CN104398709B - One kind five tiger dissipate and preparation method thereof - Google Patents
One kind five tiger dissipate and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
Dissipated the invention discloses the tiger of one kind five and preparation method thereof, which comprises the following steps：(1) take Angelica sinensis, it is windproof be crushed and screened into coarse powder, first with ethanol immersion 12~24 it is small when, then heating extracted, collect extracting solution and add ethanol extraction for several times, merge extracting solution, be concentrated to give thick paste, thick paste drying, grinding and sieving are obtained into dried cream powder；(2) safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and starts cleaner and carries out dedusting, crushing is carried out at the same time, sieves, obtain medicinal material powder；(3) medicinal material powder and dried cream powder are loaded in three-dimensional mixer, after mixing packing obtain five tiger and dissipate.The scattered content of five tigers obtained using the preparation method is higher, and drug effect is more preferable, and solves and be not easy to store (caking, go bad discoloration, deliquescence), poor fluidity phenomenon.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, and in particular to one kind five tiger dissipate and preparation method thereof.
Background technology
Five tigers dissipate to be made of Angelica sinensis, windproof, safflower, the root of Dahurain angelica, arisaema cum bile five kinds of Chinese medicine, has promoting blood circulation to remove blood stasis, swelling and pain relieving
And other effects Chinese patent drug, for traumatic injury, the treatment of blood stasis and swelling pain.Treating acute and chronic soft tissue injury, it is all to fall outside servant's sudden strain of a muscle etc.
Power causes the damage soft tissues such as muscle ligament, and patient can be in severe pain, hemostasis, swelling and dysfunction, and such as common is acute
Lumbar sprain, ectocondyle are sprained and the interior contusion of the side of body all can be used.In use, can take orally or external application, when taking orally with warm yellow rice wine or
Warm water delivery service, outer used time dress affected part with white wine.
The scattered traditional preparation method of five tigers is directly using Angelica sinensis, windproof, safflower, the root of Dahurain angelica, arisaema cum bile gomi herbs as raw material, is crushed
Into fine powder, sieving, mixes i.e. available.Obtain in the method five tiger dissipate in active ingredient (macrotin glycosides and 5-O-
Methyl visamminol glycosides total amount) content it is relatively low, and easily reunite, influence to dispense and use.
The Chinese patent application of Publication No. CN 1364476A discloses a kind of nano five-tiger medicine, it is to receive
Meter Dang Gui, nano safflower, nanometer are windproof, nanometer rhizoma arisaematis (system), nano angelica root, are raw material, prepare in proportion, new medicine is made
Thing preparation, for its grain fineness up to 1200~1500 mesh, particle diameter is 0.1~200cm, wherein most particle diameters are less than 100cm, is adopted
With microwave abstracting, be concentrated under reduced pressure, supersonic jet technology be spray-dried and etc. be made.The preparation of the nano five-tiger medicine
Complex process, requirement to equipment is high, and the character and curative effect of the product of acquisition are not verified.
The content of the invention
Dissipated the present invention provides the tiger of one kind five and preparation method thereof, the preparation method process is simple, quality controllable and be suitable for
Industrialized production；Five obtained tigers dissipate not only active constituent content height, improve drug effect, also unexpectedly solve and be not easy to store
(caking, go bad discoloration, deliquescence), the phenomenon of poor fluidity.
A kind of scattered preparation method of five tiger, comprises the following steps：
(1) take Angelica sinensis, it is windproof be crushed and screened into coarse powder, first with ethanol water immersion 12~24 it is small when, be then heated to
50~60 DEG C are extracted, and are collected extracting solution and are added ethanol water extraction for several times (including 1 time), merge extracting solution, concentration
Thick paste is obtained, thick paste drying, grinding and sieving are obtained into dried cream powder；
(2) safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and starts cleaner and carries out dedusting, together
Shi Jinhang is crushed, and sieving, obtains medicinal material powder；
(3) medicinal material powder and the dried cream powder of step (1) obtained step (2) loads in three-dimensional mixer, is dispensed after mixing
Five tiger is obtained to dissipate.
In the present invention, Angelica sinensis and windproof taking-up during five tigers are dissipated, are first soaked with ethanol water, are then carried out again
Heating extraction, the obtained extract preparation together with other medicinal materials again, it is possible to increase active ingredient macrotin glycosides in preparation and
The content of 5-O- methyl visamminol glycosides, also, the mobility that five obtained tigers dissipate is more preferable and prevented from caking.
Preferably, five tigers dissipate medicinal material used and the parts by weight of extractant are as follows：
Windproof 300~400 parts of 300~400 parts of Angelica sinensis, 300~400 parts of safflower
300~400 parts of Rhizoma Arisaematis (processed), 200~300 parts of the root of Dahurain angelica
7000~9000 parts of ethanol water.
