CN104382947A - Pulvis for treating intestinal infection of pet and preparation method thereof - Google Patents
Pulvis for treating intestinal infection of pet and preparation method thereof Download PDFInfo
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- CN104382947A CN104382947A CN201410581651.4A CN201410581651A CN104382947A CN 104382947 A CN104382947 A CN 104382947A CN 201410581651 A CN201410581651 A CN 201410581651A CN 104382947 A CN104382947 A CN 104382947A
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- intestinal infection
- intestinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Abstract
The invention discloses pulvis for treating intestinal infection of a pet and a preparation method thereof, and aims to provide the pulvis for quickly treating the intestinal infection of the pet. On one hand, the invention provides the pulvis for treating the intestinal infection of the pet. The pulvis comprises the following components in parts by weight: 1-10 parts of bacillus subtillis, 1-10 parts of bacillus licheniformis, 1-5 parts of clostridium butyricum, 1-10 parts of glyceride butyrate powder, 75-95 parts of auxiliary material and 0.1-1 part of essence. On the other hand, the invention further provides the preparation method of the pulvis. The pulvis and the preparation method thereof belong to the technical field of animal medicines.
Description
Technical field
The present invention relates to a kind of powder for the treatment of house pet intestinal infection, specifically, relate to and a kind ofly treat powder of house pet intestinal infection and preparation method thereof, belong to animal medicine technical field.
Background technology
Along with the raising of people's living standard, the lifting of quality of life, the arrival of aging society, increasing people like pet feeding, namely can wear down lie Fallow Time, also can be used as companion, as pet dog, pet cat, pet rabbit etc.
Intestinal infection is the multiple disease of a kind of common property of house pet, and reason mostly is bacteriovirus infection, feeding environment is severe, feeding manner is improper etc. also can cause alteration of intestinal flora to cause harmful intestinal tract flora breed and fall ill.The medicine of market being treated intestinal infection is many, has tablet, powder, injection, oral liquid etc.; Great majority are antibiotic formulations.And along with antibiotic application, there is increasing untoward reaction or potential danger: nervous system toxic reaction; Haematological toxicity reacts; Liver, nephrotoxicity reaction; Gastrointestinal reaction; Antibiotic can cause dysbacteriosis, and antibiotic-associated diarrhea (AAD) refers to the diarrhoea of secondary after application antibiotic, is more common adverse effect, and its incidence rate looks different antibiotic and different, is about 5%-39%; Antibiotic anaphylaxis; Antibiotic after effect.
Summary of the invention
One object of the present invention is to provide a kind of powder for the treatment of house pet intestinal infection, and this powder can treat intestinal infection, the intestines and stomach coordinating, fast quick-recovery function of intestinal canal.
Another object of the present invention also provides the preparation method of above-mentioned powder.
For solving the problems of the technologies described above, technical scheme of the present invention is such:
On the one hand, a kind of powder for the treatment of house pet intestinal infection, is made up of the component of following weight parts: Bacillus subtillis 1 ~ 10 part, bacillus licheniformis 1 ~ 10 part, Clostridium butyricum 1 ~ 5 part, 1 ~ 10 part, tributyrin powder, adjuvant 75 ~ 95 parts, 0.1 ~ 1 part, essence.
The powder of above-mentioned treatment house pet intestinal infection, is made up of the component of following weight parts: Bacillus subtillis 2 ~ 8 parts, bacillus licheniformis 2 ~ 8 parts, Clostridium butyricum 1.5 ~ 4.5 parts, 2 ~ 8 parts, tributyrin powder, adjuvant 80 ~ 95 parts, 0.2 ~ 0.8 part, essence.
Further, the powder of above-mentioned treatment house pet intestinal infection, described adjuvant is glucose powder.
On the other hand, the present invention also provides a kind of preparation method for the treatment of the powder of house pet intestinal infection, comprises the steps: successively
1) weight portion takes each component of following weight parts: Bacillus subtillis 1 ~ 10 part, bacillus licheniformis 1 ~ 10 part, Clostridium butyricum 1 ~ 5 part, 1 ~ 10 part, tributyrin powder, adjuvant 75 ~ 95 parts, 0.1 ~ 1 part, essence.
