CN104435945A - 一种用于缓解癌痛的中药麻醉止痛擦剂 - Google Patents

一种用于缓解癌痛的中药麻醉止痛擦剂 Download PDF

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CN104435945A
CN104435945A CN201410614312.1A CN201410614312A CN104435945A CN 104435945 A CN104435945 A CN 104435945A CN 201410614312 A CN201410614312 A CN 201410614312A CN 104435945 A CN104435945 A CN 104435945A
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Abstract

本发明公开了一种用于缓解癌痛的中药麻醉止痛擦剂。根据中医中药止痛理论，本发明选择具有行气活血化瘀的中药金牛草、姜叶三七、云雾七、观音苋根、丝瓜根、南瓜七、绵枣儿、木芙蓉叶、龙眼核、散血草，用75％酒精浸泡1周后取过滤液制成搽剂，经临床试验，轻、中、重度度疼痛缓解率分别达到96.7％、93.3％和76％，疗效显著，而且无副作用。

Description

一种用于缓解癌痛的中药麻醉止痛擦剂
技术领域
本发明涉及一种中药组合物，尤其涉及一种用于缓解癌痛的中药麻醉止痛擦剂。
背景技术
疼痛是癌症病人常见的症状，给晚期癌症患者带来极大的痛苦，严重影响了患者的心情和生活质量，癌性疼痛的治疗可以使患者摆脱抑郁，焦虑的情绪。西药治疗癌痛疗效虽然确定，但存在易成瘾，毒副作用大等缺点。中医外治法是祖国医学的重要组成部分，对治疗癌痛的具有较好的作用。中医外治法比较西药止痛具有疗效可靠，使用安全，毒副作用少，且无成瘾性和戒断性等优点，将中医外治法引入对癌痛的治疗上不但方法方便，价格低廉，而且中药外治为体表直接给药，经皮肤或粘膜表面吸收后，药力直达病所，止痛迅速有效，避免了口服药经消化道吸收所遇到的多环节灭活作用及一些内服药物带来的某些毒副作用；特别对于晚期癌症患者，正气虚弱，不耐攻伐，单靠内服药疗效不佳，中医外治法更具优势。
发明内容
本发明的目的是提供一种用于缓解癌痛的中药麻醉止痛擦剂。中医认为治疗疼痛应以行气活血化瘀法为主。
本发明的目的是通过以下技术方案实现的，该用于缓解癌痛的中药麻醉止痛擦剂由以下重量份的中药制成：金牛草10-20份、姜叶三七1-3份、云雾七3-8份、观音苋根30-50份、丝瓜根3-9份、南瓜七9-15份、绵枣儿10-15份、木芙蓉叶15-25份、龙眼核3-9份、散血草15-20份。
优选的，金牛草15份、姜叶三七2份、云雾七5份、观音苋根40份、丝瓜根6份、南瓜七12份、绵枣儿13份、木芙蓉叶20份、龙眼核6份、散血草17份。
制备方法以上药用75％酒精浸泡1周(酒精用量以没过中药为度)，过滤后将药物浓度调至每毫升含生药1g即可。
方中：金牛草活血散瘀、止痛止咳；姜叶三七活血散瘀、消肿止痛；云雾七活血止痛；观音苋根活血行气；丝瓜根活血、通经、消肿；南瓜七活血行瘀；绵枣儿消肿止痛、解毒活血；木芙蓉叶消肿止痛、凉血解毒；龙眼核止血、理气、定痛、化湿；散血草止血、消肿、散瘀。
临床资料
1、一般资料本组100例均为我院住院癌症患者，其中男60例，女40例；年龄26～84岁。癌症患者均经影像医学、实验室检查确诊。其中肺癌38例、肝癌12例、胰腺癌3例、消化道肿瘤17例、乳腺癌20例，其它部位肿瘤10例。疼痛程度参照世界卫生组织规定，轻度：为可忍受的疼痛，能正常生活和睡眠，共30例；中度：为持续剧烈疼痛，影响睡眠，需要镇静剂，共45例；重度：为强烈持续疼痛，伴被迫体位及植物神经紊乱，严重干扰生活及睡眠，共25例。
2、治疗及护理方法患者使用根本发明所述中药麻醉止痛擦剂。称取金牛草15g、姜叶三七2g、云雾七5g、观音苋根40g、丝瓜根6g、南瓜七12g、绵枣儿13g、木芙蓉叶20g、龙眼核6g、散血草17g。以上药用75％酒精浸泡1周(酒精用量以没过中药为度)，过滤后将药物浓度调至每毫升含生药1g即可。使用时首先洗净疼痛部位皮肤，棉签蘸取中药涂于痛处皮肤，用药面积应大于疼痛周边2～3cm，每日涂药3～4次，见效后可连续应用，无疗程限制，连用2日后无效者可停止使用。
4、疗效标准疗效判断分为4级，即完全缓解(CR)：完全无疼痛；明显缓解(PR)：疼痛明显减轻，或虽有痛感但不影响睡眠和正常生活；轻度缓解(MR)：疼痛减轻但仍有明显疼痛，影响睡眠；无效(NR)：治疗前后无变化。
5、治疗结果见下表。
表中结果显示，中药麻醉止痛擦剂对缓解癌痛具有显著的作用，其中对于轻中度疼痛缓解率较高，且镇痛持续时间较长。所有患者在治疗前后，呼吸、心率、脉率、血压，血，尿，粪常规，肝肾功能及心电图均无明显异常变化，观察期间均未出现不良反应。
具体实施方式
实施例一：称取金牛草15g、姜叶三七2g、云雾七5g、观音苋根40g、丝瓜根6g、南瓜七12g、绵枣儿13g、木芙蓉叶20g、龙眼核6g、散血草17g。以上药用75％酒精浸泡1周(酒精用量以没过中药为度)，过滤后将药物浓度调至每毫升含生药1g即可。
实施例二：称取金牛草20g、姜叶三七1g、云雾七8g、观音苋根30g、丝瓜根9g、南瓜七9g、绵枣儿15g、木芙蓉叶25g、龙眼核9g、散血草15g。以上药用75％酒精浸泡1周(酒精用量以没过中药为度)，过滤后将药物浓度调至每毫升含生药1g即可。
实施例三：称取金牛草10g、姜叶三七3g、云雾七3g、观音苋根50g、丝瓜根3g、南瓜七15g、绵枣儿10g、木芙蓉叶15g、龙眼核3g、散血草20g。以上药用75％酒精浸泡1周(酒精用量以没过中药为度)，过滤后将药物浓度调至每毫升含生药1g即可。

