CN104366486A - Formula and preparation method of quintuplet probiotic chewable tablet - Google Patents
Formula and preparation method of quintuplet probiotic chewable tablet Download PDFInfo
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- CN104366486A CN104366486A CN201410747498.8A CN201410747498A CN104366486A CN 104366486 A CN104366486 A CN 104366486A CN 201410747498 A CN201410747498 A CN 201410747498A CN 104366486 A CN104366486 A CN 104366486A
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- quintuplet
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- 239000007910 chewable tablet Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000006041 probiotic Substances 0.000 title abstract description 9
- 235000018291 probiotics Nutrition 0.000 title abstract description 9
- 230000000529 probiotic effect Effects 0.000 title abstract description 7
- 229940068682 chewable tablet Drugs 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title 1
- 239000000843 powder Substances 0.000 claims abstract description 69
- 239000003826 tablet Substances 0.000 claims abstract description 15
- 241000186016 Bifidobacterium bifidum Species 0.000 claims abstract description 10
- 241001608472 Bifidobacterium longum Species 0.000 claims abstract description 10
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 10
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims abstract description 10
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims abstract description 10
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims abstract description 10
- 229940009291 bifidobacterium longum Drugs 0.000 claims abstract description 10
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims abstract description 10
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims abstract description 10
- 239000008267 milk Substances 0.000 claims abstract description 10
- 210000004080 milk Anatomy 0.000 claims abstract description 10
- 235000013336 milk Nutrition 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 238000003825 pressing Methods 0.000 claims abstract description 6
- 241000186672 Lactobacillus delbrueckii subsp. bulgaricus Species 0.000 claims abstract 4
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 8
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 7
- 238000007493 shaping process Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- -1 oligoisomaltose Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 12
- 239000003053 toxin Substances 0.000 abstract description 5
- 231100000765 toxin Toxicity 0.000 abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 2
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 abstract 2
- 241000194017 Streptococcus Species 0.000 abstract 2
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 abstract 2
- 235000019359 magnesium stearate Nutrition 0.000 abstract 2
- 239000000600 sorbitol Substances 0.000 abstract 2
- 108700012359 toxins Proteins 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a formula and a preparation method of a quintuplet probiotic chewable tablet. The quintuplet probiotic chewable tablet comprises, by weight, 3-6 parts of bifidobacterium longum powder, 3-6 parts of bifidobacterium bifidum powder, 3-6 parts of lactobacillus acidophilus, 3-6 parts of lactobacillus bulgaricus powder, 3-6 parts of streptococcus thermophiles powder, 75-150 parts of isomaltose hypgather, 240-480 parts of milk powder, 35-55 parts of apple powder, 15-30 parts of magnesium stearate and 1140-2280 parts of sorbitol. The preparation method includes weighing the bifidobacterium longum powder, the bifidobacterium bifidum powder, the lactobacillus acidophilus, the lactobacillus bulgaricus powder, the streptococcus thermophiles powder, the isomaltose hypgather, the milk powder, the apple powder and the magnesium stearate respectively according to the formula, mixing the said components in a V-shaped powder mixer and adding into the sorbitol to be uniformly mixed; placing the mixture in a tablet press and directly cold pressing the mixture to obtain the finished tablet. The quintuplet probiotic chewable tablet is convenient to carry and take, and five kinds of probiotics are combined in the tablet, so that the probiotics in gastrointestinal tracts can take the advantage and suppress propagation of harmful bacteria, toxins are degraded and human health is promoted.
Description
Technical field
The present invention relates to formula of a kind of health care chewable tablets and preparation method thereof, particularly relate to five kinds of probiotic combination and use formula of chewable tablets and preparation method thereof.
Background technology
Probio can protect gastro-intestinal health, prevention and therapy constipation and diarrhoea; Build up resistance effectively antiviral, balanced immune regulates, and prevents anaphylactia; Prevention and auxiliary for treating cancer, suppress or delay the process of some cancer; Prevent and treat diabetes and control body weight; Reducing blood lipid is hypotensive; It is the natural therapy of women vaginitis and yeast infection; By safeguarding the endocrine of gastrointestinal health balance adjustment.
Probiotic supplemented, make the beneficial bacterium place superiority in intestines and stomach, suppress harmful bacteria breeding and the plain kill harmful bacterium of secreting bacteria by competitive occupy-place exclusion harmful bacteria and prevent external pathogenic bacteria from invading, degraded or point toxolysin, nuisance, promote that toxin shifts and toxin expelling in enteric cavity, prevent treating constipation, suffering from diarrhoea.Ensure by regulating GI immune system that intestines and stomach bring into normal play digest and assimilate, the three zones such as Immune defense and nerve modulation.Fundamentally ensure each organ of Whole Body and tissue health and carry out normal physiological metabolism, reaching each organ-tissue harmonious, healthy comprehensively.
