CN104382038A - Soft capsule for improving immunity - Google Patents
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- CN104382038A CN104382038A CN201410755392.2A CN201410755392A CN104382038A CN 104382038 A CN104382038 A CN 104382038A CN 201410755392 A CN201410755392 A CN 201410755392A CN 104382038 A CN104382038 A CN 104382038A
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- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical group [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a soft capsule for improving immunity. The soft capsule is prepared from the following specific preparation steps: (1) evenly mixing the following raw materials in parts by weight: 2-5 parts of silkworm chrysalis compound amino acid, 9-30 parts of radix pseudostellariae, 5-12 parts of roots of bidentate achyranthes, 2-10 parts of honey-fried licorice root, 3-10 parts of rhizoma curculiginis, 3-10 parts of Chinese hawthorn leaves, 6-10 parts of desertliving cistanche, 6-9 parts of panax japonicas, 3-9 parts of native copper, 9-24 parts of tortoise shell and 1-2 parts of cornua cervi pantotrichum, so as to obtain a premix; (2) preparing a glue solution from purified water, glycerol, gelatin, titanium dioxide and lemon yellow; (3) preparing mixed oil from corn oil and beewax; (4) feeding the premix to the mixed oil, so as to prepare a content material; and (5) pelleting the glue solution and the content material, setting, washing, drying and sorting pills. The soft capsule has the advantages that the traditional Chinese herbal medicines and basic human body component amino acid are perfectly matched, so that the immunity of the human body can be effectively enhanced.
Description
Technical field
The present invention relates to Chinese medicine health-care technical field, especially relate to the soft capsule that a kind of herbal composite that can strengthen body immunity prepares.
Background technology
Immunologic function food in the market mainly contains the algae such as chlorella, spirulina; The bacterium such as lactic acid bacteria, Bifidobacterium class; The edible fungus such as lentinan, basidiomycetes class; The plant components such as yellow green vegetables and fruit, Soybean Peptide, aloe; The animal components such as chitin, royal jelly, beeswax, oyster meat; The Chinese traditional herbs classes such as ginseng, glossy ganoderma, wilsonii, Chinese caterpillar fungus; Also has synthetic such as epiphysin, nucleic acid etc.These compositions can be divided into two large classes substantially by its mechanism of action above, the first kind be with p-lentinan for representative, have the effect of stimulation leukocyte surface film, cytokine generative capacity strengthened; Another kind of with sulfur-containing compound in vegetables for representative, dialogue endocellular metabolism has regulating action.For a long time, strengthen immunologic function food and welcome by consumers in general always, its sales volume is abroad always in the steady growth impetus.
Along with society and economic progress, the raising of people's living standard, the development of science and technology, the change of disease pattern and the pursuit to good health and a long life, functional food dark people's popular feeling gradually of develop immunitypty, people have started heavily to prevent from heavily treating to turn to, and this will greatly promote the development of the functional food of develop immunitypty.21 century will be the century that functional food is exhibited one's skill to the full.China has the huge treasure-house of this functional food of Chinese herbal medicine and other characteristic resources, the impetus that we should develop in conjunction with the functional food development trend of develop immunitypty and China, make great efforts to excavate these precious resources, develop the functional food of develop immunitypty with Chinese characteristics, to obtain due status in the international competition of fierceness.
Summary of the invention
For the problems referred to above that prior art exists, the applicant provides a kind of soft capsule for improving immunity.Advantage of the present invention is that Chinese tradition Chinese herbal medicine and human body basic composition substance amino acid carry out gold collocation, effectively can strengthen body immunity.
