CN104352820B - A kind of Chinese patent drug for being used to treat sciatica - Google Patents

A kind of Chinese patent drug for being used to treat sciatica Download PDF

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CN104352820B
CN104352820B CN201410732171.3A CN201410732171A CN104352820B CN 104352820 B CN104352820 B CN 104352820B CN 201410732171 A CN201410732171 A CN 201410732171A CN 104352820 B CN104352820 B CN 104352820B
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parts
chinese patent
patent drug
sciatica
pain
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CN104352820A (en
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范瑞康
闫国樑
薛立群
张福成
张永年
甑金香
高来梅
张丹丹
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Shanxi coal central hospital
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Abstract

The invention provides a kind of Chinese patent drug for being used to treat sciatica, mainly including following component, the Radix Astragali, Radix Codonopsis, part sealwort, Radix Angelicae Sinensis, Ligusticum wallichii, Semen Cuscutae, the root of Chinese clematis is windproof, cassia twig, rhizoma Gastrodiae, pawpaw, pyrola.It can be made into different dosage forms.Chinese patent drug provided by the invention, have and eliminate neuroinflamation and oedema, nutrition and regulation nerve, recover neural normal function, immunity is improved simultaneously, the effect of strengthening vital QI to eliminate pathogenic factors is also just served, is substantially better than traditional therapy according to clinical verification, risk and the expensive surgery cost that operative treatment is brought are avoided, suitable for different groups sufferer.

Description

A kind of Chinese patent drug for being used to treat sciatica
Technical field
The present invention relates to the field of Chinese medicines, is more particularly a kind of Chinese patent drug for being used to treat sciatica.
Background technology
Sciatica is the syndrome based on sciatic nerve pathway and distributed areas pain.Treatment side traditional at present Method unsatisfactory curative effect, conventional therapy dehydrating agent mannitol add hormone therapy or with the molten core art of clostridiopetidase A and various decompression methods Satisfactory effect can not be played, easily repeatedly, course for the treatment of length, surgery cost is high risky and is difficult thoroughly radical cure.
The content of the invention
Inventor thinks according to the theoretical clinical practice experience combined for many years in Chinese and Western：Sciatica is because a variety of causes is led Causing human body to produce immune factor causes scorching ischium to stretch through and cause pain, work of the inflammation in protrasion of the lumbar intervertebral disci nerve root injury With people are usually classified as the nervous lesions such as the pain in waist and lower extremities that the protrasion of the lumbar intervertebral disci (LDH) occurs the machinery of Lumbar intervertebral disc protrusion Compressing.Recent study shows that in the change of the neurobehaviorals such as numbness, root pain, inflammation damnification has risen more importantly Effect.
The source of inflammation：
The many scholars of autoimmune response think that nucleus pulposus is isolated under physiological status with self immune system, dash forward The nucleus pulposus gone out contacts with immune system causes autoimmune response.People are from LDH patient and the blood plasma of animal model In isolate the antibody of anti-nucleus pulposus, LDH patient, which is protruded in tissue, has antigen antibody complex, it was demonstrated that autoimmunity be present Reaction.
The existing research of nonspecific inflammation reaction is found, scorching containing many strong causes in the nucleus pulposus that LDH patient protrudes Thing, such as interleukin-6 (IL -6), nitric oxide (NO), TNF (TNF), matrix metalloproteinase, prostate Plain E2 (PGE2), phospholipase A 2 (PLA2), interleukin 1 (IL -1) etc..Mechanical pressure may also lead to the non-of nerve root in itself Specific inflammatory, and blood-nerve barrier can be destroyed.
Neurogenic inflammation Recent study finds, the portion such as the fibrous ring outer layer of interverbebral disc, posterior longitudinal ligament, Minor articulus capsule Position is rich in neuropeptides such as Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), CGRPs (CGRP).It has been found that the position such as these condyles is rich in P things The neuropeptides such as matter (SP), CGRP (CGRP).It has been found that these tissue congestion and edemas, can also stimulate hypertrophy Cell, macrophage, polymorphonuclear cell etc. discharge other pro-inflammatory cytokines, such as IL -1.
