CN104383268A - 一种治疗高血压的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗高血压的中药组合物,属于中药技术领域,由下述原料制备而成:地龙,龟板,淫羊藿,知母,菊花,麦冬,枸杞子,黄芩,当归,栝蒌,钩藤,茯苓,生地,泽泻,羌活,葛根,白芍,杜仲,丹参,黄精,草决明,山药,甘草。本发明具有活血化瘀、平肝清热、益肾固涩、祛湿利水之功效。降血压效果明显,疗效稳定,且对高血压引起的头痛、头晕、脑梗塞、四肢乏力等症状有着很好的治疗缓解效果,解决了高血压易反复、难治愈的医学难题。
Description
技术领域
本发明涉及一种治疗高血压的中药组合物,属于中药技术领域。
背景技术
凡正常成人收缩压应小于或等于140mmHg(18.6kPa),舒张压小于或等于90mmHg(12kPa)。如果成人收缩压大于或等于160mmHg(21.3kPa),舒张压大于或等于95mmHg(12.6kPa)为高血压。高血压早期患者临床表现为头晕、耳鸣、心悸、记忆力减退、手脚麻木等症状。后期患者的血压常持续在较高水平,并伴有脑、心、肾等器官受损的表现,易导致功能障碍,甚至发生衰竭。遗传,脾气不好,口重,压力大,饮食不规律,生活坐息时间不规律都有可能造成高血压的。
对于该病目前西医尚无效果显著的特异疗法,多数人需要终生服药,这些西药降压药虽然作用迅速,但降压过程中血压波动大,副作用也大,只能治标不能治本,并形成药物依赖。使用中医药治疗高血压使毒副作用大大减少,目前国内治疗高血压方面的中药也很多,但是现有的中药配方效果并不是十分理想。
发明内容
本发明克服了上述现有技术的不足,提供了一种治疗高血压的中药组合物组合物,降压效果明显,并能改善本病对患者带来的头晕、耳鸣、心悸、记忆力减退、手脚麻木等症状。
本发明的技术方案是:一种治疗高血压的中药组合物,其特征是,由以下重量的中药制成:
地龙5-15克,龟板5-15克,淫羊藿5-15克,知母5-15克,菊花5-15克,麦冬5-15克,枸杞子5-15克,黄芩5-15克,当归5-15克,栝蒌10-20克,钩藤10-20克,茯苓10-20克,生地10-20克,泽泻10-20克,羌活10-20克,葛根10-20克,白芍10-20克,杜仲10-20克,丹参15-25克,黄精15-25克,草决明15-25克,山药20-30克,甘草3-10克。
优选的,由以下重量的中药制成:
地龙10克,龟板10克,淫羊藿10克,知母10克,菊花10克,麦冬10克,枸杞子10克,黄芩10克,当归10克,栝蒌15克,钩藤15克,茯苓15克,生地15克,泽泻15克,羌活15克,葛根15克,白芍15克,杜仲15克,丹参20克,黄精20克,草决明20克,山药25克,甘草6克。
制备及服用方法:先将上述原料用水浸泡2小时,水煮30分钟,倒出药液;再加水煮30分钟,倒出药液;两遍药液混一起,凉透,分别于早饭前半小时,晚饭后两小时服用。连服20天为一疗程。
各中药的药理作用:
地龙:清热,平肝,止喘,通络。治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬。
生地:苦寒清热,甘寒质润养阴,为清凉滋润之品,擅长于滋阴清热凉血。功效清热凉血,养阴生津,润肠。
龟板:能滋阴潜阳,清热去湿、消除骨热、眩晕、耳鸣等。
淫羊藿:辛甘,温。入肝、肾经。补肾壮阳,祛风除湿。治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四肢不仁。
知母:苦,寒。入肺、胃、肾经。滋阴降火,润燥滑肠。治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。
菊花:甘苦,凉。入肺、肝经。疏风,清热,明目,解毒。治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。
麦冬:甘,微苦,微寒。归心、肺、胃经。养阴生津,润肺清心。用于肺燥干咳,虚痨咳嗽,津伤口渴,心烦失眠,内热消渴,肠燥便秘,咽白喉。
枸杞子:甘,平。入肝、肾经。滋肾,润肺,补肝,明目。治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。
