CN104352583A - Traditional Chinese medicine decoction piece combination preparation with good hematogenesis function, preparation method and application package - Google Patents
Traditional Chinese medicine decoction piece combination preparation with good hematogenesis function, preparation method and application package Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Abstract
The invention discloses a traditional Chinese medicine decoction piece combination preparation with a good hematogenesis function and a preparation method of the traditional Chinese medicine decoction piece combination preparation. The traditional Chinese medicine decoction piece combination preparation with the good hematogenesis function comprises active pharmaceutical ingredients and auxiliary materials, wherein the active pharmaceutical ingredients comprise components in parts by weight as follows: 8-19 parts of eclipta, 10-15 parts of glossy privet fruit, 11-21 parts of mulberries, 10-25 parts of astragalus membranaceus, 12-24 parts of tuber fleeceflower roots, 10-24 parts of white paeony roots and 10-28 parts of rhizoma cibotii. The traditional Chinese medicine decoction piece combination preparation with the good hematogenesis function can treat normal cell damage caused by chemotherapy, particularly can inhibit reduction of blood corpuscles and white blood cells due to bone marrow and has a good curative effect on iron-deficiency anemia and aplastic anemia.
Description
Technical field
The present invention relates to Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation, preparation method and application packages.
Background technology
Tumor (Tumor) be body under various carcinogenic factor effect, some cells of local organization lose the normal regulation to its growth on gene level, cause its clonal abnormality hypertrophy and the abnormality that formed.
Now, the treatment of tumor is adopted mostly to the method for chemotherapy.Chemotherapy is the abbreviation of chemotherapy, is to utilize chemicals to stop the propagation of cancerous cell, infiltration, transfer, until finally kill cancerous cell-kind of therapeutic modality.It is-kind of systemic treatment means, and operation, radiotherapy-rise, and be called three of cancer large treatment meanss.Because the selectivity of chemotherapeutics is not strong, while killing cancerous cell, also inevitably can damage the cell of human normal, particularly for the marrow hemopoietic stem cells of molecular marker for increased proliferation, toxic action clearly.Therefore, the patient the accepting chemotherapy often complete blood cell quantity such as peripheral blood leucocyte declines, and then can cause degradation serious adverse reaction under anemia, anti-infection ability, if do not take corresponding remedy measures, can making patients's state of an illness, and cause chemotherapy failure.
For the problems referred to above, develop-the Chinese medicine composition of a little hemopoietic in prior art, to the hemopoietic function of body can be improved.But between pharmaceutical compositions and content thereof, relation is comparatively complicated, even if identical Chinese medicine ingredients, its monarch relation of different content is not identical yet, and the reduction of drug effect may be caused even to occur contrary curative effect.In prior art, the hematopoiesis of Chinese medicine composition is often bad.Therefore, for the research of Chinese medicine composition with hemopoietic function, there is reality and meaning remote.
In addition, in the prescription clinical practice of Traditional Chinese Medicine, general adopt formula system, namely after the good prescription of doctor prescribed, and grab the process of joining and completed by pharmacy room, such flow process makes the proportioning of medicine accurate, does not often reach best curative effect.
Summary of the invention
Main purpose of the present invention is to overcome the defect that in prior art, the hematopoiesis of Chinese medicine composition is bad, provides a kind of Shengxuebao-medicine for improving hematopoitic function side prepared slices of Chinese crude drugs combination preparation, preparation method and application packages.Shengxuebao-medicine for improving hematopoitic function side of the present invention prepared slices of Chinese crude drugs combination preparation can treat the damage that chemotherapy aligns normal cell, the hemocyte particularly suppressing bone marrow to cause, leukocytic minimizing, and also has good curative effect to iron deficiency anemia and aplastic anemia.
