CN104383261B - A kind of health-caring capsule and preparation method thereof and discrimination method - Google Patents
A kind of health-caring capsule and preparation method thereof and discrimination method Download PDFInfo
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Abstract
The present invention relates to health-caring capsule technical field, especially a kind of health-caring capsule and preparation method thereof and discrimination method, pass through the fleece-flower root, sealwort, the fruit of glossy privet, the appropriate proportioning of each raw material of eclipta, and pass through Feedstock treating, filtrate mixes, add the combination of the processing steps such as powder, so that the nutritional ingredient in raw material is sufficiently retained, improve the nutritive effect for the health-caring capsule made, improve the quality of health-caring capsule, strengthen health-caring capsule to insomnia and dreamful sleep, tinnitus is forgetful, epilation, the remissions such as poliosis, and then filling liver kidney, the effect of benefiting essence-blood；A kind of targetedly discrimination method is provided by the health-caring capsule prepared to technical scheme, so that the quality of health-caring capsule is further ensured.
Description
Technical field
The present invention relates to health-caring capsule technical field, especially a kind of health-caring capsule and preparation method thereof and discrimination method.
Background technology
Health is the quality of life that modern people pursue, and for health, in the prior art, substantial amounts of health occurs and protects
Strong medicine, health care soup, health-care tea, and hyperglycaemia is directed to mostly, and hypertension, diabetes, myocardial vascular disease,
Deficiency of the kidney, kidney deficiency, ephritis, constipation and other diseases, wherein the technical solution used is exactly the Chinese medicine or food materials medicine-food two-purpose nothing but
It is combined and arranges in pairs or groups, and prepared by certain technique, such as by prepared fleece flower root, sealwort system, fruit of glossy privet system, ink drought
Lotus is combined collocation with other Chinese medicines or food materials, is made and is suitable for diabetes, hypertension, hyperglycaemia, myocardial vascular disease
Pill, powder, paste, the decoction that disease or nephrotic eat, while also have konjaku, maca, wheat, corn, glutinous rice etc.
The stronger food materials of other consumptions and the Chinese medicine of other medicine-food two-purposes are combined, and are configured to the food of cake, paste etc, for
Body-care health is used, but for how the more healthy nutritional ingredient by raw material retains, and cause in raw material
The technical literature that the nutritive value of nutritional ingredient is further enhanced has not been reported, and by prepared fleece flower root, sealwort system, female
The report that loyal son system, eclipta are prepared into health-caring capsule also yet there are no.
For this reason, this researcher starts with by long-term research and discussion, and from above-mentioned technical problem, by prepared fleece flower root, Huang
The refined, raw material of fruit of glossy privet system, eclipta as health-caring capsule production field, one is provided for the production field of health-caring capsule
Kind new approaches.
The content of the invention
In order to solve the above technical problems existing in the prior art, the present invention provides a kind of health-caring capsule, it, which has, mends
The effect of liver kidney, benefiting essence-blood, strenghthening bone, to insomnia and dreamful sleep, the disease such as tinnitus is forgetful, epilation, poliosis have it is notable
The feature of therapeutic effect.
The present invention also provides a kind of preparation method of health-caring capsule, has the nutrient in protection raw medicinal material, it is ensured that
The effect of health-caring capsule, is preferable, can be that human body supplements various nutrient elements, and then relieving insomnia dreaminess, tinnitus are forgetful, hair
Come off, the disease such as poliosis, and then the effect of health care.
It is achieved particular by following technical scheme：
A kind of health-caring capsule, its raw material composition for (in parts by weight) fleece-flower root 450-550 parts, 450-550 parts of sealwort, female
Loyal sub- 200-300 parts, 200-300 parts of eclipta.
The raw material composition is fleece-flower root 480-520 parts (in parts by weight), 480-520 parts of sealwort, fruit of glossy privet 220-
280 parts, 220-280 parts of eclipta.
The raw material composition is 500 parts of the fleece-flower root, 500 parts of sealwort, 250 parts of the fruit of glossy privet, eclipta (in parts by weight)
250 parts.
