CN104382051A

CN104382051A - Full nutritional formula food for melanoma

Info

Publication number: CN104382051A
Application number: CN201410575378.4A
Authority: CN
Inventors: 胡安然
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-10-25
Filing date: 2014-10-25
Publication date: 2015-03-04

Abstract

The invention provides a full nutritional formula food, a special full nutritional formula food, or a non full nutritional formula food for patients with melanoma. According to the requirements of 'The Standard for Food for Special Medical Purpose', the formula combines the physical characteristics of patients with melanoma, various medical and edible traditional Chinese medicine extract essences which are extracted by prehydrolysis SBE technology, various microencapsulated probiotics and short peptides which are extracted by biological enzyme hydrolysis, prebiotics, amino acids, carbohydrates, vitamins and minerals are crushed and mixed to form the food. The full nutritional formula food can be used as the single nutrition source to meet the nutrition requirements of patients with melanoma, and has the efficacies of clearing heat and detoxicating, nourishing liver and kidney, expelling toxin and eliminating node, notifying kidney and spleen, reinforcing the healthy qi and inhibiting cancer, benefiting qi and nourishing blood, detoxifying and resolving stasis, and enhancing immunity.

Description

The full nutritional formulas of melanoma

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and food technology field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds the full nutritional formulas of melanoma, specific full nutritional formulas or the non-fully nutritional formulas made for auxiliary material with small peptide, prebiotics, amino acid, carbohydrate, B B-complex, composite mineral matter.

Background technology

Melanoma is the common skin neoplasin caused by abnormal melanocyte hyperplasia, grade malignancy is high, account for the extreme portions of skin neoplasin death, multiplely be born in skin or the mucous membrane close to skin, also pia mater and choroid is seen, its incidence of disease is with ethnic group, region, race difference and have institute's difference, but the incidence of disease is continuous ascendant trend in recent years, there are 25000 chromoma new cases in the annual U.S., death about 6000 people, the incidence of disease is rising rapidly, solar radiation is hazards, same hazards also comprise family history, there is pernicious macle, larger CMN and dysplastic nevus syndrome, melanocytoma can by epidermal melanocytes, mole cell or corium melanoblast composition, tumor originates is in deric neural crest, and melanocyte is positioned between epidermal area and basal cell and arranges, and after cell chromogenesis, is transported in basal cell and hair by tree-shaped dashing forward by melanin granule, the generation of most of malignant mela noma, it is the friction because melanotic nevus is subject to repeatedly, pick up and damage and cause and cancerate, unsuitablely to excavate and medicine corrosion etc., optimum melanotic nevus can be made to change into malignant mela noma, the women's federation of pregnancy period or childbearing age makes malignant mela noma develop rapidly, from the age, mostly occur the elderly, little number occurs in preadolescence, it is reported: 84% malignant mela noma is from benign nevus, report according to Wieeio, due to the cause that mole is too little, many patients do not notice at the ill initial stage, someone thinks that benign nevus is the maximum root of malignant mela noma, the traditional Chinese medical science is thought: malignant mela noma occurs to fight in vim and vigour due to ailment said due to cold or exposure, change give birth to, or the blood of train of thought, stagnant in defend point, yang-energy binding forms, in kidney, foul smell is mixed in sun, caused by yang-energy collects, relevant with factors such as the blood clotting stagnation of the circulation of vital energys, the true cause that Normal melanocytes knurl becomes it be unclear that, may be relevant with following factors: (1) atmosphere pollution, a large amount of discharges of the harmful substances such as fluorine Lyons destroy ozone layer, ultraviolet is caused to filter insufficient, harmful substance in harmful ultraviolet and air takes acting in conjunction by the hand in human body skin, cause melanocyte unconventionality expression, cause melanoma, (2) sense of loving to make up and wearing beautiful clothes does mischief, many people use chemical classes cosmetics in a large number in order to pursue the clean tender of skin, cause chemically skin contamination, people is even had to get rid of black mole on skin with chemical mordant, the result is just the contrary, have stimulated melanocytic hyper-proliferative, (3) hygienic knowledge lacks, to long at foot, the black mole that perineum etc. are subject to friction position does not cause enough attention, be squeezed for a long time and friction with it, cause it eventually and malignant transformation occurs, (4) estrogens medicine is abused, ERs is had in the cell of research discovery malignant mela noma, therefore, people suspect the generation of estrogen excessive meeting stimulation melanin knurl, (5) immune deficiency, along with growth in the living standard, Chinese obviously extend in the life-span, with the growth at age, immune function of human body fails gradually.Research finds, immunologic hypofunction is one of major reason of melanoma generation, so the melanomatous incidence of disease of the elderly is very high clinically, (6). optimum melanin patch, i.e. black mole, wherein junctional nevus the most easily cancerates, compound nevus is less, endothelium mole is then seldom cancerated, but the not black mole transformation of scalp melanoma majority, therefore this disease is not exclusively relevant with black mole to have people to think, (7). race, white man is higher than the coloured race incidence of disease, and if the annual morbidity of American caucasian is up to 42,/10 ten thousand, and Black people are only 0.8/10; Melanoma adopts the mode of parenteral nutrition (namely inputting nutritional drugs) to carry out nutritional supplementation to cancer patient clinically more, and long-term parenteral nutrition supplements and easily causes enteron aisle Villus atrophy, and accompanying infection, thus increases the weight of the harm to body; " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery.

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And the full nutritional formulas of wholefood clear stipulaties: 2.1.1 in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutritional formulas: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition.

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium Bifidum accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively.

Though direct probiotic oral has certain effect, but due to probio one cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by studying the key technology of probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis.

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with melanoma patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials is the full nutritional formulas that auxiliary material is made, specific full nutritional formulas or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising melanoma patients immunity and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, multivitamin, several mineral materials is auxiliary material, the melanoma patients institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the full nutritional formulas that the acceptable applicable melanoma patients of people is edible, specific full nutritional formulas or non-fully nutritional formulas.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", the constitutive character of the melanoma patients that binding immunoassay power is low, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt the Chinese medical extract elite of more than 7 kinds medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets melanoma patients, clearing heat and detoxicating in addition, nourishing liver and kidney, toxic removingization is tied, kidney and spleen invigorating, Fuzheng Yiliu cancer, benefiting qi and nourishing blood, the full nutritional formulas of effect of removing toxic substances stagnation resolvation and develop immunitypty, specific full nutritional formulas or non-fully nutritional formulas (compound prescription be combined into).

1, the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to melanomatous constitutive character, utilizes the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and chooses following several large class medicine and carry out compatibility; Wherein: the stem of noble dendrobium, reinforcing stomach reg fluid is nourishing Yin and clearing heat; Dried human placenta, has tonifying kidney and benefiting sperm, the merit of nourishing qi and blood; The Radix Astragali its have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely; Chinese angelica blood supplementing and blood, menstruction regulating and pain relieving, moisturizes laxation; Cogongrass rhizome, cooling blood and hemostasis, clearing heat and detoxicating; Sculellaria barbata has clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving, the function such as anticancer; Radix pseudostellariae body lubricant nature and, tonifying QI to produce body fluid; Gynostemma pentaphylla replenishes qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, clearing heat and detoxicating; Borneol has inducing resuscitation of having one's ideas straightened out, the loose poison of heat-clearing, effect of removing nebula; Cordyceps militaris, whole body function can be regulated, improve immunocompetence, strengthen the phagocytic function of macrophage, the formation of enhancing antibody, mainly contain and protect the nourishing the liver of lung kidney-nourishing, relieving cough and asthmaly to eliminate the phlegm, moisturizing wrinkle resistant anti-ageing, antimicrobial antiphlogistic, calmness, hemangiectasis, reduce blood pressure, reduce the effects such as blood sugar, antifatigue, resist oxygen lack.Cordycepin in Cordyceps militaris has effect of the growth of antiviral, antibacterial, obvious Tumor suppression, interference human body RNA and DNA synthesis; Radix et Rhizoma Gynurae divaricatae, heat-clearing, relaxing muscles and tendons, hemostasis, the stasis of blood of dispelling; Ginseng benefit blood is answered arteries and veins, mental-tranquilization, is promoted the production of body fluid to quench thirst; Date, cures mainly trusted subordinate's perverse trend, An Zhong, supports the flat stomach Qi of temper, logical nine orifices, mends weak breath, few body fluid, in poor health, frightened, heaviness of limbs, and hundred medicines; Walnut kernel, the function such as benefiting qi and nourishing blood, moistening dryness and resolving phlegm, warm lung ease constipation, loose swollen sterilization;

Medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), glossy ganoderma, dried human placenta, ground bettle, astragalus, angelica, safflower, cogongrass rhizome, Sculellaria barbata, rhubarb, radix pseudostellariae, the bighead atractylodes rhizome, gynostemma pentaphylla, borneol, Cordyceps militaris, Radix et Rhizoma Gynurae divaricatae, ginseng, date, the membrane of a chicken's gizzard, walnut kernel, water caltrop, Radix Glycyrrhizae, coix seed, honeysuckle, cordate houttuynia, purslane, dandelion, cape jasmine, chrysanthemum, kelp, marine alga, mulberry fruit, sea-buckthorn, pawpaw, matrimony vine, Poria cocos, mushroom, dried orange peel, sealwort wherein more than 7 kinds or all, biological enzymolysis or prehydrolysis SBE is adopted to extract and microencapsulation, mixture after spray-dried and cryodesiccated extract.