The present invention solves the problems of the technologies described above by the following technical programs:
An object of the present invention is, a kind of Shengxuebao-medicine for improving hematopoitic function side prepared slices of Chinese crude drugs combination preparation is provided, described Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation comprises active constituents of medicine and adjuvant, each composition of the following weight portion of described active constituents of medicine: comprise each composition Herba Ecliptae 8-19 part of following weight portion, Fructus Ligustri Lucidi 10-15 part, Fructus Mori 11-21 part, Radix Astragali 10-25 part, Radix Polygoni Multiflori 12-24 part, Radix Paeoniae Alba 10-24 part, Rhizoma Cibotii 10-28 part.
Do for mentioned component and character thereof below and further illustrate as follows:
In the present invention, described Radix Polygoni Multiflori Preparata is the Preparation process product of Radix Polygoni Multiflori, is the block sheet of irregular shrunk, thick 1cm.Surface pitchy or sepia, uneven.Matter is hard, section cutin sample, sepia or black.Feeble QI, taste is micro-sweet and pained.Bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.There is invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening effect.For blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body is empty; Hyperlipidemia.The weight portion of described Radix Polygoni Multiflori Preparata is preferably 15-20 weight portion.
In the present invention, described Radix Rehmanniae Preparata: Chinese medicine name, has another name called Radix Rehmanniae Preparata.Radix Rehmanniae is Scrophulariaceae, Radix Rehmanniae platymiscium, Radix Rehmanniae (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, to inside and outside darkish complexion glossy, quality softness is sticky.Section use, or parch to black is used.After the process of preparing Chinese medicine, the property of medicine turns tepor by being slightly cold, and tonification strengthens, " herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steams and shines, and it is sweet for turning a hardship, is the yang aspect of yin, therefore vigour in energy the kidney invigorating." described in the weight portion of Radix Rehmanniae Preparata be preferably 15-16 weight portion.
In the present invention, described Radix Angelicae Sinensis (
angelica sinensis) call dryly to return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, Radix Angelicae Sinensis body, contain Radix Angelicae Sinensis, Radix Angelicae Gigatis herbaceos perennial, for enriching blood, invigorating blood circulation, menstruction regulating and pain relieving or moisturize laxation.The weight portion of described Radix Angelicae Sinensis is preferably 12-14 weight portion.
In the present invention, described Colla Corii Asini is top grade, the panacea of enriching blood of nourishing, and sweet in the mouth is put down, enter lung, liver, kidney channel, there is tonifying blood and arresting bleeding, the effect such as nourshing Yin and drynsessmoistening prescription, medicine-food two-purpose, long-term taking can blood-supplementing blood-nourishing, beauty face-whitening-nourishing, defying age, resisting fatigue, raising immunity, is suitable for crowd extensive.Li Shizhen (1518-1593 A.D.) work Compendium of Material Medica is carried: " Colla Corii Asini " herbal classic " is top grade.Great scape is said: ' going out Donga, therefore named Colla Corii Asini ' ".Colla Corii Asini is the medical material of typical the most exquisite " genuineness " in Chinese crude drug, and genuine Colla Corii Asini must draw the water of Donga, and the strange secret skill refining obtaining inheritance people forms.Genuine Colla Corii Asini surfacing, without oil-gas hole, matter is hard and crisp, and section light is fine and smooth, and fragment is looked in brown translucent to illumination, and Li Shizhen (1518-1593 A.D.) is praised its " yellow thoroughly as amber, light Hei is as Yi paint ".The weight portion of described Colla Corii Asini is preferably 8-11 weight portion.
In the present invention, described Fructus Aurantii fruit is hemispherical, diameter 3-5.5cm.The green and brown color of crust or sepia, slightly coarse, loose have numerous little oil drop, and there are obvious style base trace or circular fruit stem trace in central authorities.The thick 0.6-1.2cm of tangent plane mesocarp, yellow-white is more smooth, slightly to turning up, has vascular bundle to scatter, and edge has brown color oil drop l-2 to arrange.Matter is hard, not frangibility, pulp 7-12 lobe, minority to 15 lobe, juice born of the same parents drying shrinkage in capsule, and brown color or burgundy, matter is soft, built-in seed.Axis is solid, wide 5-9mm, yellow-white, has the interrupted annular vascular bundle point of a circle.Gas is fragrant, bitter in the mouth, micro-acid.Green and brown with outer peel color, sarcocarp is thick, matter is hard, the dense person of fragrance is good.The weight portion of described Fructus Aurantii is preferably 5-8 weight portion.
