CN104367924A - Pharmaceutical composition for treating dyspepsia - Google Patents
Pharmaceutical composition for treating dyspepsia Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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Abstract
The invention discloses a pharmaceutical composition for treating dyspepsia. The pharmaceutical composition is prepared from raw materials including fingered citron, rhizoma pinelliae, myristica fragrans, fructus amomi, Chinese yams and liquorice. The pharmaceutical composition has the effects of strengthening the spleen and harmonizing the stomach, promoting digestion as well as helping digestion and relieving diarrhea, and particularly has an exact effect on treating anorexia and dyspepsia caused by yin deficiency of the spleen and stomach.
Description
Technical field
The present invention relates to one and treat dyspeptic pharmaceutical composition, particularly a kind of is the pharmaceutical composition that raw material is made by Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae.
Background technology
Dyspepsia is a kind of common internal medicine digestive system disease, morbidity crowd is many, its symptom main manifestations is for having epigastric discomfort or pain, glutted, heartburn (acid regurgitation), belch by spells, often be reluctant to take food or take food less as far as possible because satisfy uncomfortable in chest, morning sense, abdominal distention etc. are uncomfortable, also be difficult to sleep peacefully at night, normal with nightmare after sleeping.Also have some patient's abdominal distention obvious, abdominal part borborygmus, aerofluxus increases, even the indigested food debris of Chang Kejian in stool.
The Western medicine huge number of current treatment dyspepsia disease, as motilium, metoclopramide etc., although instant effect, good effect, but there is certain side effect, Chinese medicine is little with its toxic and side effects, the occupancy volume of the market share expands year by year, but usually there is the problems such as curative effect is rapid not, effective ingredient is not obvious, medication dose is large.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency existing in prior art, provide one to treat dyspeptic pharmaceutical composition.This pharmaceutical composition effectively can treat dyspepsia, instant effect, and dosage is little, has no side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
The dyspeptic pharmaceutical composition for the treatment of of the present invention, it is the medicament be made up of following raw material: Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae.
In pharmaceutical composition of the present invention, Fructus Citri Sarcodactylis acrid in the mouth, hardship, acid, warm in nature.Return liver, stomach, spleen, lung meridian.Depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain, drying dampness to eliminate phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted, cough with copious phlegm.
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), acrid in the mouth, warm in nature, poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Life external treatment, carbuncle sucutaneous nodule.
Semen Myristicae, acrid in the mouth, hardship, warm in nature.Return spleen, stomach, large intestine channel.Cure mainly warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted.
Fructus Amomi acrid in the mouth, warm in nature, return spleen, stomach, kidney channel.Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Rhizoma Dioscoreae, nature and flavor are sweet, flat, return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission; Cure mainly insufficiency of the spleen, chronic diarrhea, the deficiency of the lung, suffer from a deficiency of the kidney, leukorrhagia, frequent micturition.
Radix Glycyrrhizae, nature and flavor are sweet, flat, and GUIXIN, lung, spleen, stomach warp, have QI invigorating invigorating middle warmer, the function of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.
Applicant finds through test of many times, is that pharmaceutical composition made by raw material, effectively can treats indigestion by Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is made up of the raw material of following weight: Fructus Citri Sarcodactylis 5 ~ 25 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3 ~ 28 parts, Semen Myristicae 1 ~ 18 part, Fructus Amomi 2 ~ 15 parts, Rhizoma Dioscoreae 1 ~ 10 part and 1 ~ 8 part, Radix Glycyrrhizae.Applicant finds through many experiments, and pharmaceutical composition of the present invention is made up of the raw material of above-mentioned weight, better can play the synergistic function of each raw material components, not only effectively can treat indigestion, instant effect simultaneously, dosage is little, has no side effect.
Further preferably, described pharmaceutical composition is made up of the raw material of following weight: Fructus Citri Sarcodactylis 5 ~ 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 ~ 20 parts, Semen Myristicae 1 ~ 15 part, Fructus Amomi 2 ~ 14 parts, Rhizoma Dioscoreae 1 ~ 8 part and 1 ~ 6 part, Radix Glycyrrhizae.