The mechanism of action of the inflammation in LDH nerve root injuries：
Many materials have scorching cause, induced pain and nervous lesion effect, these materials in degeneration intervertebral disc and its surrounding tissue Can directly or indirectly stimulate with excited spinal nerve root, spinal ganglion, Spinal nerve root sheath, fibrous ring, posterior longitudinal ligament Minor articulus capsule etc. The c-type at position or the nociceptor of A＆ type nerve fibres, cause pain in the back or skelagia.And phosphide enzyme（PLA2）Can be by direct Enzymolysis cause neuron or Schwann cell to damage.There is the acceptor of many inflammatory mediators on Schwann cell.Regression Inflammatory mediator in interverbebral disc and its surrounding inflammatory tissue may act on the survival of these receptor influences Schwann cells, or make snow Prosperous Schwann Cells secretes other materials relevant with nervous lesion.
Inflammation is also possible to influence spinal nerve root and spinal ganglion indirectly by influenceing blood-nerve barrier or local microcirculation. Olmarker etc. has found that the transplanting of itself nucleus pulposus can dramatically increase the permeability of spinal nerve root local vascular.
Therefore, oedema, ischemic are probably the another important channel that inflammation causes nervous lesion.Inflammation can also make SP（P things Matter）、CGRP（CGRP）Deng the release increase in cornu dorsale medullae spinalis, two level sensory neuron film potential is reduced, easily Change the sensitiveness to noxious stimulation.Inflammation causes the mechanism of spinal nerve root damage extremely complex.Before have been mentioned, the interverbebral disc of regression Can direct or indirect morbid substance containing many in tissue and the inflammatory tissue of surrounding.Hydrogen ion, PGE2（Prostaglandin E2）, it is slow Kassinin kinin, lactic acid etc. are direct induced pain things, can be done directly on nerve fibre and produce pain or hyperalgia.And IL -1（It is loose thin The part pro-inflammatory cytokine of the releases such as born of the same parents, macrophage, polymorphonuclear cell, such as IL -1）、IL—6（Interleukin-6）、TNF （TNF）Although being acted on Deng without direct induced pain, the development of inflammation and the synthesis of direct induced pain thing can be promoted to release Put.If IL -1 is the key link that inflammation is formed, there is proinflammatory disease formation to act on；Meanwhile IL -1 can also promote spongiocyte to produce Raw NO（Nitric oxide）, the latter is a kind of new inflammatory mediator and neurotransmitter, not only with extremely strong expansion blood vessel and increase blood The effect of pipe permeability, plays an important role in inflammatory reaction, while can strengthen the sensitiveness of nociceptor.Because of NO（One Nitrogen oxide）Easily spread in iuntercellular, important function may have been played in the generation of cross-stimulation between nerve cell.
Many materials have with multiple action：PGE2（Prostaglandin E2）Have when concentration is 10-6M or higher direct Induced pain acts on, and then can be by G- protein coupling receptors influence second messenger cAMP, so as to increase nocuity when be less than this concentration Sensitiveness of the perceptron to other induced pain things such as bradykinin.White also found, PGE2（Prostaglandin E2）Can be with Ca2+ relying party Formula promotes the DRG neurons release SP of culture（Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2）, it is probably one of its induced pain mechanism that this, which is, is probably that it causes scorching machine again One of reason.PLA2（Phosphide enzyme）There is proinflammatory effect in interverbebral disc, also can directly destroy nerve cell phosphatide.Degeneration intervertebral disc group PLA2 in knitting can cause the reduction of mechanical nociceptor thresholding, so as to produce pain in waist and lower extremities under physiology loading conditions.
