CN104435682A - Traditional Chinese medicine for treating convalescent viral myocarditis - Google Patents
Traditional Chinese medicine for treating convalescent viral myocarditis Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Abstract
The invention relates to a traditional Chinese medicine for treating convalescent viral myocarditis. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 10 parts of radix glehniae, 8 parts of codonopsis pilosula, 6 parts of saussurea involucrata, 8 parts of herba leonuri, 6 parts of lotus seed cores, 15 parts of magnetite, 9 parts of radix isatidis, 6 parts of radix ophiopogonis, and 3 parts of raw licorice. Proved by clinical experiments, the traditional Chinese medicine disclosed by the invention can safely and effectively treat the convalescent viral myocarditis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to one and be used for the treatment of the convalescent Chinese medicine of viral myocarditis.
Background technology
Definition
Viral myocarditis convalescent period, precordial pain, felt oppressed in ambition, pale complexion, inability to breathe regularly due to shortness of breath, and weak grade is main clinical manifestation, relevant to traditional Chinese medical science various diseases usually with cardiopalmus.Though record without special in traditional Chinese medical science ancient medical book, there is the description with primary disease similar symptoms.As namely there being the description of " heart fright with palpitation like feeling of being arrested " in Huangdi's Internal Classics, and proposing this disease with abnormal weather, experiencing six climate exopathogens pathogenic factor closely related.
The cause of disease
Endogenous cause of ill: ferritic healthy energy virtual loss, exopathogenic factor: the evil invasion and attack of warm poison.The traditional Chinese medical science is thought, except exopathogen, deficiency of vital QI is that important or even main aspect occurs primary disease, i.e. being invaded by exogenous pathogen and falling ill again on weakened body resistance basis.Deficiency of vital QI or by innate deficiency, or because of overstrain, consumption is hindered caused by healthy energy.Have in Huangdi's Internal Classics " healthy energy deposit in, heresy can not be done ", " gathering of heresy, its gas must be empty ", discussions such as " BI-syndrome involved the blood vessels endlessly, feel exopathogen again, inside gives up in the heart ", all illustrate weakened body resistance body easily attack by pathogen, give up in evil poison and then can send out as primary disease in the heart.
Symptom
Pathologic through acute stage enters people's convalescent period, and the heresy of remaining pyretic toxicity continues to burn and damages battalion's the moon, can cause the impairment of both QI and YIN of the heart.The motive is impaired, and sun loses and rouses oneself, and gasification dereliction of duty, can cause palpitation with a distress feeling uneasiness.The heart-yin consumption wound, heart arteries and veins loses supports, and the moon sun not processed, can cause palpitation and uneasiness.Disease sees shortness of breath and palpitation, feeling of oppression and pain in the chest, and xerostomia is weak, the few tongue of red tongue, thready and rapid pulse.
Medical material present Research involved in the present invention is as follows:
Radix Glehniae: [source] this product is the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Summer, Qiu Erji excavate, and removing fibrous root, cleans, slightly dry in the air, and put after scalding in boiling water, and removing crust is dry.Or clean convection drying.[nature and flavor] sweet, micro-hardship, is slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.For lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound is thirsty.[usage and dosage] 4.5 ~ 9g.[attention] should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.
Radix Codonopsis: [source] this product is the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Autumn excavates, and cleans, dries.[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.[usage and dosage] 9 ~ 30g.[attention] should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.
Herba Saussureae Involueratae: [source] Compositae Genus Saussurea plant Saussurea laniceps Saussurea laniceps Hand.-Mazz. and Saussurea eriocephala S. eriocephala Franch, is used as medicine with whole herb with root.Summer gathers, and Herb pulls up, and trembles clean silt, dries.[nature and flavor] sweet, micro-hardship, temperature.[function cures mainly] kidney invigorating and YANG supporting, regulating menstruation, hemostasis.For snow blindness, toothache, rheumatic arthritis, sexual impotence, menoxenia, metrorrhagia, leucorrhea; Wound hemorrhage is controlled in external.[usage and dosage] 3 ~ 5 money; Suitable amount used externally, fresh herb mashes deposited affected part.
Herba Leonuri: [source] this product is the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Fresh goods Seedling Stage in spring is tapped to first summer flower early stage; Dry product stem and leaf in summer is luxuriant, Hua Weikai or tap when just opening, and dry, or cutting is dried.[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.[usage and dosage] 9 ~ 30g; Fresh goods 12 ~ 40g.[attention] anemia of pregnant woman is forbidden.