2) by step 1) glucose powder that takes 1/3rd, with Bacillus subtillis, bacillus licheniformis, Clostridium butyricum, yeast, tributyrin powder, essence stirring and evenly mixing, obtain mixture A;
3) to step 2) add remaining glucose powder in the mixture A that obtains and remix evenly, obtain mixture B;
4) detect, subpackage.
After employing powder of the present invention and preparation method thereof, compared with prior art, tool of the present invention has the following advantages:
When research shows the birth of children poultry in age, normally aseptic in its digestive tract, be born the antibacterial that can find in the gastrointestinal tract for latter 3 hours to invade, and after 12 hours, can detect in large intestine.According to the order of succession of aerobe, facultative anaerobe, strict anaerobes, finally formed with the anaerobe such as lactobacillus, bacillus bifidus as dominant microflora.After bacillus cereus in the present invention enters digestive tract with spore state, ramp is bred, consume the oxygen of enteral, reduce enteral oxygen concentration and redox potential, improve the growing environment of the anaerobe such as lactobacillus, bacillus bifidus, be conducive to the growth of anaerobe, keep the steady weighing apparatus of intestinal microecology system, make the growth of the pathogenic bacterium such as the aerobe enterobacteria originally existed in intestinal be suppressed because of anoxia simultaneously, play therapeutic effect.Clostridium butyricum in the present invention brings back to life after being taken and grows rapidly in gastric juice (pH=1-2), then in large intestine, caecum mucous membrane surface hypertrophy, but can not enter other organ from intestinal wall absorbed into serum, finally discharge with enteral prods.Clostridium butyricum has very strong drug resistance; It, by promoting probiotics and suppressing harmful bacteria dual function to correct alteration of intestinal flora, improves microecological environment in intestinal, reduces the generation of intestinal tract disease.
Several strain also can produce multiple digestive enzyme (as proteolipin, fatty acid, amylase, non-starch polysaccharide enzyme) in body, and activity is very strong, promotes the growth promoter of intestinal villi simultaneously, strengthen the absorption area of small intestinal, thus promote to disappear through absorbing, improve food conversion ratio; Multivitamin can be synthesized as nicotinic acid, folic acid, nicotinic acid, vitamin B1, B2, B12 etc., promote that body is to the digestion of protein, absorption; Promote that body is to the absorption of calcium, ferrum, vitamin D; The also orectic function of helpful animal.Clostridium butyricum produces prebiotic product in intestinal, and as butanoic acid, butanoic acid is the Major Nutrient material of the histiocytic regeneration of gut epithelium and reparation, general protection intestinal mucosa.Tributyrin strengthens this function of butanoic acid especially, because can produce butanoic acid after its degraded, improves the concentration of butanoic acid.
Compared with prior art products, concrete advantage of the present invention is: 1. strain content is high, for every gram contains on 20,000,000,000, can cause in intestinal and take oxygen by force instantaneously, suppress harmful bacteria, reach therapeutic effect, and similar prior art products is only hundreds of thousands, to nurse one's health, only health-care effect; 2. full intestinal protection, can know from above, the solution of the present invention is from small intestinal, large intestine, caecum general protection, and like product only acts on little intestinal segment.3. the butanoic acid of strain metabolism generation and the tributyrin of interpolation can repair impaired intestinal mucosa fast, and the normal function of protection intestinal, just house pet recovers appetite.4. use, directly can feed in house pet mouth, also can change water and drink to house pet, also can make an addition in dog grain.
In a word, the present invention sets out with environmental protection, and selected microorganism and probiotics control intestinal infection.While control diarrhoea, and repair the impaired mucosa of intestinal fast, thus recover the function of intestinal.
Detailed description of the invention
Below in conjunction with specific embodiment; claim of the present invention is described in further detail; but do not form any limitation of the invention, the amendment of anyone limited number of time made within the scope of application claims, still within claims of the present invention.
Embodiment 1
A kind of powder for the treatment of house pet intestinal infection of the present invention, is made up of the component of following weight parts: Bacillus subtillis 1 part, bacillus licheniformis 10 parts, Clostridium butyricum 1 part, 10 parts, tributyrin powder, adjuvant 78 parts, 0.1 part, essence.
Embodiment 2
The powder of another kind treatment house pet of the present invention intestinal infection, is made up of the component of following weight parts: Bacillus subtillis 10 parts, bacillus licheniformis 1 part, Clostridium butyricum 5 parts, 1 part, tributyrin powder, adjuvant 85 parts, 1 part, essence.
