CN107744572A - A kind of preparation method of the composition of hair growth - Google Patents

Abstract

The invention discloses a kind of preparation method of the composition of hair growth, its step includes：Weigh raw material：Qarnet wear in one's hair 20 30 parts, 10 20 parts of watermelon peel, 9 15 parts of the fruit of glossy privet, 7 12 parts of semen litchi, 69 parts of rice bud；Then the pretreatment of Qarnet hairpin, soaking in Chinese liquor, water immersion and merging filtrate are concentrated and dried；The raw material of the present invention is only five kinds, and species is few and is easy to get, and cost of material is low；Because bulk drug species is few, its mutual pharmacological action is relatively easy apparent, to the almost non-toxic side effect of human body；Medicine produced by the present invention is good to the therapeutic effect of alopecia, efficient up to 100%, for slight alopecia cure rate up to 81.5%, and be not easy to take off again, take off rate again and be less than 10%；It is relatively short to take the course for the treatment of, can work within 5 days, can cure within 45 days, definite effect.

Description

A kind of preparation method of the composition of hair growth

Technical field

The present invention relates to beauty treatment fields, more particularly to a kind of preparation method of the composition of hair growth.

Background technology

Because rhythm of life is accelerated, social pressures increase, environment constantly deteriorates, and the reason such as poor eating habits, existing Nowadays inferior health person is growing day by day, and hair loss patient is also more and more, has a strong impact on the image of individual, is brought to many people social tired Disturb.Pathologic alopecia refers to that hair is abnormal or excessive and come off that its reason is a lot；It is intrinsic disease from alopecia for traditional Chinese medical science angle One of external manifestation, the cause of disease is a lot, changeful, simulataneous insufficiency and excessive, and most of is the deficiency of liver-yin and kidney-yin, accompanies retention of damp-heat in the interior, the stagnation of the circulation of vital energy Blood stasis, insufficiency of vital energy and blood, liver-fire flaming etc..

The means of hair growth are many at present, including operative treatment, external-use lotion and oral drugs etc..Operative treatment is main Refer to hair Implant, but hair Implant cost is higher, and harm is very big, because the new hair of transplanting is not ecosystem, is moving Started shedding off again after the growth 2-3 to be misplaced at plant, cause the complete atresia of hair hair follicle of transplanting, forever without regeneration；Outside With not notable the effect of lotion；Oral drugs are divided to two kinds of Chinese medicine preparation and Western medicine preparation, existing Chinese medicine preparation complicated component, The course for the treatment of of taking medicine is long, curative effect is not notable, and is often taken off again after stopping using；Western medicine is presently mainly finasteride tablet, non- That male amine piece is the oral western medicine of the hair growth of U.S. FDA unique authentication, but needs long-term use, and side effect is big, right Potential threat be present in health.Hair growth at alopecia is applied to outside in addition with minoxidil solution, but minoxidil is Vasodilator, low blood pressure or cardiac can not use, and minoxidil solution has very strong accordance with tolerance, meeting after drug withdrawal Occur multiple de-.

The content of the invention

The purpose of the present invention is that：For above-mentioned problem, there is provided a kind of composition is simple, evident in efficacy, cost Cheap, safely and effectively hair growth composition, to solve the above problems.

To achieve these goals, the technical solution adopted by the present invention is such：A kind of composition of hair growth, by The component composition of following weight parts meter：

Qarnet hairpin 20-30 parts, watermelon peel 10-20 parts, fruit of glossy privet 9-15 parts, semen litchi 7-12 parts, rice bud 6-9 parts.

As preferable technical scheme：It is made up of the component of following weight parts meter：

26 parts of Qarnet hairpin, 18 parts of watermelon peel, 12 parts of the fruit of glossy privet, 10 parts of semen litchi, 6 parts of rice bud.

The present invention is compared using Qarnet hairpin, watermelon peel, the fruit of glossy privet, semen litchi, rice bud as base stock, and using suitable Example, and it is aided with special preparation method, the medicine for hair growth has been made, wherein

Qarnet is worn in one's hair（Hosta albo-marginata (Hook.) Ohwi）, it is Liliaceae Hosta herbaceos perennial, leads to Often with there is the effect of cooling blood and hemostasis, removing toxic substances, the Qarnet hairpin of the application is the herb of its autumn harvesting, and dries；Have no purple at present Jade hairpin is used for the report of alopecia, and present inventor passes through substantial amounts of clinical test, it was demonstrated that Qarnet is worn in one's hair for all kinds Alopecia, have different degrees of effect, it cooperates with above-mentioned other compositions as monarch drug in a prescription, can obtain highly significant The effect of hair growth.