The preparation method of the health-caring capsule, comprises the following steps：
(1) Feedstock treating：Take the raw material of above-mentioned raw materials part stand-by, the fleece-flower root is divided into five parts, two parts of fleece-flowers root are taken, by it
It is placed in dryer, uses programming rate to be warming up to 70 DEG C from 20 DEG C for 3 DEG C/min, carried out constant temperature processing, dries
It is 2-3% to go out fleece-flower root moisture, then the fleece-flower root of drying is placed in pulverizer and is ground into 120-140 mesh powders, is treated
With；The fruit of glossy privet is placed in steamer, uses wine steam to carry out after temperature steams 20-40min for 80-90 DEG C the fruit of glossy privet, takes
Go out the fruit of glossy privet, then by it with sealwort, eclipta and remaining three parts of fleece-flowers root after mixing, obtain mixed material, then will
Mixed material is 1 according to weight ratio with water:(3-5) is prepared, and is placed in boiler, after standing 10-12min, then by boiler
Be warming up to 110-130 DEG C according to programming rate for 11 DEG C/min, after constant temperature decocts 3-5min, then use programming rate for 5 DEG C/
Min is warming up to 150-170 DEG C, and constant temperature decocts 7-10min, then uses cooling rate to be cooled to 80 DEG C for 20 DEG C/min, and constant temperature is decocted
20-25min is boiled, then uses cooling rate to be cooled to 30 DEG C for 15 DEG C/min, then by its filtration treatment, obtains filtrate a and filter residue
a；Filter residue is placed in boiler again, adds the clear water of 3 times of weight, above-mentioned decoction step is repeated, refilters, obtains filtrate b and filter residue
b；Filter residue a is placed in boiler again, adds the clear water of 3 times of weight, above-mentioned decoction step is repeated, refilters, obtains filtrate c and filter residue
C, it is stand-by；
(2) filtrate mixes：Filtrate a, filtrate b, filtrate c made from step 1) are mixed, and is placed on temperature and is
In 70-90 DEG C of environment, it is concentrated into relative density and is 1.10~1.15 clear cream, then add ethanol thereto so that is dense
Alcohol content (mass percentage) in contracting liquid is 60%, and uses mixing speed as 60-70r/min stir process 20-
30min, then by its stewing process>24h, takes out supernatant, then subnatant is concentrated into 1/5th, obtains thick paste, then by its
It is placed in natural environment and is cooled to room temperature, it is stand-by；
(3) powder is added：The fleece-flower root powder that step 1) is obtained is added in the thick paste that step 2) obtains, and uses mixing speed
For 40-50r/min stir process 20-40min, then it is placed in dryer, uses temperature to be dried to moisture for 30-40 DEG C and contain
Measure as after 2-5%, then be placed in pulverizer and be crushed to 130-140 mesh, then add thereto superfine silica gel powder, magnesium stearate and
Starch, wherein superfine silica gel powder be 100-300nm powder, its addition be raw material gross weight 1-2%, the addition of magnesium stearate
Measure the 0.5-0.9% for gross weight, starch accounts for superfine silica gel powder and the 5-9% of magnesium stearate gross weight, and be stirred for uniformly after,
It is fitted into capsule according to 0.45g/, you can obtain health-caring capsule.
The capsule body of the capsule contains the rice bran oil that mass fraction is 7-9%.
The discrimination method of the health-caring capsule, comprises the following steps：
(1) prepared by test sample：Go bail for strong capsule 's content 0.2g, adds ethanol 25ml, be heated to 80 DEG C reflux 1 it is small when, filter
Cross, for filtrate recycling design to doing, residue adds water 10ml to make dissolving, passes through D101 type large pore resin absorption columns, its column internal diameter
1.2cm, pillar height 15cm, are eluted with water 100ml, discard eluent, again with methanol 50ml elutions, collect eluent, recycling design
To doing, residue adds methanol 2ml to make dissolving, stand-by as test solution；
(2) prepared by reference substance：Fleece-flower root 0.2g is taken, adds ethanol 25ml, control medicinal material solution is made in the method with step 1,
Reference substance solution is obtained, it is stand-by；
(3) differentiate：Draw each 5 μ l of above two solution, put respectively on same silica gel g thin-layer plate, with chloroform and
Methanol is 7 according to mass ratio:Be solvent after 3 mixing, open up to 3-4cm, taking-up, dries, then with chloroform and methanol according to
Mass ratio is 20:It is solvent after 1 mixing, opens up to 7-8cm, take out, dry, is respectively placed in the purple of daylight and wavelength for 365nm
Inspected under outer light, you can complete the discriminating of health-caring capsule.
Identification result is：In test sample chromatography, on position corresponding with control medicinal material chromatography, same color is shown under daylight
Spot, the fluorescence spot of same color is shown under ultraviolet light.
The silica gel g thin-layer plate is formed by binding agent bonding of sodium carboxymethylcellulose.
The present invention also provides the discrimination method of another health-caring capsule, comprise the following steps：
(1) health-caring capsule 1g is taken, concentration is added thereto and is 70% ethanol 4ml, then it is 80 DEG C to be placed on temperature
In water-bath, water-bath reflow treatment 1h is carried out, filtering, obtains filtrate, filtrate is concentrated 1ml at 60 DEG C, and test solution is made,
It is stand-by；
(2) 1g sealworts are taken, reference substance solution is configured to according to the operating method of step 1, it is stand-by；
(3) test solution and reference substance solution 10ul are drawn respectively, and it is put in same silica gel H lamellae respectively
Diverse location in same horizontal line, and using n-butanol, glacial acetic acid and water according to mass ratio as 4:1:The mixed liquor that 1 proportioning forms
It is placed in as solvent, and by silica gel H lamellae in solvent, makes test solution with reference substance solution in silica gel H lamellae
Upper expansion processing 20min, then further takes out, is dried under normal temperature environment, then is sprayed the ninhydrin second that percetage by weight is 2%
Alcoholic solution, then be placed in the environment that temperature is 105 DEG C, 1-9min is toasted, observes the hydrochloric acid change feelings on silica gel H lamellae
Condition, you can complete the discriminating of health-caring capsule.