Still more preferably, described pharmaceutical composition is made up of the raw material of following weight: Fructus Citri Sarcodactylis 8 ~ 18 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7 ~ 18 parts, Semen Myristicae 1 ~ 10 part, Fructus Amomi 4 ~ 12 parts, Rhizoma Dioscoreae 3 ~ 8 parts and 1 ~ 5 part, Radix Glycyrrhizae.
Still more preferably, described pharmaceutical composition is made up of the raw material of following weight: Fructus Citri Sarcodactylis 10 ~ 15 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 ~ 15 parts, Semen Myristicae 5 ~ 10 parts, Fructus Amomi 7 ~ 10 parts, Rhizoma Dioscoreae 5 ~ 8 parts and 1 ~ 5 part, Radix Glycyrrhizae.
Preferably, to the best described pharmaceutical composition be made up of the raw material of following weight: Fructus Citri Sarcodactylis 12 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Semen Myristicae 9 parts, Fructus Amomi 9 parts, Rhizoma Dioscoreae 6 parts and 3 parts, Radix Glycyrrhizae.
By preferably above, the curative effect of pharmaceutical composition can be improved further.
The dosage form of medicine of the present invention can be the existing pharmaceutical dosage form of any one in drop pill, tablet, capsule, soft capsule, granule.
The preparation method of pharmaceutical composition of the present invention is as follows:
(1) get Fructus Citri Sarcodactylis, with the water percolation 48h of 8-12 times of volume, collect percolate, by percolate by macroporous adsorbent resin, first wash with water, removing is dissolved in the impurity of polar solvent, is discarded by this water elution liquid; Use the high concentration ethanol eluting of 80% again, collect this high concentration ethanol eluent, by dry for the eluent reclaimed after ethanol, obtain Fructus Citri Sarcodactylis extract.
(2) get Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), add the alcohol reflux 3h of 85% of 8-10 times of volume, collect extracting solution, centrifugal removing precipitation, vacuum drying supernatant, obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(3) get Semen Myristicae, rub, add the water reflux, extract, three times of 8-10 times of volume, time 2h, 1.5h, 1h, collect merge extractive liquid, centrifugal removing precipitation, by supernatant vacuum drying, obtains Semen Myristicae extract.
(4) get Fructus Amomi, pulverizing of shelling, cross 20 mesh sieves, add the 70% ethanol water room temperature percolation 3 days of 8-10 times of volume, filter, under filtrate room temperature condition, decompression rotates evaporate to dryness, obtains Fructus Amomi extract.
(5) get Rhizoma Dioscoreae, defibrination, add the water of 8-10 times of volume, pH to 7-9 is regulated with 30%NaOH solution, 2h is extracted in constant temperature (60-80 DEG C) water-bath, collected by centrifugation supernatant, and the water again adding 4-8 times of volume in precipitation extracts, collected by centrifugation supernatant, concentrating under reduced pressure (60 DEG C) after mixing, adds 70% ethanol, 4 DEG C of standing 12h of 0.3-1 times of volume, centrifugal collecting precipitation, 40 DEG C of vacuum dryings, obtain Rhizoma Dioscoreae extract.
(6) extracting liquorice, adds the water boiling and extraction 2 times of 8-10 times of volume, each 1.5-2h, merge extractive liquid, concentrated, dry, obtains Radix Glycyrrhizae extract.
(7) by above-mentioned Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae extract mixing, acceptable various pharmaceutical dosage form is made.
