CN103432152A - Injection for repelling and killing internal and external parasites of livestock - Google Patents
Injection for repelling and killing internal and external parasites of livestock Download PDFInfo
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- CN103432152A CN103432152A CN2013103678962A CN201310367896A CN103432152A CN 103432152 A CN103432152 A CN 103432152A CN 2013103678962 A CN2013103678962 A CN 2013103678962A CN 201310367896 A CN201310367896 A CN 201310367896A CN 103432152 A CN103432152 A CN 103432152A
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Abstract
The invention discloses a novel prescription of an injection for repelling and killing internal and external parasites of livestock. The prescription is prepared by the following raw materials by weight: 1-2 kg ivermectin, 1-2.5 kg febantel, 0.5-1.5 kg synthetic VE oil, 20-30 kg propylene glycol, 5 kg benzyl alcohol, 15 kg benzyl benzoate, 5 kg polyoxyethylene, 15-25 kg ricinus oil and a proper amount of alcohol. The invention also provides a preparation technology of the novel prescription, which comprises the following steps: taking ivermectin and febantel according to the prescription quantity, sequentially adding propylene glycol according to the prescription quantity, and stirring to be uniformly mixed; adding the materials into the mixed solution according to the prescription quantity, and stirring to be uniformly mixed; adding ricinus oil into the mixed solution according to the prescription quantity to obtain a uniform liquid and packing the uniform liquid. The injection can well repel swine lungworm, oesophagostomum asperum, pinworm, various roundworms of horses and lung fluke.
Description
Technical field
The present invention relates to a kind of drug compound preparation and preparation technology, a kind of the injection of carcass ecto-and endoparasites and the preparation technology of killing, belong to the veterinary drug technical field specifically.
Background technology
Current, along with the density cultivated is more and more higher and environment constantly worsens, in the bodies such as pig, cattle, sheep and ectozoa constantly spread unchecked, M & M all increases, need novel wide spectrum, efficient, long-acting, low toxicity antibiotics antiparasitic, to endoparasite and ectoparasite, particularly nematicide and arthropod all have the product of the good effect of killing.We develop a kind of prescription of ivermectin and febantel being made to long-acting suspendible anthelmintic injection for this reason, repelling and killing efficacy is obvious, particularly nematicide, trematodiasis, cestode, insecticide and the acarid of inside and outside parasitism are all had to the good activity of killing, and can effectively reduce the parasite sickness rate of domestic animal, significantly promote fertility performance.
Summary of the invention
The problem to be solved in the present invention is to provide a new prescription of carcass ecto-and endoparasites injection of killing of wide spectrum, efficient, long-acting, low toxicity antibiotics.
In order to address the above problem, the present invention by the following technical solutions: a kind of new prescription of carcass ecto-and endoparasites injection of killing, this prescription is made by the raw material of following weight proportion:
Ivermectin 1-2kg; Febantel 1-2.5kg; Synthetic VE oil 0.5-1.5kg; Propylene glycol 20-30 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15-25 kg; Ethanol is appropriate.
Below the further optimization of the present invention to such scheme:
This prescription is made by the raw material of following weight proportion: ivermectin 1.5kg; Febantel 2.0kg; Synthetic VE oil 1.0kg; Propylene glycol 25 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 20 kg; Ethanol is appropriate.
Another kind of optimization: this prescription is made by the raw material of following weight proportion: ivermectin 1.0kg; Febantel 1.0kg; Synthetic VE oil 0.5kg; Propylene glycol 20kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15 kg; Ethanol is appropriate.
Another kind of optimization: this prescription is made by the raw material of following weight proportion: ivermectin 1.5kg; Febantel 1.0kg; Synthetic VE oil 1.0kg; Propylene glycol 20kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15 kg; Ethanol is appropriate.
Another kind of optimization: this prescription is made by the raw material of following weight proportion: ivermectin 2.0kg; Febantel 2.0kg; Synthetic VE oil 1.5kg; Propylene glycol 25kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 20 kg; Ethanol is appropriate.
Another kind of optimization: this prescription is made by the raw material of following weight proportion: ivermectin 2.0kg; Febantel 2.5kg; Synthetic VE oil 1.5kg; Propylene glycol 30 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 25kg; Ethanol is appropriate.
