CN104352607A - 治疗奶牛气滞血瘀型卵巢性不孕症的口服液及其制备方法 - Google Patents

治疗奶牛气滞血瘀型卵巢性不孕症的口服液及其制备方法 Download PDF

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CN104352607A
CN104352607A CN201410536935.1A CN201410536935A CN104352607A CN 104352607 A CN104352607 A CN 104352607A CN 201410536935 A CN201410536935 A CN 201410536935A CN 104352607 A CN104352607 A CN 104352607A
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李迎梅
陈庆忠
安同伟
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Tianjin Hlinte Biotechnology Co ltd
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Abstract

本发明涉及一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其口服液的组分及其重量份数比分别为：黄芪10-35份；益母草10-20份；赤芍5-30份；当归5-15份；陈皮10-20份；川芎10-30份；丹参10-20份；青皮5-10份。本发明具有消积化滞、活血通经、理气健脾、凉血、消肿等功效，毒副作用小，生物利用度高，无药物残留，符合安全兽药、保障动物源食品安全的要求，是一种较为理想的治疗奶牛气滞血瘀型卵巢性不孕症的口服液。

Description

治疗奶牛气滞血瘀型卵巢性不孕症的口服液及其制备方法
技术领域
本发明属于兽药领域，尤其是一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液及其制备方法。
背景技术
气滞血瘀型不孕症多由长期舍饲运动不足，发情漏配，或胞宫原有痼疾或气候骤变，使胞宫气滞血瘀所致，需理气活血、祛瘀止痛之中药才可根治。同时，中药是动物体最易吸收的纯天然物质，含有多种生物有效成分，毒副作用甚微，几乎无残留、无抗药性、对肉制品、奶制品无副作用、不污染环境，使得中药在治疗奶牛相关疾病方面具有独特的优势。
发明内容
本发明的目的在于提供一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，该口服液具有理气活血、祛瘀止痛的功效，毒副作用小，不易产生耐药性，生物利用度高，无药物残留。
本发明的另一个目的在于提供一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法。
本发明主要通过以下技术方案实现的：
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其口服液的组分及其重量份数比分别为：
而且，该口服液的组分及其最优重量份数比分别为：
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法，其步骤为：
(1)按照重量配比分别称取黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮，进行粉碎；
(2)将步骤(1)中粉碎后的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮加水浸泡一小时后煎煮三次，每次加水量为药材总量的3-15倍，各煎煮0.5-1小时，合并煎液，滤过，滤液合并，浓缩至相对密度为1.01-1.03，加入95％乙醇，使含醇量达40％，搅匀，静置24小时，过滤，回收乙醇至无醇味，加适量水，离心取上清液，备用；
(3)向步骤(2)所得的上清液中加入25-45％体积的乙醇和4-6％体积的吐温-80，搅匀，过滤，分装，即得治疗奶牛气滞血瘀型卵巢性不孕症的口服液成品。
本发明的优点及有益效果是：
1、本治疗奶牛气滞血瘀型卵巢性不孕症的中药口服液中含有的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮等中药成份，可以共奏理气活血、祛瘀止痛之效。
2、本治疗奶牛气滞血瘀型卵巢性不孕症的中药口服液通过提取中药内的有效成分，加入矫味剂、抑菌剂等附加剂，并按照口服液的加工方法合成的口服液体制剂，具有服用剂量小、味道好、吸收快、奏效迅速、质量稳定、便于运输、易于保存等优点。
具体实施方式
本发明通过以下实施例进一步详述。需要说明的是：下述实施例是说明性的，不是限定性的，不能以下述实施例来限定本发明的保护范围。
实施例1
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其口服液的组分及其重量分别为：黄芪10g；益母草10g；赤芍5g；当归5g；陈皮10g；川芎10g；丹参10g；青皮5g。
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法，制备方法的步骤如下：