黄芩:苦,寒。入心、肺、胆、大肠经。泻实火,去湿热,止血,安胎。治壮热烦渴,肺热咳嗽,湿热泻痢,黄疸,热淋,吐、衄、崩、漏,目赤肿痛,胎动不安,痈肿疔疮。
当归:甘辛,温。入心、肝、脾经。补血和血,调经止痛,润燥滑肠。治月经不调,经闭腹痛,癥瘕结聚,崩漏;血虚头痛,眩晕,痿痹;肠燥便难,赤痢后重;痈疽疮窃,跌扑损伤。
栝蒌:甘苦,寒。入肺、胃、大肠经。润肺,化痰,散结,滑肠。治痰热咳嗽,胸痹,结胸,肺痿咳血,消渴,黄疸,便秘,痈肿初起。
钩藤:甘,凉。入肝、心经。清热平肝,熄风定惊。治小儿惊痫瘈疭,大人血压偏高,头晕、目眩,妇人子痫。
茯苓:甘淡,平。入心、脾、肺经。渗湿利水,益脾和胃,宁心安神。治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。
泽泻:甘,寒。入肾、膀胱经。利水,渗湿,泄热。治小便不利,水肿胀满,呕吐,泻痢,痰饮,脚气,淋病,尿血。
羌活:辛苦,温。入膀胱、肾经。散表寒,祛风湿,利关节.治感冒风寒,头痛无汗,风寒湿痹。
葛根:甘辛,平。入脾、胃经。升阳解肌,透疹止泻,除烦止渴,治伤寒,温热头痛项强,烦热消渴。
白芍:苦酸,凉。入肝、脾经。养血柔肝,缓中止痛,敛阴收汗.治胸腹胁肋疼痛,自汗盗汗,阴虚发热。
杜仲:入肝、肾经。补肝肾,强筋骨,安胎。治腰脊酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,胎动不安,高血压。
丹参:苦,微寒;归心、肝经。活血化淤,凉血宁心。本品降而行血,善入血分,能通经脉、化淤滞、清心火、凉血热,安神志、除悸烦,常用于胸痹心痛,月经部调、疮疡肿痛,失眠及淤血肿痛等症。
黄精:补中益气,润心肺,强筋骨。治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。
草决明:味微苦微甘,性平,微凉。归肝、肾、大肠经。具有清热明目,润肠通便。主要用于目赤涩痛,羞明多泪,头痛眩晕,目暗不明,大便秘结。还具有减肥之功效。
山药:味甘,温。入肺、脾、肾经。健脾,补肺,固肾,益精。治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数;补脾养胃,生津益肺,补肾涩精。用于脾虚食少、久泻不止、肺虚喘咳、肾虚遗精、带下、尿频、虚热消渴。
甘草:甘,平。归心、肺、脾、胃经。补脾益气,滋咳润肺,缓急解毒,调和百药。主治咽喉肿痛,痛疽疮疡,胃肠道溃疡以及解药毒、食物中毒等。
传统医学认为,高血压主要由肝脏经络的气血失调、阴阳失衡所致;在中医理论上,其病机为风、火、痰、瘀、虚所致血压升高,高血压发病的原因主要是伤肾、郁怒伤肝造成的,针对本病的病因病机,本方以栝蒌、当归、黄芩、白芍、丹参活血化瘀;地龙、生地、龟板、菊花、麦冬、钩藤、草决明平肝清热;知母、山药、黄精、枸杞子益肾固涩;淫羊藿、茯苓、泽泻、羌活、葛根、杜仲祛湿利水。甘草调和诸药,诸药配伍,共奏活血化瘀、平肝清热、益肾固涩、祛湿利水之功效。降血压效果明显,疗效稳定,且对高血压引起的头痛、头晕、脑梗塞、四肢乏力等症状有着很好的治疗缓解效果,解决了高血压易反复、难治愈的医学难题。
以下结合临床资料及典型病例对本发明的有益效果进一步说明。
一、临床观察
1、选取门诊原发性高血压病人50例,并除外合并冠心病心绞痛,心律失常,糖尿病等其它疾病的患者。其中男性26例,女性24例,年龄在33~75岁之间。平均为54.3岁。病程为1年~20年不等,平均11.5年。高血压分级:Ⅰ级25例,Ⅱ级21例,Ⅲ级4例。
2、诊断标准:参考卫生部《中药新药治疗高血压病临床研究指导原则》规定的标准。
3、治疗方法:服用本发明药物,水煎煮,分两次早晚服用。20天为1个疗程。
4、疗效评定标准:
参照1993年卫生部颁布的《中药新药治疗高血压病的临床研究指导原则》中制定的降压疗效标准评定[2]。
显效:(1)DBP降低≥1.3kPa,并达到正常范围;(2)DBP虽未下降至正常,但已下降≥2.7kPa,须具备其中1项。
有效:(1)DBP下降<1.3kPa,但已达到正常范围;(2)DBP较治疗前下降1.3~2.5kPa,但未达到正常范围;(3)SBP较治疗前下降≥4.0kPa,须具备其中1项。