Technical scheme of the present invention is as follows:
For improving a soft capsule for immunity, concrete preparation process is as follows:
(1) raw material of following parts by weight pulverized, cross 120 mesh sieves: silkworm compound amino acid: 2 ~ 5 parts; Radix pseudostellariae: 9 ~ 30 parts; The root of bidentate achyranthes: 5 ~ 12 parts; Honey-fried licorice root: 2 ~ 10 parts; Thizoma curculiginis: 3 ~ 10 parts; Leaves of Hawthorn: 3 ~ 10 parts; Saline cistanche: 6 ~ 10 parts; Panax japonicus: 6 ~ 9 parts; Native copper: 3 ~ 9 parts; Tortoise plastron: 9 ~ 24 parts; Pilose antler: 1 ~ 2 part;
(2) each raw material that step (1) obtains is mixed, obtain premix;
(3) by purified water 106 ~ 120 parts, glycerine 15 ~ 20 parts of being placed in glue tanks, after being heated to 60 DEG C, by 10 ~ 12 parts, gelatin, titanium dioxide 5 ~ 8 parts, lemon yellow 3 ~ 5 parts of inputization glue tanks, continue to be heated to 80 DEG C, heat while stirring, make Gelatin complete, be incubated 1 ~ 2 hour, leave standstill after foam floats, vacuumizing and defoaming, cross 100 mesh sieves, obtain glue, be incubated for subsequent use;
(4) get corn oil 10 ~ 12 parts, 4 ~ 5 parts, beeswax is placed in blend tank, be heated to 70 ~ 80 DEG C, dissolving stirs and evenly mixs, and cooling, obtains mixing oil plant;
(5) premix step (2) obtained drops in mixing oil plant, mixing and stirring, mixing time 20 ~ 30 minutes, and after colloid mill grinding 2 ~ 3 times, vacuumizing and defoaming, crosses 80 mesh sieves, obtain content material, for subsequent use;
(6) under the environment of room temperature 18 ~ 22 DEG C, relative humidity≤45%, content material and glue being put into pelleting in encapsulating machine respectively, then shapes, wash ball, drying, pick ball, obtaining this for improving the soft capsule of immunity.
Sizing described in step (6), wash ball, drying, pick ball process and be: dry 2 ~ 4 hours of the capsule and pill sizing obtained after pelleting, the edible ethanol of rear 95wt% of shaping washes ball, then go to temperature 25 ~ 28 DEG C, relative humidity is under the environment of≤40% dry 18 ~ 24 hours; Pick ball after drying, reject special-shaped ball, have the defective work such as bubble or leakage of oil ball, obtain qualified capsule and pill.
The specification of the soft capsule for improving immunity that step (6) obtains is 0.5g/ grain.The production process of step (1) ~ (6) all operates under 100,000 grades of production clean area conditions.
The technique effect that the present invention is useful is:
The adequate nutrition supply of protein is the material base maintaining Cellular Immunity and humoral immunity ability, and amino acid is the base unit forming protein.Selection compound amino acid meets nutrition, nutrition immune basic theories and application practice as the functional component improving immunity.In the raw material screening producing compound amino acid, select pupa albumen, have raw material resources and enrich, its Amino acid profile ratio is that essential amino acid accounts for more than 46% of total amino acid content, meets very much the amino acid pattern that FAO/WHO proposes.And silkworm chrysalis dry product contains albumen quality up to 45 ~ 50%, high containing albumen quality, silkworm chrysalis belongs to bread and cheese again, edible safety.
The silkworm chrysalis that China produces is for belonging to the starting stage in food and medicine.The amino acid being hydrolyzed production again, the peptide class of silkworm chrysalis and protein utilization thereof have very high nutritive value, medical value.And as good health food functional component, these all repeatedly experimental study proved.Hydrolysis pupa albumen Preparation of amino acid, has acid hydrolysis, enzyme hydrolysis, basic hydrolysis and microorganism glycolysis method, and due to the difference of hydrolysising condition, the amino acid products that some hydrolysis generates, also becomes amino acid whose peptide containing a certain amount of non-complete hydrolysis.Silkworm compound amino acid and peptide are all effect materials of develop immunitypty.