(1)按照重量配比分别称取黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮，进行粉碎；
(2)将步骤(1)中粉碎后的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮加水浸泡1小时后煎煮三次，每次加水量为药材总量的3倍，各煎煮0.5小时，合并煎液，滤过，滤液合并，浓缩至相对密度为1.01-1.03。加入95％乙醇，使含醇量达40％，搅匀，静置24小时，过滤，回收乙醇至无醇味，加适量水，离心取上清液，备用；
(3)向步骤(2)所得的上清液中加入25％体积的乙醇和4％体积吐温-80，搅匀，过滤，分装，即得治疗奶牛气滞血瘀型卵巢性不孕症的口服液成品。
实施例2
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其口服液的组分及其重量分别为：黄芪35g；益母草20g；赤芍30g；当归15g；陈皮20g；川芎30g；丹参20g；青皮10g。
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法，制备方法的步骤如下：
(1)按照重量配比分别称取黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮，进行粉碎；
(2)将步骤(1)中粉碎后的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮加水浸泡一小时后煎煮三次，每次加水量为药材总量的10倍，各煎煮1小时，合并煎液，滤过，滤液合并，浓缩至相对密度为1.01-1.03。加入95％乙醇，使含醇量达40％，搅匀，静置24小时，过滤，回收乙醇至无醇味，加适量水，离心取上清液，备用；
(3)向步骤(2)所得的上清液中加入45％体积的乙醇和6％体积吐温-80，搅匀，过滤，分装，即得治疗奶牛气滞血瘀型卵巢性不孕症的口服液成品。
实施例3
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其中药口服液的组分及其重量分别为：黄芪20g；益母草20g；赤芍10g；当归10g；陈皮20g；川芎20g；丹参20g；青皮10g。
一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法，制备方法的步骤如下：
(1)按照重量配比分别称取黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮进行粉碎；
(2)将步骤(1)中粉碎后的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮加水浸泡一小时后煎煮三次，每次加水量为药材总量的15倍，各煎煮1小时，合并煎液，滤过，滤液合并，浓缩至相对密度为1.01-1.03。加入95％乙醇，使含醇量达40％，搅匀，静置24小时，过滤，回收乙醇至无醇味，加适量水，离心取上清液，备用；
(3)向步骤(2)所得的上清液中加入30％体积的乙醇和5％体积的吐温-80，搅匀，过滤，分装，即得治疗奶牛气滞血瘀型卵巢性不孕症的口服液成品。
临床应用
为了验证本发明对奶牛气滞血瘀型卵巢性不孕症的临床治疗效果，于山东收集4个奶牛场16头诊断为气滞血瘀型卵巢性不孕症奶牛，均使用本发明，按1ml/Kg体重给药，每头奶牛每日两次，根据病情缓急，连用3-5天，检测奶牛愈全数、有效数、无效数、发情率和受孕率(见表1)。
表1 本发明治疗气滞血瘀型卵巢囊肿的效果  单位/头
牛场 1 2 3 4 合计
病例数 6 3 3 4 16
痊愈 4 3 3 3 13
有效 2 0 0 1 3
无效 0 0 0 0 0
发情率％ 100 100 100 100 100
受孕率％ 83.3 100 100 75 89.6
由上表可知，使用本发明仅一个疗程(3-5天)发情率达到了100％，受孕率平均也近90％，彻底改变了用药前口色晦暗、脉象沉细和久不发情等症状。

Claims (3)

1.一种治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其特征在于：该口服液的组分及其重量份数比分别为：
2.根据权利要求1所述的治疗奶牛气滞血瘀型卵巢性不孕症的口服液，其特征在于：该口服液的组分及其最优重量份数比分别为：
3.一种如权利要求1所述的治疗奶牛气滞血瘀型卵巢性不孕症的口服液的制备方法，其特征在于：该制备方法步骤为：
(1)按照重量配比分别称取黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮，进行粉碎；
(2)将步骤(1)中粉碎后的黄芪、益母草、赤芍、当归、陈皮、川芎、丹参和青皮加水浸泡一小时后煎煮三次，每次加水量为药材总量的3-15倍，各煎煮0.5-1小时，合并煎液，滤过，滤液合并，浓缩至相对密度为1.01-1.03，加入95％乙醇，使含醇量达40％，搅匀，静置24小时，过滤，回收乙醇至无醇味，加适量水，离心取上清液，备用；
(3)向步骤(2)所得的上清液中加入25-45％体积的乙醇和4-6％体积的吐温-80，搅匀，过滤，分装，即得治疗奶牛气滞血瘀型卵巢性不孕症的口服液成品。
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