In a word, inflammation has served extremely important in LDH nervous lesion, particularly the change in neurobehavioral In, effect is more important.But its mechanism of action is extremely complex, immune inflammation, neurogenic inflammation and nonspecific inflammation three A complicated network is likely to form between person, is influenced each other, the common formation for participating in inflammation.This is probably part LDH patient One of the reason for surgical effect is bad.Particularly there may be different spies from traditional inflammation in chronic phase, the development of LDH inflammation Point, so as to cause traditional treatment method unsatisfactory curative effect, conventional therapy dehydrating agent mannitol adds hormone therapy or uses clostridiopetidase A Molten core art and various decompression methods can not play satisfactory effect, and easily repeatedly, course for the treatment of length, surgery cost is high risky and very Difficult thoroughly radical cure.
Based on this, the defects of the invention reside in prior art is overcome, there is provided it is a kind of be used to treat in sciatica into Medicine preparation.Its technical scheme is as follows：
A kind of Chinese patent drug for being used to treat sciatica, according to the mass fraction, mainly including following component, the Radix Astragali：15- 30 parts, Radix Codonopsis：15-30 part sealworts：15-30 parts, Radix Angelicae Sinensis：12-15 parts, Ligusticum wallichii：10-12 parts, Semen Cuscutae：15-30 parts, Wheeling It is celestial：10-12 parts are windproof：10-12 parts, cassia twig：10-12 parts, rhizoma Gastrodiae：10-12 parts, pawpaw：10-12 parts, pyrola 10- 12 parts.
The Chinese patent drug being formulated above more than, the formulations such as decoct soup agent, tablet, oral liquid, tincture, particle are can be made into be applicable In all ages and classes colony patient.
Inventor's clinical practice, the Chinese patent drug provided by the present invention for treating sciatica, is suitable as treating Various sciatica（Gently, Medium or severe type sciatica）Medicament；It is equally applicable to as treatment cervical vertebra, hyperosteogeny vertebra Neck, shoulder, waist and leg pain caused by disk protrusion or bulging is numb, powerless, the medicament of Whole Body Bone Scanning painful swelling of joints；It also is used as treating Body is declined with age, the pain of brothers' tendon and vessel contraction caused by weakness due to chronic disease is walked with difficulty the medicament of symptom.
Chinese patent drug provided by the present invention for treating sciatica, each raw material Analysis on action mechanism in raw material components It is as follows：
It is micro- that Radix Astragali air making-up and spleen enlivening yang invigorating benefit defends solid table inducing diuresis to remove edema promoting pus discharge and tissue regeneration polysaccharide flavones amino acid Secondary element etc.
Chemical composition mainly the Radix Astragali of pharmacological action containing glycoside can promote organism metabolism, it is antifatigue, can strengthen and adjust machine Body immunity function, there is facilitation to interferon system, body's resistance to disease can be improved, may act on rheumatism, apoplexy sequelae etc. The deficiency of vital energy and cause stasis, tendon and vessel lose support, card see numbness or hemiplegia, also to tonifying Qi promoting circulation of blood treat wind-cold-dampness arthralgia.
Radix Codonopsis tonifying middle-Jiao and Qi, tonifying spleen nourishing the stomach, moistening lung and production of body fluid, suitable for qi-blood deficiency, there is benefiting qi for promoting production of blood strengthening vital QI to eliminate pathogenic factors
The micro member of Codonopsis pilosula polysaccharide codonolactone of chemical composition tangshenoside containing sterol alkaloid inorganic elements amino acid Element etc., all have an impact to excited and two kinds of nerve processes of suppression, can adjust nervous function, red blood cell, hemoglobin can be improved.
Sealwort energy boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing
Chemical composition is containing Siberian solomonseal rhizome polysaccharide, oligosaccharide, lymphatic temperament etc.
Lymphatic temperament, starch and several amino acids etc., can benefiting kidney-essence, anti-aging, soreness and weakness of waist and knees helps muscles and bones, resistance to cold and heat, Energy benefit taste, embellish lung, mend all void, replenishing essence marrow
Radix Angelicae Sinensis can enrich blood, invigorates blood circulation, relieve the pain
Containing neutral oil components such as nopinene, australene, amphenes in chemical composition Radix Angelicae Sinensis.Containing p- methylbenzyl alcohol, Acid oil component, organic acid, carbohydrate, vitamin, the amino acid such as 5- methoxyl groups -2,3 xylidine phenol etc..It can be enriched blood with blood, it is living The blood stasis of blood, cold dispelling relieve the pain, and zoopery can remarkably promote the generation of hemoglobin and red blood cell.
