CN104434970A - Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine - Google Patents
Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine Download PDFInfo
- Publication number
- CN104434970A CN104434970A CN201410644830.8A CN201410644830A CN104434970A CN 104434970 A CN104434970 A CN 104434970A CN 201410644830 A CN201410644830 A CN 201410644830A CN 104434970 A CN104434970 A CN 104434970A
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- China
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- medicine
- sheep
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- cattle
- trematodiasis
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Abstract
The invention discloses a medicine for treating nematodosis and trematodiasis of cattle and sheep. The medicine is prepared from the following raw materials: ivermectin, copper sulfate, methylcellulose, propylene glycol and benzyl alcohol. A preferable preparation method of the medicine is used for preparing the medicine into a suspension. The expelling rate and the weight gain condition of a preferable preparation form of the medicine are obviously superior to that of the common medicine; the expelling rate reaches 100%; the medicine is free of obvious toxic and side effect and safe and reliable to take.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of cattle and sheep nematicide, trematodiasis, particularly relating to a kind of is the anthelmintic drug that primary raw material is made with compound preparation, the invention still further relates to the preparation method of this medicine.
Background technology
Animal parasite is sick by protozoon, anthelmintic and the disease of Aranea entomophagous parasite in family's carcass or caused by body surface.Ubiquity in domestic animal, in global.Based on chronic consumption process, show thin and weak, anemia, malnutrition and retarded growth etc., finally cause fertility performance to reduce.Acute not a lot ofly to see, first severe infection or can occur serious acute symptom when calling in epidemic-stricken area, serious causes death.Multiple parasitic invasion and attack can be suffered in a carcass simultaneously, and often duplicate infection.Majority has incomplete immunity.Also harm humans is healthy.
The treatment of current animal parasite adopts chemicals anthelmintic or parasite killing mostly.Conventional chemical anthelmintic drug is based on ivermectin, avilamycin, albendazole, nitroclofene, iodo-ether salicylamine etc., but above-mentioned preparation is main mainly with single preparations of ephedrine greatly, also exist that anthelmintic spectrum is narrow, anthelminthic effect is not obvious, preparation formulation is single, uses inconvenient shortcoming.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of cattle and sheep nematicide, trematodiasis, its curative effect is fast, and good effect, and the medicine of non-evident effect, the invention still further relates to the preparation method of this medicine.
The present invention is a kind of treats cattle and sheep nematicide, the medicine of trematodiasis is made up of the crude drug of following mass parts:
Ivermectin 1-3 part, copper sulfate 115-125 part, methylcellulose 6-8 part, propylene glycol 25-35 part, benzyl alcohol 9 ~ 11 parts.
The preferred mass proportioning of each crude drug of medicine of the present invention is:
Ivermectin 2 parts, 120 parts, copper sulfate, methylcellulose 7 parts, propylene glycol 30 parts, benzyl alcohol 10 parts.
Preparation method of the present invention is by propylene glycol heating for dissolving ivermectin, and add in the aqueous solution of copper sulfate, stir, add benzyl alcohol, add water to enough, methylate cellulose is stirred to evenly, makes suspension, and filter, subpackage, to obtain final product.
In prescription of the present invention, ivermectin has nematicide in endoparasite and ectoparasite particularly arthropod and body and well kills effect.
Copper sulfate is used for cattle, sheep monesiosis and haemonchiasis, propylene glycol is as the cosolvent dissolving water-fast ivermectin, benzyl alcohol is as antibacterial, methylcellulose is as suspending agent, by indissoluble for each active ingredient, add the compound recipe suspension that purified water is obtained again, be used for the treatment of the nematicide of domestic animal, acaricide and parasitic insect sick.
The present invention is that inventor combines technical experience for many years and Clinical practice experience, through repetition test, progressively improves, and finally develops a kind of parasitic medicine for the treatment of of inexpensive, convenient drug administration, anthelmintic wide spectrum.
For verifying the actual effect of medicine of the present invention, applying medicine of the present invention, to carry out clinical trial as follows:
test example
1, materials and methods
Compound ivermectin suspension, by Double Eagle Animal Pharmaceutical Co., Ltd. Shanxi's product batch number: 20140301
Ivermectin injection, by Double Eagle Animal Pharmaceutical Co., Ltd. Shanxi's product batch number: 20140501
2, experimental animal
Select that the sheep clinical manifestation of Jiexiu City, Shanxi Province Yang Chang is become thin, anemia, gastroenteritis, dysentery, edema etc., severe infections can cause death.Faecal egg inspection infects the serious sheep 100 of gastrointestinal nematode only as subjects.A sheep age in days differs, and has stud ram, ewe, young sheep, also has part pregnancy ewes.Test sheep searches for food normally.
3, test grouping
Under same rearing conditions, sample sheep is divided into 5 groups at random, often organizes 30, often organize process and refer to table one.
table one tests grouping and processing method.
4, excrement inspection
Before administration, 1d respectively organizing test sheep marking, weighing, by only gathering fresh excreta, every part takes 1g saturated saline floatation and checks gastrointestinal nematode, calculate every gram of faecal egg number (EPG), take 3g and be separated thread lungworm larva by Bel's Man method, microscopy counts, within after administration 7th ~ 8 days, respectively organizing sheep by only gathering fresh excreta, carrying out faecal egg, larva checks statistics EPG and larva number.
5, inspection is cutd open
After administration the 14th day often group cut open and kill 30 sheep, do the inspection of general helminthology respectively, collect whole polypide, identify and belong to or plant, statistics lotus borer population.