Furthermore the present invention also provides the discrimination method of following several health-caring capsules：
1st, take this product content 2.7g, add 70% ethanol 30ml, be heated to reflux 1 it is small when, filter while hot, filtrate water-bath steam
Dry, residue acetone 20ml, water-bath low-grade fever makes dissolving, and filtration, filtrate water-bath is concentrated into about 1ml, as test solution.Separately take Yunnan
Sealwort (system) control medicinal material 3g, when adding water 50ml refluxing extractions 1 small, filtering, filtrate water-bath is concentrated into about 10ml, lets cool, and adds second
Alcohol adjusts ethanol content to 60%, and centrifugal filtering (3500 revs/min, 5 minutes), supernatant water bath method, residue adds acetone
20ml same treatments, as control medicinal material solution.Tested according to thin-layered chromatography (annex VI B), draw above two solution each 5
~10 μ l, put on same silica gel g thin-layer plate, with cyclohexane-ethyl acetate-formic acid (2 respectively:4:0.5) it is solvent, exhibition
Open, take out, dry, spray with 2,4-dinitrophenylhydrazine ethanol test solution, dry, inspect in the sunlight.In test sample chromatography, with it is right
According on medicinal material chromatography relevant position, the spot of same color is shown.
2nd, this product content 2.5g is taken, is put in conical flask, adds Diluted Alcohol 25ml, is ultrasonically treated (power 250W, frequency
60kHz) 30 minutes, let cool, shake up, filter, subsequent filtrate is as test solution.Separately take Specnuezhenide reference substance appropriate, it is accurate
It is weighed, add methanol that solution of every 1ml containing 0.1mg is made, as reference substance solution.According to high performance liquid chromatography (Chinese Pharmacopoeia
The one annex VID of version in 2010) experiment, using octadecylsilane chemically bonded silica as filler；It is stream with methanol-water (40: 60)
Dynamic phase；Detection wavelength is 224nm.Number of theoretical plate is calculated by Specnuezhenide peak should be not less than 3000.It is accurate respectively to draw reference substance
Solution and each 10 μ l of test solution, inject liquid chromatograph.It should be presented in test solution chromatography with being protected in reference substance chromatography
Stay the chromatographic peak that the time is identical.
3rd, this product content 5.4g is taken, adds 70% methanol 25ml, is ultrasonically treated 45 minutes, filtration, filtrate is concentrated into about
8ml, adds water 15ml, stirs evenly, filtration, and filtrate is extracted 3 times, each 20ml with (60-90 DEG C) shaking of petroleum ether, merges petroleum ether
Liquid, recycling design is to doing, and residue adds methanol 0.5ml to make dissolving, as test solution.Eclipta control medicinal material 0.5g separately is taken,
Add water 50ml, when heating slightly boiling 1 is small, let cool, filter, filtrate is concentrated into about 30ml, " is carried certainly with (60-90 DEG C) shaking of petroleum ether
Take 3 times " rise, it is made in the same way of control medicinal material solution.Tested according to thin-layered chromatography (annex VI B), draw 5~10 μ of test solution
L, 2 μ l of control medicinal material solution, put on same silica gel g thin-layer plate, with petroleum ether (30-60 DEG C)-Ethyl formate-formic acid respectively
(20:5:1) upper solution is solvent, is unfolded, and takes out, dries, inspected under ultraviolet light (365nm), in test sample chromatography,
On position corresponding with control medicinal material chromatography, the fluorescence spot of same color is shown.
Compared with prior art, technique effect of the invention is embodied in：
1. match by the fleece-flower root, sealwort, the fruit of glossy privet, the appropriate of each raw material of eclipta, and mixed by Feedstock treating, filtrate
The combination of the processing steps such as powder is closed, added, so that the nutritional ingredient in raw material is sufficiently retained, improves what is made
The nutritive effect of health-caring capsule, improves the quality of health-caring capsule, and enhancing health-caring capsule is to insomnia and dreamful sleep, tinnitus is forgetful, hair takes off
Fall, the remission such as poliosis, and then the effect of filling liver kidney, benefiting essence-blood.
2. a kind of targetedly discrimination method is provided by the health-caring capsule prepared to technical scheme, into
And make it that the quality of health-caring capsule is further ensured.