Preferably, five tigers dissipate medicinal material used and the parts by weight of extractant are as follows：
Windproof 350 parts of 350 parts of Angelica sinensis, 350 parts of safflower
350 parts of Rhizoma Arisaematis (processed), 240 parts of the root of Dahurain angelica
7000~9000 parts of ethanol water.
The concentration of ethanol water and extraction time can produce large effect to extraction efficiency, preferably, ethanol water
The concentration of volume percent of solution is 80~95%, every time during extraction, when heating 1~3 is small.
Compared with the existing technology, invention increases extraction and dry technique, dry temperature are excessive, it is possible to causes
The effect of active ingredient extracted is degraded, reduction product, therefore, it is necessary to stringent control is carried out to dry temperature
System.Preferably, in step (1), dry temperature is below 80 DEG C.
Preferably, in step (1), the coarse powder mesh number is 10~20 mesh, and dried cream powder crosses 100 mesh sieves.It is ground into thick
It is convenient for extracting after powder, is convenient for being uniformly mixed after dried cream powder sieving.
Preferably, in step (3), incorporation time is 30~60 minutes.
Present invention also offers the tiger of one kind five to dissipate, and is prepared by the method.This five tiger dissipate compared with five tiger dissipate
Compare, the content of active ingredient is high, better efficacy, and mobility is preferable, and is not easy to lump.
Crude drug of the present invention is described in detail below：
Angelica sinensis：From the root of umbelliferae angelica, there is replenishing and activating blood, menstruction regulating and pain relieving, relax bowel and other effects.
Safflower：Dicotyledon, composite family, dry tubular flower, has invigorate blood circulation, stasis eliminatings analgesic.Invigorate blood circulation medicine.
It is windproof：It is the windproof root of Umbelliferae herbaceos perennial, cures mainly and deliver, wind-dispelling, victory is wet, the symptom such as analgesic.
Rhizoma Arisaematis (processed)：For aroid Gouzhua Banxia, medicinal effects are its stem tuber, have it is eliminating dampness and eliminating phlegm, wind-dispelling stops
Convulsion, mass dissipating and swelling eliminating and other effects.
The root of Dahurain angelica：For the plant of Umbelliferae angelica, there is wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving and other effects.
This product specification is per packed 6 grams；Usage and dosage：Warm yellow rice wine or warm water delivery service, a 6g, 2 times a day；External application,
White wine dresses affected part.
Compared with the existing technology, beneficial effects of the present invention are：
For Angelica sinensis of the present invention with windproof after ethanol extracts, content is higher, improves drug effect, and unexpectedly solve and be not easy
Storage (caking, go bad discoloration, deliquescence), poor fluidity phenomenon.Product stablizes safety, soaked to dissolve quickly, with the shape of liquid
State exists.Preparation process of the present invention is simple, controllable, cost-effective woth no need to special equipment, shortens technological process, suitable for work
Industry metaplasia is produced.
Embodiment
Embodiment 1
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g root of Dahurain angelica 240g ethanol 8500g
1), take Angelica sinensis, it is windproof be crushed and screened into coarse powder, with 95% ethanol of 4500g immersion 12 it is small when, be heated to 55~60
DEG C extraction 2 it is small when, collect extracting solution；Then again plus 90% ethanol of 4000g be heated to 55~60 DEG C extraction 1 it is small when, collect extraction
Liquid, merges extracting solution twice, filtration, and filtrate is concentrated to give thick paste；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
2), safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner and carry out dedusting, into
Row crushes, and crosses 100 mesh sieves, spare；
3), by step 2) crush three taste medicines and step 1) dried cream powder load three-dimensional mixer in, mix 30 minutes, by point
Specification is filled, dispenses and is dissipated up to five tigers.
Embodiment 2
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g root of Dahurain angelica 240g ethanol 8500g
1), take Angelica sinensis, it is windproof be crushed and screened into coarse powder, with 90% ethanol of 4500g immersion 15 it is small when, be heated to 50~55
DEG C extraction 2 it is small when, collect extracting solution；Then again plus 90% ethanol of 4000g be heated to 55~60 DEG C extraction 1 it is small when, collect extraction
Liquid, merges extracting solution twice, filtration, and filtrate is concentrated to give thick paste；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
2), safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner and carry out dedusting, into
Row crushes, and crosses 100 mesh sieves, spare；
3), by step 2) crush three taste medicines and step 1) dried cream powder load three-dimensional mixer in, mix 30 minutes, by point
Specification is filled, dispenses and is dissipated up to five tigers.