Ligusticum wallichii blood-activating and qi-promoting, wind-dispelling relieve the pain
Chemical composition Ligusticum wallichii contains volatile oil（Predominantly Z-ligustilide, fragrant braised alkene etc.）, alkaloid (such as ligustrazine), phenol Class material（Such as forulic acid）Visfatin and vitamin A, folic acid, sucrose, sterol, fat oil etc..Central nervous system has town Quiet effect, the absorption of fracture local hematoma can be accelerated, promote poroma formation and antihistaminicum effect.
Semen Cuscutae tonifying kidney and benefiting sperm, nourishing the liver（The liver that all manadesmas all belong to）Improving eyesight
Chemical composition Semen Cuscutae is containing cortin, courage alcohol, soaps, starch.Zoopery, Semen Cuscutae water decoction can substantially increase The activity of cardiac stimulant muscular tissue lactic dehydrogenase, to myocardium catalase and the lactic dehydrogenase and hydrogen peroxide enzyme activity of brain tissue Property has enhancing trend.
Root of Chinese clematis wind-damp dispelling, remove obstruction in channels to relieve pain, disappear bone sticking.Can current twelve channels and collaterals, can wind-damp dispelling, and can degrading the channel And induced pain, all arthralgia pain due to rheumatism, extremity numbness, muscle arteries and veins contraction, joint stuffiness, no matter can all apply up and down, the careful clothes of asthenia of qi and blood weak person.
Chemical composition contains protoanemonin（Protoanemonin is easily-synthesized virose Anemonin）, anemonol, steroid Alcohol, carbohydrate, saponin(e etc..
It is windproof expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion, treat wind-cold-dampness arthralgia, podomere pain, Spasm of the tendons person.
Cassia twig warming meridian, helps yang transforming qi, the effect with warming meridian eliminating cold to stop pain, treat wandering arthritis arthralgia.
Chemical composition cassia twig contains volatile oil, and main component is cinnaldehydrum, separately containing phenols, organic acid, polysaccharide, glycoside, perfume (or spice) Beans essence and tannin etc..
Rhizoma Gastrodiae Inflammation Zhijing, suppressing liver-YANG, dispelling wind and removing obstruction in the meridians, extremity numbness, hands and feet caused by paralysis, arthralgia pain due to rheumatism can be treated.
Chemical composition is containing Gastrodine, gastrodia elata genin, β-sterioside alcohol, daucosterol, citric acid, mono-methyl, palmitic acid, amber Amber acid and sucrose etc., it is separately real containing gastrodia elata polysaccharide, vitamin A, several amino acids, Alkaloid and various trace elements, animal Obvious analgesic and anti-inflammatory effects are tested, and gastrodia elata polysaccharide has immunization.
Numbness, waist and knee joint acid weight pain are gone in the relaxing tendons and activating collaterals of pawpaw energy, stomach dampness elimination, beneficial muscle and blood, clearing damp.
Chemical composition is containing oleanolic acid, malic acid, citric acid, tartaric acid and saponin(e etc..
Pyrola（Wintergreen）Wind-damp dispelling, strengthening the bones and muscles, for rheumatism with the passing of time, arthralgia and myalgia, add smart mends marrow, promote longevity, Numbness pain and waist-leg weakness.
Chemical composition contains Pyrolin, N- phenyl-2-naphthylamines, homoarbutin, Chimaphila umbellata element, gallic acid, original Catechuic acid, alkaloid, renifolin, 6-0- nutgall acyl homoarbutins, Quercetin, Hyperoside.Nutgall Hyperoside etc..
Chinese patent drug provided by the present invention for treating sciatica, principle are to cause the inflammation of nerve pain for eliminating Disease and mitigate, eliminate pain and reach improvement or cure sciatica, Chinese medicinal formulae composition compatibility, which has, eliminates neuroinflamation and water It is swollen, nutrition and regulation nerve, recover neural normal function, while immunity is improved, also just serve strengthening vital QI to eliminate pathogenic factors Effect, is substantially better than traditional therapy according to clinical verification, avoids risk and expensive surgery cost that operative treatment is brought, It can be made into different dosage forms and be applied to different groups sufferer.
Embodiment
Embodiments of the invention are described in detail below：
A kind of Chinese patent drug for being used to treat sciatica, according to the mass fraction, takes the raw material of following components, the Radix Astragali：15- 30 parts（Gram）, Radix Codonopsis：15-30 part sealworts：15-30 parts, Radix Angelicae Sinensis：12-15 parts, Ligusticum wallichii：10-12 parts, Semen Cuscutae：15-30 parts, The root of Chinese clematis：10-12 parts, windproof 10-12 parts, cassia twig 10-12 parts, rhizoma Gastrodiae 10-12 parts, pawpaw：10-12 parts, pyrola 10- 12 parts.
All medicines weigh according to quantity by more than, dry, crush, tablet is made in finely ground post-processing.Each taking 8 ~ 12 grams, daily three It is secondary before meals, it is used for that sciatica is relatively light or convalescence consolidates the patient of curative effect.
The formulations such as decoct soup agent, tablet, oral liquid, tincture, particle can also be made in all medicines above.
Then tablet is treated to sciatica patient, using oral method, each oral 12g ~ 15g is three times a day （It is early, middle and late to be administered at empty stomach）, it was that a course for the treatment of is taken with one month.
By the Ureteral Calculus to 60 randomized patients, all low backs of tablet 1-2 and lower limb pain, acid of the invention are taken It is stranded, suppresses the clinical symptoms such as swollen, numb and be eased, clinical symptoms disappears substantially after taking for 2-4 weeks, for severe sciatic nerve Pain, have a strong impact on that sufferer of taking care of oneself takes above metering decoction, decocted per decoction and be divided to two in one day three times to taking three times, coordinated Neurotrophic drugs upper Liao acupoint（First sacrum hole, is subordinate to the urinary bladder channel of foot-Taiyang）Inject curative effect more preferably, its total effective rate up to more than 90%, And produced without any toxic side effect of discovery.
It is several model case therapeutic effects below：
Hao so-and-so, female, 42 years old, sick time was longer, and through multi-treatment during patient, effect is undesirable, in October, 2002, Start to take provided by the invention, tablet, it is bfore meals, three times a day, take a course for the treatment of, hence it is evident that take a turn for the better, take the 3rd The course for the treatment of, return to one's perfect health, do not recur again so far.
Discriminate so-and-so, female, 46 years old, sick time was longer, through multi-treatment, after effect is undesirable, 2006 years 11 during patient Start to take our pulvis the moon, it is early, middle and late it is each once, one time 15 grams, take a course for the treatment of, hence it is evident that take a turn for the better, take the 3rd treatment Journey, return to one's perfect health, do not recur again so far.
Yang, man, 53 years old, sick time was longer, and aggravation breaking-out is controlled long repeatedly produces effects bad, and night in June, 2003 Aggravate after cool, can't take care of oneself, through taking our decoction, one portion per day, decoct for every dose and convert three times together, sooner or later at twice before meals Take, taken a turn for the better after one week, is clearly better after two weeks, fully recover after two months, do not recur so far.
Zhang, man, 55 years old, sick time was longer, repeatedly aggravation breaking-out long control produce effects it is bad, after fatigue in July, 2008 Aggravation, can't take care of oneself, and through taking our decoction, one portion per day, decocts for every dose and converts three times together, sooner or later before meals at twice With taking a turn for the better after one week, be clearly better after two weeks, fully recover after two months, do not recur so far.
Mr. Wang, female, 46 years old, sick time was longer, and aggravation breaking-out is controlled long repeatedly produces effects bad, and in May, 2009 holds a baby in one's arms Aggravate after heavy burden, can't take care of oneself, through taking decoction, one portion per day, decoct for every dose and convert three times together, it is sooner or later before meals at twice With, take a turn for the better after one week, be clearly better after two weeks, after use our pulvis instead, it is early, middle and late it is each once, one time 15 grams, take two The course for the treatment of, return to one's perfect health, do not recur again so far.