It is 3. especially right by preparation method, carrying out accurate appropriate control to the technological parameter in processing step
Decoct the control of temperature, it is ensured that the biochemical reaction accurately oriented occurs between the nutritional ingredient in raw material, further
Abundant health-caring capsule in trophic structure, reduce the Harmful ingredient content in raw material, and then prepare and have no toxic side effect, and
Can immunity in reinforcement, reduce blood glucose, improve the health-caring capsule of sexual function.
Embodiment
Limited with reference to specific embodiment technical scheme is further, but claimed
Scope is not only limited to made description.
Embodiment 1
A kind of health-caring capsule, its raw material is fleece-flower root 450kg, sealwort 450kg, fruit of glossy privet 200kg, eclipta 200kg.
The preparation method of the health-caring capsule, comprises the following steps：
(1) Feedstock treating：Take the raw material of above-mentioned raw materials part stand-by, the fleece-flower root is divided into five parts, two parts of fleece-flowers root are taken, by it
It is placed in dryer, uses programming rate to be warming up to 70 DEG C from 20 DEG C for 3 DEG C/min, carried out constant temperature processing, dries
It is 2% to go out fleece-flower root moisture, then the fleece-flower root of drying is placed in pulverizer and is ground into 120 mesh powders, stand-by；By female
Loyal son is placed in steamer, uses wine steam to carry out after temperature steams 20min for 80 DEG C the fruit of glossy privet, takes out the fruit of glossy privet, then will
It after mixing, obtains mixed material, then mixed material and water are pressed with sealwort, eclipta and remaining three parts of fleece-flowers root
It is 1 according to weight ratio:3 prepare, and are placed in boiler, after standing 10min, then by boiler according to programming rate are 11 DEG C/min
110 DEG C, after constant temperature decocts 3min are warming up to, then uses programming rate to be warming up to 150 DEG C for 5 DEG C/min, constant temperature decocts 7min, then
Cooling rate is used to be cooled to 80 DEG C for 20 DEG C/min, constant temperature decocts 20min, then uses cooling rate to be cooled to for 15 DEG C/min
30 DEG C, then by its filtration treatment, obtain filtrate a and filter residue a；Filter residue is placed in boiler again, adds the clear water of 3 times of weight, is repeated
Above-mentioned decoction step, refilters, and obtains filtrate b and filter residue b；Filter residue a is placed in boiler again, adds the clear water of 3 times of weight, is repeated
Above-mentioned decoction step, refilters, and obtains filtrate c and filter residue c, stand-by；
(2) filtrate mixes：Filtrate a, filtrate b, filtrate c made from step 1) are mixed, and is placed on temperature and is
In 70 DEG C of environment, it is concentrated into relative density and is 1.10 clear cream, then add ethanol thereto so that containing in concentrate
Alcohol amount (mass percentage) is 60%, and uses mixing speed as 60r/min stir process 20min, then by its stewing process>
24h, takes out supernatant, then subnatant is concentrated into 1/5th, obtains thick paste, then be placed in natural environment and be cooled to often
Temperature, it is stand-by；
(3) powder is added：The fleece-flower root powder that step 1) is obtained is added in the thick paste that step 2) obtains, and uses mixing speed
For 40r/min stir process 20min, then it is placed in dryer, it is 2% to use temperature to be dried to moisture for 30 DEG C
Afterwards, then it is placed in pulverizer and is crushed to 130 mesh, then adds superfine silica gel powder, magnesium stearate and starch, wherein micro mist thereto
Silica gel is the powder of 100nm, its addition is the 1% of raw material gross weight, and the addition of magnesium stearate is the 0.5% of gross weight,
Starch accounts for the 5% of superfine silica gel powder and magnesium stearate gross weight, and be stirred for uniformly after, by its according to 0.45g/ load capsules
In, you can obtain health-caring capsule.
The capsule body of the capsule contains the rice bran oil that mass fraction is 7%.
The discrimination method of the health-caring capsule, comprises the following steps：
(1) prepared by test sample：Go bail for strong capsule 's content 0.2g, adds ethanol 25ml, be heated to 80 DEG C reflux 1 it is small when, filter
Cross, for filtrate recycling design to doing, residue adds water 10ml to make dissolving, passes through D101 type large pore resin absorption columns, its column internal diameter
1.2cm, pillar height 15cm, are eluted with water 100ml, discard eluent, again with methanol 50ml elutions, collect eluent, recycling design
To doing, residue adds methanol 2ml to make dissolving, stand-by as test solution；
(2) prepared by reference substance：Fleece-flower root 0.2g is taken, adds ethanol 25ml, control medicinal material solution is made in the method with step 1,
Reference substance solution is obtained, it is stand-by；
(3) differentiate：Draw each 5 μ l of above two solution, put respectively on same silica gel g thin-layer plate, with chloroform and
Methanol is 7 according to mass ratio:It is solvent after 3 mixing, opens up to 3.5m, take out, dry, then with chloroform and methanol according to matter
Amount is than being 20:It is solvent after 1 mixing, opens up to 7.5cm, take out, dry, it is the ultraviolet of 365nm to be respectively placed in daylight and wavelength
Inspected under light, you can complete the discriminating of health-caring capsule.