The present invention also provides the preparation technology of above-mentioned new prescription, and this technique comprises the following steps:
A, the ivermectin of getting the prescription amount, febantel, add successively the propylene glycol of prescription amount to stir to make its mix homogeneously, repeatedly grind 3 times to evenly in colloid mill, the feel uniform and smooth;
The benzyl alcohol, polyoxyethylene castor oil, the benzyl benzoate that add the prescription amount in B, the mixed liquor in above-mentioned steps A, stir and make mix homogeneously again, with homogenizer, grinds 2 times, makes liquid be even suspension, the feel uniform and smooth;
In C, the mixed liquor in above-mentioned steps B, add the Oleum Ricini of prescription amount, synthetic VE oil to stir, ethanol adds to 100,000 ml, with homogenizer, grinds 2 times, makes into uniform liquid, embedding after the assay was approved again, and the lamp inspection foreign is unsterilised, packing.
In above-mentioned prescription:
1, ivermectin: the Macrolide antiparasitic, kill inside and outside nematicide and arthropod; Be widely used in gastrointestinal nematode parasites, thread lungworm and the parasitic arthropod of cattle, sheep, horse, pig, the intestinal nematodes of dog, ear demodicid mite, acaricide, heartworm and microfilariae of ohchocerciasis, and poultry gastrointestinal nematode and vermin.
2, febantel: a kind of broad-spectrum de-worming medicine all has high activity to each nematicide, adult and the larva of the animals such as Canis familiaris L., sheep, pig, horse.
3, synthetic VE oil: antioxidant and nutritional supplement prevent muscle damage.
4, propylene glycol: antifreeze and solvent.
5, benzyl alcohol: antibacterial, pain relieving.
6, benzyl benzoate: solvent, hydrotropy.
7, polyoxyethylene castor oil: solvent, hydrotropy.
8, Oleum Ricini: solvent.
9, ethanol: solubilising, excipient.
The present invention adopts above-mentioned prescription, be widely used in killing of gastrointestinal nematode parasites in the bodies such as horse, cattle, sheep, pig, dog, cat, ascarid, the capillaria of, birds sick to all kinds roundworm, ascarid, gentle nematicide, Uronema, cattle and sheep acaricide, the sheep magenta of Pulmonis Sus domestica worm, Oesophagostomum, pinworm, trichinella and heartworm thereof, bomb fly cellulitis, sheep nose fly cellulitis, Parafilaria bovicola, horse, nematicide, distoma hepaticum, lung fluke have fabulous dispel effect side by side.
The present invention has the following advantages: 1, general disease medication is once good; A drug can act on more than 7 days, was depot drug product.2, application method is simple, and subcutaneous injection gets final product.3, use by recommended dose, have no adverse reaction.4, medical expense is low, only inject once, and long action time, easily by the raiser, accepted.
Below by instantiation, the invention will be further described, but the present invention is not limited by following instance.
The specific embodiment
Embodiment, a kind of new prescription of carcass ecto-and endoparasites injection of killing, this prescription is made by the raw material of following weight proportion:
| Main Ingredients and Appearance | Prescription 1 | Prescription 2 | Prescription 3 | Prescription 4 | Prescription 5 |
| Ivermectin | 1.5kg | 1.0kg | 1.5kg | 2.0kg | 2.0kg |
| Febantel | 2.0kg | 1.0kg | 1.0kg | 2.0kg | 2.5kg |
| Synthetic VE oil | 1.0kg | 0.5kg | 1.0kg | 1.5kg | 1.5kg |
| Propylene glycol | 25 kg | 20 kg | 20 kg | 25 kg | 30 kg |
| Benzyl alcohol | 5? kg | 5? kg | 5? kg | 5? kg | 5? kg |
| Benzyl benzoate | 15 kg | 15 kg | 15 kg | 15 kg | 15 kg |
| Polyoxyethylene | 5? kg | 5? kg | 5? kg | 5? kg | 5? kg |
| Oleum Ricini | 20 kg | 15kg | 15 kg | 20 kg | 25 kg |
| Ethanol | Add to 100,000 ml | Add to 100,000 ml | Add to 100,000 ml | Add to 100,000 ml | Add to 100,000 ml |
Because company is type of production company, facilitate company technique to transform, company's prescription all carries out with the pattern of producing greatly, lab scale is 10:1, and pilot scale is 10:5, and above prescription is pilot-scale experiment, prescription 1～5 is process of the test, finally according to result of the test, filters out prescription 1 for best prescription.