Embodiment 3
Of the present invention also have a kind of powder for the treatment of house pet intestinal infection, is made up of: Bacillus subtillis 5 parts, bacillus licheniformis 5 parts, Clostridium butyricum 2.5 parts, 5 parts, tributyrin powder, adjuvant 90 parts, 0.5 part, essence the component of following weight parts.
Embodiment 4
The present invention also has a kind of powder for the treatment of house pet intestinal infection, is made up of: Bacillus subtillis 3 parts, bacillus licheniformis 7 parts, Clostridium butyricum 3 parts, 7 parts, tributyrin powder, adjuvant 80 parts, 0.3 part, essence the component of following weight parts.
Embodiment 5
The powder of another kind treatment house pet of the present invention intestinal infection, is made up of the component of following weight parts: Bacillus subtillis 7 parts, bacillus licheniformis 3 parts, Clostridium butyricum 4 parts, 3 parts, tributyrin powder, adjuvant 83 parts, 0.7 part, essence.
In embodiment 1 to 5, a kind of preparation method for the treatment of the powder of house pet intestinal infection is: 1) take each component by the arbitrary compound mode in embodiment 1 to 5;
2) by step 1) glucose powder that takes 1/3rd, with Bacillus subtillis, bacillus licheniformis, Clostridium butyricum, yeast, tributyrin powder, essence stirring and evenly mixing, obtain mixture A;
3) to step 2) add remaining glucose powder in the mixture A that obtains and remix evenly, obtain mixture B;
4) extracting the assay that some mixture carry out certain material, getting final product subpackage as met content standard.
In concrete using method: 1. oral, mix and together eat with food in pet food, or Direct-fed after mixing homogeneously with warm water, suspension can be sucked with needle tubing when appetite is given up exhausted and inject pet's oral cavity, allow house pet drink by force.
2. disease phase and convalescence: once a day, each half bag of below 5kg, each bag of 5-20kg, each two bags of more than 20kg, multiplicable use of following the doctor's advice when being in a bad way.To feed first doubled amount.It within one week, is a course for the treatment of.
3. daily maintenence health care amount: every 3 days one bags.Often bag can be divided into 1-3 use.This product can be used as daily intestines and stomach health-care life-time service.
In order to advantage place of the present invention is better described, provides use case of the present invention below and be explained.
Case 1
Kind of dog: capital is clung to
Dog age: more than 6 years old
Symptom: chronic diarrhea is many for half a year, suffers from diarrhoea always, defecates shapeless.
Case describes:
Article one, the capital bar dog more than 6 years old, the general 7KG of body weight, chronic diarrhea is many for half a year, and Liver and kidney is no problem, does not also find any problem, just suffer from diarrhoea always, defecate shapeless through other examination in hospital.
When this summer, the owner of capital bar avoids heat in other places with capital bar, and capital bar is suffered from diarrhoea suddenly serious and drawn blood, and owner is just with Ba Hui Chongqing, capital.After examination in hospital, hospital, to capital bar transfusion, draw blood a period of time good, but the old trouble of diarrhoea never has.
Mid-September, owner is brought in Chongqing capital bar dog and forever likes pets hospital, and poplar president has done every inspection to this dog, and Liver and kidney is intact does not find any problem.Estimation is that intestinal mucosa damage is too serious, and give Jing Bakai one box the intestines and stomach glad so tentative, eaten 3 days, molding completely of defecating when the 4th day, the problem of chronic diarrhea have also been obtained solution.
Case 2
Kind of dog: string string
Dog age: 7 years old half
Symptom: suffer from indiestion, inappetence, always tells yellow fluid.
Case describes:
String string, small-sized dog, suffers from indiestion, and inappetence always tells yellow fluid, sometimes eats bone and also tells.Told severe and just fed this medicine, basic half a day just can take effect.
Case 3
Kind of dog: Alaska
Dog age: 1 years old
Symptom: digestive disorders, has loose bowels.
Case describes:
Alaska digestive system is not fine, has fed meat and fish, has then had loose bowels, and advises feeding pup grain before 1 years old half, and has opened glad the going back of the intestines and stomach and take, and takes antidiarrheal on the same day, in Canis familiaris L. grain, adds that the intestines and stomach is glad, within 1 month, get off and all do not had loose bowels.