The silica gel g thin-layer plate is formed by binding agent bonding of sodium carboxymethylcellulose.
Embodiment 2
On the basis of embodiment 1, other steps are the fleece-flower root with embodiment 1, a kind of health-caring capsule, its raw material composition
480kg, sealwort 480kg, fruit of glossy privet 220kg, eclipta 220kg.
The preparation method of the health-caring capsule, comprises the following steps：
(1) Feedstock treating：Take the raw material of above-mentioned raw materials part stand-by, the fleece-flower root is divided into five parts, two parts of fleece-flowers root are taken, by it
It is placed in dryer, uses programming rate to be warming up to 70 DEG C from 20 DEG C for 3 DEG C/min, carried out constant temperature processing, dries
It is 3% to go out fleece-flower root moisture, then the fleece-flower root of drying is placed in pulverizer and is ground into 140 mesh powders, stand-by；By female
Loyal son is placed in steamer, uses wine steam to carry out after temperature steams 40min for 90 DEG C the fruit of glossy privet, takes out the fruit of glossy privet, then will
It after mixing, obtains mixed material, then mixed material and water are pressed with sealwort, eclipta and remaining three parts of fleece-flowers root
It is 1 according to weight ratio:5 prepare, and are placed in boiler, after standing 12min, then by boiler according to programming rate are 11 DEG C/min
130 DEG C, after constant temperature decocts 5min are warming up to, then uses programming rate to be warming up to 170 DEG C for 5 DEG C/min, constant temperature decocts 10min,
Cooling rate is used to be cooled to 80 DEG C for 20 DEG C/min again, constant temperature decocts 25min, then uses cooling rate to cool down for 15 DEG C/min
To 30 DEG C, then by its filtration treatment, filtrate a and filter residue a is obtained；Filter residue is placed in boiler again, adds the clear water of 3 times of weight, weight
Multiple above-mentioned decoction step, refilters, and obtains filtrate b and filter residue b；Filter residue a is placed in boiler again, adds the clear water of 3 times of weight, weight
Multiple above-mentioned decoction step, refilters, and obtains filtrate c and filter residue c, stand-by；
(2) filtrate mixes：Filtrate a, filtrate b, filtrate c made from step 1) are mixed, and is placed on temperature and is
In 90 DEG C of environment, it is concentrated into relative density and is 1.15 clear cream, then add ethanol thereto so that containing in concentrate
Alcohol amount (mass percentage) is 60%, and uses mixing speed as 70r/min stir process 30min, then by its stewing process>
24h, takes out supernatant, then subnatant is concentrated into 1/5th, obtains thick paste, then be placed in natural environment and be cooled to often
Temperature, it is stand-by；
(3) powder is added：The fleece-flower root powder that step 1) is obtained is added in the thick paste that step 2) obtains, and uses mixing speed
For 50r/min stir process 40min, then it is placed in dryer, it is 5% to use temperature to be dried to moisture for 40 DEG C
Afterwards, then it is placed in pulverizer and is crushed to 140 mesh, then adds superfine silica gel powder, magnesium stearate and starch, wherein micro mist thereto
Silica gel is the powder of 300nm, its addition is the 2% of raw material gross weight, and the addition of magnesium stearate is the 0.9% of gross weight,
Starch accounts for the 9% of superfine silica gel powder and magnesium stearate gross weight, and be stirred for uniformly after, by its according to 0.45g/ load capsules
In, you can obtain health-caring capsule.
The capsule body of the capsule contains the rice bran oil that mass fraction is 9%.
Embodiment 3
On the basis of embodiment 1, it is the fleece-flower root that other, which are illustrated with embodiment 1, a kind of health-caring capsule, its raw material composition,
500kg, sealwort 500kg, fruit of glossy privet 250kg, eclipta 250kg.
