CN104435890A - Traditional Chinese medicine composition for treating hepatic calculus - Google Patents
Traditional Chinese medicine composition for treating hepatic calculus Download PDFInfo
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Abstract
The invention relates to the field of application of traditional Chinese medicines and particularly relates to a traditional Chinese medicine composition for treating hepatic calculus. The traditional Chinese medicine composition for treating hepatic calculus is prepared by mixing the following twenty Chinese herbal medicines which are taken as the raw materials in a certain weight proportion: brandisia herb, desmodium styracifolium, glechoma hedracea, clerodendranthus spicatus, corydalis amabilis, trogopterus dung, frankincense, sedum sarmentosum, juncus roemerianus, semen nigellae, capillary artemisia and the like. The traditional Chinese medicine composition provided by the invention is simple to prepare, good in absorption effect, long in duration of effect, remarkable in curative effect, free of side effects, high in safety and low in production cost, thereby facilitating immediate reduction of symptoms of the disease.
Description
(1) technical field
The present invention relates to application in TCM field, particularly a kind of Chinese medicine composition for the treatment of liver and bile stone.
(2) background technology
Cholelithiasis is the common disease in one way of life, academicly become " cholelithiasis ", he is modal rank in biliary system, comprise cholelithiasis, duct ligation stone in choledocholithiasis and liver and gall, its morbidity often with cholestasis, cholesterol metabolism as following complication can be there is after common bile duct: jaundice, cholangitis and pancreatitis etc.; Major part patient can without any symptom, or unconjugated bilirubin relatively increases in bile.Calculus is caused by colloid in body and crystal metabolic dysequilibrium, and the factors such as, urinary system foreign body disorderly with infection, Nutrition and Metabolism and geography and climate are relevant.Male's trouble this disease easier than women.This disease is more easily suffered from than youngster over the people of 30 years old.It is rarer to there is this disease in child.Can cause violent renal colic in calculus discharge process, pain may continue several days.When calculus is less, non-evident sympton performance, only just can find when clapping X-ray film.Can occur when calculus is larger being with blood etc. in homonymy lumbago, renal colic, urine.Renal calculus also can be stuck in ureter once in a while, blocks the urine stream of side.Renal calculus complication is acute pyelonephritis, and severe patient causes chronic renal failure.The relapse rate of renal calculus is higher, changes growth and morbidity that living habit could prevent and reduce calculus.
(3) summary of the invention
The present invention, in order to make up the deficiencies in the prior art, provides a kind of Chinese medicine preparing treatment liver and bile stone simple, evident in efficacy.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for liver and bile stone, be made up of the raw material of following parts by weight:
Treating stranguria careless 10-25 part, Herba Desmodii Styracifolii 11-26 part, Herba Glechomae 10-23 part, kidney tea 11-25 part, Rhizoma Corydalis Decumbentis 11-26 part, Oletum Trogopterori 12-26 part, Olibanum 10-24 part, Herba Sedi 11-26 part, Medulla Junci 10-23 part, Semen Nigellae 10-24 part, Polyporus 10-27 part, Endothelium Corneum Gigeriae Galli 12-27 part, Semen Hoveniae (Fructus Hoveniae) 11-27 part, Semen Coicis 10-26 part Rhizoma Dioscoreae Septemlobae 10-24 part, Caulis Clematidis Armandii 10-26 part, Flos Chrysanthemi Indici 11-26 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10-23 part, Bulbus Allii Macrostemonis 11-24 part, Herba Artemisiae Scopariae 10-26 part.
The weight proportion of its preferred each raw material is:
Treating stranguria careless 10 parts, Herba Desmodii Styracifolii 11 parts, Herba Glechomae 10 parts, kidney tea 11 parts, Rhizoma Corydalis Decumbentis 11 parts, Oletum Trogopterori 12 parts, Olibanum 10 parts, Herba Sedi 11 parts, Medulla Junci 10 parts, Semen Nigellae 10 parts, Polyporus 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Semen Hoveniae (Fructus Hoveniae) 11 parts, Semen Coicis 10 parts of Rhizoma Dioscoreae Septemlobaes 10 parts, Caulis Clematidis Armandii 10 parts, Flos Chrysanthemi Indici 11 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Bulbus Allii Macrostemonis 11 parts, Herba Artemisiae Scopariae 10 parts.
Chinese medicine of the present invention is powder or pill, after being cleaned up by various raw material, plays powder mixing, makes powder or pill, quantitatively take.
The pharmaceutical characteristic of each raw material is as follows:
Treating stranguria grass: lithodialysis, calculus, anti-inflammatory analgesic, heat-clearing and toxic substances removing, anti-inflammatory analgetic, fossil, diuresis of blood circulation promoting, controls stranguria caused by urinary stone, urinary tract infection.