The preparation technology of above-mentioned prescription 1, this technique comprises the following steps:
A, the ivermectin of getting the prescription amount, febantel, add successively the propylene glycol of prescription amount to stir to make its mix homogeneously, repeatedly grind 3 times to evenly in colloid mill, the feel uniform and smooth;
The benzyl alcohol, polyoxyethylene castor oil, the benzyl benzoate that add the prescription amount in B, the mixed liquor in above-mentioned steps A, stir and make mix homogeneously again, with homogenizer, grinds 2 times, makes liquid be even suspension, the feel uniform and smooth;
In C, the mixed liquor in above-mentioned steps B, add the Oleum Ricini of prescription amount, synthetic VE oil to stir, ethanol adds to 100,000 ml, with homogenizer, grinds 2 times, makes into uniform liquid, embedding after the assay was approved again, and the lamp inspection foreign is unsterilised, packing.
The present invention adopts best prescription 1, carries out following test:
This EXPERIMENTAL DESIGN: choose respectively 2 of pig, sheep, cattle farms, wherein infect each, acarid and gastrointestinal nematode parasites factory, add up to case 342 examples, random packet, and set up the blank group: choose 2 pig farms 96,114 of 2 cattle farms, 132 of 2 sheep fields, by specification respectively after concentrating, depending on body weight with infect the order of severity and carry out subcutaneous injection, number of times is controlled at 1 time and gets final product, and injects observed and recorded result after 7 days.
treatment:subcutaneous injection: once measure every 1kg body weight cattle, sheep 0.02ml, pig 0.03ml(is every 100kg body weight cattle, sheep 2ml, pig 3ml).And only limit to subcutaneous injection, because intramuscular, intravenous injection easily cause toxic reaction.Each subcutaneous injection point, should not be over 10 milliliters.
Result of the test: (unit: head)
By subcutaneous injection, observed and recorded result after 7 days, cure rate is up to more than 90%, average cure rate 94.2%, other suffer from also obviously improvement of poultry, owing to there is no in test the concrete inside and outside of distinguishing, after being diagnosis, random the selection suffered from poultry, can show thus, evident in efficacy.
The present invention is by above-mentioned test: 1, general disease medication is once good; A drug can act on more than 7 days, was depot drug product.2, application method is simple, and subcutaneous injection gets final product.3, use by recommended dose, have no adverse reaction.4, medical expense is low, only inject once, and long action time, easily by the raiser, accepted.
Points for attention: while 1, injecting, there are discomfort or edema fugax in injection site; 2, with front shaking up.
Above-described embodiment is for inventive concept of the present invention and actual use of explaining, and allly utilizes this design and actual the use to carry out the change of unsubstantiality to the present invention, all should fall into protection scope of the present invention.
Claims (7)
1. kill a new prescription of carcass ecto-and endoparasites injection for one kind, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 1-2kg; Febantel 1-2.5kg; Synthetic VE oil 0.5-1.5kg; Propylene glycol 20-30 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15-25 kg; Ethanol is appropriate.
2. a kind of new prescription of carcass ecto-and endoparasites injection of killing according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 1.5kg; Febantel 2.0kg; Synthetic VE oil 1.0kg; Propylene glycol 25 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 20 kg; Ethanol is appropriate.
3. a kind of new prescription of carcass ecto-and endoparasites injection of killing according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 1.0kg; Febantel 1.0kg; Synthetic VE oil 0.5kg; Propylene glycol 20kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15kg; Ethanol is appropriate.
4. a kind of new prescription of carcass ecto-and endoparasites injection of killing according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 1.5kg; Febantel 1.0kg; Synthetic VE oil 1.0kg; Propylene glycol 20kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 15 kg; Ethanol is appropriate.
5. a kind of new prescription of carcass ecto-and endoparasites injection of killing according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 2.0kg; Febantel 2.0kg; Synthetic VE oil 1.5kg; Propylene glycol 25kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 20 kg; Ethanol is appropriate.
6. a kind of new prescription of carcass ecto-and endoparasites injection of killing according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Ivermectin 2.0kg; Febantel 2.5kg; Synthetic VE oil 1.5kg; Propylene glycol 30 kg; Benzyl alcohol 5kg; Benzyl benzoate 15kg; Polyoxyethylene 5kg; Oleum Ricini 25kg; Ethanol is appropriate.