无效:未达到上述标准。
5、治疗结果:治愈41,治愈率86%;显效3人,显效率88%;有效6人,有效率100%。
综上所述,本发明用于治疗高血压的中药组合物,经临床试验,表明其可有效抑制高血压,改善患者因高血压引发的其它症状、体征,有效率高达100%,且无明显毒副作用。
二、典型病例
病例1:孙某某,女,58岁。患者三年前自觉头晕目眩,经县医院检查:血压165/100mmHg,确诊为原发性高血压,服用西药卡托普利,阿司匹林效果不明显,经人介绍服用本发明药物治疗,服用本方一个疗程,症状明显减轻,血压降至140/90mmHg而稳定,继续服药两个疗程,血压130/85mmHg,并发症现象全部消失。随访半年,未见复发。
病例2:夏某某,男,年龄62岁。患者一年前患者自觉头晕、目眩、心悸、多梦,测血压170/95mmHg,医院诊断为高血压,一年来一直坚持服用西药治疗,血压一直控制在正常范围内,但其它症状未见明显改善。后来经服用本发明药物治疗一个疗程,头晕、心悸症状消失,睡眠也好了,血压维持在收缩压140/90mmHg,继续服药一个疗程,全身症状消失,达到临床治愈,随访半年,未见复发。
病例3:姜某某,女,54岁。患者高血压一年,测血压170/90mmHg,患有头晕、目眩、心率不齐等并发症,常年服用西药降血压,血压虽得以维持在较标准的水平,但并发症不见好转,连服本方一个疗程,头晕、目眩、心率不齐等症状明显减轻,血压降至155/85mmHg,继续服药两个疗程,血压降至130/82mmHg,症状完全消失,随访未见复发。
具体实施方式
实施例1:一种治疗高血压的中药组合物,由以下重量的中药制成:
地龙10克,龟板10克,淫羊藿10克,知母10克,菊花10克,麦冬10克,枸杞子10克,黄芩10克,当归10克,栝蒌15克,钩藤15克,茯苓15克,生地15克,泽泻15克,羌活15克,葛根15克,白芍15克,杜仲15克,丹参20克,黄精20克,草决明20克,山药25克,甘草6克。
制备及服用方法:先将上述原料用水浸泡2小时,水煮30分钟,倒出药液;再加水煮30分钟,倒出药液;两遍药液混一起,凉透,分别于早饭前半小时,晚饭后两小时服用。连服20天为一疗程。
实施例2:一种治疗高血压的中药组合物,由以下重量的中药制成:
地龙10克,龟板10克,淫羊藿10克,知母10克,菊花10克,麦冬10克,枸杞子10克,黄芩10克,当归10克,栝蒌10克,钩藤10克,茯苓10克,生地15克,泽泻15克,羌活15克,葛根15克,白芍10克,杜仲10克,丹参15克,黄精15克,草决明20克,山药20克,甘草6克。
制备及服用方法:同例1。
实施例3:一种治疗高血压的中药组合物,由以下重量的中药制成:
地龙10克,龟板10克,淫羊藿10克,知母10克,菊花10克,麦冬10克,枸杞子15克,黄芩15克,当归15克,栝蒌15克,钩藤10克,茯苓10克,生地15克,泽泻10克,羌活10克,葛根15克,白芍15克,杜仲15克,丹参15克,黄精15克,草决明15克,山药20克,甘草3克。
制备及服用方法:同例1。
Claims (2)
1.一种治疗高血压的中药组合物,其特征是,由以下重量的中药制成:
地龙5-15克,龟板5-15克,淫羊藿5-15克,知母5-15克,菊花5-15克,麦冬5-15克,枸杞子5-15克,黄芩5-15克,当归5-15克,栝蒌10-20克,钩藤10-20克,茯苓10-20克,生地10-20克,泽泻10-20克,羌活10-20克,葛根10-20克,白芍10-20克,杜仲10-20克,丹参15-25克,黄精15-25克,草决明15-25克,山药20-30克,甘草3-10克。
2.根据权利要求1所述的治疗高血压的中药组合物,其特征是,由以下重量的中药制成:
地龙10克,龟板10克,淫羊藿10克,知母10克,菊花10克,麦冬10克,枸杞子10克,黄芩10克,当归10克,栝蒌15克,钩藤15克,茯苓15克,生地15克,泽泻15克,羌活15克,葛根15克,白芍15克,杜仲15克,丹参20克,黄精20克,草决明20克,山药25克,甘草6克。
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