In the present invention's formula, radix pseudostellariae and honey-fried licorice root are arranged in pairs or groups the effect of invigorating the spleen and benefiting qi, arrange in pairs or groups between the root of bidentate achyranthes, thizoma curculiginis, saline cistanche, tortoise plastron, pilose antler, effect of tonifying kidney and benefiting sperm blood, leaves of Hawthorn, panax japonicus and native copper are arranged in pairs or groups, and have promoting blood circulation and removing obstruction in channels, the effect that strong muscle is healthy and strong, above medicine collocation can accomplish blood-enrich, strong spleen kidney, relaxes through dredging collateral, promoting blood circulation and removing blood stasis.This formula, by qi-blood tonifying, that this traditional health-care method of the two benefit of spleen kidney arranges in pairs or groups needed by human again amino acid, reaches and strengthens the immunity of human body body.
Detailed description of the invention
Embodiment 1:
This is for improving the soft capsule of immunity, and concrete preparation process is as follows:
(1) raw material of following parts by weight pulverized, cross 120 mesh sieves: silkworm compound amino acid: 3 parts; Radix pseudostellariae: 18 parts; The root of bidentate achyranthes: 8 parts; Honey-fried licorice root: 5 parts; Thizoma curculiginis: 7 parts; Leaves of Hawthorn: 7 parts; Saline cistanche: 8 parts; Panax japonicus: 7 parts; Native copper: 5 parts; Tortoise plastron: 15 parts; Pilose antler: 2 parts;
(2) each raw material that step (1) obtains is mixed, obtain premix;
(3) by purified water 110 parts, glycerine 18 parts of being placed in glue tanks, after being heated to 60 DEG C, by 11 parts, gelatin, titanium dioxide 6 parts, lemon yellow 4 parts of inputization glue tanks, continue to be heated to 80 DEG C, heat while stirring, make Gelatin complete, be incubated 1 hour, leave standstill after foam floats, vacuumizing and defoaming, cross 100 mesh sieves, obtain glue, be incubated for subsequent use;
(4) get corn oil 11 parts, 4 parts, beeswax is placed in blend tank, be heated to 70 DEG C, dissolving stirs and evenly mixs, and cooling, obtains mixing oil plant;
(5) premix step (2) obtained drops in mixing oil plant, mixing and stirring, mixing time 25 minutes, and after colloid mill grinds 3 times, vacuumizing and defoaming, crosses 80 mesh sieves, obtain content material, for subsequent use;
(6) under the environment of room temperature 20 DEG C, relative humidity≤45%, content material and glue being put into pelleting in encapsulating machine respectively, then shapes, wash ball, drying, pick ball, obtaining this for improving the soft capsule of immunity.
Sizing described in step (6), wash ball, drying, pick ball process and be: dry 3 hours of the capsule and pill sizing obtained after pelleting, the edible ethanol of rear 95wt% of shaping washes ball, then go to temperature 26 DEG C, relative humidity is under the environment of≤40% dry 20 hours; Pick ball after drying, reject special-shaped ball, have the defective work such as bubble or leakage of oil ball, obtain qualified capsule and pill.The specification of the soft capsule for improving immunity that step (6) obtains is 0.5g/ grain.The production process of step (1) ~ (6) all operates under 100,000 grades of production clean area conditions.