The present invention's various raw medicinal materials used are the Chinese crude drug meeting country or provincial standard and specify.The dyspeptic pharmaceutical composition for the treatment of of the present invention, based on theory of Chinese medical science, in conjunction with clinical practice, filter out from Chinese medicine material treasure-house and there is invigorating the stomach and promoting digestion, invigorating the spleen and benefiting QI, regulating QI to relieve pain, digestive pure purification of tcm forms, and regulate the weight of each raw material, make the effect playing Synergistic between each raw material, can latent heat in clearing stomach, let out the fire of liver taste, adjust liver QI of the spleen and stomach, the abdominal discomfort that treatment dyspepsia is caused or pain, glutted, heartburn (acid regurgitation), the symptoms such as belch have significant curative effect, effective treatment rate reaches more than 90%.Pharmaceutical composition instant effect of the present invention simultaneously, dosage is little, has no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The dyspeptic pharmaceutical composition for the treatment of described in the present embodiment, be made up of the raw material of following weight:
Fructus Citri Sarcodactylis 12g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15g, Semen Myristicae 9g, Fructus Amomi 9g, Rhizoma Dioscoreae 6g and Radix Glycyrrhizae 3g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) get Fructus Citri Sarcodactylis, with the water percolation 48h of 8 times of volumes, collect percolate, by percolate by macroporous adsorbent resin, first wash with water, removing is dissolved in the impurity of polar solvent, is discarded by this water elution liquid; Use the high concentration ethanol eluting of 80% again, collect this high concentration ethanol eluent, by dry for the eluent reclaimed after ethanol, obtain Fructus Citri Sarcodactylis extract.
(2) get Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), add the alcohol reflux 3h of 85% of 8 times of volumes, collect extracting solution, centrifugal removing precipitation, vacuum drying supernatant, obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(3) get Semen Myristicae, rub, add the water reflux, extract, three times of 8 times of volumes, time 2h, 1.5h, 1h, collect merge extractive liquid, centrifugal removing precipitation, by supernatant vacuum drying, obtains Semen Myristicae extract.
(4) get Fructus Amomi, pulverizing of shelling, cross 20 mesh sieves, add the 70% ethanol water room temperature percolation 3 days of 8 times of volumes, filter, under filtrate room temperature condition, decompression rotates evaporate to dryness, obtains Fructus Amomi extract.
(5) get Rhizoma Dioscoreae, defibrination, add the water of 8 times of volumes, pH to 8 is regulated with 30%NaOH solution, 2h is extracted in constant temperature (80 DEG C) water-bath, collected by centrifugation supernatant, and the water again adding 8 times of volumes in precipitation extracts, collected by centrifugation supernatant, concentrating under reduced pressure (60 DEG C) after mixing, adds 70% ethanol, 4 DEG C of standing 12h of 0.6 times of volume, centrifugal collecting precipitation, 40 DEG C of vacuum dryings, obtain Rhizoma Dioscoreae extract.
(6) extracting liquorice, adds the water boiling and extraction 2 times of 10 times of volumes, each 2h, merge extractive liquid, concentrated, dry, obtains Radix Glycyrrhizae extract.
(7) by above-mentioned Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae extract mix homogeneously.
(8) said mixture is mixed homogeneously with starch 200g, adopt capsules preparation technique, the pharmaceutical composition of obtained capsule.
Embodiment 2
The dyspeptic pharmaceutical composition for the treatment of described in the present embodiment, be made up of the raw material of following weight:
Fructus Citri Sarcodactylis 20g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12g, Semen Myristicae 4g, Fructus Amomi 8g, Rhizoma Dioscoreae 4g and Radix Glycyrrhizae 4g.
Above-mentioned raw materials is prepared into tablet, and preparation method is as follows:
(1) get Fructus Citri Sarcodactylis, with the water percolation 48h of 12 times of volumes, collect percolate, by percolate by macroporous adsorbent resin, first wash with water, removing is dissolved in the impurity of polar solvent, is discarded by this water elution liquid; Use the high concentration ethanol eluting of 80% again, collect this high concentration ethanol eluent, by dry for the eluent reclaimed after ethanol, obtain Fructus Citri Sarcodactylis extract.
(2) get Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), add the alcohol reflux 3h of 85% of 10 times of volumes, collect extracting solution, centrifugal removing precipitation, vacuum drying supernatant, obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(3) get Semen Myristicae, rub, add the water reflux, extract, three times of 10 times of volumes, time 2h, 1.5h, 1h, collect merge extractive liquid, centrifugal removing precipitation, by supernatant vacuum drying, obtains Semen Myristicae extract.
(4) get Fructus Amomi, pulverizing of shelling, cross 20 mesh sieves, add the 70% ethanol water room temperature percolation 3 days of 10 times of volumes, filter, under filtrate room temperature condition, decompression rotates evaporate to dryness, obtains Fructus Amomi extract.
(5) get Rhizoma Dioscoreae, defibrination, add the water of 10 times of volumes, pH to 9 is regulated with 30%NaOH solution, 2h is extracted in constant temperature (60 DEG C) water-bath, collected by centrifugation supernatant, and the water again adding 8 times of volumes in precipitation extracts, collected by centrifugation supernatant, concentrating under reduced pressure (60 DEG C) after mixing, adds 70% ethanol, 4 DEG C of standing 12h of 1 times of volume, centrifugal collecting precipitation, 40 DEG C of vacuum dryings, obtain Rhizoma Dioscoreae extract.
(6) extracting liquorice, adds the water boiling and extraction 2 times of 10 times of volumes, each 2h, merge extractive liquid, concentrated, dry, obtains Radix Glycyrrhizae extract.
(7) by above-mentioned Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae extract mix homogeneously.
(8) by said mixture and 100g starch, 20g polyvidone mixes, and adopts existing pressed-disc technique, the pharmaceutical composition of obtained tablet.
Embodiment 3
The dyspeptic pharmaceutical composition for the treatment of described in the present embodiment, be made up of the raw material of following weight:
Fructus Citri Sarcodactylis 25g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 28g, Semen Myristicae 18g, Fructus Amomi 15g, Rhizoma Dioscoreae 10g and Radix Glycyrrhizae 8g.
Above-mentioned raw materials is prepared into tablet, and preparation method is as follows:
(1) get Fructus Citri Sarcodactylis, with the water percolation 48h of 10 times of volumes, collect percolate, by percolate by macroporous adsorbent resin, first wash with water, removing is dissolved in the impurity of polar solvent, is discarded by this water elution liquid; Use the high concentration ethanol eluting of 80% again, collect this high concentration ethanol eluent, by dry for the eluent reclaimed after ethanol, obtain Fructus Citri Sarcodactylis extract.
(2) get Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), add the alcohol reflux 3h of 85% of 9 times of volumes, collect extracting solution, centrifugal removing precipitation, vacuum drying supernatant, obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(3) get Semen Myristicae, rub, add the water reflux, extract, three times of 9 times of volumes, time 2h, 1.5h, 1h, collect merge extractive liquid, centrifugal removing precipitation, by supernatant vacuum drying, obtains Semen Myristicae extract.
(4) get Fructus Amomi, pulverizing of shelling, cross 20 mesh sieves, add the 70% ethanol water room temperature percolation 3 days of 8 times of volumes, filter, under filtrate room temperature condition, decompression rotates evaporate to dryness, obtains Fructus Amomi extract.
(5) get Rhizoma Dioscoreae, defibrination, add the water of 8 times of volumes, pH to 7-9 is regulated with 30%NaOH solution, 2h is extracted in constant temperature (70 DEG C) water-bath, collected by centrifugation supernatant, and the water again adding 6 times of volumes in precipitation extracts, collected by centrifugation supernatant, concentrating under reduced pressure (60 DEG C) after mixing, adds 70% ethanol, 4 DEG C of standing 12h of 0.3 times of volume, centrifugal collecting precipitation, 40 DEG C of vacuum dryings, obtain Rhizoma Dioscoreae extract.
(6) extracting liquorice, adds the water boiling and extraction 2 times of 9 times of volumes, each 2h, merge extractive liquid, concentrated, dry, obtains Radix Glycyrrhizae extract.
(7) by above-mentioned Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae extract mix homogeneously.
(8) by said mixture and 50g starch, 20g polyvidone mixes, and adopts existing pressed-disc technique, obtained tablet.
Embodiment 4
The dyspeptic pharmaceutical composition for the treatment of described in the present embodiment, be made up of the raw material of following weight:
Fructus Citri Sarcodactylis 20g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g, Semen Myristicae 10g, Fructus Amomi 7g, Rhizoma Dioscoreae 8g and Radix Glycyrrhizae 6g.