Herba Desmodii Styracifolii: dampness removing jaundice eliminating, inducing diuresis for treating stranguria syndrome, for jaundice dark coloured urine, pyretic stranguria, stranguria caused by urinary stone, the puckery disease of urine, edema oliguria.
Herba Glechomae: dampness removing is treating stranguria, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, for pyretic stranguria, stranguria caused by urinary stone, jaundice due to damp-heat, sore, carbuncle and painful swelling, traumatic injury.
Kidney tea: clearing heat and removing internal wetness, calculus diuretic.Control acute nephritis, cystitis, lithangiuria, rheumatic arthritis.
Rhizoma Corydalis Decumbentis: promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, for apoplectic hemiplegia, headache, injury from falling down, rheumatic arthralgia, lumbago and skelalgia.
Oletum Trogopterori: promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Herba Sedi: dampness removing jaundice eliminating, heat-clearing and toxic substances removing.For jaundice due to damp-heat, dysuria, carbuncle skin infection.
Medulla Junci: clearing heart fire, inducing diuresis for treating stranguria syndrome.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.Control gonorrhea, edema, dysuria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, wound.
Semen Nigellae: conditioning stomach-fire, aid digestion, teeth consolidating.Cure mainly dyspepsia, hepatalgia, liver function fails.Promoting blood circulation to restore menstrual flow; Diuresis and expelling stone; Kidney-tonifying and brain tonic.Cure mainly menoxenia; Amenorrhea; Breast is few; Edema; Lithangiuria; Dizziness and tinnitus; Early whitening of beard and hair; Cough with asthma; Scabies; Vitiligo
Polyporus: promoting diuresis to eliminate damp pathogen.Control dysuria, edema, to have loose bowels, stranguria with turbid discharge, leukorrhagia.
Endothelium Corneum Gigeriae Galli: property is sweet puts down, be slightly cold, nontoxic, returns spleen, stomach, kidney, urinary bladder channel.Can promoting digestion and invigorating the stomach, arresting seminal emission.Cure mainly removing food stagnancy stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Semen Hoveniae (Fructus Hoveniae): control drunk, dysphoria with smothery sensation, thirsty, vomiting, difficulty in urination and defecation.
Semen Coicis: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Rhizoma Dioscoreae Septemlobae: wind-damp dispelling; Dampness removing is turbid; Detumescence poison.Main air pain of dampness syndrome; Soreness of waist and knee joint; Turbid urine; Drench drop; Leucorrhea.
Caulis Clematidis Armandii: cure mainly hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Interior without damp and hot, body fluid deficiency, gas is weak, and essence is sliding.
Flos Chrysanthemi Indici: fever caused by exogenous pathogens, laryngopharynx swelling and pain, cough expectorant is yellow, wind-fire acute conjunctivitis, sore swollen toxin, the diseases such as skin pruritus.
Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): antitussive, eliminate the phlegm, antiasthmatic effect: stimulate mice to cause the method for coughing and show with ammonia mist, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) acid alcohol extract 112, flavonoid glycoside, total acid phenol, total alkaloids, crystallization (I) and Saponin, all there is certain antitussive action, wherein the antitussive action similar intensity of flavonoid glycoside (2.5mg/ only) and codeine (0.4mg/ only); It act as and directly suppresses coughing centre.Prove that acid alcohol extract 112, flavonoid glycoside, total acid phenol, alkaloid and crystallization (I) all have certain phlegm-dispelling functions by the phenol red method of mice; It act as directly stimulates respiratory mucosa secretory cell, secretion is increased, to expectorant inner acidic mucopolysaccharide fiber, also there is certain dissolution, and have the effect reducing capillary permeability, the permeability of trachea when illustrating that its flavonoid glycoside can reduce inflammation, thus play antiinflammatory phlegm-dispelling functions.Acid alcohol extract, flavonoid glycoside and alkaloid have antiasthmatic effect in various degree to experimental animal models asthma, and wherein the flavonoid glycoside of 250mg/kg equals the antiasthmatic effect of 125mg/kg aminophylline; Antiasthmatic effect is due to direct expansion bronchus smooth muscle and has caused by stronger anti-infectious function.Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) effective ingredient luteolin 250mg/kg gavage, 25mg/kg lumbar injection, draw ammonia mist and cough mice and all have antitussive effect, 30mg/kg intravenous injection, stimulates superior laryngeal nerve to draw to cough and also have inhibitory action to anesthetized cat; 100mg/kg gavage, shows there is phlegm-dispelling functions to mice PSP method, 100mg/kg intravenous injection, and the bronchial smooth muscle that can cause antihistamine shrinks.2. antiinflammatory immunity function: luteolin intramuscular injection, the mouse ear inflammation that xylol causes has obvious inhibitory action, and its ED50 is 106mg/kg.Luteolin 80,160mg/kg intramuscular injection, on Carrageenan, the rat ankle joint that yeast brings out is swollen, and swollen and Oleum Tiglii brings out has rat granuloma all to have obvious inhibitory action, but 30,60mg/kg intramuscular injection, continuous 30 days, can increase the sickness rate of the experimental allergic encephalomyelitis of Cavia porcellus, prompting has immunological enhancement.Luteolin 80,120,160mg/kg intramuscular injection, the rat pleural that Dichlorodiphenyl Acetate brings out is scorching, and its transudate can be made to reduce, and to total white blood cells in transudate without obvious change.Luteolin 180mg/kg gavage, generates normal mouse hemolytic antibody and special red rose pigment rate has no significant effect, but improves the immunologic function of cyclophosphamide suppression rabbit epidemic disease mice, and these two indexs are all improved.When luteolin final concentration is 1.09 × 10-4mol/L, can suppress sensitized guinea pig isolated ileal rings anaphylaxis contractile response, shrink the guinea pig ileum that SRS-A causes, also have inhibitory action, its IC50 is 2.76 × 10-5mol/L.Luteolin 4 × 10-4 concentration also has inhibitory action to egg protein sensitized guinea pig lung rat tissue release histamine and SRS-A.3. antibacterial, antivirus action: alcohol-ether extract has inhibitory action to alpha streptococcus, staphylococcus aureus, streptococcus pneumoniae, escherichia coli and bacillus pyocyaneus; Flavonoid glycoside (10mg/ml) all has inhibitory action to staphylococcus glucose coccus, alpha streptococcus, micrococcus catarrhalis and streptococcus pneumoniae; 10% Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) preserved material, 10% coated tablet and flavone all have the effect suppressing 68-1 influenza virus in obvious Embryo Gallus domesticus.Luteolin 10mg/ml has inhibitory action to staphylococcus aureus, α-hemolytic streptococcus, micrococcus catarrhalis, streptococcus pneumoniae, bacillus pyocyaneus, 700mg/kg gavage, has anti-infectious function, obviously reduce mortality rate to the mice infecting staphylococcus aureus.
Bulbus Allii Macrostemonis: regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice; Dysuria; Eczema pruritus etc. the effects such as pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating.
Clinical observation:
(1) clinical data
The present inventor treated 249 examples altogether in 2012, patient age 22 ~ 74 years old, men and women Bi Lie 4.5: 1. wherein renal calculus 103 is routine, calculus of urethra 75 example, cholelithiasis 59 example, hematuria patient 12 example.
(2) Therapeutic Method
Oral, three times on the one, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 ~ 15 day, and severe case serve on 60 ~ 90 days and can fully recover.
(3) curative effect determinate standard
1. clinical cure: ultrasonic examination calculi in vivo disappears.
2. effectively clinical: calculus volume-diminished.
3. clinical invalid: calculus volume is without change or increase.
4. invalid: clinical symptoms is without being clearly better or increasing the weight of.
(4) clinical effectiveness
1 day ~ 3 months course for the treatment of, treatment after ultrasound diagnosis find, through control a cycle be cured 73 example, through control two cycles be cured 107 example, through control 4 cycles be cured 41 example.Invalid 21 examples, midway stops treatment 7 example.Effective percentage 91%.Treatment terminates return visit in two years, and no case was recurrence.
The present invention prepares simply, good absorbing effect, and duration of efficacy is long, evident in efficacy, has no side effect, and safety is high, and production cost is low, is conducive to sufferer and alleviates condition of illness in time.