The preparation method of the health-caring capsule, comprises the following steps：
(1) Feedstock treating：Take the raw material of above-mentioned raw materials part stand-by, the fleece-flower root is divided into five parts, two parts of fleece-flowers root are taken, by it
It is placed in dryer, uses programming rate to be warming up to 70 DEG C from 20 DEG C for 3 DEG C/min, carried out constant temperature processing, dries
It is 2.5% to go out fleece-flower root moisture, then the fleece-flower root of drying is placed in pulverizer and is ground into 130 mesh powders, stand-by；Will
The fruit of glossy privet is placed in steamer, uses wine steam to carry out after temperature steams 30min for 85 DEG C the fruit of glossy privet, takes out the fruit of glossy privet, then
By it with sealwort, eclipta and remaining three parts of fleece-flowers root after mixing, mixed material is obtained, then by mixed material and water
It is 1 according to weight ratio:4 prepare, and are placed in boiler, after standing 11min, then by boiler according to programming rate for 11 DEG C/
Min is warming up to 120 DEG C, after constant temperature decocts 4min, then uses programming rate to be warming up to 160 DEG C for 5 DEG C/min, and constant temperature decocts
9min, then use cooling rate to be cooled to 80 DEG C for 20 DEG C/min, constant temperature decocts 23min, then use cooling rate for 15 DEG C/
Min is cooled to 30 DEG C, then by its filtration treatment, obtains filtrate a and filter residue a；Filter residue is placed in boiler again, adds 3 times of weight
Clear water, repeats above-mentioned decoction step, refilters, and obtains filtrate b and filter residue b；Filter residue a is placed in boiler again, adds 3 times of weight
Clear water, repeats above-mentioned decoction step, refilters, and obtains filtrate c and filter residue c, stand-by；
(2) filtrate mixes：Filtrate a, filtrate b, filtrate c made from step 1) are mixed, and is placed on temperature and is
In 80 DEG C of environment, it is concentrated into relative density and is 1.13 clear cream, then add ethanol thereto so that containing in concentrate
Alcohol amount (mass percentage) is 60%, and uses mixing speed as 65r/min stir process 25min, then by its stewing process>
24h, takes out supernatant, then subnatant is concentrated into 1/5th, obtains thick paste, then be placed in natural environment and be cooled to often
Temperature, it is stand-by；
(3) powder is added：The fleece-flower root powder that step 1) is obtained is added in the thick paste that step 2) obtains, and uses mixing speed
For 45r/min stir process 30min, then it is placed in dryer, it is 3% to use temperature to be dried to moisture for 35 DEG C
Afterwards, then it is placed in pulverizer and is crushed to 135 mesh, then adds superfine silica gel powder, magnesium stearate and starch, wherein micro mist thereto
Silica gel is the powder of 200nm, its addition is the 1.5% of raw material gross weight, and the addition of magnesium stearate is gross weight
0.8%, starch accounts for the 7% of superfine silica gel powder and magnesium stearate gross weight, and be stirred for uniformly after, by its according to 0.45g/ fill
Enter in capsule, you can obtain health-caring capsule.
The capsule body of the capsule contains the rice bran oil that mass fraction is 8%.
The discrimination method of the health-caring capsule, comprises the following steps：
(1) health-caring capsule 1g is taken, concentration is added thereto and is 70% ethanol 4ml, then it is 80 DEG C to be placed on temperature
In water-bath, water-bath reflow treatment 1h is carried out, filtering, obtains filtrate, filtrate is concentrated 1ml at 60 DEG C, and test solution is made,
It is stand-by；
(2) 1g sealworts are taken, reference substance solution is configured to according to the operating method of step 1, it is stand-by；
(3) test solution and reference substance solution 10ul are drawn respectively, and it is put in same silica gel H lamellae respectively
Diverse location in same horizontal line, and using n-butanol, glacial acetic acid and water according to mass ratio as 4:1:The mixed liquor that 1 proportioning forms
It is placed in as solvent, and by silica gel H lamellae in solvent, makes test solution with reference substance solution in silica gel H lamellae
Upper expansion processing 20min, then further takes out, is dried under normal temperature environment, then is sprayed the ninhydrin second that percetage by weight is 2%
Alcoholic solution, then be placed in the environment that temperature is 105 DEG C, 1-9min is toasted, observes the hydrochloric acid change feelings on silica gel H lamellae
Condition, you can complete the discriminating of health-caring capsule.
Embodiment 4
On the basis of embodiment 1, other are with embodiment 1, and a kind of health-caring capsule, its raw material is fleece-flower root 550g, Huang
Smart 550g, fruit of glossy privet 300g, eclipta 300g.It is made 1200.
Its discrimination method is to take this product content 2.5g, is put in conical flask, adds Diluted Alcohol 25ml, is ultrasonically treated (power
250W, frequency 60kHz) 30 minutes, let cool, shake up, filter, subsequent filtrate is as test solution.Separately take Specnuezhenide reference substance
In right amount, it is accurately weighed, add methanol that solution of every 1ml containing 0.1mg is made, as reference substance solution.According to high performance liquid chromatography (in
One annex VID of state's pharmacopeia version in 2010) experiment, using octadecylsilane chemically bonded silica as filler；With methanol-water (40:
60) it is mobile phase；Detection wavelength is 224nm.Number of theoretical plate is calculated by Specnuezhenide peak should be not less than 3000.It is accurate respectively to draw
Reference substance solution and each 10 μ l of test solution, inject liquid chromatograph.It should be presented in test solution chromatography and reference substance color
The identical chromatographic peak of retention time in spectrum.
This product every is containing prepared fleece flower root with 2,3,5,4 '-tetrahydroxystilbene -2-O- β-D-Glucose glycosides (C20H22O9)
Meter, must not >=2.5mg.