Bifidobacterium longum can adjust function of intestinal canal disorder, has very strong targeting simultaneously, can in enteron aisle field planting and continued propagation; Bifidobacterium bifidum can prevent disease of digestive system, promotes food digestion; Lactobacillus acidophilus can increase the quantity of probio in enteron aisle, strengthen their vitality, causes the patient of gastrointestinal dysfunction to have the effect of good function of intestinal canal and gut flora quick adjustment to some Long-term Oral antibiotic simultaneously; Lactobacillus bulgaricus can promote secretion and the intestines peristalsis of digestive ferment, removes enteron aisle rubbish.Streptococcus thermophilus can suppress the growth of pathogen, prevents bad bacterium from growing, improves intestinal microenvironment.Prebiotics oligoisomaltose, just as the food of probio, can promote the growth of probio in human body, increases the quantity of probio.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of taking convenience can protect again formula of the 5-linked probio chewable tablets of gastro-intestinal health and preparation method thereof.
Its formula is:
Bifidobacterium longum powder 3-6 part, bifidobacterium bifidum powder 3-6 part, lactobacillus acidophilus powder 3-6 part, lactobacillus bulgaricus powder 3-6 part, streptococcus thermophilus powder 3-6 part, oligoisomaltose 75-150 part, milk powder 240-480 part, apple powder 35-55 part, dolomol 15-30 part, sorbierite 1140-2280 part.
Preparation method:
(1) pretreatment of raw material, takes bifidobacterium longum powder, bifidobacterium bifidum powder respectively by formula, lactobacillus acidophilus powder, lactobacillus bulgaricus powder, streptococcus thermophilus powder, oligoisomaltose, milk powder, malic acid, dolomol, is placed in mixing 15min-30min in V-type powder mixer, add sorbierite mixing 15min-30min again, fully mix;
(2) compressing tablet: be placed in tablet press machine directly cold pressing plate, Φ=12mm, h=4-5mm, sheet weight=0.78-0.84g, checks once sheet weight in every 15 minutes;
(3) check: check the shaping and compact structure situation of tablet;
(4) packaging warehouse-in: the product through being up to the standards can pack warehouse-in.
The invention has the beneficial effects as follows: this product is chewable tablets, easy to carry and use, oligoisomaltose is added in formula, milk powder and apple powder, mouthfeel is better, used by five kinds of probiotic combination, make the beneficial bacterium place superiority in intestines and stomach, suppress harmful bacteria breeding and the plain kill harmful bacterium of secreting bacteria by competitive occupy-place exclusion harmful bacteria and prevent external pathogenic bacteria from invading, degraded or point toxolysin, nuisance, promote that toxin shifts and toxin expelling in enteric cavity, prevent treating constipation, suffering from diarrhoea, promote health.Add pure natural apple powder simultaneously, both can flavor adjustment, abundant vitamin and dietary fiber can also be supplemented to human body, improve the health care of this product further.
Detailed description of the invention
Embodiment 1
Take by formula: 4 parts, bifidobacterium longum powder, 5 parts, bifidobacterium bifidum powder, 5 parts, lactobacillus acidophilus powder, 3 parts, lactobacillus bulgaricus powder, 6 parts, streptococcus thermophilus powder, oligoisomaltose 110 parts, milk powder 380 parts, apple powder 50 parts, dolomol 20 parts, be placed in mixing 30min in V-type powder mixer, then add sorbierite mixing 17min, fully mix; Be placed in tablet press machine directly cold pressing plate, Φ=12mm, h=4-5mm, sheet weight=0.78-0.84g, checks once sheet weight in every 15 minutes; Shaping and the compact structure situation of tablet is checked before packaging; Product through being up to the standards can pack warehouse-in.
Embodiment 2
Take by formula: 6 parts, bifidobacterium longum powder, 3 parts, bifidobacterium bifidum powder, 4 parts, lactobacillus acidophilus powder, 5 parts, lactobacillus bulgaricus powder, 3 parts, streptococcus thermophilus powder, oligoisomaltose 130 parts, milk powder 400 parts, apple powder 55 parts, dolomol 16 parts, be placed in mixing 20min in V-type powder mixer, then add sorbierite mixing 23min, fully mix; Be placed in tablet press machine directly cold pressing plate, Φ=12mm, h=4-5mm, sheet weight=0.78-0.84g, checks once sheet weight in every 15 minutes; Shaping and the compact structure situation of tablet is checked before packaging; Product through being up to the standards can pack warehouse-in.
Embodiment 3
Take by formula: 5 parts, bifidobacterium longum powder, 6 parts, bifidobacterium bifidum powder, 3 parts, lactobacillus acidophilus powder, 3 parts, lactobacillus bulgaricus powder, 4 parts, streptococcus thermophilus powder, oligoisomaltose 90 parts, milk powder 300 parts, apple powder 40 parts, dolomol 15 parts, be placed in mixing 30min in V-type powder mixer, then add sorbierite mixing 15min, fully mix; Be placed in tablet press machine directly cold pressing plate, specification and method, with example 1, checked once sheet weight every 16 minutes, and checked the shaping and compact structure situation of tablet; Product through being up to the standards can pack warehouse-in.