In the present invention, described Rhizoma Corydalis is under the jurisdiction of Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.The weight portion of described Rhizoma Corydalis is preferably 11-13 weight portion.
In the present invention, described Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..These product are avette, oval or kidney shape.Surface black purple or grey black, shrinkage is uneven, and base portion has carpopodium trace or tool Constellation calyx and short stalk.Body is light.Outer peel is thin, and mesocarp is softer, easily peels off, and endocarp is wooden, yellowish-brown, and tool indulges rib, breaks rear seed and is generally 1, kidney shape, atropurpureus, oiliness.Odorless, sweet in the mouth, micro-bitterness.The weight portion of described Fructus Ligustri Lucidi is preferably 11-15 weight portion.
In the present invention, described Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal.Sweet in flavor and warm in property, nontoxic, enter Liver Channel, there is dredging blood vessel, effect of eliminating stasis to stop pain.The weight portion of described Oletum Trogopterori is preferably 10-12 weight portion.
In the present invention, described active constituents of medicine also comprises the Radix Paeoniae Alba.The described Radix Paeoniae Alba (formal name used at school: Paeonia lactiflora Pall.) also claims Paeonia sterniana Fletcher in Journ., is Ranunculaceae Paeonia plant.Have long cultivation history in China, have won fame both at home and abroad, its root is also used as medicine.Perennial herb or undershrub, underground part is block or slightly thick; Phyllopodium is raw or stem raw, greatly, and alternate, pinniform or trifoliolate leaf or drastic crack; Spend large and beautiful, be singly born in branch top or bunchy sometimes, white; Sepal 5, Su Cun; Petal 5-10, but normal in cultigen is polyphyll; Stamen is most; Floral disc ring-type or cup-shaped; Carpel 2-5, centrifugal growth, during result, Bian is Follicle radish, and each have seed number.The weight portion of the described Radix Paeoniae Alba is preferably 9-20 weight portion, is more preferably 11-16 weight portion.
In the present invention, described active constituents of medicine also comprises Olibanum.Described Olibanum comprises resin 60%-70%, gummy 27%-35% and volatile oil 3%-8%, and described percentage ratio is weight percentage.The main component of resin is free α-boswellic acid (α-Boswellic acid), β-boswellic acid (β-Boswellic acid), in conjunction with boswellic acid, olibanoresene (Olibanoresene).Natural gum is the calcium salt of arabitic acid (Arabic acid) and magnesium salt, the glutinous element of tragacanth (Bassorin) and amaroid.Volatile oil is containing pinene (Pinene), camphene (Camphene), sabinene (Sabinene), elemene (Elemene), racemization-limonene (Dipentene) and α-phellandrene (α-Phellandrene), β-phellandrene (β-Phellandrene), 1-nonene (1-Nonene), hexanal (Hexanal), enanthaldehyde (Heptanal), octanal (Octanal), aldehyde C-9 (Nonanal), 2, 4-nonadienal (2, 4-Nonadional), m-isopropyl toluene (1-Methyl-3-isopropyl benze-ne), eucalyptole (Cineole), isooctanol (Isooctanol), 1-capryl alcohol (1-Octanol), 1 nonyl alcohol (1-Nonanol), multiple in acetic acid n-octyl (Octyl acetate) and borneol acetate (Bornyl acetate).The weight portion of described Olibanum is preferably 8-15 weight portion, is more preferably 10-12 weight portion.