Claims (2)

1.一种用于缓解癌痛的中药麻醉止痛擦剂，其特征在于该中药麻醉止痛擦剂由以下重量份的中药制成：金牛草10-20份、姜叶三七1-3份、云雾七3-8份、观音苋根30-50份、丝瓜根3-9份、南瓜七9-15份、绵枣儿10-15份、木芙蓉叶15-25份、龙眼核3-9份、散血草15-20份。
2.如权利要求1所述的一种用于缓解癌痛的中药麻醉止痛擦剂，其特征在于该中药麻醉止痛擦剂由以下重量份的中药制成：金牛草15份、姜叶三七2份、云雾七5份、观音苋根40份、丝瓜根6份、南瓜七12份、绵枣儿13份、木芙蓉叶20份、龙眼核6份、散血草17份。
CN201410614312.1A 2014-10-28 2014-10-28 一种用于缓解癌痛的中药麻醉止痛擦剂 Pending CN104435945A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106190140A (zh) * 2016-06-30 2016-12-07 山东胜伟园林科技有限公司 一种含金牛草的抗盐碱组合物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101926911A (zh) * 2010-09-03 2010-12-29 杜江 一种止痛的中药组合物及其制备方法
CN102580000A (zh) * 2012-03-21 2012-07-18 山东省千佛山医院 一种治疗癌性疼痛药物及其制备方法
CN102824595A (zh) * 2011-06-13 2012-12-19 张金清 一种治疗癌症疼痛的中药组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101926911A (zh) * 2010-09-03 2010-12-29 杜江 一种止痛的中药组合物及其制备方法
CN102824595A (zh) * 2011-06-13 2012-12-19 张金清 一种治疗癌症疼痛的中药组合物
CN102580000A (zh) * 2012-03-21 2012-07-18 山东省千佛山医院 一种治疗癌性疼痛药物及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106190140A (zh) * 2016-06-30 2016-12-07 山东胜伟园林科技有限公司 一种含金牛草的抗盐碱组合物及其制备方法

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Application publication date: 20150325