Watermelon peel is the outside rind after the rejecting pulp of cucurbitaceous plant watermelon；The watermelon peel of the present invention is fresh watermelon Skin uses natural air drying or freeze-drying, and the drying watermelon skin after preferably freeze drying, its aqueous mass ratio is less than 5%, its property It is cool, it is sweet, it is nontoxic, generally with clearing away summerheat, promote the production of body fluid to quench thirst the effect of.

The fruit of glossy privet（Ligustrum lucidum Ait）For Oleaceae plants glossy privet Ligustrum lucidum Ait.'s Dry mature fruit, it is kidney tonifying enriching yin simply, the Chinese medicine to nourish the liver to improve visual acuity, kidney deficiency and liver, dizzy syrigmus, graying of hair and two can be controlled Blurred vision paste etc..Also there is the report that the fruit of glossy privet is used for hair growth at present, for example, it is Publication No. CN103655902A, entitled The Chinese patent application of " Chinese medicine composition and preparation method of Anti-hair loss ", and the such as A of CN 103495102, it is entitled " a kind of The Chinese patent application of the Chinese medicine composition of hair growth ", still, it is more the complex component of composition to be all present in these compositions The shortcomings of uncertain therapeutic efficacy is cut.

Semen litchi be sapindaceous plant lichee Litchi chinensis Sonn. dry mature seed, Return liver, kidney Through generally there is the effect of promoting the circulation of qi dissipating bind, cold-dispelling pain-relieving.

Rice bud（OryzasativaL）Returns spleen, stomach, generally there is the effect of helping digestion with, spleen benefiting and stimulating the appetite.

The preparation method of above-mentioned composition, comprises the following steps：

（1）Weigh raw material：By weight, following raw materials are weighed：

Qarnet hairpin 20-30 parts, watermelon peel 10-20 parts, fruit of glossy privet 9-15 parts, semen litchi 7-12 parts, rice bud 6-9 parts；

（2）Qarnet hairpin pretreatment：First Qarnet is worn in one's hair and adds water, the amount of water is 2-3 times of Qarnet hairpin volume, and adds 0.1 part Sodium bicarbonate, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes Qarnet hairpin slag and liquid；

（3）Soaking in Chinese liquor：By remaining raw material and step（2）The pretreatment thing of gained, which is added in 50-60 part white wine, soaks 2-3 Hour, and keeping temperature is 40-50 DEG C, the volumn concentration of ethanol is 50-60% in the white wine, filters, obtains after immersion Primary filtrate and filter residue；

（4）Water soaks：To step（3）Edible white vinegar 3-5 parts, water 50-60 parts are added in the filter residue of gained, and keeping temperature is 80-100 DEG C, 2-3 hour, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（5）The dry product of gained, can directly warm water take, different auxiliary material and excipient can be added, make Into granule, tablet, capsule etc. formulation.

Present inventor, by many experiments, pass through above-mentioned special processing sequence, immersion solvent, soak time And soaking temperature so that suitable composition is leached in raw material, is mutually cooperateed between composition, can to the treated effect of alopecia Up to 99.5%.

As preferred：Step（3）In, time of soaking in Chinese liquor is 3 hours, alcohol content 60%.

As preferred：Step（4）During middle immersion, keeping temperature is 100 DEG C.

In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：The raw material of the present invention is only five Kind, species is few and is easy to get, and cost of material is low；Because bulk drug species is few, its mutual pharmacological action is relatively easy apparent, To the almost non-toxic side effect of human body；Medicine produced by the present invention is good to the therapeutic effect of alopecia, and efficient reachable 100%, for The cure rate of slight alopecia is not easy to take off again up to 81.5%, takes off rate again and is less than 10%；It is relatively short to take the course for the treatment of, can rise within 5 days Effect, can be cured, definite effect for 45 days.

Embodiment

Below in conjunction with embodiment, the present invention is described in detail.

In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.