Chinese medicine preparation provided by the invention, it is additionally operable to treat patient with cervical Spondylopathy, works well.Model case therapeutic effect：
Zhao so-and-so, female, 42 years old, strength vertebra physiological camber changed, and intervertebral disc of cervical vertebra protrudes, double swollen numb, hands of upper myasthenia of limbs acid Refer to numb, influence to take care of oneself, sick time is longer, and through multi-treatment during patient, effect is undesirable, in August, 2007, starts Through taking decoction, one portion per day, decoct for every dose and convert three times together, it is sooner or later bfore meals at twice, taken a turn for the better after two weeks, it is obvious after January Take a turn for the better, after use our pulvis instead, it is early, middle and late it is each once, one time 15 grams, take two courses for the treatment of, return to one's perfect health, so far without again Recurrence.
Liang, female, 50 years old, strength vertebra physiological camber changed, and intervertebral disc of cervical vertebra protrudes heavier, the swollen fiber crops of double upper myasthenia of limbs acid Wood, the numbness of fingers, double lower limb are powerless, influence to take care of oneself, and sick time is longer, pay no attention to during patient through multi-treatment, effect Think that refusal operative treatment in March, 2003 starts, through taking decoction, one portion per day, to decoct for every dose and convert three times together, sooner or later at twice It is bfore meals, take a turn for the better after two weeks, be clearly better after January, after use our pulvis instead, it is early, middle and late it is each once, one time 15 grams, clothes With three courses for the treatment of, basic rehabilitation, do not recur again so far.
Embodiment described above only expresses the embodiment of the present invention, and its description is more specific and detailed, but simultaneously Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention Protect scope.

Claims (3)

  1. A kind of 1. Chinese patent drug for being used to treat sciatica, it is characterised in that：According to the mass fraction, by following raw medicinal material system Into the Radix Astragali：15-30 parts, Radix Codonopsis：15-30 parts, sealwort：15-30 parts, Radix Angelicae Sinensis：12-15 parts, Ligusticum wallichii：10-12 parts, Semen Cuscutae： 15-30 parts, the root of Chinese clematis：10-12 parts are windproof：10-12 parts, cassia twig：10-12 parts, rhizoma Gastrodiae：10-12 parts, pawpaw：10-12 parts, deer Hold in the mouth careless 10-12 parts.
  2. A kind of 2. Chinese patent drug for being used to treat sciatica according to claim 1, it is characterised in that or decoct soup is made Agent, or film-making agent, or oral liquid processed or tincture processed or pelleting.
  3. 3. purposes of a kind of Chinese patent drug for being used to treat sciatica in medicine is prepared described in claim 1, its feature It is, or is dashed forward as the Chinese patent drug for preparing the various sciatica for the treatment of, or as preparation treatment cervical vertebra, hyperosteogeny interverbebral disc Go out or bulging caused by neck, shoulder, waist and leg pain it is numb, powerless, the Chinese patent drug of Whole Body Bone Scanning painful swelling of joints, or old body is treated as preparing Decline, the pain of brothers' tendon and vessel contraction caused by weakness due to chronic disease, the Chinese patent drug for symptom of walking with difficulty.
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CN106692782A (en) * 2016-12-30 2017-05-24 无为县大蜀山马蹄种植专业合作社 Traditional Chinese medicine composition for treating referred pain of leg tendons and preparation method of traditional Chinese medicine composition

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CN101966238A (en) * 2010-09-29 2011-02-09 孙芳芳 Medicament for treating sciatica and preparation method thereof
CN102225108A (en) * 2011-05-24 2011-10-26 赵福祥 Medicinal liquor for treating lumbago and protrusion of lumbar vertebral disc

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CN102225108A (en) * 2011-05-24 2011-10-26 赵福祥 Medicinal liquor for treating lumbago and protrusion of lumbar vertebral disc

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