AU4874500A - Anthelmintic formulation - Google Patents
Anthelmintic formulation Download PDFInfo
- Publication number
- AU4874500A AU4874500A AU48745/00A AU4874500A AU4874500A AU 4874500 A AU4874500 A AU 4874500A AU 48745/00 A AU48745/00 A AU 48745/00A AU 4874500 A AU4874500 A AU 4874500A AU 4874500 A AU4874500 A AU 4874500A
- Authority
- AU
- Australia
- Prior art keywords
- composition
- agent
- present
- range
- macrolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Regulation 3.2
AUSTRALIA
Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT
APPLICANT:
Invention Title: ANCARE NEW ZEALAND LIMITED ANTHELMINTIC FORMULATION The following statement is a full description of this invention, including the best method of performing it known to me: -2- FIELD OF THE INVENTION This invention relates to formulations containing a combination of the anthelmintics.
BACKGROUND
Praziquantel and macrolides have different parasite specificities. In general macrolides are effective in the elimination of a broad spectrum of internal and external parasites of cattle, sheep and other farm animals. However they are substantially ineffective against the trematodes and in particular tapeworms.
There are a number of trematodes which are important parasites of cultivated farm species.
These include by way of example Monezia spp and the horse tapeworm Anacephlea.
Praziquantel by comparison is effective against tapeworms. However it is difficult to formulate a liquid composition of praziquantel.
It is therefore desirable to treat animals with a combination of at least one macrolide and praziquantel to obtain maximum benefit of treatment.
Obviously it is possible to administer the two independently but within a limited time of 15 each other. However this is costly and time consuming. The time involved in double dosing all of a herd of cattle or a flock of sheep is considerable.
SIt is therefore desirable to formulate a composition which is capable of maintaining both macrolides and praziquantel in bioavailable states in a stable formulation.
For the purposes of this specification "stable veterinary liquid anthelmintic composition suitable for administration to warm-blooded animals" means: A liquid composition having the required shelf life enabling it to be sold as an animal remedy or veterinary medicine.
Such a composition should also be capable of being st6red at ambient temperatures; it should travel well; and should be easily mass-administered to farm animals throughout its shelf life. This term includes liquids which van be delivered as an injection, or as a pour on, or as an oral drench. Registration in accordance with the Animal Remedies Act 1967 (or -3equivalent legislation) typically requires such a composition to exhibit a shelf life of one to two years preferably at least 2 years.
OBJECT
It is an object of this invention to provide a. composition which stably contains both praziquantel and at least one macrolide, or one which at least provides the public with a useful choice.
STATEMENT OF THE INVENTION In one aspect the invention relates to a composition suitable for administration to warmblooded non-human animals comprising an effective amount of at least one macrolide and S 10 an effective amount of praziquantel in suspension, together with a wetting agent, a preservative, buffer salts, a defoaming agent, a dispersing agent and water to volume.
Preferably the macrolide is present in the range 0.05 to 0.5% w/v.
Preferably the macrolide is selected from the group comprising the avermectins and the milbemycins.
More preferably the macrolide is selected from moxidectin, ivermectin, abamectin, and doramectin.
Preferably the praziquantel is present in the range from 1-5% w/v.
Preferably the wetting agent is present in the range of 1-30% w/v.
Preferably the wetting agent is selected from the group polyoxyethylated vegetable oils, polyoxyethylene sorbitan monoisostearate, and polyoxyethylene (20) sorbitan monooleate.
Preferably the wetting agent is polyoxyethylene (20) sorbitan monooleate.
Preferably the preservative is present in the range 0-5% w/v.
Preferably the preservative is selected from the group benzyl alcohol, methyl paraben and formalin.
-4- More preferably the preservative is benzyl alcohol.
Preferably the defoaming agent is present in the range from 0.5-2% w/v.
Preferably the defoaming agent is silicon dioxide or defoaming agent RD.
More preferably the defoaming agent is silicon dioxide.
Preferably the dispersing agent is present in the range from 0-1% w/v.
Preferably the dispersing agent is selected from the group comprising PEG 6000 and other PEG compounds.
More preferably the dispersing agent is PEG 6000.
In addition the composition may include buffering agents, thickeners and other adjuivants 10 whish assist in the final formulation. In addition the composition may include mineral and elements which assist in the action of the actives.
PREFERRED EMBODIMENT These and other aspects of this invention, which should be considered in all its novel aspects will be apparent from the following example.
*o It has been surprisingly found that it is possible to devise a formulation which satisfies the requirements of both macrolides and praziquantel.
Example Raw Material: w/v Water 52.00 PEG 40 Stearate 3.50 PEG 6000 4.00 Defoamer RD 0.20 Praziquantel Aerosil 200'
MPG
Xanthan Gum Water Sodium dihydrogen phosphate 4 Disodium hydrogen phosphate 0Na2FWO0s.2112O) Selenium chelate chelated minerals NZ mix Abamnectin Beozyl alcohol Polysorbate 80 Water 3.75 0.50 0.40 0.20 0.25 10.00 0.10 2.00 1.00 100.00mL Manufacturing Instructions: i. n a clean, dry mixing vessel, stir and heat to dissolve the first water aliquot, the PEG stearate and the PEG 6000.
2. Stir in the Defoamer RD.
3. Silverson in the praziquantel.
4. Silverson in the Aerosil 200.
Premi x the MPG and the xanthan gum and silverson this into the batch, until it is smooth and lump free.