Embodiment 1：

A kind of composition of hair growth, is made up of the component of following weight parts meter：

30 parts of Qarnet hairpin, 10 parts of watermelon peel, 9 parts of the fruit of glossy privet, 7 parts of semen litchi, 6 parts of rice bud,

Its preparation method, comprise the following steps：

（1）Weigh raw material：By above-mentioned weight than weighing above-mentioned raw materials：

（2）Qarnet hairpin pretreatment：First Qarnet is worn in one's hair and adds water, the amount of water is 2 times of Qarnet hairpin volume, and 0.1 part of addition is small Soda, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes purple Jade hairpin slag and liquid；

（3）Soaking in Chinese liquor：By remaining raw material and step（2）The pretreatment thing of gained is added to 3 hours of immersion in 50 parts of white wine, And keeping temperature is 40 DEG C, the volumn concentration of ethanol is 60% in the white wine, is filtered after immersion, obtains primary filtrate and filter Slag；

（4）Water soaks：To step（3）In the filter residue of gained add 5 parts of edible white vinegar, 50 parts of water, and keeping temperature be 100 DEG C, 2 hours, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（5）The dry product of gained, auxiliary material and excipient are added, granule is made, obtains " product A "

Embodiment 2：

A kind of composition of hair growth, is made up of the component of following weight parts meter：

20 parts of Qarnet hairpin, 20 parts of watermelon peel, 15 parts of the fruit of glossy privet, 12 parts of semen litchi, 9 parts of rice bud,

Its preparation method, comprise the following steps：

（1）Weigh raw material：By above-mentioned weight than weighing above-mentioned raw materials：

（2）Qarnet hairpin pretreatment：First Qarnet is worn in one's hair and adds water, the amount of water is 2 times of Qarnet hairpin volume, and 0.1 part of addition is small Soda, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes purple Jade hairpin slag and liquid；

（3）Soaking in Chinese liquor：By remaining raw material and step（2）The pretreatment thing of gained is added to 3 hours of immersion in 50 parts of white wine, And keeping temperature is 40 DEG C, the volumn concentration of ethanol is 50% in the white wine, is filtered after immersion, obtains primary filtrate and filter Slag；

（4）Water soaks：To step（3）In the filter residue of gained add 3 parts of edible white vinegar, 50 parts of water, and keeping temperature be 80 DEG C, 2 hours, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（5）The dry product of gained, auxiliary material and excipient are added, granule is made, obtains " product B "

Embodiment 3：

A kind of composition of hair growth, is made up of the component of following weight parts meter：

26 parts of Qarnet hairpin, 18 parts of watermelon peel, 12 parts of the fruit of glossy privet, 10 parts of semen litchi, 6 parts of rice bud,

Its preparation method, comprise the following steps：

（1）Weigh raw material：By above-mentioned weight than weighing above-mentioned raw materials：

（2）Qarnet hairpin pretreatment：First Qarnet is worn in one's hair and adds water, the amount of water is 2 times of Qarnet hairpin volume, and 0.1 part of addition is small Soda, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes purple Jade hairpin slag and liquid；

（3）Soaking in Chinese liquor：By remaining raw material and step（2）The pretreatment thing of gained is added to 3 hours of immersion in 50 parts of white wine, And keeping temperature is 50 DEG C, the volumn concentration of ethanol is 60% in the white wine, is filtered after immersion, obtains primary filtrate and filter Slag；

（4）Water soaks：To step（3）In the filter residue of gained add 5 parts of edible white vinegar, 50 parts of water, and keeping temperature be 100 DEG C, 2 hours, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（5）The dry product of gained, auxiliary material and excipient are added, granule is made, obtains " products C "

Comparative example 1：

A kind of composition of hair growth, compared with Example 3, remove except Qarnet wear in one's hair 26 parts in addition to other components,

Its preparation method, comprise the following steps：

（1）Weigh raw material：Worn in one's hair by above-mentioned weight weighing Qarnet：

（2）Qarnet hairpin pretreatment：Qarnet is worn in one's hair and adds water, the amount of water is 2 times of Qarnet hairpin volume, and adds 0.1 part of little Su Beat, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes Qarnet Hairpin slag and liquid；

（3）Soaking in Chinese liquor：Step（2）The pretreatment thing of gained is added to 3 hours of immersion in 50 parts of white wine, and keeping temperature is 50 DEG C, the volumn concentration of ethanol is 60% in the white wine, is filtered after immersion, obtains primary filtrate and filter residue；

（4）Water soaks：To step（3）In the filter residue of gained add 5 parts of edible white vinegar, 50 parts of water, and keeping temperature be 100 DEG C, 2 hours, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（5）The dry product of gained, auxiliary material and excipient are added, granule is made, obtain " contrast A "；

Comparative example 2

A kind of composition of hair growth, compared with Example 3, the other components in addition to 12 parts of the fruit of glossy privet are removed,

Its preparation method, comprise the following steps：

（1）Weigh raw material：By the above-mentioned weight weighing fruit of glossy privet：

（2）Soaking in Chinese liquor：The fruit of glossy privet is added to 3 hours of immersion in 50 parts of white wine, and keeping temperature is 50 DEG C, the white wine The volumn concentration of middle ethanol is 60%, is filtered after immersion, obtains primary filtrate and filter residue；