Comparative example 1
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g roots of Dahurain angelica 240g
1), Angelica sinensis, safflower, windproof, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner
Dedusting is carried out, is crushed, crosses 100 mesh sieves, it is spare；
2), step 1) medicinal powder is loaded in three-dimensional mixer, is mixed 30 minutes, by packing specification, dispenses and is dissipated up to five tigers.
Comparative example 2
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g root of Dahurain angelica 240g ethanol 17000g
1), take Angelica sinensis to be crushed and screened into coarse powder, with 95% ethanol of 4500g immersion 12 it is small when, be heated to 55~60 DEG C extraction
2 it is small when, collect extracting solution；Then again plus 90% ethanol of 4000g be heated to 55~60 DEG C extraction 1 it is small when, collect extracting solution, close
And extracting solution, filtration, filtrate are concentrated to give thick paste twice；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
2), take it is windproof be crushed and screened into coarse powder, with 450095% ethanol immersion 12 it is small when, be heated to 55~60 DEG C extraction 2
Hour, collect extracting solution；Then again plus 400090% ethanol be heated to 55~60 DEG C extraction 1 it is small when, collect extracting solution, merge two
Secondary extracting solution, filtration, filtrate are concentrated to give thick paste；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
3), safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner and carry out dedusting, into
Row crushes, and crosses 100 mesh sieves, spare；
4) the three taste medicines and step 1) for, crushing step 3) load in three-dimensional mixer with dried cream powder 2), mix 30 points
Clock, by packing specification, dispenses and is dissipated up to five tigers.
Comparative example 3
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g root of Dahurain angelica 240g ethanol 8500g
1), take Angelica sinensis, it is windproof be crushed and screened into coarse powder, with 450095% ethanol be heated to 55~60 DEG C extraction 3 it is small when, receive
Collect extracting solution；Then again plus 400090% ethanol be heated to 55~60 DEG C extraction 1 it is small when, collect extracting solution, merging extract twice
Liquid, filtration, filtrate are concentrated to give thick paste；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
2), safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner and carry out dedusting, into
Row crushes, and crosses 100 mesh sieves, spare；
3), by step 2) crush three taste medicines and step 1) dried cream powder load three-dimensional mixer in, mix 30 minutes, by point
Specification is filled, dispenses and is dissipated up to five tigers.
Comparative example 4
The windproof 350g of Angelica sinensis 350g safflowers 350g
Rhizoma Arisaematis (processed) 350g root of Dahurain angelica 240g ethanol 8500g
1), take Angelica sinensis, it is windproof be crushed and screened into coarse powder, with 95% ethanol of 4500g immersion 12 it is small when, it is small to be heated to reflux 2
When, collect extracting solution；Then again plus 90% ethanol of 4000g be heated to reflux 1 it is small when, collect extracting solution, merge extracting solution twice,
Filtration, filtrate are concentrated to give thick paste；It dry, pulverize below 80 DEG C, cross 100 mesh sieves, it is spare.
2), safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and start cleaner and carry out dedusting, into
Row crushes, and crosses 100 mesh sieves, spare；
3), by step 2) crush three taste medicines and step 1) dried cream powder load three-dimensional mixer in, mix 30 minutes, by point
Specification is filled, dispenses and is dissipated up to five tigers
Five tigers made from embodiment 1~2 and the difference of comparative example 1~4 are dissipated and carry out stability tests, using accelerated test
Method carries out study on the stability to it, and in 28 DEG C~32 DEG C of temperature, 55%~65% condition of relative humidity accelerates to place 6 months,
Press《Chinese Pharmacopoeia》The one progress quality inspection of version in 2010, specific inspection result such as table 1：
The scattered inspection result of the tiger of table 1 five
Learnt by data above, after Angelica sinensis and windproof first extraction, then carry out five tigers that preparation obtains and dissipate not only contents height,
Drug effect is improved, and solves and is not easy to store (caking, go bad discoloration, deliquescence), poor fluidity phenomenon, meets production requirement；Such as
Fruit is by after Angelica sinensis and windproof each extraction, then carries out the scattered performances of five tigers that preparation obtains and be nothing like both being carried together
Take, it is seen that when by Angelica sinensis and windproof common extraction, the dissolution of active ingredient can be promoted；Comparative example 3 the result shows that,
Before being extracted with ethanol, first immersion for a period of time, also has large effect to the result of product at room temperature；Comparative example 4
The result shows that, to Angelica sinensis and it is windproof extract when, if heating-up temperature is excessive, although other performances are also improved,
But the decomposition of active ingredient can be caused, the content of active ingredient is even lower than standard value.