2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;

Multiple probio of the present invention all adopts the probio after microencapsulation, except streptococcus thermophilus, wherein Bifidobacterium: refer to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus are wherein a kind of, several or all mix.

3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.

4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, enterocinesia is stimulated to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of enhancing melanoma resistance;

Prebiotics of the present invention is 2 classes

A. very strong field planting effect prebiotics is had to external source probio: the extract of Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke, stachyose, yeast wherein several or all mix;

B. common prebiotics: oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

Originally oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix is referred to.

5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

6. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

7. vitamin and mineral matter:

Vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.

8. the present invention is with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product strengthen melanoma resistance significantly improves compared with the like product of market.

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

The characteristic of this full nutritional formulas of filling a prescription and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of melanoma patients, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility.

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect.

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, melanoma patients desired nutritional can be supplemented rapidly.

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, have and strengthen the effect of resistance of human body, clearing heat and detoxicating, nourishing liver and kidney, toxic removing knot, kidney and spleen invigorating in addition, effect of Fuzheng Yiliu cancer, benefiting qi and nourishing blood, removing toxic substances stagnation resolvation and develop immunitypty.

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced.

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve melanoma patients negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.

7. this prescription have employed this team by over nearly 3 year to the achievement that the key technology of probio field planting mechanism in enteron aisle is studied, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio.

8. prebiotics contained in the present invention's formula; by promoting the growth and breeding of probio in intestines; suppress the growth of spoilage organisms; form one protective barrier at intestinal mucosal surface simultaneously; the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted; reduce the absorption of intestinal toxic material; intestines peristalsis can also be promoted; accelerate the discharge of residuals in intestines; constipation can be prevented; and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy.

9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce.

10, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development.

11, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for melanoma patients, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element.

12, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following examples, the invention will be further described, and it will contribute to understanding the present invention.

Embodiment one

Realizing the full nutritional formulas of the object of the invention melanoma is constitutive character in conjunction with melanoma patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 7 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;

Fill a prescription by following raw materials according and consumption thereof: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 8g, stem of noble dendrobium 8g, lucidum spore powder (broken wall) 8g ,glossy ganoderma 8g, dried human placenta 8g, ground bettle 8g, Radix Astragali 8g, Radix Angelicae Sinensis 8g, safflower 8g, cogongrass rhizome 6g, Sculellaria barbata 6g, rhubarb 6g, radix pseudostellariae 6g, bighead atractylodes rhizome 6g, gynostemma pentaphylla 6g, borneol 6g, Cordyceps militaris 6g, Radix et Rhizoma Gynurae divaricatae 6g, ginseng 6g, date 4g, the membrane of a chicken's gizzard 4g, walnut kernel 4g, water caltrop 4g, Radix Glycyrrhizae 4g, coix seed 4g, honeysuckle 4g, cordate houttuynia 4g, purslane 4g, dandelion 4g, cape jasmine 4g, chrysanthemum 4g, kelp 2g, marine alga 2g, mulberry fruit 2g, sea-buckthorn 2g, pawpaw 2g, matrimony vine 2g, Poria cocos 2g, mushroom 2g, dried orange peel 2g, sealwort 2g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

First will to be glossy ganoderma during making, dried human placenta, ground bettle, astragalus, angelica, safflower, cogongrass rhizome, Sculellaria barbata, rhubarb, radix pseudostellariae, the bighead atractylodes rhizome, gynostemma pentaphylla, borneol, Radix et Rhizoma Gynurae divaricatae, ginseng, date, water caltrop, Radix Glycyrrhizae, honeysuckle, cordate houttuynia, purslane, dandelion, cape jasmine, chrysanthemum, kelp, marine alga, mulberry fruit, sea-buckthorn, pawpaw, matrimony vine, mushroom, dried orange peel, sealwort, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter pulverize together and add Poria cocos, walnut kernel, coix seed mixing after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

Embodiment two

The full nutritional formulas of above-mentioned melanoma also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 10g, Radix et Rhizoma Gynurae divaricatae 10g, ginseng 10g, date 10g, the membrane of a chicken's gizzard 10g, walnut kernel 10g, water caltrop 10g, Radix Glycyrrhizae 10g, coix seed 8g, honeysuckle 8g, cordate houttuynia 8g, purslane 8g, dandelion 8g, cape jasmine 8g, chrysanthemum 8g, kelp 8g, marine alga 8g, mulberry fruit 6g, sea-buckthorn 6g, pawpaw 6g, matrimony vine 6g, Poria cocos 6g, mushroom 6g, dried orange peel 6g, sealwort 6g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.