（3）Water soaks：To step（2）In the filter residue of gained add 5 parts of edible white vinegar, 50 parts of water, and keeping temperature be 100 DEG C, 2 hours, filtering, obtain filter liquor；

（4）Merging filtrate：By step（2）Primary filtrate and step（3）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

Step（4）The dry product of gained, auxiliary material and excipient are added, granule is made, obtain " contrast B "；

Comparative example 3：

Using the raw material and method of embodiment 1 in the specification of the A of Publication No. CN 103495102 Chinese patent application, system Obtain " contrast C "

Compliance test result is tested

Using product A, product B, products C made from above-described embodiment 1-3, and comparative example 1-3 contrast A, contrast B and right Than C, the clinical effect trial of hair growth is carried out,

Experimental method is specific as follows with reference to method described in the specification of the A of CN 103495102 Chinese patent application：

First, experimental subjects：According to doctor trained in Western medicine diagnosis and Standards of Chinese Medical Syndrome Differentiation, different degrees of hair loss patient is selected to amount to 300, year Age is 20-60 year, male 250, women 50, and according to following standards, confirms patients with mild 165, moderate patient 82 Name, severe patient 53, the medicine of any hair growth is taken in the Zhou Qianwei of medication two, does not also use the outer of any hair growth With agent, using random double-blind method, it is divided into six groups, every group of 50 people, wherein different degrees of distribution situation such as table 1

The different degrees of distribution situation of table 1

	Slightly	Moderate	Severe
				Product A groups	27	14	9
Product B groups	28	13	9
				Products C group	27	15	8
Contrast A groups	28	13	9
				Contrast B groups	27	14	9
Contrast C groups	28	13	9

Slightly：Average daily alopecia quantity is less than 20, and crown hair is more sparse；

Moderate：Average daily alopecia quantity 20-50 roots, crown hair is few, and scalp is visible；

Moderate, average daily alopecia quantity are more than 50, part crown hair without a head

2nd, usage and dosage

Each group respectively takes corresponding medicine, three times a day, each taking equivalent to net medicine（Remove respective auxiliary material And excipient）2g, continuously take 45 days and counted, and counted after disabling 60 days and take off phenomenon again；

3rd, effect standard：

1st, cure：Depilation phenomenon mitigates, and average daily alopecia quantity is less than 10, and crown hair is dense；

2nd, effectively：Alopecia quantity ratio take before reduce 30% and more than, crown hair increases；

3rd, it is invalid：With taking preceding ratio, alopecia quantity is not reduced, and crown hair does not increase

Statistical result is shown in Table 2

The effect statistical form of table 2

From table 2 it can be seen that the composition of the present invention, takes 45 days, can reach 100% for the effective percentage of slight alopecia, control More rate reaches 81.5%, while de- rate is low again, for the effect of moderate alopecia and severe alopecia also highly significant.

Claims (3)

1. a kind of preparation method of the composition of hair growth, it is characterised in that comprise the following steps：

（1）Weigh raw material：By weight, following raw materials are weighed：

Qarnet hairpin 20-30 parts, watermelon peel 10-20 parts, fruit of glossy privet 9-15 parts, semen litchi 7-12 parts, rice bud 6-9 parts；

（2）Qarnet hairpin pretreatment：First Qarnet is worn in one's hair and adds water, the amount of water is 2-3 times of Qarnet hairpin volume, and adds 0.1 part Sodium bicarbonate, after soaking 12h, boil, keep boil condition 30min, be cooled to room temperature, obtain pre-processing thing, pretreatment thing includes Qarnet hairpin slag and liquid；

（3）Soaking in Chinese liquor：By remaining raw material and step（2）The pretreatment thing of gained, which is added in 50-60 part white wine, soaks 2-3 Hour, and keeping temperature is 40-50 DEG C, the volumn concentration of ethanol is 50-60% in the white wine, filters, obtains after immersion Primary filtrate and filter residue；

（4）Water soaks：To step（3）Edible white vinegar 3-5 parts, water 50-60 parts are added in the filter residue of gained, and keeping temperature is 80-100 DEG C, 2-3 hour, filtering, obtain filter liquor；

（5）Merging filtrate：By step（3）Primary filtrate and step（4）Filter liquor be well mixed, be concentrated to give medicinal extract, It is freeze-dried and produces.

2. preparation method according to claim 1, it is characterised in that：Step（3）In, the time of soaking in Chinese liquor is 3 small When, alcohol content 60%.

3. preparation method according to claim 1, it is characterised in that：Step（4）During middle immersion, keeping temperature is 100 DEG C.