CN104383424A - 促进骨折愈合的药物组合物 - Google Patents
促进骨折愈合的药物组合物 Download PDFInfo
- Publication number
- CN104383424A CN104383424A CN201410755436.1A CN201410755436A CN104383424A CN 104383424 A CN104383424 A CN 104383424A CN 201410755436 A CN201410755436 A CN 201410755436A CN 104383424 A CN104383424 A CN 104383424A
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Abstract
本发明涉及一种促进骨折愈合的药物组合物,其由红花、伸筋草、六道木、牛膝、蒲公英、草果、川芎、桃仁、血竭、山慈菇、乌梅、续断、知母、枸杞子、桑椹、乳香、没药、大腹皮、丹参、鸡血藤、山楂、肉桂、巴戟天、昆布、合欢皮制备而得,其成本低廉,疗效显著,具有广阔的应用前景。
Description
技术领域
本发明涉及中医中药技术领域,特别是一种促进骨折愈合的药物组合物。
背景技术
骨折是指骨结构的连续性完全或部分断裂。多见于儿童及老年人,中青年人也时有发生。病人常为—个部位骨折,少数为多发性骨折。经及时恰当处理,多数病人能恢复原来的功能,少数病人可遗留有不同程度的后遗症。其主要临床表现为:骨折部有局限性疼痛和压痛,局部肿胀和出现瘀斑,肢体功能部位或完全丧失,完全性骨折尚可出现肢体畸形及异常活动。随着居民生活水平的提高,生活节奏的加快,生活中各种劳损随着交通运输工具的发展,由高速度、高能量所致的损伤越来越多,交通运输导致的车祸、运动意外造成的运动伤逐年上升。据资料统计,骨伤科疾病发病率达13.3%,其中12.1%可能致残,我国每年仅骨折的医疗费高达200亿元人民币。如何使骨折、创伤早期康复,减少伤残率;如何防治骨性疾病,减少残废率,同时降低医疗费用,保护劳动力和维护人民健康,是中医药研究者的任务。
目前治疗骨折的方法主要采用手术治疗,及通过校正断裂骨头,用石膏等物固定,涂抹内服一些中西药物来彻底治愈,但是往往疗程长,费用高,容易留下后遗症。虽然治疗骨折的药物品种很多,但是由于效果不十分明显,治疗周期长,且收费高,给患者及家庭带来了诸多困难和痛苦。
中医中药在治疗外伤性骨折,扭伤肿痛病症方面有其独特的疗效,根据唯物辩证法的哲学思想和中医学中“天人合一,药食同源;辩证施治,标本兼治,内外同治;筋骨并重,动静结合;肝主筋、肾主骨,补肝肾,强筋骨;通经络、祛湿痹、舒筋脉、消肿痛、利关节;气滞则血瘀、气行则血行;不通则痛、通则不痛;中病即止”的重要理论。结合现代药物成分分析和掌握科学的治疗方法。重点加强对机体整合调节作用,降低血液粘稠度,促进血流,加强血中营养物质输送,改善微循环;提高机体抗氧化能力,免疫功能和调节性激素水平,以增加机体对钙的吸收和利用,促进骨细胞生成和增殖,有利于骨痂生长和抗折能力,促进骨折愈合。达到消肿止痛、筋骨强壮的治疗目的。
发明内容
本发明的目的是为了克服现有技术的不足,而提供的一种使用方便、价格低廉、骨折愈合快、治疗周期短的中药组合物配方。根据骨折损伤后, 整个愈合过程始终存在气血疲滞, 疲血不去新血不生, 新血不生则骨不能接,筋不能续的原则,通过对传统中药的研究,并结合辩证论证,多方收集众家之长,寻求最佳治疗方案,采用纯天然中药原料,结合传统中医技术精心配制成本发用于促进骨折愈合的药物组合物,其配制方法简单,效果显著。
为实现上述目的,本发明采用的技术方案如下:
促进骨折愈合的药物组合物,其由下述原料制备而得:
红花、伸筋草、六道木、牛膝、蒲公英、草果、川芎、桃仁、血竭、山慈菇、乌梅、续断、知母、枸杞子、桑椹、乳香、没药、大腹皮、丹参、鸡血藤、山楂、肉桂、巴戟天、昆布、合欢皮。
优选地,促进骨折愈合的药物组合物,其由下述重量配比的原料制备而得:
红花40份、伸筋草35份、六道木35份、牛膝35份、蒲公英35份、
草果30份、川芎30份、桃仁28份、血竭28份、山慈菇25份、
乌梅25份、续断25份、知母20份、枸杞子20份、桑椹20份、
乳香15份、没药15份、大腹皮15份、丹参10份、鸡血藤10份、
山楂8份、肉桂8份、巴戟天7份、昆布5份、合欢皮5份。
本发明的药物组合物的制备方法为:取上述重量份数的原料药制备胶囊制剂,具体操作为:
1)称取各原料药,备用;
2)取六道木、牛膝、草果、川芎、桃仁、乌梅、续断、枸杞子、乳香、没药、肉桂、巴戟天、合欢皮混合均匀,加3倍重量的水武火煮沸,然后文火煎煮半小时,过滤收集滤液和滤渣;往滤渣中添加水,以没过滤渣为准,武火煮沸,然后文火煎煮半小时,过滤收集滤液;合并上述两次滤液,冷却后,浓缩成密度为1.2g/ml的浸膏;80℃烘干后,粉碎成粉末,即为复合物A;
3)取剩余成分加入相对于混合物5倍重量75%的乙醇,回流提取2次,每次1小时,提取液合并,浓缩至密度为1.2g/ml的清膏,80℃烘干,粉碎制备复合物B;
4) 将复合物A和复合物B混合搅拌均匀,灭菌消毒制得胶囊剂产品。
用法用量:一次0.5g,一日三次,30天为一个疗程。
本发明药物的组分均采用天然的中药原料,其配制简便,药源广泛,成本低廉,诸药合用,相得益彰,全方共奏活血化癖、行气止痛, 接骨续筋之效。
具体实施方式
实施例1:
一种促进骨折愈合的药物组合物,其由下述重量配比的原料制备而得:
红花40份、伸筋草35份、六道木35份、牛膝35份、蒲公英35份、
草果30份、川芎30份、桃仁28份、血竭28份、山慈菇25份、
乌梅25份、续断25份、知母20份、枸杞子20份、桑椹20份、
乳香15份、没药15份、大腹皮15份、丹参10份、鸡血藤10份、
山楂8份、肉桂8份、巴戟天7份、昆布5份、合欢皮5份。
上述药物组合物的制备方法为:取上述重量份数的原料药制备胶囊制剂,具体操作为:
1)称取各原料药,备用;
2)取六道木、牛膝、草果、川芎、桃仁、乌梅、续断、枸杞子、乳香、没药、肉桂、巴戟天、合欢皮混合均匀,加3倍重量的水武火煮沸,然后文火煎煮半小时,过滤收集滤液和滤渣;往滤渣中添加水,以没过滤渣为准,武火煮沸,然后文火煎煮半小时,过滤收集滤液;合并上述两次滤液,冷却后,浓缩成密度为1.2g/ml的浸膏;80℃烘干后,粉碎成粉末,即为复合物A;
3)取剩余成分加入相对于混合物5倍重量75%的乙醇,回流提取2次,每次1小时,提取液合并,浓缩至密度为1.2g/ml的清膏,80℃烘干,粉碎制备复合物B;
4) 将复合物A和复合物B混合搅拌均匀,灭菌消毒制得胶囊剂产品。
用法用量:一次0.5g,一日三次,30天为一个疗程。
实施例2
临床资料
从具有完整病例的骨折病人中选择122例,随机分成治疗组和对照组,每组各61例,治疗组和对照组所选用的病例中病史、病情、年龄、性别尽量相当;治疗组和对照组均为住院治疗。
治疗组61例,年龄18-62岁,平均年龄40岁。其中肱骨外科颈骨折9例,肱骨踝上骨折12例,尺桡骨骨折15例,股骨干骨折16例,胫脉骨骨折9例。
对照组61例,年龄20-60岁,平均年龄41岁。其中肱骨外科颈骨折10例,肱骨踝上骨折13例,尺桡骨骨折13例,股骨干骨折15例,胫脉骨骨折10例。
两组治疗前均未用过任何治疗骨折药物。以上病例多有外伤史,如高处跌伤、骑车碰伤、木头砸伤及汽车撞伤等。患者局部肿胀疼痛,功能性障碍,外观畸形,可触及骨擦音及假关节活动。
治疗组给予实施例1制备的药物组合物,一次0.5g,一日三次,30天为一个疗程;