Embodiment three

The full nutritional formulas of above-mentioned melanoma also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 10g, Radix et Rhizoma Gynurae divaricatae 10g, ginseng 10g, date 10g, the membrane of a chicken's gizzard 10g, walnut kernel 10g, water caltrop 10g, Radix Glycyrrhizae 10g, coix seed 8g, honeysuckle 8g, cordate houttuynia 8g, purslane 8g, dandelion 8g, cape jasmine 8g, chrysanthemum 8g, kelp 8g, marine alga 8g, mulberry fruit 6g, sea-buckthorn 6g, pawpaw 6g, matrimony vine 6g, Poria cocos 6g, mushroom 6g, dried orange peel 6g, sealwort 6g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, carbohydrate 150g, prebiotics 100g, several amino acids 100g.

Embodiment four

The full nutritional formulas of above-mentioned melanoma also comprises following component by weight: small peptide 350g, carbohydrate 300g, several amino acids 100g, Bifidobacterium 50g, lactobacillus 50g, streptococcus thermophilus 25g, prebiotics 100g, B B-complex and mineral matter 25g; Energy contained by every 100 g should be not less than 295 kJ (70 kcal).

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product improve melanoma patients immunity significantly improves compared with the like product of market.

Claims

1. the full nutritional formulas of melanoma, it is characterized in that the constitutive character in conjunction with melanoma patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 7 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;

Its preparation method is first will to be glossy ganoderma, dried human placenta, ground bettle, astragalus, angelica, safflower, cogongrass rhizome, Sculellaria barbata, rhubarb, radix pseudostellariae, the bighead atractylodes rhizome, gynostemma pentaphylla, borneol, Radix et Rhizoma Gynurae divaricatae, ginseng, date, water caltrop, Radix Glycyrrhizae, honeysuckle, cordate houttuynia, purslane, dandelion, cape jasmine, chrysanthemum, kelp, marine alga, mulberry fruit, sea-buckthorn, pawpaw, matrimony vine, mushroom, dried orange peel, sealwort, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter pulverize together and add Poria cocos, walnut kernel, coix seed mixing after carry out pasteurization 1 hour, then the various batchings that the Bifidobacterium after adding microencapsulation, lactobacillus, streptococcus thermophilus also add appropriate carbohydrate mixing again mix solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.

2. the full nutritional formulas formula of melanoma according to claim 1, it is characterized in that described medicine-food two-purpose Chinese herbal medicine extract is: Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), glossy ganoderma, dried human placenta, ground bettle, astragalus, angelica, safflower, cogongrass rhizome, Sculellaria barbata, rhubarb, radix pseudostellariae, the bighead atractylodes rhizome, gynostemma pentaphylla, borneol, Cordyceps militaris, Radix et Rhizoma Gynurae divaricatae, ginseng, date, the membrane of a chicken's gizzard, walnut kernel, water caltrop, Radix Glycyrrhizae, coix seed, honeysuckle, cordate houttuynia, purslane, dandelion, cape jasmine, chrysanthemum, kelp, marine alga, mulberry fruit, sea-buckthorn, pawpaw, matrimony vine, Poria cocos, mushroom, dried orange peel, sealwort wherein more than 7 kinds or all mix.

3. the full nutritional formulas formula of melanoma according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. the full nutritional formulas formula of melanoma according to claim 1, also comprises following component by weight: small peptide 350g, carbohydrate 300g, several amino acids 100g, Bifidobacterium 50g, lactobacillus 50g, streptococcus thermophilus 25g, prebiotics 100g, B B-complex and mineral matter 25g.

5. the full nutritional formulas formula of melanoma according to claim 1, is characterized in that described prebiotics is. have that very strong field planting effect prebiotics is Chinese yam to external source probio, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, the extract of jerusalem artichoke, stachyose, yeast and common prebiotics wherein several or all mix.

6. require the full nutritional formulas formula of the melanoma described in 1, it is characterized in that described amino acid is Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

7. the full nutritional formulas formula of melanoma according to claim 1, is characterized in that described carbohydrate is Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

8. the full nutritional formulas formula of melanoma according to claim 1, is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, make product prevent and treat melanoma effect and significantly improve compared with the like product of market.

9. the full nutritional formulas formula of melanoma according to claim 1, is characterized in that described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix; Described mineral matter is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix.

10. the full nutritional formulas formula of melanoma according to claim 1, is characterized in that described small peptide is marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide is wherein a kind of, several or all mix.