6, efficacy determination is calculated as follows: Negative rate on the egg=worm's ovum is turned out cloudy number of animals/experimental animal number; Before Redution of eggs (%)=(before anthelmintic after EPG-anthelmintic EPG)/anthelmintic; Rough anthelminthic rate (%)=(matched group lotus borer population-anthelmintic group lotus borer population)/matched group lotus borer population.
7, weightening finish and deworming rates situation
From experimental result table 2, medicine of the present invention, by the dosage of regulation, can prevent the parasitic disease of sheep effectively, each medication group and not medication group (organizing 1) average weight gain difference examine it significantly (P < 0.01), may be not good relevant with this sheep field sanitary condition.From the results of view, medicine of the present invention all significantly better than matched group, reaches 100% deworming rates at deworming rates and Gain weight.
。
Detailed description of the invention
embodiment 1
Get ivermectin 0.25 kilogram, 12.5 kilograms, copper sulfate, methylcellulose 0.8 kilogram, propylene glycol 3.5 kilograms, benzyl alcohol 1.1 kilograms, after batching, filtration, fill, be the drug suspension for the treatment of treatment livestock nematodiasis, acaricide and parasitic insect disease.
embodiment 2
Get ivermectin 0.15 kilogram, 11.5 kilograms, copper sulfate, methylcellulose 0.6 kilogram, propylene glycol 2.5 kilograms, benzyl alcohol 0.9 kilogram, after batching, filtration, fill, be the drug suspension for the treatment of treatment livestock nematodiasis, acaricide and parasitic insect disease.
embodiment 3
Get ivermectin 0.2 kilogram, 12 kilograms, copper sulfate, methylcellulose 0.7 kilogram, propylene glycol 3 kilograms, benzyl alcohol 1.0 kilograms, after batching, filtration, fill, be treatment livestock nematodiasis, acaricide and parasitic insect medicine suspension.
Claims (3)
1. treat a medicine for cattle and sheep nematicide, trematodiasis, it is characterized in that described medicine is is that raw material prepares by the Chinese herbal medicine of following quality proportioning: ivermectin 1-3 part, copper sulfate 115-125 part, methylcellulose 6-8 part, propylene glycol 25-35 part, benzyl alcohol 9 ~ 11 parts.
2. a kind of medicine for the treatment of cattle and sheep nematicide, trematodiasis according to claim 1, is characterized in that the quality proportioning of each crude drug is: ivermectin 2 parts, 120 parts, copper sulfate, methylcellulose 7 parts, propylene glycol 30 parts, benzyl alcohol 10 parts.
3. the preparation method of the medicine for the treatment of cattle and sheep nematicide according to claim 1 and 2, trematodiasis, by propylene glycol heating for dissolving ivermectin, add in the aqueous solution of copper sulfate, stir, add benzyl alcohol, add water to enough, methylate cellulose is stirred to evenly, makes suspension, filters, subpackage, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410644830.8A CN104434970A (en) | 2014-11-14 | 2014-11-14 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410644830.8A CN104434970A (en) | 2014-11-14 | 2014-11-14 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104434970A true CN104434970A (en) | 2015-03-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410644830.8A Pending CN104434970A (en) | 2014-11-14 | 2014-11-14 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Country Status (1)
| Country | Link |
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| CN (1) | CN104434970A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2613145C1 (en) * | 2016-02-25 | 2017-03-15 | Государственное научное учреждение Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии Российской академии сельскохозяйственных наук (ГНУ ВНИВИПФиТ Россельхозакадемии) | Method of cattle thelaziosis treatment |
| CN109043159A (en) * | 2018-08-24 | 2018-12-21 | 广东群林牧业有限公司 | A kind of internal expelling parasite ewe feed formulation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4874500A (en) * | 1999-07-21 | 2001-01-25 | Ancare New Zealand Limited | Anthelmintic formulation |
| CN1500492A (en) * | 2002-11-18 | 2004-06-02 | 王玉万 | Veterinary antiparasite suspension injection |
| CN1533770A (en) * | 2003-03-26 | 2004-10-06 | 王玉万 | Saspension injection containing benzimidazole kind vermifuge |
| CN103432152A (en) * | 2013-08-22 | 2013-12-11 | 潍坊富邦药业有限公司 | Injection for repelling and killing internal and external parasites of livestock |
-
2014
- 2014-11-14 CN CN201410644830.8A patent/CN104434970A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4874500A (en) * | 1999-07-21 | 2001-01-25 | Ancare New Zealand Limited | Anthelmintic formulation |
| CN1500492A (en) * | 2002-11-18 | 2004-06-02 | 王玉万 | Veterinary antiparasite suspension injection |
| CN1533770A (en) * | 2003-03-26 | 2004-10-06 | 王玉万 | Saspension injection containing benzimidazole kind vermifuge |
| CN103432152A (en) * | 2013-08-22 | 2013-12-11 | 潍坊富邦药业有限公司 | Injection for repelling and killing internal and external parasites of livestock |
Non-Patent Citations (1)
| Title |
|---|
| 赵从民: "硫酸铜在养殖业中的应用", 《河北农业科技》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2613145C1 (en) * | 2016-02-25 | 2017-03-15 | Государственное научное учреждение Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии Российской академии сельскохозяйственных наук (ГНУ ВНИВИПФиТ Россельхозакадемии) | Method of cattle thelaziosis treatment |
| CN109043159A (en) * | 2018-08-24 | 2018-12-21 | 广东群林牧业有限公司 | A kind of internal expelling parasite ewe feed formulation method |
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Application publication date: 20150325 |