对照组采用常规药物接骨续筋片,一次5片,一日三次,30天为一个疗程;
随时观察治疗效果和患部肿胀消退时间,每7日摄片一次,检查对位和骨痂生长情况及患肢功能恢复时间。
疗效评定标准
治愈:骨折对线对位满意,有连续性骨痂形成,断端无压痛,无冲击痛,功能恢复。好转:对位及对线尚可,或骨折对位不佳,但功能恢复尚好。未愈:骨折不愈合成局部明显畸形,功能障碍。
治疗结果如下表所示:
例数 | 治愈 | 好转 | 未愈 | 总有效率 | |
治疗组 | 61 | 31 | 25 | 5 | 91.8% |
对照组 | 61 | 18 | 26 | 17 | 72.1% |
对照组与治疗组相比呈显著性差异。
实施例3
典型病例:
(1)夏某,女,51岁,从窗台上跌落,骨折,经X线片检查,发现左锁骨中外1/3处骨折,断端错位重叠,右外踝骨折,断端对位线可。诊断为:左锁骨骨折,右外踝骨折伴三角韧带损伤。住院经手术后给予实施例1制备的促进骨折愈合的药物组合物,一日3次,服用两周后,X线检查,左肱骨中段骨折部位无移位,有少量骨痂生长;服用三周后,X线检查,左肱骨中段骨折部位有明显骨痂生长,骨折线开始模糊;继续服用至两个疗程,X线检查,左肱骨中段骨折部位有大量骨痂生长,骨折线模糊并消失,符合骨折临床愈合标准,恢复正常工作和家务劳动。
(2)谭某,男,49岁,左尺、挠骨闭合性骨折,进行手法复位,小夹板固定,并给予实施例1制备的促进骨折愈合的药物组合物,一日3次,用药一周后肿痛消除,两周后 X线可见原始骨痂生成,一个疗程可见骨小梁通过骨折线。 X线检查,骨痂生长,骨折线模糊并消失。符合骨折临床愈合标准,下地负重行走,并逐渐恢复正常。
本发明采用的上述各中药互作配伍,能发挥其协同治病作用,所用中药原料各成分之间具有药效相互交织相互促进和协调效能,经临床验证,适用于人体全身各部位闭合性骨折及各部位粉碎性骨折,能够舒筋活络、祛瘀生新、止血止痛,本申请人近十年的医疗实践中,治愈的病例数目众多,均取得良好的效果,而且成本低廉,减轻患者的负担,应用前景良好。
Claims (4)
1.一种促进骨折愈合的药物组合物,其特征在于,所述药物组合物由下述原料制备而得:
红花、伸筋草、六道木、牛膝、蒲公英、草果、川芎、桃仁、血竭、山慈菇、乌梅、续断、知母、枸杞子、桑椹、乳香、没药、大腹皮、丹参、鸡血藤、山楂、肉桂、巴戟天、昆布、合欢皮。
2.根据权利要求1所述的药物组合物,其特征在于,所述药物组合物由下述重量份的原料药制备而得:
红花40份、伸筋草35份、六道木35份、牛膝35份、蒲公英35份、
草果30份、川芎30份、桃仁28份、血竭28份、山慈菇25份、
乌梅25份、续断25份、知母20份、枸杞子20份、桑椹20份、
乳香15份、没药15份、大腹皮15份、丹参10份、鸡血藤10份、
山楂8份、肉桂8份、巴戟天7份、昆布5份、合欢皮5份。
3.权利要求1-2所述的药物组合物,其特征在于,所述药物组合物的制备方法包括如下步骤:
1)称取各原料药,备用;
2)取六道木、牛膝、草果、川芎、桃仁、乌梅、续断、枸杞子、乳香、没药、肉桂、巴戟天以及合欢皮,混合均匀,加3倍重量的水武火煮沸,然后文火煎煮半小时,过滤收集滤液和滤渣;往滤渣中添加水,以没过滤渣为准,武火煮沸,然后文火煎煮半小时,过滤收集滤液;合并上述两次滤液,冷却后,浓缩成密度为1.2g/ml的浸膏;80℃烘干后,粉碎成粉末,即为复合物A;
3)取剩余原料药,混合,加入相对于混合物5倍重量75%的乙醇,回流提取2次,每次1小时,提取液合并,浓缩至密度为1.2g/ml的清膏,80℃烘干,粉碎制得复合物B;
4) 将复合物A和复合物B混合搅拌均匀,灭菌消毒即得。
4.权利要求1-3所述药物组合物用于促进骨折愈合的用途。
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