-6- 6. in anlQther clean, dry,'mixing vessel, stir and h~eat if necessary to dissolve each one before the next is added; the second water aliquot, the sodium dihydrogen phosphate, the disodium hydrogen phosphate, the selenium chelate and the c'hejlated minerals NZ 'mix.
57. In another clean dry mnixing vessel, heat and stir to dissolve the abamnectin in the benzyl alcohol.
.1.
V .00 400* 8. Stir in the polysorbate 9. To the prazzquantel phase, add the mineral phase and rnix well.
10. Then silverson in the abarnectin phase.
10 11. Make up to volume with water and mix well.
12. Package the product.
Example 2 Raw Material: Moxidectin Tween 80 Benzyl Alcohol Sodium Phosphate Dibasic Sodium Phosphate Monobasic Praziquantel PEG 6000 Silicon dioxide Water WLv 0.5- 0.05 5-30 0-2% Less than Less than 1 0.5-2 To volum 100 .OOML -7- Manufacturing Instructions: 1. In one vessel use 1/3 volume of warm water dissolve the PEG 6000.
2. Separately warm the Tween and dissolve the moxidectin in it. The resultant solution is then dispersed in the warm water and PEG 6000.
3. Suspend the praziquantel into this solution 4. Add the benzyl alcohol or other preservative.
5. The suspension is made up to volume and other ingredients added.
6. Finally the pH is adjusted to
VARIATIONS
The inclusion of macrolides other than abamectin as outlined in the example will necessitate variation of the above to compensate for the modified solubility properties of the new macrolide. Also more that one macrolide may be included.
The example formulation given is suitable for administration by oral drench, the invention is equally applicable to formulations suitable for administration by injection and pour on.
Finally, it will be appreciated that various other alterations and modifications may be made to the forgoing without departing from the spirit and scope of this invention.
Claims (15)
1. A composition suitable for administration to warm-blooded non-human animals including an effective amount of at least one macrolide and an effective amount of praziquantel in suspension, together with a wetting agent, a preservative, buffer salts, a defoaming agent, a dispersing agent and water to volume.
2. A composition as claimed in claim 1. wherein the macrolide is present in the range 0.05 to 0.5% w/v.
3. A composition as claimed in either of claims 1 or 2 wherein the macrolide is selected from the group comprising the avermectins and the milbemycins. 10 4. A composition as claimed in any of claims 1 to 3 wherein, macrolide is moxidectin, ivermectin, abamectin, or doramectin.
5. A composition as claimed in any of claims I to 4 wherein, the praziquantel is present in the range from 1-5% w/v.
6. A composition as claimed in any of claims 1 to 5 wherein, the wetting agent is present in the range of 1-30% wiv.
7. A composition as claimed in any of claims 1 to 6 wherein, the wetting agent is selected from the group polyoxyethylated vegetable oils, polyoxyethylene sorbitan monoisostearate, and polyoxyethylene (20) sorbitan monooleate.
8. A composition as claimed in any of claims I to 7 wherein, the wetting agent is polyoxyethylene (20) sorbitan monooleate.
9. A composition as claimed in any of claims 1 to 8 wherein, the preservative is present in the range 0-5% w/v. A composition as claimed in any of claims 1 to 9 wherein, the preservative is selected from the group benzyl alcohol, methyl paraben and formalin. -9- 1.A composition as claimed in any of claims t. to 10 wherein the preservative is benzyli alcohol.
12. A composition as claimed in any of claims present in the rafige from 0.5-2% wI/r.
13. A composition as claimed in any of claims silicon dioxide or defoarniug agent RJD.
14. A composition as claimed in any of claims silicon dioxide.
15. A composition as claimed in any of claims 10 present in- the range from 0- 1% w/v. I to 11 wherein the defoamung agent is 1 to 12 wherein the defoaming agent is 1 to 13 wherein the defoaming agent is 1 to 14 wherein the dispersing agent is 9 9 9 9**9 9 9
16. A composition as claimed in any of claims 1 to 15 wherein the dispersing agent is selected from the group comprising PEG 6000 and other PEG compounds.
17. A compositon as claimed in any of claims 1 to 16 wherein the dispersing agent is PEG
6000. 15 18. A composition suitable for administration to warm blooded nxon-human animals, substantially as herein described. 19. A method of treatment of trematodes in warm blooded animals by application of the composition as claimed in any previous claim. 9 S 9*99 99 9 99 99
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ33683299A NZ336832A (en) | 1999-07-21 | 1999-07-21 | Anthelmintic formulation comprising praziquantel, a macrolide, a preservative, buffer salts, defoaming agent, dispersing agent and water |
NZ336832 | 1999-07-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU4874500A true AU4874500A (en) | 2001-01-25 |
Family
ID=19927393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU48745/00A Abandoned AU4874500A (en) | 1999-07-21 | 2000-07-20 | Anthelmintic formulation |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4874500A (en) |
NZ (1) | NZ336832A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7563773B2 (en) | 2002-06-21 | 2009-07-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
CN104434970A (en) * | 2014-11-14 | 2015-03-25 | 山西双鹰动物药业有限公司 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893652B2 (en) * | 2001-08-27 | 2005-05-17 | Wyeth | Endoparasiticidal gel composition |
-
1999
- 1999-07-21 NZ NZ33683299A patent/NZ336832A/en unknown
-
2000
- 2000-07-20 AU AU48745/00A patent/AU4874500A/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7563773B2 (en) | 2002-06-21 | 2009-07-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
CN104434970A (en) * | 2014-11-14 | 2015-03-25 | 山西双鹰动物药业有限公司 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Also Published As
Publication number | Publication date |
---|---|
NZ336832A (en) | 2000-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |