CN104367793A - Traditional Chinese medicine composition for treating postpartum hypogalactia as well as preparation method and application - Google Patents

Traditional Chinese medicine composition for treating postpartum hypogalactia as well as preparation method and application Download PDF

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CN104367793A
CN104367793A CN201410662254.XA CN201410662254A CN104367793A CN 104367793 A CN104367793 A CN 104367793A CN 201410662254 A CN201410662254 A CN 201410662254A CN 104367793 A CN104367793 A CN 104367793A
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parts
radix
chinese medicine
medicine composition
traditional chinese
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卞毓平
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

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Abstract

The invention provides a traditional Chinese medicine composition for treating postpartum hypogalactia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: crotalaria mairei, galium bungei, astragalus membranaceus, codonopsis pilosula and the like. The traditional Chinese medicine composition provided by the invention can be used for treating postpartum hypogalactia.

Description

A kind of Chinese medicine composition and preparation method and application treating puerperal hypogalactia
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat puerperal hypogalactia.
Background technology
Puerperal hypogalactia system, can not lactogenesis because of insufficiency of vital energy and blood, or stagnation of QI due to depression of the liver, and newborn arteries and veins hangs down plug, cause puerpera age of sucking milk very less or completely without, also known as lack of lactation after delivery.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat puerperal hypogalactia.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for puerperal hypogalactia, it is prepared by the raw material of following parts by weight: headdress flower Herba crotalariae mucronatae 15 parts, four leaf humulus 12 parts, the Radix Astragali 25 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 6 parts, the Radix Angelicae Dahuricae 10 parts, Radix Ophiopogonis 6 parts, Rhizoma Dioscoreae 12 parts, Semen Vaccariae 10 parts, Medulla Tetrapanacis 10 parts, Squama Manis 6 parts, Rhizoma Cyperi 12 parts, Radix Platycodonis 10 parts, Radix Bupleuri 10 parts, Fructus Trichosanthis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 10 parts, 5 parts, Radix Glycyrrhizae.
The application of Chinese medicine composition in the medicine of preparation treatment puerperal hypogalactia of described treatment puerperal hypogalactia.
In the present invention, headdress flower Herba crotalariae mucronatae is pulse family Genus Crotalaria Linn headdress flower Herba crotalariae mucronatae Crotalaria capitata Benth., is used as medicine with root.Four leaf humulus, Latin is called Galium bungei Steud., is Rubiaceae, galium.Perennial herb, grows thickly, high 30 ~ 50 centimetres.All the other medicines all meet standards of pharmacopoeia or are documented in Chinese medicine voluminous dictionary.
Beneficial effect: the medicine that the present invention obtains can safe and effective treatment puerperal hypogalactia.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1. prepare embodiment
1.1 take headdress flower Herba crotalariae mucronatae 15g, four leaf humulus 12g, Radix Astragali 25g, Radix Codonopsis 10g, Radix Angelicae Sinensis 6g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 6g, Rhizoma Dioscoreae 12g, Semen Vaccariae 10g, Medulla Tetrapanacis 10g, Squama Manis 6g, Rhizoma Cyperi 12g, Radix Platycodonis 10g, Radix Bupleuri 10g, Fructus Trichosanthis 12g, Radix Salviae Miltiorrhizae 10g, Fructus Crataegi 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of puerperal hypogalactia.Oral, every bu is taken for twice sooner or later.
1.2 take headdress flower Herba crotalariae mucronatae 15g, four leaf humulus 12g, Radix Astragali 25g, Radix Codonopsis 10g, Radix Angelicae Sinensis 6g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 6g, Rhizoma Dioscoreae 12g, Semen Vaccariae 10g, Medulla Tetrapanacis 10g, Squama Manis 6g, Rhizoma Cyperi 12g, Radix Platycodonis 10g, Radix Bupleuri 10g, Fructus Trichosanthis 12g, Radix Salviae Miltiorrhizae 10g, Fructus Crataegi 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, must meet the granule of adult normal's 1 day consumption.Be used for the treatment of puerperal hypogalactia.Oral, every bu is taken for twice sooner or later.
1.3 take headdress flower Herba crotalariae mucronatae 15g, four leaf humulus 12g, Radix Astragali 25g, Radix Codonopsis 10g, Radix Angelicae Sinensis 6g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 6g, Rhizoma Dioscoreae 12g, Semen Vaccariae 10g, Medulla Tetrapanacis 10g, Squama Manis 6g, Rhizoma Cyperi 12g, Radix Platycodonis 10g, Radix Bupleuri 10g, Fructus Trichosanthis 12g, Radix Salviae Miltiorrhizae 10g, Fructus Crataegi 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, and tabletting, can obtain the tablet meeting adult normal's 1 day consumption.Be used for the treatment of puerperal hypogalactia.Oral, every bu is taken for twice sooner or later.
2. the present invention is to the clinical research of puerperal hypogalactia
2.1 physical data: inventor collects the out-patient of 50 routine puerperal hypogalactia-2013 years in March, 2012 altogether between December, age 22-36 year, be divided at random: treatment group 30 example, blank group 20 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
2.2 diagnostic criterias:
The milk amount of 2.2.1 discharging puerperal is few, even completely without, inadequate feeding infant.
2.2.2 breast examination is soft, not swollen not bitterly, extruding milk drop and going out, matter is rare.Or breast enlargement mammary gland in bulk, extruding milk pain difficulty goes out, and matter is thick.
2.2.3 getting rid of the milk caused because of crater nipple and cracked nipple stops up long-pending obstructed, dysilthia.
2.2.4 syndrome-classification
2.2.4.1 deficiency of qi and blood: puerperal, breast was few, even completely without, milk is rare clearly, soft breast, without swollen sense.Companion's lustreless complexion, mental fatigue with loss of appetite.Light red tongue, few tongue, deficient and thready pulse.
2.2.4.2 irritability stasis: puerperal milk very less or completely without, milk is thick, and the hard and pain of mammary swelling.Depressed emotion is discomfort, distending pain in the chest and hypochondrium, loss of appetite, or has slight fever.Dimly red tongue or sharp limit red, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.
2.3 test method
2.3.1 the oral the present invention for the treatment of group is according to the obtained capsule of specific embodiment 1.1, sooner or later each once.15 days courses for the treatment of.
2.3.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
2.4 criterions of therapeutical effect and therapeutic outcome
2.4.1 criterion of therapeutical effect
Recovery from illness: galactopoiesis is normal, can normal suckling.Take a turn for the better: galactopoiesis increases, or galactopoiesis is normal, but the few inadequate feeding infant of amount.Invalid: galactopoiesis is without change.
2.4.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 30 12 14 4 86.7
Blank group 20 0 2 18 10
Visible, the medicine that the present invention obtains can safe and effective treatment puerperal hypogalactia.
2.5 model case
Zhang, female, 28 years old, the milk amount that puerperal discharges was few, inadequate feeding infant, breast examination is soft, not swollen not bitterly, extruding milk drop and going out, matter is rare, the milk heap soil or fertilizer over and around the roots that eliminating causes because of crater nipple and cracked nipple is long-pending obstructed, dysilthia, companion's lustreless complexion, mental fatigue with loss of appetite.Light red tongue, few tongue, deficient and thready pulse is deficiency of qi and blood type hypogalactia after diagnosing, the capsule that oral the present invention obtains according to specific embodiment 1.1, and sooner or later each once after 15 days, galactopoiesis is normal, can normally suckling.

Claims (2)

1. treat the Chinese medicine composition of puerperal hypogalactia for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: headdress flower Herba crotalariae mucronatae 15 parts, four leaf humulus 12 parts, the Radix Astragali 25 parts, Radix Codonopsis 10 parts, Radix Angelicae Sinensis 6 parts, the Radix Angelicae Dahuricae 10 parts, Radix Ophiopogonis 6 parts, Rhizoma Dioscoreae 12 parts, Semen Vaccariae 10 parts, Medulla Tetrapanacis 10 parts, Squama Manis 6 parts, Rhizoma Cyperi 12 parts, Radix Platycodonis 10 parts, Radix Bupleuri 10 parts, Fructus Trichosanthis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 10 parts, 5 parts, Radix Glycyrrhizae.
2. treat the application of Chinese medicine composition in the medicine for the treatment of puerperal hypogalactia of puerperal hypogalactia as claimed in claim 1.
CN201410662254.XA 2014-11-19 2014-11-19 Traditional Chinese medicine composition for treating postpartum hypogalactia as well as preparation method and application Pending CN104367793A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04501106A (en) * 1989-04-28 1992-02-27 アレクサンドル　ミハイロビチ　デリアビン Medicinal products for the treatment of mastitis in animals and humans
CN101584795A (en) * 2008-05-19 2009-11-25 魏巧玲 A kind of Chinese medicine for the treatment of breast obstruction and pain
CN102600335A (en) * 2011-10-18 2012-07-25 宋协勘 Traditional Chinese medicine for treating postpartum hypogalactia
CN103920133A (en) * 2014-05-07 2014-07-16 张华� Traditional Chinese medicine application and preparing method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04501106A (en) * 1989-04-28 1992-02-27 アレクサンドル　ミハイロビチ　デリアビン Medicinal products for the treatment of mastitis in animals and humans
CN101584795A (en) * 2008-05-19 2009-11-25 魏巧玲 A kind of Chinese medicine for the treatment of breast obstruction and pain
CN102600335A (en) * 2011-10-18 2012-07-25 宋协勘 Traditional Chinese medicine for treating postpartum hypogalactia
CN103920133A (en) * 2014-05-07 2014-07-16 张华� Traditional Chinese medicine application and preparing method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
范国霞等: "乳充汤治疗产后缺乳40例临床观察", 《山东中医药大学学报》 *

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