Clinical test
Test topic：The scattered clinical test of five tigers that data below is organized and implemented by commission Xianyang central hospital of our company,
The tiger of evaluation five dissipates treatment acute lumbar muscle sprain, achieves the effect of preferable, now reports as follows：
1st, clinical data
Meet doctor trained in Western medicine diagnosis, Standards of Chinese Medical Syndrome Differentiation；In treatment group 120, man 67, female 53, the oldest 72 years old, most
It is 16 years old small；Occupation：Student 19, office worker 38, worker 50, the retired 13.The course of disease most elder 15 days, most short person 1 day,
Position：Lumbosacral region 74, both sides spinal muscle 46.Control group 87, man 57, female 30 are the oldest 71 years old, 17 years old minimum；
Occupation：Student 19, office worker 38, worker 50, the retired 13.The course of disease most elder 18 days, most short person 1 day, position：Waist
54, sacrum portion, both sides spinal muscle 23.Two groups of equal no statistical significances of data difference (P ＞ 0.05), it is harmonious good.
2nd, treatment method
Test group：Five tigers dissipate and (are prepared according to the method for embodiment 1), warm yellow rice wine or warm water delivery service, a 6g, one day 2
It is secondary；
Control group：Five tigers are scattered (Beijing TongrenTang Co., Ltd Tongrentang Pharmaceutical Factory), and green tea is taken after mixing it with water after meal.One time 3
~6 grams, 2 times a day.
2 clinical test results of table
| Group | Total example | Recovery from illness | It is effective | Effectively | It is invalid | It is total effective |
| Number | Example | |||||
| Experimental group | 120 | 97 (80.9%) | 15 (12.5%) | 7 (5.8%) | 1 (0.8%) | 99% |
| Control group | 87 | 61 (70.2%) | 11 (12.6%) | 10 (11.5%) | 5 (5.7%) | 94% |
As shown in Table 2, the present invention is using the preparation method of 95% ethanol extraction, the scattered effective percentage of obtained five tiger
For more than 99%.
Claims (7)
1. the scattered preparation method of a kind of five tiger, it is characterised in that comprise the following steps：
(1) take Angelica sinensis, it is windproof be crushed and screened into coarse powder, first with ethanol water immersion 12~24 it is small when, be then heated to 50~
60 DEG C are extracted, and are collected extracting solution and are added ethanol water extraction for several times, merge extracting solution, be concentrated to give thick paste, will
Thick paste is dry, grinding and sieving obtains dried cream powder；
(2) safflower, Rhizoma Arisaematis (processed), the root of Dahurain angelica are put into the hopper of pulverizer respectively, and starts cleaner and carries out dedusting, carries out powder
Broken, sieving, obtains medicinal material powder；
(3) medicinal material powder and the dried cream powder of step (1) obtained step (2) loads in three-dimensional mixer, dispenses and obtains after mixing
Five tiger dissipates；
Five tigers dissipate medicinal material used and the parts by weight of extractant are as follows：
Windproof 300~400 parts of 300~400 parts of Angelica sinensis, 300~400 parts of safflower
300~400 parts of Rhizoma Arisaematis (processed), 200~300 parts of the root of Dahurain angelica
7000~9000 parts of ethanol water.
2. the scattered preparation methods of five tiger according to claim 1, it is characterised in that five tigers dissipate medicinal material used and
The parts by weight of extractant are as follows：
Windproof 350 parts of 350 parts of Angelica sinensis, 350 parts of safflower
350 parts of Rhizoma Arisaematis (processed), 240 parts of the root of Dahurain angelica
7000~9000 parts of ethanol water.
3. the scattered preparation method of five tiger according to claim 1, it is characterised in that in step (1), the body of ethanol water
Product percent concentration is 80~95%, every time during extraction, when heating 1~3 is small.
4. the scattered preparation method of five tiger according to claim 1, it is characterised in that in step (1), dry temperature is 80
Below DEG C.
5. the scattered preparation method of five tiger according to claim 1, it is characterised in that in step (1), the coarse powder mesh number
For 10~20 mesh, dried cream powder crosses 100 mesh sieves.
6. the scattered preparation methods of five tiger according to claim 1, it is characterised in that in step (3), incorporation time for 30~
60 minutes.
7. the tiger of one kind five dissipates, it is characterised in that is prepared by claim 1~6 any one of them method.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364476A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano five-tiger medicine and its preparing method |
| CN102085341A (en) * | 2010-11-29 | 2011-06-08 | 霸王（广州）有限公司 | Degreasing and hair-growing preparation for preventing and treating seborrheic alopecia and preparation method thereof |
-
2014
- 2014-11-28 CN CN201410704657.6A patent/CN104398709B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364476A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano five-tiger medicine and its preparing method |
| CN102085341A (en) * | 2010-11-29 | 2011-06-08 | 霸王（广州）有限公司 | Degreasing and hair-growing preparation for preventing and treating seborrheic alopecia and preparation method thereof |
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| CN104398709A (en) | 2015-03-11 |
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