Embodiment 2:
This is for improving the soft capsule of immunity, and concrete preparation process is as follows:
(1) raw material of following parts by weight pulverized, cross 120 mesh sieves: silkworm compound amino acid: 5 parts; Radix pseudostellariae: 30 parts; The root of bidentate achyranthes: 12 parts; Honey-fried licorice root: 10 parts; Thizoma curculiginis: 10 parts; Leaves of Hawthorn: 10 parts; Saline cistanche: 10 parts; Panax japonicus: 9 parts; Native copper: 9 parts; Tortoise plastron: 24 parts; Pilose antler: 2 parts;
(2) each raw material that step (1) obtains is mixed, obtain premix;
(3) by purified water 120 parts, glycerine 20 parts of being placed in glue tanks, after being heated to 60 DEG C, by 12 parts, gelatin, titanium dioxide 8 parts, lemon yellow 5 parts of inputization glue tanks, continue to be heated to 80 DEG C, heat while stirring, make Gelatin complete, be incubated 2 hours, leave standstill after foam floats, vacuumizing and defoaming, cross 100 mesh sieves, obtain glue, be incubated for subsequent use;
(4) get corn oil 12 parts, 5 parts, beeswax is placed in blend tank, be heated to 80 DEG C, dissolving stirs and evenly mixs, and cooling, obtains mixing oil plant;
(5) premix step (2) obtained drops in mixing oil plant, mixing and stirring, mixing time 30 minutes, and after colloid mill grinds 3 times, vacuumizing and defoaming, crosses 80 mesh sieves, obtain content material, for subsequent use;
(6) under the environment of room temperature 22 DEG C, relative humidity≤45%, content material and glue being put into pelleting in encapsulating machine respectively, then shapes, wash ball, drying, pick ball, obtaining this for improving the soft capsule of immunity.
Sizing described in step (6), wash ball, drying, pick ball process and be: dry 4 hours of the capsule and pill sizing obtained after pelleting, the edible ethanol of rear 95wt% of shaping washes ball, then go to temperature 28 DEG C, relative humidity is under the environment of≤40% dry 24 hours; Pick ball after drying, reject special-shaped ball, have the defective work such as bubble or leakage of oil ball, obtain qualified capsule and pill.The specification of the soft capsule for improving immunity that step (6) obtains is 0.5g/ grain.The production process of step (1) ~ (6) all operates under 100,000 grades of production clean area conditions.
Embodiment 3:
This is for improving the soft capsule of immunity, and concrete preparation process is as follows:
(1) raw material of following parts by weight pulverized, cross 120 mesh sieves: silkworm compound amino acid: 2 parts; Radix pseudostellariae: 9 parts; The root of bidentate achyranthes: 5 parts; Honey-fried licorice root: 2 parts; Thizoma curculiginis: 3 parts; Leaves of Hawthorn: 3 parts; Saline cistanche: 6 parts; Panax japonicus: 6 parts; Native copper: 3 parts; Tortoise plastron: 9 parts; Pilose antler: 1 part;
(2) each raw material that step (1) obtains is mixed, obtain premix;
(3) by purified water 106 parts, glycerine 15 parts of being placed in glue tanks, after being heated to 60 DEG C, by 10 parts, gelatin, titanium dioxide 5 parts, lemon yellow 3 parts of inputization glue tanks, continue to be heated to 80 DEG C, heat while stirring, make Gelatin complete, be incubated 1 hour, leave standstill after foam floats, vacuumizing and defoaming, cross 100 mesh sieves, obtain glue, be incubated for subsequent use;
(4) get corn oil 10 parts, 4 parts, beeswax is placed in blend tank, be heated to 70 DEG C, dissolving stirs and evenly mixs, and cooling, obtains mixing oil plant;
(5) premix step (2) obtained drops in mixing oil plant, mixing and stirring, mixing time 20 minutes, and after colloid mill grinds 2 times, vacuumizing and defoaming, crosses 80 mesh sieves, obtain content material, for subsequent use;
(6) under the environment of room temperature 18 DEG C, relative humidity≤45%, content material and glue being put into pelleting in encapsulating machine respectively, then shapes, wash ball, drying, pick ball, obtaining this for improving the soft capsule of immunity.
Sizing described in step (6), wash ball, drying, pick ball process and be: dry 2 hours of the capsule and pill sizing obtained after pelleting, the edible ethanol of rear 95wt% of shaping washes ball, then go to temperature 25 DEG C, relative humidity is under the environment of≤40% dry 18 hours; Pick ball after drying, reject special-shaped ball, have the defective work such as bubble or leakage of oil ball, obtain qualified capsule and pill.The specification of the soft capsule for improving immunity that step (6) obtains is 0.5g/ grain.The production process of step (1) ~ (6) all operates under 100,000 grades of production clean area conditions.