7. described a kind of preparation technology of the new prescription of carcass ecto-and endoparasites injection that kills as arbitrary as claim 1-6, this technique comprises the following steps:
A, the ivermectin of getting recipe quantity, febantel, add successively the propylene glycol of recipe quantity to stir to make its mix homogeneously, repeatedly grind 3 times to evenly in colloid mill;
The benzyl alcohol, polyoxyethylene castor oil, the benzyl benzoate that add recipe quantity in B, the mixed liquor in above-mentioned steps A, stir and make mix homogeneously again, with homogenizer, grinds 2 times, makes liquid be even suspension;
In C, the mixed liquor in above-mentioned steps B, add the Oleum Ricini of recipe quantity, synthetic VE oil to stir, ethanol adds to 100,000 ml, with homogenizer, grinds 2 times, makes into uniform liquid, embedding after the assay was approved, packing again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103678962A CN103432152A (en) | 2013-08-22 | 2013-08-22 | Injection for repelling and killing internal and external parasites of livestock |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103678962A CN103432152A (en) | 2013-08-22 | 2013-08-22 | Injection for repelling and killing internal and external parasites of livestock |
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| CN103432152A true CN103432152A (en) | 2013-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013103678962A Pending CN103432152A (en) | 2013-08-22 | 2013-08-22 | Injection for repelling and killing internal and external parasites of livestock |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735559A (en) * | 2014-01-22 | 2014-04-23 | 哈尔滨千合动物药品制造有限公司 | Parasite expelling oil emulsion for veterinary use and preparation method thereof |
| CN104434970A (en) * | 2014-11-14 | 2015-03-25 | 山西双鹰动物药业有限公司 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
Citations (4)
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| CN1304727A (en) * | 2000-10-20 | 2001-07-25 | 王玉万 | Injection containing evericin or ivermectin and using benzyl benzoate or nitrone as co-solvent |
| CN1533770A (en) * | 2003-03-26 | 2004-10-06 | 王玉万 | Saspension injection containing benzimidazole kind vermifuge |
| WO2008072985A2 (en) * | 2006-12-13 | 2008-06-19 | Bomac Research Limited | Pour on formulation |
| CN103181925A (en) * | 2011-12-31 | 2013-07-03 | 瑞普（天津）生物药业有限公司 | Compound febantel gel and preparation method thereof |
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2013
- 2013-08-22 CN CN2013103678962A patent/CN103432152A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304727A (en) * | 2000-10-20 | 2001-07-25 | 王玉万 | Injection containing evericin or ivermectin and using benzyl benzoate or nitrone as co-solvent |
| CN1533770A (en) * | 2003-03-26 | 2004-10-06 | 王玉万 | Saspension injection containing benzimidazole kind vermifuge |
| WO2008072985A2 (en) * | 2006-12-13 | 2008-06-19 | Bomac Research Limited | Pour on formulation |
| CN103181925A (en) * | 2011-12-31 | 2013-07-03 | 瑞普（天津）生物药业有限公司 | Compound febantel gel and preparation method thereof |
Non-Patent Citations (3)
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| 化学工业出版社: "《中国化工产品大全 下卷》", 28 February 2000, 化学工业出版社, article "维生素E", pages: 492 * |
| 毕殿洲: "《药剂学 第四版》", 28 February 2003, 人民卫生出版社, article "注射液", pages: 92 - 240-241 * |
| 韩瑞亭: "《药物制剂技术》", 31 March 2009, 中国农业大学出版社, article "混悬剂的制备", pages: 259 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735559A (en) * | 2014-01-22 | 2014-04-23 | 哈尔滨千合动物药品制造有限公司 | Parasite expelling oil emulsion for veterinary use and preparation method thereof |
| CN103735559B (en) * | 2014-01-22 | 2016-01-06 | 哈尔滨千合动物药品制造有限公司 | A kind of anthelmintic oil emulsion for animals and preparation method thereof |
| CN104434970A (en) * | 2014-11-14 | 2015-03-25 | 山西双鹰动物药业有限公司 | Medicine for treating nematodosis and trematodiasis of cattle and sheep and preparation method of medicine |
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