Above-mentioned raw materials is prepared into soft capsule, and preparation method is as follows:
(1) get Fructus Citri Sarcodactylis, with the water percolation 48h of 8 times of volumes, collect percolate, by percolate by macroporous adsorbent resin, first wash with water, removing is dissolved in the impurity of polar solvent, is discarded by this water elution liquid; Use the high concentration ethanol eluting of 80% again, collect this high concentration ethanol eluent, by dry for the eluent reclaimed after ethanol, obtain Fructus Citri Sarcodactylis extract.
(2) get Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), add the alcohol reflux 3h of 85% of 9 times of volumes, collect extracting solution, centrifugal removing precipitation, vacuum drying supernatant, obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(3) get Semen Myristicae, rub, add the water reflux, extract, three times of 10 times of volumes, time 2h, 1.5h, 1h, collect merge extractive liquid, centrifugal removing precipitation, by supernatant vacuum drying, obtains Semen Myristicae extract.
(4) get Fructus Amomi, pulverizing of shelling, cross 20 mesh sieves, add the 70% ethanol water room temperature percolation 3 days of 10 times of volumes, filter, under filtrate room temperature condition, decompression rotates evaporate to dryness, obtains Fructus Amomi extract.
(5) get Rhizoma Dioscoreae, defibrination, add the water of 10 times of volumes, pH to 8 is regulated with 30%NaOH solution, 2h is extracted in constant temperature (60 DEG C) water-bath, collected by centrifugation supernatant, and the water again adding 6 times of volumes in precipitation extracts, collected by centrifugation supernatant, concentrating under reduced pressure (60 DEG C) after mixing, adds 70% ethanol, 4 DEG C of standing 12h of 1 times of volume, centrifugal collecting precipitation, 40 DEG C of vacuum dryings, obtain Rhizoma Dioscoreae extract.
(6) extracting liquorice, adds the water boiling and extraction 2 times of 8-10 times of volume, each 1.5h, merge extractive liquid, concentrated, dry, obtains Radix Glycyrrhizae extract.
(7) by above-mentioned Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae extract mix homogeneously.
(8) by said mixture and vegetable oil 25g, mixing, uses ' Yanming ' capsules for clearing shell material, adopts existing soft capsule preparation technology, be pressed into soft capsule.
Comparative example 1
The dyspeptic pharmaceutical composition for the treatment of described in this comparative example, be made up of the raw material of following weight:
Fructus Citri Sarcodactylis 12g, Semen Myristicae 9g, Fructus Amomi 9g, Rhizoma Dioscoreae 6g and Radix Glycyrrhizae 3g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Comparative example 2
The dyspeptic pharmaceutical composition for the treatment of described in the present embodiment, be made up of the raw material of following weight:
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15g, Semen Myristicae 9g, Fructus Amomi 9g and Rhizoma Dioscoreae 6g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of tablet.
Embodiment 5
The curative effect of pharmaceutical composition of the present invention and advantage thereof are by following clinical trial certificate:
1, Subject Population:
Be divided into A, B, C tri-experimental grouies by disease symptom, group result is as described in Table 1:
Table 1 patient group result
2, efficacy result evaluation
(1) pharmaceutical composition of the present invention is to the therapeutic outcome of A group patient
A group patient is equally divided into six groups (a ~ f groups), often organizes 50 people.Give pharmaceutical composition prepared by six groups of oral embodiment of the present invention 1 ~ 4 of patient and comparative example 1 ~ 2 respectively, every day is early, middle and late respectively to be taken 2 (sheets) after meal, and serve on 5 days, accumulated dose of taking medicine is 0.73g raw medicinal herbs/kg every day.
Efficacy evaluation: symptom is invalid without alleviation or DeGrain; Symptom substantially disappears or disappears completely is effective, and the therapeutic effect of medicine of the present invention to A group patient is as shown in table 2.
Table 2 pharmaceutical composition of the present invention is to the therapeutic outcome of A group patient
(2) pharmaceutical composition of the present invention is to the therapeutic outcome of B group patient
B group patient is equally divided into six groups (a ~ f groups), often organizes 50 people.Give pharmaceutical composition prepared by six groups of oral embodiment of the present invention 1 ~ 4 of patient and comparative example 1 ~ 2 respectively, every day is early, middle and late respectively to be taken 2 (sheets) after meal, and serve on 5 days, accumulated dose of taking medicine is 0.73g raw medicinal herbs/kg every day.
