CN104383376A - 治疗妇女外阴鳞状上皮细胞增生的中药组合物 - Google Patents

治疗妇女外阴鳞状上皮细胞增生的中药组合物 Download PDF

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CN104383376A
CN104383376A CN201410122081.2A CN201410122081A CN104383376A CN 104383376 A CN104383376 A CN 104383376A CN 201410122081 A CN201410122081 A CN 201410122081A CN 104383376 A CN104383376 A CN 104383376A
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牛振侠
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Abstract

本发明提供了一种治疗妇女外阴鳞状上皮细胞增生的中药组合物及制备方法应用，主要原料药有黄柏、连翘、指甲花、白花草等按一定重量配比制备成，该药物具有清热除湿、消斑止痒、燥湿、祛风杀虫、活血通络、软坚散结、温肾滋阴、阻止癌前病变等。多药还具备了协同作用，用药合理，配伍科学，且复发率低，治愈率高，远期疗效好，外用无副作用，优于目前其他治疗方法。

Description

治疗妇女外阴鳞状上皮细胞增生的中药组合物
技术领域
本发明属中医药领域，特别涉及治疗妇女外阴鳞状上皮细胞增生的外用中药组合物。
背景技术
妇女外阴鳞状上皮细胞增生病，以往称外阴白斑，又称外阴营养不良等名称，发病原因目前不明确，但一般认为长期外阴局部潮刺激。原因不明的反复瘙痒，可致本病，过敏体质或自身免疫代谢障碍有关。一般发生30-36岁妇女，但赤可发生老年妇女，主要症状外阴奇痒，外阴粘膜变白，皮肤变粗或萎缩、色素增加，皮嵴隆起等表现，本病久治不愈，应警惕有无恶变，现代医学多采用激光治疗，药物局部激素治疗，还有外科手术治疗，但近期复发率高约50%，目前尚没有理想治疗方法。祖国医学无特定的名称，根据症状可属“软阴痒”、“阴疱”等范畴。根据有关中医理论，以清执泻火、活血通经、日坚散结、养血祛风、清热除湿、祛风杀虫、消斑止痒、补肾等辩证施治方法进行调理以及外用药治疗。是目前临床上治疗外阴磷鱼状上皮细胞增生一个亟待解决的问题。
发明内容
为了解决上述目的，本发明多年反复应用、试验、总结最佳中药治疗方法，得到了本发明的有效中药组合物及配制应用。具有药源易得，制备简易，远期疗效高，医疗成本低，复发率低，患者易接受等优点。
本发明技术方案为：
治疗妇女外阴鳞状上皮细胞增生中药组合物，其特征在于：各原料药组分的重量份为（克）：黄柏5-15、连翘5-15、指甲花3-9、白花草3-9、千里光3-9、蛇床子4-12、怀牛膝4-12、土茯苓4-12、白术3-9、补骨脂10-20、苦参10-20、皂夹3-9、红花3-9、生蒲黄3-9、白芍2-6、地骨皮2-6、八角枫2-6、重楼4-8、白花蛇草4-12。
本发明的中药组合物制备方法为：
优选已炮制黄柏、连翘、指甲花、白花草、千里光、蛇床子、怀牛膝、大艾、土茯苓、白术、补骨脂、苦参、皂夹、红花、生蒲黄、白芍、地骨皮、八角枫、皂夹、白花蛇草、重楼为原料药去除杂质和非药用部分，将诸入锅按常规煎煮药液2次，合并虑液备用，再将药液入盆中加入热水（40-60度）、2000-2500ml与药混均，进行熏洗，每次20-30分钟，每天1-2次。每剂药可用2天，连用20-30天为一疗程，基本治愈。一种治疗妇女外阴鳞状上皮细胞增生中药组合物制剂也可以煎取药液灭菌装瓶，按一定量备用。
该中药组合物主要性味功效如下表：
该中药组合物外用熏洗的综合有益功效为：
清热除湿、消斑止痒、燥湿、祛风杀虫、活血通络、软坚散结、温肾滋阴、阻止癌前病变等。多药还具备了协同作用，用药合理，配伍科学，且复发率低，治愈率高，远期疗效好，外用无副作用，优于目前其他治疗方法。
具体实施方式
实施例1：
一种用于治疗妇女外阴鳞状上皮细胞增生中药组合物，由下列重量的原料药组成，黄柏5g、连翘5g、指甲花3g、白花草4g、千里光5g、蛇床子6g、怀牛膝6g、土茯苓4g、白术3g、补骨脂6g、苦参15g、皂夹3g、红花3g、生蒲黄3g、白芍4g、地骨皮4g、八角枫2g、白花蛇草6g、重楼叶4g。为一剂量。
