and remaining magnesium carbonate of proportional quantity are added in the mixture for obtaining step (1), after stirring
Freeze-drying；
(3) the dried mixture grinding of step (2) is sieved, is obtained final product containing biological peptide combinations foot-powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410759445.8A CN104436164B (en) | 2014-12-10 | 2014-12-10 | Foot powder containing biologic peptide composition, as well as preparation thereof |
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|---|---|---|---|
| CN201410759445.8A CN104436164B (en) | 2014-12-10 | 2014-12-10 | Foot powder containing biologic peptide composition, as well as preparation thereof |
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| CN104436164B true CN104436164B (en) | 2017-05-03 |
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| CN106726957A (en) * | 2016-12-23 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of deodorant antibacterial foot-powder and preparation method thereof |
| CN106619519A (en) * | 2016-12-24 | 2017-05-10 | 叶宗瑞 | Bacteriostatic foot powder and preparation method thereof |
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| CN100360016C (en) * | 2003-10-16 | 2008-01-09 | 上海高科生物工程有限公司 | Foot disinfectant |
| CN101810720A (en) * | 2010-04-08 | 2010-08-25 | 徐金刚 | Skin disease external powder for comprehensively killing and inhibiting bacteria and diminishing inflammation and using method thereof to beriberi skin disease |
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