Embryo nelumbinis: [source] this product is the green radicle (Plumula Nelumbinis) in the middle of the mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..Take out, dry.[nature and flavor] are bitter, cold.[return through] GUIXIN, kidney channel.[function cures mainly] clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.For heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood is spitted blood.[usage and dosage] 2 ~ 5g.
Magnetitum: [source] this product is oxide-based mineral spinelle race magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).After excavating, except roguing stone.[nature and flavor] are salty, cold.[return through] returns liver, the heart, kidney channel.[function cures mainly] suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.For having a dizzy spell, blurring of vision, Hiccough and deaf, palpitation with fear insomnia, asthma of suffering from a deficiency of the kidney.[usage and dosage] 9 ~ 30g, is decocted first.
Radix Isatidis: [source] this product is the dry root of cruciferae isatis Isatis indigotica Fort..Autumn excavates, and removing silt, dries.[nature and flavor] are bitter, cold.[return through] GUIXIN, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.[usage and dosage] 9 ~ 15g.
Radix Ophiopogonis: [source] this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Summer excavates, and cleans, is repeatedly exposed to the sun, banks up, to doing very likely, and removing fibrous root, dry.[nature and flavor] are sweet, and micro-hardship, is slightly cold.[return through] GUIXIN, lung, stomach warp.[function cures mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.[usage and dosage] 6 ~ 12g.
Radix Glycyrrhizae: [source] this product is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and removing fibrous root, dries.Nature and flavor] sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.[usage and dosage] 1.5 ~ 9g.[attention] should not with Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui with using.
Summary of the invention
The present invention aims to provide one and is used for the treatment of the convalescent Chinese medicine of viral myocarditis, by selecting suitable medical material and proportioning thereof, reaches the safe and effective object being applied to viral myocarditis convalescent care.
In order to achieve the above object, the present invention is by the following technical solutions:
One is used for the treatment of the convalescent Chinese medicine of viral myocarditis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Glehniae 10 parts, Radix Codonopsis 8 parts, Herba Saussureae Involueratae 6 parts, Herba Leonuri 8 parts, embryo nelumbinis 6 parts, Magnetitum 15 parts, Radix Isatidis 9 parts, Radix Ophiopogonis 6 parts, Radix Glycyrrhizae 3 parts.
Inventor thinks that the viral myocarditis cause of disease is positive QI-insufficiency, and the heart invaded in an opponent's defence by warm evil poison is primary disease morbidity main cause, and blood stasis, expectorant are turbid be pathological product in pathological process, and consumption impairment of QI is cloudy, and blood vessels retardance is main pathological change; Viral myocarditis convalescent period pathogenesis is deficiency of both QI and YIN, and residual poison is most, therefore assembly is our.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Outpatient service is collected and viral myocarditis reconvalescent 254 example of being in hospital altogether in inventor in July, 2010 ~ 2013 between year March, be divided into treatment group 127 example and matched group 127 example at random, treatment group man 67 example, female 60 example, 15.5 ~ 50.6 years old age, 22.5 years old mean age, the course of disease 1 ~ 3 year; Matched group man 69 example, female 58 example, 15.1 ~ 48.8 years old age, 21.3 years old mean age, the course of disease 1 ~ 3 year.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.4 weeks courses for the treatment of.
Matched group oral vitamin C, inosine (VITAMIN C TABLET by Tag pharmaceutcal corporation, Ltd of Heilongjiang Province produce, lot number: 20030504, every sheet 0.05g, every bag of 0.1g; Inosine tablets is produced by Shanghai modern Ha Sen pharmaceutcal corporation, Ltd, lot number: 05090302, every sheet 0.1, and every bag of 0.1g takes according to its description).4 weeks courses for the treatment of.
3, therapeutic outcome
Diagnostic criteria
Cure: clinical symptoms, sign disappear, the every inspection of the laboratorys such as electrocardiogram myocardium enzyme recovers normal;
Effective: the every inspections of laboratory such as clinical symptoms, sign disappear substantially, electrocardiogram myocardium enzyme recover normal substantially:
Effective: the every inspections of laboratory such as clinical symptoms, sign make moderate progress, electrocardiogram myocardium enzyme have certain improvement:
Invalid: clinical symptoms, sign and lab testing are all without improvement.