Test example:
1, sample and dosage: the soft capsule that embodiment 1 ~ 3 prepares, each adult, each serving with 2, often takes 2 times day by day.Convert according to adult human body weight 60kg, the average mice body weight that test example uses is 20g, need take the amount of the 0.06wt% of the soft capsule content that embodiment 1 ~ 3 prepares at every turn, take in 2 every day.Animal used as test and grouping: SPF level Kunming kind female mice, body weight 18g ~ 22g, by east, Changsha Kaifu District, wound experimental animal science service portion provides, and production licence number is SCXK (Hunan) 2009-0012, and feed is provided by same unit.
2, experiment grouping: 40 mouse are all got in each test, are divided into 4 groups.First group is control group, take in the white space board Radix Astragali medlar-poria amino acid tablet produced by Hao Yu bio tech ltd, Hangzhou, take in dosage to be converted by the adult human dose on the description of this product: the amount once taking in the 0.03wt% of every sheet, every day takes in twice.Second group is low dose group, and each amount taking in the 0.03wt% of the soft capsule content that embodiment 1 prepares, every day takes in twice.3rd group is normal dose group, and each amount taking in the 0.06wt% of the soft capsule content that embodiment 1 prepares, every day takes in twice.4th group is high dose group, and each amount taking in the 0.12wt% of the soft capsule content that embodiment 1 prepares, every day takes in twice.
3, the mouse lymphocyte transformation experiment (mtt assay) of ConA induction
Asepticly get spleen, be placed in the little plate filling appropriate aseptic Hank ' s liquid, make cell suspension, filter through 200 eye mesh screens.2 times are washed, at every turn centrifugal 10 minutes (l000r/min) with Hank ' s liquid.Then being suspended in by cell in lmL complete culture solution, living cell counting number, is 3 × 106/mL with RPMI1640 nutrient solution adjustment cell concentration.Add in 24 well culture plates by a cell suspension point holes again, every hole lmL, a hole adds 75 μ LConA liquid (being equivalent to 7.5 μ g/mL) wherein, and 5% carbon dioxide in contrast, is put in another hole, cultivates 72h for 37 DEG C.Cultivation terminates front 4h, and every hole sucks supernatant 0.7mL gently, adds 0.7mL not containing the RPMI1640 nutrient solution of calf serum, adds MTT (5mg/mL) 50uL/ hole simultaneously, continues to cultivate 4h.After cultivation terminates, every hole adds lmL acid isopropyl alcohol, and piping and druming mixing, makes purple crystal dissolve completely.Then be dispensed in 96 well culture plates, 3 parallel holes are made in each hole, with ELIASA, measure OD value with 570nm wavelength.Lymphocytic multiplication capacity deducts with the OD value adding ConA hole the OD value not adding ConA hole and represents.Four groups of medicine impacts on mouse lymphocyte conversion capability are as shown in table 1.
Table 1
From table 1, per os gives the product 30 days of mouse various dose, and high dose can increase mouse lymphocyte conversion capability, has conspicuousness (P<0.05) with control group comparing difference.
4, antibody-producting cell detects (Jerne improves slide method)
Get sheep blood brine 3 times, centrifugal (2000r/min) 10min, is made into the cell suspension of 2% (v/v) by hematocrit SRBC physiological saline at every turn, every mouse lumbar injection 0.2ml.By sacrifice after 5 days, get spleen, grind gently, make cell suspension with Hanks liquid, 200 eye mesh screens filter, washing, centrifugal 2 times, finally cell is suspended in 8mlHanks liquid.Counting cells, and cell concentration is adjusted to 5 × l06/mL.Mix after the culture medium heating for dissolving of top layer with the pH7.4 of equivalent, the Hanks liquid of 2 times of concentration, packing small test tube, often pipe 0.5ml, the 10%SRBC50ul (v/v) with the preparation of SA liquid, 20ul splenocyte suspension (5 × l06/mL) is added again in pipe, be poured on the slide of brush thin layer agarose after rapid mixing, being put down by slide to buckle after agarose solidifies is placed on slide frame, put into CO2gas incubator incubation 1.5h, the complement (1:8) diluted is joined after continuing incubation 1.5h in slide groove count hemolysis plaque number with SA liquid.Four groups of medicine impacts on mouse antibodies cellulation number are as shown in table 2.
