CN104363894B - 用于治疗关节疼痛或运动性降低的囊泡制剂 - Google Patents
用于治疗关节疼痛或运动性降低的囊泡制剂 Download PDFInfo
- Publication number
- CN104363894B CN104363894B CN201380031159.3A CN201380031159A CN104363894B CN 104363894 B CN104363894 B CN 104363894B CN 201380031159 A CN201380031159 A CN 201380031159A CN 104363894 B CN104363894 B CN 104363894B
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- CN
- China
- Prior art keywords
- formulation
- surfactant
- lipid
- buffer
- edta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1206486.1A GB201206486D0 (en) | 2012-04-12 | 2012-04-12 | Vesicular formulations and uses thereof |
| GB1206486.1 | 2012-04-12 | ||
| PCT/EP2013/057742 WO2013153221A1 (en) | 2012-04-12 | 2013-04-12 | Vesicular formulations for use in the treatment of pain or reduced mobility of a joint |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104363894A CN104363894A (zh) | 2015-02-18 |
| CN104363894B true CN104363894B (zh) | 2016-11-23 |
Family
ID=46208989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380031159.3A Expired - Fee Related CN104363894B (zh) | 2012-04-12 | 2013-04-12 | 用于治疗关节疼痛或运动性降低的囊泡制剂 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20150065461A1 (https=) |
| EP (1) | EP2836203B1 (https=) |
| JP (1) | JP2015512926A (https=) |
| KR (1) | KR102204725B1 (https=) |
| CN (1) | CN104363894B (https=) |
| AU (1) | AU2013246822A1 (https=) |
| BR (1) | BR112014025507B1 (https=) |
| CA (1) | CA2870111A1 (https=) |
| CL (1) | CL2014002706A1 (https=) |
| CO (1) | CO7141430A2 (https=) |
| DK (1) | DK2836203T3 (https=) |
| EA (1) | EA039626B1 (https=) |
| ES (1) | ES2916803T3 (https=) |
| GB (2) | GB201206486D0 (https=) |
| HR (1) | HRP20220700T1 (https=) |
| HU (1) | HUE058972T2 (https=) |
| IL (1) | IL234862A0 (https=) |
| IN (1) | IN2014DN08259A (https=) |
| LT (1) | LT2836203T (https=) |
| MX (1) | MX2014012198A (https=) |
| PH (1) | PH12014502079A1 (https=) |
| PL (1) | PL2836203T3 (https=) |
| PT (1) | PT2836203T (https=) |
| SG (1) | SG11201406251VA (https=) |
| SI (1) | SI2836203T1 (https=) |
| WO (1) | WO2013153221A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100255080A1 (en) * | 2009-04-02 | 2010-10-07 | Sesvalia Usa, Llc | Liposomal ALA pharmaceutical and cosmeceutical compositions and methods of treatment |
| BR112012003834A2 (pt) | 2009-08-21 | 2017-08-08 | Targeted Delivery Tech Limited | métodos para tratamento de distúrbios e para tratamentos de deficiências em ácidos graxos, hipertrigliceridemia ou hipercolesterolemia e pacote |
| GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
| GB201505532D0 (en) * | 2015-03-31 | 2015-05-13 | Sequessome Technology Holdings Ltd | Formulations |
| PL3316856T3 (pl) | 2015-06-30 | 2021-10-25 | Sequessome Technology Holdings Limited | Zmieszane formulacje |
| CN111065423B (zh) * | 2017-08-22 | 2022-04-12 | 莫比斯医疗有限公司 | 用于关节润滑的脂质体制剂 |
| EP3681479B1 (en) | 2017-09-15 | 2024-01-31 | Dyve Biosciences, Inc. | Sodium bicarbonate for use in the treatment of gout and related disorders |
| CN110314137B (zh) * | 2018-03-30 | 2022-04-05 | 北京泰德制药股份有限公司 | 一种含有脂质囊泡的冻干制剂 |
| KR102912060B1 (ko) | 2021-09-17 | 2026-01-14 | 서울대학교산학협력단 | 골관절염 예방 또는 치료용 약학 조성물 및 건강기능식품 |
| EP4522178A1 (en) | 2023-01-19 | 2025-03-19 | Moebius Medical Ltd. | A long-acting liposomal composition for treatment of pain in articular disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0648114B1 (de) * | 1992-07-08 | 1997-09-17 | DIANORM G. Maierhofer GmbH | Liposomen, verfahren zu ihrer herstellung und ihre verwendung zur herstellung eines arzneimittels |
| AUPN723395A0 (en) * | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| KR20040033286A (ko) * | 2001-05-31 | 2004-04-21 | 파마시아 코포레이션 | 선택적인 사이클로옥시게나제-2 억제제 및 1가 알콜을포함하는 피부-침투성 조성물 |
| CA2451245A1 (en) * | 2001-06-25 | 2003-01-03 | Depuy International Limited | Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints |
| US7115666B2 (en) * | 2002-10-15 | 2006-10-03 | Renovis, Inc. | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain |
| ES2599630T3 (es) * | 2006-09-28 | 2017-02-02 | Hadasit Medical Research Services & Development Limited | Uso de glicerofosfolípidos para lubricación de las articulaciones |
| MX349417B (es) * | 2009-06-03 | 2017-07-28 | Charles Mayo John | Formulaciones para el tratamiento de dolor de tejido profundo. |
| BR112012003834A2 (pt) * | 2009-08-21 | 2017-08-08 | Targeted Delivery Tech Limited | métodos para tratamento de distúrbios e para tratamentos de deficiências em ácidos graxos, hipertrigliceridemia ou hipercolesterolemia e pacote |
| EP2340819A1 (en) * | 2009-12-23 | 2011-07-06 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising venlafaxine and celecoxib in the treatment of pain |
| US9125786B2 (en) * | 2011-03-31 | 2015-09-08 | Phillip Anthony FEMANO | Method and device to alleviate carpal tunnel syndrome and dysfunctions of other soft tissues |
| CN108130373A (zh) * | 2013-03-13 | 2018-06-08 | 豪夫迈·罗氏有限公司 | 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 |
-
2012
- 2012-04-12 GB GBGB1206486.1A patent/GB201206486D0/en not_active Ceased
-
2013
- 2013-04-12 LT LTEPPCT/EP2013/057742T patent/LT2836203T/lt unknown
- 2013-04-12 DK DK13715989.3T patent/DK2836203T3/da active
- 2013-04-12 JP JP2015504977A patent/JP2015512926A/ja active Pending
- 2013-04-12 EP EP13715989.3A patent/EP2836203B1/en active Active
- 2013-04-12 GB GB1419074.8A patent/GB2515439B/en not_active Expired - Fee Related
- 2013-04-12 IN IN8259DEN2014 patent/IN2014DN08259A/en unknown
- 2013-04-12 HU HUE13715989A patent/HUE058972T2/hu unknown
- 2013-04-12 SG SG11201406251VA patent/SG11201406251VA/en unknown
- 2013-04-12 EA EA201491583A patent/EA039626B1/ru unknown
- 2013-04-12 WO PCT/EP2013/057742 patent/WO2013153221A1/en not_active Ceased
- 2013-04-12 KR KR1020147031478A patent/KR102204725B1/ko not_active Expired - Fee Related
- 2013-04-12 PL PL13715989T patent/PL2836203T3/pl unknown
- 2013-04-12 US US14/391,754 patent/US20150065461A1/en not_active Abandoned
- 2013-04-12 HR HRP20220700TT patent/HRP20220700T1/hr unknown
- 2013-04-12 ES ES13715989T patent/ES2916803T3/es active Active
- 2013-04-12 MX MX2014012198A patent/MX2014012198A/es unknown
- 2013-04-12 SI SI201331990T patent/SI2836203T1/sl unknown
- 2013-04-12 CN CN201380031159.3A patent/CN104363894B/zh not_active Expired - Fee Related
- 2013-04-12 PT PT137159893T patent/PT2836203T/pt unknown
- 2013-04-12 BR BR112014025507-5A patent/BR112014025507B1/pt not_active IP Right Cessation
- 2013-04-12 AU AU2013246822A patent/AU2013246822A1/en not_active Abandoned
- 2013-04-12 CA CA2870111A patent/CA2870111A1/en not_active Abandoned
-
2014
- 2014-09-22 PH PH12014502079A patent/PH12014502079A1/en unknown
- 2014-09-28 IL IL234862A patent/IL234862A0/en unknown
- 2014-10-08 CL CL2014002706A patent/CL2014002706A1/es unknown
- 2014-11-12 CO CO14249925A patent/CO7141430A2/es unknown
-
2016
- 2016-11-11 US US15/349,792 patent/US20170128473A1/en not_active Abandoned
-
2021
- 2021-01-06 US US17/142,624 patent/US20210393655A1/en not_active Abandoned
Also Published As
Similar Documents
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| CN104363894B (zh) | 用于治疗关节疼痛或运动性降低的囊泡制剂 | |
| CN102770162B (zh) | 囊泡制剂 | |
| CN102639113A (zh) | 用于治疗深部组织疼痛的制剂 | |
| US9555051B2 (en) | Vesicular formulations | |
| US20150125407A1 (en) | Vesicular Formulations, Uses and Methods | |
| US20150132349A1 (en) | Vesicular Formulations, Kits and Uses | |
| HK1202250A1 (en) | Vesicular formulations for use in the treatment of pain or reduced mobility of a joint | |
| HK1202250B (en) | Vesicular formulations for use in the treatment of pain or reduced mobility of a joint |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161123 |