Case 4
Kind of dog: chihuahua
Dog age: 1 years old 3 months
Symptom: stress after vaccinating, diarrhoea, inappetence.
Case describes:
Canis familiaris L. Canis familiaris L. has diarrhoea, uncomfortable after vaccinating back, food is not very positive situation, and it is glad to feed some the intestines and stomach, within 2 days, just can recover afterwards.
Claims (4)
1. treat a powder for house pet intestinal infection, it is characterized in that, be made up of the component of following weight parts: Bacillus subtillis 1 ~ 10 part, bacillus licheniformis 1 ~ 10 part, Clostridium butyricum 1 ~ 5 part, 1 ~ 10 part, tributyrin powder, adjuvant 75 ~ 95 parts, 0.1 ~ 1 part, essence.
2. according to claim 1 for the osteoarticular health-care agent of house pet, it is characterized in that, be made up of the component of following weight parts: Bacillus subtillis 2 ~ 8 parts, bacillus licheniformis 2 ~ 8 parts, Clostridium butyricum 1.5 ~ 4.5 parts, 2 ~ 8 parts, tributyrin powder, adjuvant 80 ~ 95 parts, 0.2 ~ 0.8 part, essence.
3., according to the powder of the arbitrary described treatment house pet intestinal infection of claim 1 or 2, it is characterized in that, described adjuvant is glucose powder.
4. a preparation method for the powder of the arbitrary described treatment house pet intestinal infection of claim 1 or 2, is characterized in that, comprise the steps: successively
1) each component is taken by weight portion according to claim 1;
2) by step 1) glucose powder that takes 1/3rd, with Bacillus subtillis, bacillus licheniformis, Clostridium butyricum, tributyrin powder, essence stirring and evenly mixing, obtain mixture A;
3) to step 2) add remaining glucose powder in the mixture A that obtains and remix evenly, obtain mixture B;
4) detect, subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410581651.4A CN104382947A (en) | 2014-10-27 | 2014-10-27 | Pulvis for treating intestinal infection of pet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410581651.4A CN104382947A (en) | 2014-10-27 | 2014-10-27 | Pulvis for treating intestinal infection of pet and preparation method thereof |
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| Publication Number | Publication Date |
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| CN104382947A true CN104382947A (en) | 2015-03-04 |
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| CN201410581651.4A Pending CN104382947A (en) | 2014-10-27 | 2014-10-27 | Pulvis for treating intestinal infection of pet and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106247A (en) * | 2015-09-29 | 2015-12-02 | 武汉中博绿亚生物科技有限公司 | Medicinal preparation for treating intestinal problem of pet cat and preparation method thereof |
| CN108323641A (en) * | 2018-02-07 | 2018-07-27 | 上海宠幸宠物用品有限公司 | A kind of health food and preparation method thereof for improving pet dog cat function of intestinal canal |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102138639A (en) * | 2011-01-26 | 2011-08-03 | 龙岩新奥生物科技有限公司 | Digestion aiding compound as well as preparation method and application thereof to feed additive |
| WO2014020138A2 (en) * | 2012-08-03 | 2014-02-06 | Dupont Nutrition Biosciences Aps | Feed additive composition |
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2014
- 2014-10-27 CN CN201410581651.4A patent/CN104382947A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138639A (en) * | 2011-01-26 | 2011-08-03 | 龙岩新奥生物科技有限公司 | Digestion aiding compound as well as preparation method and application thereof to feed additive |
| WO2014020138A2 (en) * | 2012-08-03 | 2014-02-06 | Dupont Nutrition Biosciences Aps | Feed additive composition |
Non-Patent Citations (1)
| Title |
|---|
| 马红莲: "惠风广披 泽洎幽荒 嘉业善行 内敛行张——访浙江惠嘉生物科技有限公司董事长 刘金松", 《饲料研究》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106247A (en) * | 2015-09-29 | 2015-12-02 | 武汉中博绿亚生物科技有限公司 | Medicinal preparation for treating intestinal problem of pet cat and preparation method thereof |
| CN108323641A (en) * | 2018-02-07 | 2018-07-27 | 上海宠幸宠物用品有限公司 | A kind of health food and preparation method thereof for improving pet dog cat function of intestinal canal |
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Application publication date: 20150304 |