Table 2
As shown in Table 2, per os gives the white space board Radix Astragali matrimony vine amino acid tablet 30 days of mouse various dose, and high dose can increase mouse antibodies cellulation number, has conspicuousness (P<0.05) with control group comparing difference.
5, the mensuration (determination of lactate dehydrogenase method) of NK cytoactive
Test mice cervical dislocation is put to death, asepticly get spleen, make splenocyte suspension, 2 times are washed with Hank ' s liquid, each centrifugal 10min (1000r/min), abandon supernatant cytoplasm is upspring, add 0.5ml aqua sterilisa 20 seconds, 0.5ml 2 times of Hank ' s liquid and 8mlHank ' s liquid is added again after splitting erythrocyte, the centrifugal l0min of l000rpm, resuspended containing the RPMI1640 complete culture solution of 10% calf serum with lmL, with the blue dyeing counting of platform phenol (viable count should more than 95%), adjustment cell concentration be 2 × 107/mL this be effector cell, get well-grown YAC-1 of 24h after going down to posterity cell RPMI1640 complete culture solution adjustment cell concentration be 4 × 105/ml this be target cell, get target cell and each l00ul of effector cell (effect target is than 50:1), add in U-shaped 96 well culture plates, target cell Spontaneous release hole adds target cell and each l00ul of nutrient solution, the maximum release aperture of target cell adds target cell and each l00ul of 2.5%Triton is above-mentioned everyly all establishes three parallel holes, in 37 DEG C, 4h is cultivated in 5% CO2gas incubator, then by 96 well culture plates with the centrifugal 5min of 1500r/min, every hole is drawn in 96 well culture plates at the bottom of supernatant 100ul horizontalization, add LDH matrix liquid 100ul simultaneously, according to room temperature reaction 3-10min, every hole adds the HC130ul of lmol/L, measures optical density (OD) at ELIASA 490nm place.
NK cytoactive=[(reacting hole OD-Spontaneous release hole OD)/(maximum release aperture OD-Spontaneous release hole OD)] × 100%.Four groups of medicine impacts on NK cells in mice activity are as shown in table 3.
Table 3
From table 3, per os gives the product 30 days of mouse various dose, and middle and high dosage can increase NK cytoactive, has conspicuousness (P<0.05) with control group comparing difference.
Claims (4)
1., for improving a soft capsule for immunity, it is characterized in that concrete preparation process is as follows:
(1) raw material of following parts by weight pulverized, cross 120 mesh sieves: silkworm compound amino acid: 2 ~ 5 parts; Radix pseudostellariae: 9 ~ 30 parts; The root of bidentate achyranthes: 5 ~ 12 parts; Honey-fried licorice root: 2 ~ 10 parts; Thizoma curculiginis: 3 ~ 10 parts; Leaves of Hawthorn: 3 ~ 10 parts; Saline cistanche: 6 ~ 10 parts; Panax japonicus: 6 ~ 9 parts; Native copper: 3 ~ 9 parts; Tortoise plastron: 9 ~ 24 parts; Pilose antler: 1 ~ 2 part;
(2) each raw material that step (1) obtains is mixed, obtain premix;
(3) by purified water 106 ~ 120 parts, glycerine 15 ~ 20 parts of being placed in glue tanks, after being heated to 60 DEG C, by 10 ~ 12 parts, gelatin, titanium dioxide 5 ~ 8 parts, lemon yellow 3 ~ 5 parts of inputization glue tanks, continue to be heated to 80 DEG C, heat while stirring, make Gelatin complete, be incubated 1 ~ 2 hour, leave standstill after foam floats, vacuumizing and defoaming, cross 100 mesh sieves, obtain glue, be incubated for subsequent use;
(4) get corn oil 10 ~ 12 parts, 4 ~ 5 parts, beeswax is placed in blend tank, be heated to 70 ~ 80 DEG C, dissolving stirs and evenly mixs, and cooling, obtains mixing oil plant;
(5) premix step (2) obtained drops in mixing oil plant, mixing and stirring, mixing time 20 ~ 30 minutes, and after colloid mill grinding 2 ~ 3 times, vacuumizing and defoaming, crosses 80 mesh sieves, obtain content material, for subsequent use;
(6) under the environment of room temperature 18 ~ 22 DEG C, relative humidity≤45%, content material and glue being put into pelleting in encapsulating machine respectively, then shapes, wash ball, drying, pick ball, obtaining this for improving the soft capsule of immunity.