Therapeutic outcome is in table 1.
Table 1 liang group comparitive study
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) | Serious adverse reaction example |
| Treatment group | 127 | 61 | 34 | 27 | 5 | 96.1% | 0 |
| Matched group | 127 | 31 | 43 | 22 | 31 | 75.6% | 0 |
Compare with matched group,
*p<0.05.
Visible, the medicine that the present invention obtains can safe and effective treatment viral myocarditis convalescent period, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Radix Glehniae 10 grams, Radix Codonopsis 8 parts, Herba Saussureae Involueratae 6 grams, Herba Leonuri 8 grams, embryo nelumbinis 6 grams, Magnetitum 15 grams, Radix Isatidis 9 grams, Radix Ophiopogonis 6 grams, Radix Glycyrrhizae 3 grams; First Magnetitum is added 6 times of water gagings, decoct 1 hour, filter; Filtering residue and all the other 8 herbal medicines add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of viral myocarditis convalescent period.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: Radix Glehniae 10 grams, Radix Codonopsis 8 parts, Herba Saussureae Involueratae 6 grams, Herba Leonuri 8 grams, embryo nelumbinis 6 grams, Magnetitum 15 grams, Radix Isatidis 9 grams, Radix Ophiopogonis 6 grams, Radix Glycyrrhizae 3 grams; First Magnetitum is added 6 times of water gagings, decoct 1 hour, filter; Filtering residue and all the other 8 herbal medicines add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of viral myocarditis convalescent period.Oral, daily once.
Specific embodiment 3
Take: Radix Glehniae 10 grams, Radix Codonopsis 8 parts, Herba Saussureae Involueratae 6 grams, Herba Leonuri 8 grams, embryo nelumbinis 6 grams, Magnetitum 15 grams, Radix Isatidis 9 grams, Radix Ophiopogonis 6 grams, Radix Glycyrrhizae 3 grams; First Magnetitum is added 6 times of water gagings, decoct 1 hour, filter; Filtering residue and all the other 8 herbal medicines add 6 times of water gagings, decoct 3 times, and each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of viral myocarditis convalescent period.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. one kind is used for the treatment of the convalescent Chinese medicine of viral myocarditis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Glehniae 10 parts, Radix Codonopsis 8 parts, Herba Saussureae Involueratae 6 parts, Herba Leonuri 8 parts, embryo nelumbinis 6 parts, Magnetitum 15 parts, Radix Isatidis 9 parts, Radix Ophiopogonis 6 parts, Radix Glycyrrhizae 3 parts.
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| CN201410677920.7A CN104435682A (en) | 2014-11-24 | 2014-11-24 | Traditional Chinese medicine for treating convalescent viral myocarditis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172656A (en) * | 1996-08-02 | 1998-02-11 | 何众 | Medicine for treating asthenia-syndrome type viral myocarditis coused by enterovirus |
| US20080167372A1 (en) * | 2005-07-22 | 2008-07-10 | The Hong Kong University Of Science And Technology | Schisandrin b preparation |
| CN101637563A (en) * | 2008-08-01 | 2010-02-03 | 上海慈济药业有限公司 | Chinese medicinal composition for treating viral myocarditis and preparation process thereof |
-
2014
- 2014-11-24 CN CN201410677920.7A patent/CN104435682A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172656A (en) * | 1996-08-02 | 1998-02-11 | 何众 | Medicine for treating asthenia-syndrome type viral myocarditis coused by enterovirus |
| US20080167372A1 (en) * | 2005-07-22 | 2008-07-10 | The Hong Kong University Of Science And Technology | Schisandrin b preparation |
| CN101637563A (en) * | 2008-08-01 | 2010-02-03 | 上海慈济药业有限公司 | Chinese medicinal composition for treating viral myocarditis and preparation process thereof |
Non-Patent Citations (4)
| Title |
|---|
| 杨爱东: "《温病学传承与现代研究》", 31 January 2013, 上海科学技术出版社 * |
| 郑克勤: "益气养阴活血法治病毒性心肌炎48例体会", 《江西中医药》 * |
| 金银生等: "中西医结合分期治疗急性病毒性心肌炎31例", 《实用中西医结合临床》 * |
| 陈凯等: "中西医结合治疗病毒性心肌炎62例", 《时珍国医国药》 * |
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Application publication date: 20150325 |