(4) detailed description of the invention
Embodiment 1:
Get treating stranguria careless 10g, Herba Desmodii Styracifolii 11g, Herba Glechomae 10g, kidney tea 11g, Rhizoma Corydalis Decumbentis 11g, Oletum Trogopterori 12g, Olibanum 10g, Herba Sedi 11g, Medulla Junci 10g, Semen Nigellae 10g, Polyporus 10g, Endothelium Corneum Gigeriae Galli 12g, Semen Hoveniae (Fructus Hoveniae) 11g, Semen Coicis 10g, Rhizoma Dioscoreae Septemlobae 10g, Caulis Clematidis Armandii 10g, Flos Chrysanthemi Indici 11g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10g, Bulbus Allii Macrostemonis 11g, Herba Artemisiae Scopariae 10g, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 2:
Get treating stranguria 25g, Herba Desmodii Styracifolii 26g, Herba Glechomae 23g, kidney tea 25g, Rhizoma Corydalis Decumbentis 26g, Oletum Trogopterori 26g, Olibanum 24g, Herba Sedi 26g, Medulla Junci 23g, Semen Nigellae 24g, Polyporus 27g, Endothelium Corneum Gigeriae Galli 27g, Semen Hoveniae (Fructus Hoveniae) 27g, Semen Coicis 26g, Rhizoma Dioscoreae Septemlobae 24g, Caulis Clematidis Armandii 26g, Flos Chrysanthemi Indici 26g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 23g, Bulbus Allii Macrostemonis 24g, Herba Artemisiae Scopariae 26g, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 3:
Get treating stranguria careless 18g, Herba Desmodii Styracifolii 18g, Herba Glechomae 19g, kidney tea 17g, Rhizoma Corydalis Decumbentis 18g, Oletum Trogopterori 18g, Olibanum 17g, Herba Sedi 17g, Medulla Junci 16g, Semen Nigellae 16g, Polyporus 18g, Endothelium Corneum Gigeriae Galli 18g, Semen Hoveniae (Fructus Hoveniae) 18g, Semen Coicis 17g, Rhizoma Dioscoreae Septemlobae 16g, Caulis Clematidis Armandii 14g, Flos Chrysanthemi Indici 13g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g, Bulbus Allii Macrostemonis 16g, Herba Artemisiae Scopariae 18g, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Claims (3)
1. treat the Chinese medicine composition of liver and bile stone for one kind, it is characterized by, be made up of the raw material of following parts by weight: treating stranguria careless 10-25 part, Herba Desmodii Styracifolii 11-26 part, Herba Glechomae 10-23 part, kidney tea 11-25 part, Rhizoma Corydalis Decumbentis 11-26 part, Oletum Trogopterori 12-26 part, Olibanum 10-24 part, Herba Sedi 11-26 part, Medulla Junci 10-23 part, Semen Nigellae 10-24 part, Polyporus 10-27 part, Endothelium Corneum Gigeriae Galli 12-27 part, Semen Hoveniae (Fructus Hoveniae) 11-27 part, Semen Coicis 10-26 part, Rhizoma Dioscoreae Septemlobae 10-24 part, Caulis Clematidis Armandii 10-26 part, Flos Chrysanthemi Indici 11-26 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10-23 part, Bulbus Allii Macrostemonis 11-24 part, Herba Artemisiae Scopariae 10-26 part.
2. the Chinese medicine for the treatment of liver and bile stone according to claim 1, is characterized by, and is made up of the raw material of following parts by weight: treating stranguria careless 10 parts, Herba Desmodii Styracifolii 11 parts, Herba Glechomae 10 parts, kidney tea 11 parts, Rhizoma Corydalis Decumbentis 11 parts, Oletum Trogopterori 12 parts, Olibanum 10 parts, Herba Sedi 11 parts, Medulla Junci 10 parts, Semen Nigellae 10 parts, Polyporus 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Semen Hoveniae (Fructus Hoveniae) 11 parts, Semen Coicis 10 parts of Rhizoma Dioscoreae Septemlobaes 10 parts, Caulis Clematidis Armandii 10 parts, Flos Chrysanthemi Indici 11 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Bulbus Allii Macrostemonis 11 parts, Herba Artemisiae Scopariae 10 parts.
3. the Chinese medicine for the treatment of liver and bile stone according to claim 1 and 2, is characterized in that: described Chinese medicine is powder or pill.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940837A (en) * | 2015-07-15 | 2015-09-30 | 龚灿锋 | Traditional Chinese medicine for treating gall-stone |
| CN104940729A (en) * | 2015-07-10 | 2015-09-30 | 唐芳勇 | Traditional Chinese medicine for treating cholelithiasis |
| CN105106733A (en) * | 2015-09-30 | 2015-12-02 | 吴淑芬 | Traditional Chinese medicinal composition for treating gallstone |
| CN105232819A (en) * | 2015-11-10 | 2016-01-13 | 云晓静 | Traditional Chinese medicine for treating hepatic calculus |
| CN105456392A (en) * | 2016-01-14 | 2016-04-06 | 隆守惠 | Composition for preventing and treating liver diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1357342A (en) * | 2000-12-07 | 2002-07-10 | 王跃辉 | Nephrolithiasis treating medicine |
| CN103566238A (en) * | 2012-07-24 | 2014-02-12 | 蔡义和 | Traditional Chinese medicine stone removing pill for treating stones |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940729A (en) * | 2015-07-10 | 2015-09-30 | 唐芳勇 | Traditional Chinese medicine for treating cholelithiasis |
| CN104940837A (en) * | 2015-07-15 | 2015-09-30 | 龚灿锋 | Traditional Chinese medicine for treating gall-stone |
| CN105106733A (en) * | 2015-09-30 | 2015-12-02 | 吴淑芬 | Traditional Chinese medicinal composition for treating gallstone |
| CN105232819A (en) * | 2015-11-10 | 2016-01-13 | 云晓静 | Traditional Chinese medicine for treating hepatic calculus |
| CN105456392A (en) * | 2016-01-14 | 2016-04-06 | 隆守惠 | Composition for preventing and treating liver diseases |
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