Claims (1)
1. the formula of a 5-linked probio chewable tablets, its formula is: bifidobacterium longum powder 3-6 part, bifidobacterium bifidum powder 3-6 part, lactobacillus acidophilus powder 3-6 part, lactobacillus bulgaricus powder 3-6 part, streptococcus thermophilus powder 3-6 part, oligoisomaltose 75-150 part, milk powder 240-480 part, apple powder 35-55 part, dolomol 15-30 part, sorbierite 1140-2280 part.Its preparation method is:
(1) pretreatment of raw material, takes bifidobacterium longum powder, bifidobacterium bifidum powder respectively by formula, lactobacillus acidophilus powder, lactobacillus bulgaricus powder, streptococcus thermophilus powder, oligoisomaltose, milk powder, apple powder, dolomol, is placed in mixing 15min-30min in V-type powder mixer, add sorbierite mixing 15min mono-30min again, fully mix;
(2) compressing tablet: be placed in tablet press machine directly cold pressing plate, diameter is 12mm, high 4-5mm, the heavy 0.78-0.84g of sheet, checks once sheet weight in every 15 minutes;
(3) check: check the shaping and compact structure situation of tablet;
(4) packaging warehouse-in: the product through being up to the standards can pack warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410747498.8A CN104366486A (en) | 2014-12-10 | 2014-12-10 | Formula and preparation method of quintuplet probiotic chewable tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410747498.8A CN104366486A (en) | 2014-12-10 | 2014-12-10 | Formula and preparation method of quintuplet probiotic chewable tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104366486A true CN104366486A (en) | 2015-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410747498.8A Pending CN104366486A (en) | 2014-12-10 | 2014-12-10 | Formula and preparation method of quintuplet probiotic chewable tablet |
Country Status (1)
| Country | Link |
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| CN (1) | CN104366486A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104770639A (en) * | 2015-04-09 | 2015-07-15 | 福建农大食品安全科技有限公司 | Complex lactobacillus bifidus based hericium erinaceus polysaccharide chewable tablet and preparation method thereof |
| CN105341918A (en) * | 2015-11-22 | 2016-02-24 | 威海百合生物技术股份有限公司 | Probiotic chewing tablet for children |
| CN105685342A (en) * | 2016-02-18 | 2016-06-22 | 江苏微康生物科技有限公司 | Probiotic buccal tablet and preparation method thereof |
| CN107279649A (en) * | 2017-07-25 | 2017-10-24 | 杭州诺利康健康管理有限公司 | A kind of probiotics solid beverage formula and its manufacture method |
| CN107319567A (en) * | 2017-08-02 | 2017-11-07 | 安徽金源药业有限公司 | It is a kind of to promote the compound probiotic chewable tablets of Instestinal motility |
| CN107712074A (en) * | 2017-10-19 | 2018-02-23 | 安徽珠峰生物科技有限公司 | A kind of processing method of compound probiotic chewable tablets |
| WO2018126310A1 (en) * | 2017-01-04 | 2018-07-12 | Jamieson Laboratories Ltd. | Isomalto-oligosaccharide prebiotic formulations |
| CN108967543A (en) * | 2017-05-31 | 2018-12-11 | 江苏汉典生物科技股份有限公司 | Cow's milk Biocal and preparation method thereof |
| CN114128882A (en) * | 2020-09-03 | 2022-03-04 | 香港科技大学深圳研究院 | Desert cistanche probiotic chewable tablet with function of relaxing bowel and preparation method and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104770639A (en) * | 2015-04-09 | 2015-07-15 | 福建农大食品安全科技有限公司 | Complex lactobacillus bifidus based hericium erinaceus polysaccharide chewable tablet and preparation method thereof |
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| CN108967543A (en) * | 2017-05-31 | 2018-12-11 | 江苏汉典生物科技股份有限公司 | Cow's milk Biocal and preparation method thereof |
| CN107279649A (en) * | 2017-07-25 | 2017-10-24 | 杭州诺利康健康管理有限公司 | A kind of probiotics solid beverage formula and its manufacture method |
| CN107319567A (en) * | 2017-08-02 | 2017-11-07 | 安徽金源药业有限公司 | It is a kind of to promote the compound probiotic chewable tablets of Instestinal motility |
| CN107712074A (en) * | 2017-10-19 | 2018-02-23 | 安徽珠峰生物科技有限公司 | A kind of processing method of compound probiotic chewable tablets |
| CN114128882A (en) * | 2020-09-03 | 2022-03-04 | 香港科技大学深圳研究院 | Desert cistanche probiotic chewable tablet with function of relaxing bowel and preparation method and application thereof |
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