Embodiment 5
On the basis of embodiment 1, other are the fleece-flower root with embodiment 1, a kind of health-caring capsule, its raw material composition
520g, sealwort 520g, fruit of glossy privet 280g, eclipta 280g.It is made 1000.
The present invention has：Filling liver kidney, benefiting essence-blood, strengthens the bone.Cure mainly：Insomnia and dreamful sleep, tinnitus is forgetful, epilation and beard and hair
The illness such as early white.
Usage and dosage is：The two Monday courses for the treatment of, three times per day, one time six.
Test example：
The secondary experiment of the poison of test example 1
Mouse 40 is taken, is averaged and is divided into two groups, marked as A, B, every group 20；A groups are made using the embodiment of the present invention 2
100 millings of health-caring capsule+conventional feed 2kg is obtained to be fed；The physiological saline of the weight such as the use of B groups and health-caring capsule+often
The 2kg mixing of rule feed is fed；After feeding 3 days, the physiological change situation of mouse is observed, mouse is without abnormal, and A groups are small
The average daily activity time of mouse, the excrement of the excretion of A group mouse was normal, the drying of B groups stool in mice than B long 3-4h；Continue to feed
Support to 100 days, and continue to observe the physiological change situation of mouse and the changes of weight situation of mouse, A groups mouse was at the 100th day
Weigh, average every weightening 1.12kg；B groups mouse was weighed at the 100th day, average every weightening 0.73kg.
Have in above-mentioned experimentation as can be seen that the health-caring capsule of the present invention has no toxic side effect, and can be obviously improved
Enteron aisle, enhancing digestion, promotes mouse development and weightening.
2 immunity of test example is tested
The test example 1A groups feeding mouse of 100 days is taken, and is surveyed after the 100th day feeding 30min from ear's bloodletting of mouse
Determine the sugar content in blood, and observe the content of the phagocyte in blood；The small of test example B groups feeding 100 days is taken at the same time
Mouse, and the sugar content in blood is measured, and observe in blood from ear's bloodletting of mouse after the 100th day feeding 30min
The content of phagocyte；And the sugar content in the mouse blood of A groups and B groups and the accounting of phagocyte are carried out to score
Analysis, the sugar content in A group mouse bloods have 17 to maintain relatively low level, have 3 it is somewhat higher；In B group mouse bloods
Sugar content there are 6 to maintain relatively low level, have 14 it is somewhat higher；And the phagocyte in A group mouse bloods accounts for
Frequently the accounting of the phagocyte in B groups mouse blood is 4-8 percentage points high.
It can thus be seen that the health-caring capsule of the present invention can significantly reduce the sugar content of blood, and then reduce blood
Sugar, also being capable of strengthen immunity.
It is important to point out that, above example and test example are only limitted to and reason further elucidated above to the present invention herein
Solution, is not limitation, non-protruding essential characteristics that those skilled in the art make on this basis and non-significant progress
Improve, belong to the protection category of the present invention.
Claims (4)
1. a kind of health-caring capsule, it is characterised in that its raw material composition is, in parts by weight：450-550 parts of the fleece-flower root, sealwort
450-550 parts, 200-300 parts of the fruit of glossy privet, 200-300 parts of eclipta；
The preparation method of the health-caring capsule, comprises the following steps：
（1）Feedstock treating：Take the raw material of above-mentioned raw materials part stand-by, the fleece-flower root is divided into five parts, take two parts of fleece-flowers root, be placed on
In dryer, use programming rate to be warming up to 70 DEG C from 20 DEG C for 3 DEG C/min, carried out constant temperature processing, what is dried out
Tuber of multiflower knotweed moisture is 2-3%, then the fleece-flower root of drying is placed in pulverizer and is ground into 120-140 mesh powders, stand-by；Will
The fruit of glossy privet is placed in steamer, is used wine steam to carry out after temperature steams 20-40min for 80-90 DEG C the fruit of glossy privet, is taken out glossy privet
Son, then by it with sealwort, eclipta and remaining three parts of fleece-flowers root after mixing, obtain mixed material, then will mixing it is former
Material is 1 according to weight ratio with water:（3-5）Prepare, and be placed in boiler, after standing 10-12min, then by boiler according to liter
Warm speed is warming up to 110-130 DEG C, after constant temperature decocts 3-5min for 11 DEG C/min, then uses programming rate to heat up for 5 DEG C/min
To 150-170 DEG C, constant temperature decocts 7-10min, then uses cooling rate to be cooled to 80 DEG C for 20 DEG C/min, and constant temperature decocts 20-