In the present invention, described active constituents of medicine also comprises Fructus Mori.In the present invention, described Fructus Mori contains abundant activated protein, vitamin, aminoacid, carotene, mineral matter and other components, and nutrition is 5-6 times of Fructus Mali pumilae, is 4 times of Fructus Vitis viniferae, there is multiple efficacies, be described as " the best health fruit of 21st century " by medical circle.Often eat Fructus Mori and can significantly improve body immunity, there is slow down aging, effect of looks improving and the skin nourishing.Be dark green during Fructus Mori growth, graduate into orange red, being become from bright red of growing up is purple black.The wine brewing of general black Fructus Mori the best, red is tasty.The weight portion of described Fructus Mori is preferably 12-19 weight portion, is more preferably 13-16 weight portion.
Described adjuvant preferably comprises disintegrating agent, lubricant and filler.
Described disintegrating agent is preferably one or more in carboxymethyl starch sodium, hyprolose, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose.The consumption of described disintegrating agent is preferably the 2-5% of described active constituents of medicine.
Described lubricant is preferably one or more in colloidal silica, sodium stearyl fumarate, Pulvis Talci and magnesium stearate.The consumption of described lubricant is preferably the 3-9% of described active constituents of medicine.
Described filler is preferably one or more in lactose, Lactis Anhydrous, mannitol, microcrystalline Cellulose, starch, xylitol, pregelatinized Starch and maltose alcohol.The consumption of described filler be preferably the 2-5 of described active constituents of medicine weight doubly.
Two of object of the present invention is, the preparation method of Shengxuebao-medicine for improving hematopoitic function side as above prepared slices of Chinese crude drugs combination preparation is provided, described preparation method comprises the steps: described Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii immersion, rinsing, drying, impact, collision, friction, shearing, grinding and synchronously ruptures, make the superfine powder of nanoscale 1-65nm, mix homogeneously with described adjuvant again, decoction pieces is made according to the preparation method of the conventional decoction pieces in this area.
Wherein, the time of described immersion is preferably 35-40min.
The hydraulic pressure of described flushing is preferably 2-12MPa.
Preferably brittle at-19 DEG C before described impact.
After described synchronous fracture, preferably also carry out ozone sterilization.
The particle diameter of described superfine powder is preferably 55nm.
An application packages for Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation, comprises Herba Ecliptae processed, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, and Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii are packaged into bag in proportion.
Also comprise adjuvant in described packaging, wherein Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, the total amount of Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii and the proportioning of adjuvant are 1:1.
Described adjuvant is HP-β-CD.
On the basis meeting this area general knowledge, above-mentioned each optimum condition, can combination in any, obtains the preferred embodiments of the invention.
Agents useful for same of the present invention and raw material are all commercially.
Positive progressive effect of the present invention is: Shengxuebao-medicine for improving hematopoitic function side of the present invention prepared slices of Chinese crude drugs combination preparation can treat the damage that chemotherapy aligns normal cell, the hemocyte particularly suppressing bone marrow to cause, leukocytic minimizing, and also have good curative effect to iron deficiency anemia and aplastic anemia.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.
Composition and the content thereof of Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation of embodiment 1-8 and the product of comparative example 1-5 are as shown in table 1.
The composition of table 1 Shengxuebao-medicine for improving hematopoitic function side prepared slices of Chinese crude drugs combination preparation and content thereof
The adjuvant of Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation of embodiment 1-8 is as shown in table 2.
The adjuvant of table 2 Shengxuebao-medicine for improving hematopoitic function side prepared slices of Chinese crude drugs combination preparation
The preparation method of Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation of embodiment 1-8 and the product of comparative example 1-5:
Mentioned component is soaked rinsing, drying under 40min, 10MPa hydraulic condition, brittle at-19 DEG C, impact, collision, friction, shear, grinding and synchronously rupturing, ozone sterilization, makes the superfine powder of nanoscale 55nm, then mixs homogeneously with adjuvant, film-making.
Embodiment 9
Herba Ecliptae 8 parts, Fructus Ligustri Lucidi 10 parts, 11 parts, Fructus Mori, the Radix Astragali 10 parts, Radix Polygoni Multiflori 12 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Cibotii 10 parts.