Efficacy evaluation: symptom is invalid without alleviation or DeGrain; Symptom substantially disappears or disappears completely is effective, and the therapeutic effect of medicine of the present invention to B group patient is as shown in table 3.
Table 3 pharmaceutical composition of the present invention is to the therapeutic outcome of B group patient
(3) pharmaceutical composition of the present invention is to the therapeutic outcome of C group patient
C group patient is equally divided into six groups (a ~ f groups), often organizes 50 people.Give pharmaceutical composition prepared by six groups of oral embodiment of the present invention 1 ~ 4 of patient and comparative example 1 ~ 2 respectively, every day is early, middle and late respectively to be taken 2 (sheets) after meal, and serve on 5 days, accumulated dose of taking medicine is 0.73g raw medicinal herbs/kg every day.
Efficacy evaluation: symptom is invalid without alleviation or DeGrain; Symptom substantially disappears or disappears completely is effective, and the therapeutic effect of medicine of the present invention to C group patient is as shown in table 4.
Table 4 pharmaceutical composition of the present invention is to the therapeutic outcome of C group patient
In experimentation, before and after patient medication, all do not find untoward reaction, also that is to say that Chinese medicine composition of the present invention has no side effect to patient body.
According to the data in table 2 ~ 4, the dyspeptic pharmaceutical composition for the treatment of of the present invention effectively can treat A, B, C tri-kinds of symptoms, and effective percentage reaches more than 90%.The effective percentage of pharmaceutical composition described in embodiment 1 ~ 4 is compared with the effective percentage of pharmaceutical composition described in comparative example 1 ~ 2, all improve about 20%, show that pharmaceutical composition of the present invention needs the mutual compatibility of each raw material components, play the effect of Synergistic, just can reach best therapeutic effect.
Claims (5)
1. treat a dyspeptic pharmaceutical composition, it is characterized in that, it is the medicament be made up of following raw material: Fructus Citri Sarcodactylis, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Semen Myristicae, Fructus Amomi, Rhizoma Dioscoreae and Radix Glycyrrhizae.
2. treat a dyspeptic pharmaceutical composition, it is characterized in that, it is the medicament be made up of following raw material: Fructus Citri Sarcodactylis 5 ~ 25 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3 ~ 28 parts, Semen Myristicae 1 ~ 18 part, Fructus Amomi 2 ~ 15 parts, Rhizoma Dioscoreae 1 ~ 10 part and 1 ~ 8 part, Radix Glycyrrhizae.
3. pharmaceutical composition according to claim 1, is characterized in that, the weight of described each raw material is: Fructus Citri Sarcodactylis 5 ~ 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 ~ 20 parts, Semen Myristicae 1 ~ 15 part, Fructus Amomi 2 ~ 14 parts, Rhizoma Dioscoreae 1 ~ 8 part and 1 ~ 6 part, Radix Glycyrrhizae.
4. pharmaceutical composition according to claim 2, is characterized in that, the weight of described each raw material is: Fructus Citri Sarcodactylis 8 ~ 18 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7 ~ 18 parts, Semen Myristicae 1 ~ 10 part, Fructus Amomi 4 ~ 12 parts, Rhizoma Dioscoreae 3 ~ 8 parts and 1 ~ 5 part, Radix Glycyrrhizae.
5. pharmaceutical composition according to claim 4, is characterized in that, the weight of described each raw material is: Fructus Citri Sarcodactylis 12 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Semen Myristicae 9 parts, Fructus Amomi 9 parts, Rhizoma Dioscoreae 6 parts and 3 parts, Radix Glycyrrhizae.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940843A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating dyspepsia |
| CN102940844A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating dyspepsia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940843A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating dyspepsia |
| CN102940844A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating dyspepsia |
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| 王昊: "枳术汤联合针刺冶疗功能性消化不良120例", 《光明中医》 * |
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