25min, then use cooling rate to be cooled to 30 DEG C for 15 DEG C/min, then by its filtration treatment, obtain filtrate a and filter residue a；Again will
Filter residue is placed in boiler, adds the clear water of 3 times of weight, is repeated above-mentioned decoction step, is refiltered, and obtains filtrate b and filter residue b；Again will
Filter residue a is placed in boiler, adds the clear water of 3 times of weight, is repeated above-mentioned decoction step, is refiltered, and is obtained filtrate c and filter residue c, is treated
With；
（2）Filtrate mixes：By step 1）Obtained filtrate a, filtrate b, filtrate c are mixed, and it is 70-90 to be placed on temperature
DEG C environment in, be concentrated into the clear cream that relative density is 1.10~1.15, then add ethanol thereto so that in concentrate
Alcohol content, mass percent is calculated as 60%, and uses mixing speed as 60-70r/min stir process 20-30min, then by its
Stewing process>24h, takes out supernatant, then subnatant is concentrated into 1/5th, obtains thick paste, then be placed on natural environment
In be cooled to room temperature, it is stand-by；
（3）Add powder：By step 1）The fleece-flower root powder of acquisition adds step 2）In the thick paste of acquisition, and use mixing speed for
40-50r/min stir process 20-40min, then be placed in dryer, use temperature to be dried to moisture for 30-40 DEG C
After 2-5%, then it is placed in pulverizer and is crushed to 130-140 mesh, then adds superfine silica gel powder, magnesium stearate and shallow lake thereto
Powder, wherein superfine silica gel powder be 100-300nm powder, its addition be raw material gross weight 1-2%, the addition of magnesium stearate
For the 0.5-0.9% of gross weight, starch accounts for superfine silica gel powder and the 5-9% of magnesium stearate gross weight, and be stirred for uniformly after, by it
It is fitted into according to 0.45g/ in capsule, you can obtain health-caring capsule；
The discrimination method of health-caring capsule, comprises the following steps：
（1）It is prepared by test sample：Go bail for strong capsule 's content 0.2g, adds ethanol 25ml, be heated to 80 DEG C reflux 1 it is small when, filter, filter
For liquid recycling design to doing, residue adds water 10ml to make dissolving, passes through D101 type large pore resin absorption columns, its column internal diameter 1.2cm, column
High 15cm, is eluted with water 100ml, discards eluent, again with methanol 50ml elutions, collects eluent, recycling design to dry,
Residue adds methanol 2ml to make dissolving, stand-by as test solution；
（2）It is prepared by reference substance：Fleece-flower root 0.2g is taken, adds ethanol 25ml, control medicinal material solution is made in the method with step 1, obtains
Reference substance solution, it is stand-by；
（3）Differentiate：Each 5 μ l of above two solution are drawn, are put respectively on same silica gel g thin-layer plate, with chloroform and methanol
It is 7 according to mass ratio:It is solvent after 3 mixing, opens up to 3-4cm, take out, dry, then with chloroform and methanol according to quality
Than for 20:It is solvent after 1 mixing, opens up to 7-8cm, take out, dry, is respectively placed in the ultraviolet light of daylight and wavelength for 365nm
Under inspect, you can complete the discriminating of health-caring capsule；The capsule body of the capsule contains the rice bran oil that mass fraction is 7-9%.
2. health-caring capsule as claimed in claim 1, it is characterised in that the raw material composition is, in parts by weight：The fleece-flower root
480-520 parts, 480-520 parts of sealwort, 220-280 parts of the fruit of glossy privet, 220-280 parts of eclipta.
3. health-caring capsule as claimed in claim 1, it is characterised in that the raw material composition is, in parts by weight：The fleece-flower root
500 parts, 500 parts of sealwort, 250 parts of the fruit of glossy privet, 250 parts of eclipta.
4. health-caring capsule as claimed in claim 1, it is characterised in that the silica gel g thin-layer plate is with carboxymethyl cellulose
Sodium forms for binding agent bonding.
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| CN1840087A (en) * | 2006-02-06 | 2006-10-04 | 贵州神奇集团控股有限公司 | King solomonseal- and fleece-flower root-containing Chinese medicinal formulation for treating chronic fatigue syndrome and its preparation method |
| CN103235082A (en) * | 2013-04-27 | 2013-08-07 | 贵州盛世龙方制药股份有限公司 | Method for detecting Jingwu capsule |
| CN103977352A (en) * | 2014-05-26 | 2014-08-13 | 徐殿红 | Traditional Chinese medicine composition for treating cancers and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1840087A (en) * | 2006-02-06 | 2006-10-04 | 贵州神奇集团控股有限公司 | King solomonseal- and fleece-flower root-containing Chinese medicinal formulation for treating chronic fatigue syndrome and its preparation method |
| CN103235082A (en) * | 2013-04-27 | 2013-08-07 | 贵州盛世龙方制药股份有限公司 | Method for detecting Jingwu capsule |
| CN103977352A (en) * | 2014-05-26 | 2014-08-13 | 徐殿红 | Traditional Chinese medicine composition for treating cancers and preparation method thereof |
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