制作方法：优选诸药去除杂质及非药用部分，诸药以法炮制，称取诸药重量混合加水，按常规方法煎煮药液2次，合并虑液即得药液约1000毫升，将药液入盆中加入执水50-60度2000毫升，先熏后洗。    
实施例2：
一种用治疗妇女外阴鳞状上皮细胞增生中药组合物制剂方法还可以为：称取多剂量药物，煎制后，过滤分装灭菌保存备用。
试验例本发明实施例的药液治疗妇女外阴鳞状上皮细胞增生中药组合物临床观察。
、诊断标准
一般发生于30-36的妇女，但也可发生老年妇女。主要表现为外阴瘙痒，多难以忍受，抓伤后疼痛加剧。病变范围不等。可波及大阴唇、小阴唇、阴蒂包皮，以后可向会阴部及肛门周围蔓延。病变呈对称性，早期皮肤呈粉红色，角化过度呈白色。长期搔抓和摩擦，病变皮肤增厚，色素增加，形成扁平丘疹，出现苔癣样变。随着上皮增厚，外阴呈浸渍状。形成界线清晰白色斑块。经久治不愈。病理检查具有确诊意义。本病应于白癜风、外阴炎等鉴别。
观察指标：
治疗后：应确诊，观察局部皮肤颜色，有无溃烂，范围大小，病变消退情况，以及用药过程的表现。
治疗前：通过妇科外阴检查以及病理检验，确诊并排其它外阴皮肤病，得出诊断为外阴鳞状上皮细胞增生。
、治疗方法。按常规外用熏洗方法，进行治疗。
治疗期间，禁食有刺激性食物，局部忌用肥皂等其他洗剂，保持局部干燥。
、疗效评定标准
痊愈：通过该药物外用重洗，病变部位瘙痒减轻或消失，皮损恢复，治疗时间为20-40天，颜色趋于正常，半年回访无复发。
有效：皮损变蒲或恢复正常，局部仍有瘙痒，或有小部分皮色异常，继续治疗仍不能痊愈者。
无效：治疗前后病变，症状无改变，治疗10天即可确定。
、疾病总体治疗结果
通过近3年中药外用治疗90例，痊愈79人，有效7人，无效4人，痊愈率88%，有效率7.4%，无效率4.4%。
具体病例
例1、黄某，女，35岁，本地农民，于2010年5月7日就诊，主治：外阴瘙痒半年，近期溃烂，经妇科及病理检查，排除外阴其它皮肤病。确诊为：外阴鳞状上皮细胞增生。取上述中药10剂，属外用治疗方法，经复诊，病情趋于好转，继用20余剂，3个月后，随访，无复发，痊愈。
例2、赵某，女，36岁，本地农民，于2010年7月8日就诊，主治：外阴痒3月，曾多次外用“药膏”无效，妇科呈外阴大阴唇，皮肤暗红色并增厚，有丘疹隆起，经病理报告后，确认为：外阴鳞状上皮细胞增生。取上述中药20剂，并嘱用法注意事项，30天后复诊，局部明显好转，继用15剂后，半年随访无复发，痊愈。
例3、马某，女，41岁，市，于2013年8月21日就诊，主诉：外阴丘疹、搔痒、皮肤增厚，半年前确认该病，并手术，经妇科检查最后确诊：磷状上皮细胞增生术后复发，取上述中药20剂，嘱用法，1月后复查好转，继用15剂，后痊愈，半年随访无复发。
例4、李某，女，34岁，教师，于2011年11月12日就诊，主治：外阴瘙痒1年余，近来加重，经妇科检查，外阴及肛周围皮肤有散在溃疡，皮肤呈暗红色和白色斑点，但无萎缩及粘连，经病理多点取标本诊断为：磷状上皮增生，确诊后，用上述中药15剂，后复诊继用10剂，随诊皮肤溃疡恢复仍有瘙痒皮色暗红，为有效。
例5、李某，妇，37岁，干部，2012年10月18日就诊，在外地医院诊来我院门诊经20余剂中药外用，好转，继用15剂，后随访，诸症消失、痊愈。

Claims (2)

1.一种治疗妇外阴鳞状上皮细胞增生的中药组合物，其特征在于：它由下列重量（克）范围内的原料药制成：黄柏5-15、连翘5-15、指甲花3-9、白花草3-9、千里光3-9、蛇床子4-12、怀牛膝4-12、土茯苓4-12、白术3-9、补骨脂10-20、苦参10-20、皂夹3-9、红花3-9、生蒲黄3-9、白芍2-6、地骨皮2-6、八角枫2-6、重楼4-8、白花蛇草4-12。
2.根据权利要求1所述的外用药物，其中各原料用量为：黄柏5g、连翘5g、指甲花3g、白花草4g、千里光5g、蛇床子6g、怀牛膝6g、土茯苓4g、白术3g、补骨脂6g、苦参15g、皂夹3g、红花3g、生蒲黄3g、白芍4g、地骨皮4g、八角枫2g、白花蛇草6g、重楼叶4g。
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CN104825940A (zh) * 2015-05-28 2015-08-12 张卫民 一种用于外阴鳞状细胞癌中药制剂及其制备方法
CN106177652A (zh) * 2016-08-30 2016-12-07 孟玲 一种治疗外阴鳞状上皮细胞增生的药物组合物

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