2. the soft capsule for improving immunity according to claim 1, it is characterized in that the sizing described in step (6), wash ball, drying, pick ball process and be: dry 2 ~ 4 hours of the capsule and pill sizing obtained after pelleting, the edible ethanol of rear 95wt% of shaping washes ball, then go to temperature 25 ~ 28 DEG C, relative humidity is under the environment of≤40% dry 18 ~ 24 hours; Pick ball after drying, reject special-shaped ball, have the defective work such as bubble or leakage of oil ball, obtain qualified capsule and pill.
3. the soft capsule for improving immunity according to claim 1, is characterized in that the specification of the soft capsule for improving immunity that step (6) obtains is 0.5g/ grain.
4. the soft capsule for improving immunity according to claim 1, is characterized in that the production process of step (1) ~ (6) operates under all producing clean area condition at 100,000 grades.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036276A (en) * | 2016-06-06 | 2016-10-26 | 焦克凡 | Drink capable of enhancing immunity |
| CN106420816A (en) * | 2016-09-28 | 2017-02-22 | 北京瑞济善健康科技有限公司 | Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof |
| CN108142931A (en) * | 2017-12-26 | 2018-06-12 | 湖州品创孵化器有限公司 | A kind of health food for improving immunity |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085785A (en) * | 1993-05-04 | 1994-04-27 | 宝鸡民族医药保健品厂 | Ginseng deer YIYUAN GAO and preparation method thereof |
| CN1194843A (en) * | 1997-04-01 | 1998-10-07 | 李恩洪 | Method for producing green health medicine |
| CN101095717A (en) * | 2006-06-27 | 2008-01-02 | 陈国栋 | Agent for improving body immune function |
| CN101444590A (en) * | 2008-09-25 | 2009-06-03 | 成钢 | Formula process of micro-element snake penis preparation for perfuming body and tonifying yang |
| CN101856430A (en) * | 2009-04-08 | 2010-10-13 | 周艳 | Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof |
-
2014
- 2014-12-10 CN CN201410755392.2A patent/CN104382038B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085785A (en) * | 1993-05-04 | 1994-04-27 | 宝鸡民族医药保健品厂 | Ginseng deer YIYUAN GAO and preparation method thereof |
| CN1194843A (en) * | 1997-04-01 | 1998-10-07 | 李恩洪 | Method for producing green health medicine |
| CN101095717A (en) * | 2006-06-27 | 2008-01-02 | 陈国栋 | Agent for improving body immune function |
| CN101444590A (en) * | 2008-09-25 | 2009-06-03 | 成钢 | Formula process of micro-element snake penis preparation for perfuming body and tonifying yang |
| CN101856430A (en) * | 2009-04-08 | 2010-10-13 | 周艳 | Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036276A (en) * | 2016-06-06 | 2016-10-26 | 焦克凡 | Drink capable of enhancing immunity |
| CN106420816A (en) * | 2016-09-28 | 2017-02-22 | 北京瑞济善健康科技有限公司 | Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof |
| CN108142931A (en) * | 2017-12-26 | 2018-06-12 | 湖州品创孵化器有限公司 | A kind of health food for improving immunity |
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