Embodiment 10
Herba Ecliptae 19 parts, Fructus Ligustri Lucidi 15 parts, 21 parts, Fructus Mori, the Radix Astragali 25 parts, Radix Polygoni Multiflori 24 parts, the Radix Paeoniae Alba 24 parts, Rhizoma Cibotii 28 parts.
Effect example 1
On the impact of medullary cell nucleic acid and protein metabolism
Materials and methods: hybrid mice male and female half and half, grouping, matched group and administration group is established according to this area routine, administration group administration Shengxuebao-medicine for improving hematopoitic function side prepared slices of Chinese crude drugs combination preparation, totally 12 days, put to death, peripheral blood routine is looked in blood sampling, aseptically get bone marrow, pour in Eagle, cross No. 4 syringe needle centrifuge washings to make to beat in Eagle liquid in 2.5x10'/ml, often add cell suspension O.lml in pipe, Eagle culture fluid 0. 8m1, isotope 0. 1m137 DEG C temperature bath 4 hours, centrifugally to remove in supernatant free 3H, again in turn 49 type glass membrane sucking filtration, 70 DEG C of dryings 1 hour, add scintillation solution with domestic Fj353 type liquid flashing determining, and with 10
7cell number/ml, middle precursor participates in DNA, and the PmOL value in RNA or protein calculates.
Isotope used (
3h) TdR (mixing DNA) is than degree 23CL/Mm < 3H) UR (mixing RNA) than degree 23CL/mM, 3HLeu (mixing protein) than degree 22CL/Mm, radiochemicsl purity more than 96%.
Experimental result:
1.1: Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation is to the change of bone marrow depression caused by radiating streptozotocin D (administration and 12 hours) mouse peripheral blood elephant, and result is as shown in table 3:
The change of table 3 peripheral hemogram
1.2: Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation is to the suppression situation of bone marrow nucleic acid caused by radiating streptozotocin D and protein synthesis, and result is as shown in table 4:
The suppression situation of table 4 bone marrow nucleic acid and protein synthesis
The above; be only preferred embodiment of the present invention; not to any formal and substantial restriction of the present invention; should be understood that; for those skilled in the art; under the prerequisite not departing from the inventive method, also can make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.All those skilled in the art, without departing from the spirit and scope of the present invention, a little change made when utilizing disclosed above technology contents, the equivalent variations of modifying and developing, be Equivalent embodiments of the present invention; Meanwhile, all according to substantial technological of the present invention to the change of any equivalent variations that above-described embodiment is done, modify and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (13)
1. Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation, it is characterized in that: comprise each composition Herba Ecliptae 8-19 part of following weight portion, Fructus Ligustri Lucidi 10-15 part, Fructus Mori 11-21 part, Radix Astragali 10-25 part, Radix Polygoni Multiflori 12-24 part, Radix Paeoniae Alba 10-24 part, Rhizoma Cibotii 10-28 part.
2. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 1 prepared slices of Chinese crude drugs combination preparation, is characterized in that: also comprise Radix Rehmanniae Preparata 8-19 weight portion, Radix Angelicae Sinensis 10-15 weight portion, Colla Corii Asini 5-14 weight portion, Fructus Aurantii 4-12 weight portion, Rhizoma Corydalis 10-15 weight portion and Oletum Trogopterori 7-15 weight portion.
3. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 1 prepared slices of Chinese crude drugs combination preparation, is characterized in that: described active constituents of medicine also comprise in the Radix Paeoniae Alba, Olibanum and Fructus Mori one or more.
4. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 3 prepared slices of Chinese crude drugs combination preparation, is characterized in that: the weight portion of the described Radix Paeoniae Alba is 9-20 weight portion; The weight portion of described Olibanum is 8-15 weight portion; The weight portion of described Fructus Mori is 12-19 weight portion.
5. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 4 prepared slices of Chinese crude drugs combination preparation, is characterized in that: the weight portion of the described Radix Paeoniae Alba is 11-16 weight portion; The weight portion of described Olibanum is 10-12 weight portion; The weight portion of described Fructus Mori is 13-16 weight portion.
6. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 1 prepared slices of Chinese crude drugs combination preparation, is characterized in that: described adjuvant comprises disintegrating agent, lubricant and filler.
7. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 6 prepared slices of Chinese crude drugs combination preparation, is characterized in that: described disintegrating agent is one or more in carboxymethyl starch sodium, hyprolose, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose; The consumption of described disintegrating agent is the 2-5% of described active constituents of medicine;
Described lubricant is one or more in colloidal silica, sodium stearyl fumarate, Pulvis Talci and magnesium stearate; The consumption of described lubricant is the 3-9% of described active constituents of medicine;
Described filler is one or more in lactose, Lactis Anhydrous, mannitol, microcrystalline Cellulose, starch, xylitol, pregelatinized Starch and maltose alcohol; The consumption of described filler be the 2-5 of described active constituents of medicine weight doubly.
8. the preparation method of the Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparation according to any one of claim 1-7, it is characterized in that: described preparation method comprises the steps: described Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii immersion, rinsing, drying, impact, collision, friction, shearing, grinding and synchronously ruptures, make the superfine powder of nanoscale 1-65nm, mix homogeneously with described adjuvant again, decoction pieces is made according to the preparation method of the conventional decoction pieces in this area.
9. the preparation method of Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 8 prepared slices of Chinese crude drugs combination preparation, is characterized in that: the time of described immersion is 35-40min; The hydraulic pressure of described flushing is 2-12MPa; Brittle at-19 DEG C before described impact; After described synchronous fracture, also carry out ozone sterilization; The particle diameter of described superfine powder is 55nm.
10. the preparation method of Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 8 prepared slices of Chinese crude drugs combination preparation, is characterized in that: Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii weight portion are packaged into bag in proportion.
The application packages of 11. Shengxuebao-medicine for improving hematopoitic function side's prepared slices of Chinese crude drugs combination preparations as described in any one of claim 1-6, it is characterized in that: by Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii are packaged into bag in proportion.
The application packages of 12. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 11 prepared slices of Chinese crude drugs combination preparations, it is characterized in that: in described packaging, also comprise adjuvant, wherein Herba Ecliptae, Fructus Ligustri Lucidi, Fructus Mori, the Radix Astragali, the total amount of Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Cibotii and the proportioning of adjuvant are 1:1.
The application packages of 13. Shengxuebao-medicine for improving hematopoitic function side as claimed in claim 11 prepared slices of Chinese crude drugs combination preparations, is characterized in that: described adjuvant is HP-β-CD.
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| CN115590906A (en) * | 2022-10-12 | 2023-01-13 | 四川御鼎堂中药饮片有限公司（Cn） | Traditional Chinese medicine decoction pieces and preparation method thereof |
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| CN1660290A (en) * | 2004-12-13 | 2005-08-31 | 郭来旺 | Hematogenesis capsule and preparation method |
| CN1785260A (en) * | 2004-12-08 | 2006-06-14 | 湖南中达骛马制药有限责任公司 | Chinese medicine for treating vacuity detriment |
| CN102119990A (en) * | 2010-09-21 | 2011-07-13 | 孙玉宝 | Chinese medicinal preparation for nourishing liver and kidney, supplementing qi, engendering blood, promoting blood circulation, removing obstruction in channels and relieving pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1785260A (en) * | 2004-12-08 | 2006-06-14 | 湖南中达骛马制药有限责任公司 | Chinese medicine for treating vacuity detriment |
| CN1660290A (en) * | 2004-12-13 | 2005-08-31 | 郭来旺 | Hematogenesis capsule and preparation method |
| CN102119990A (en) * | 2010-09-21 | 2011-07-13 | 孙玉宝 | Chinese medicinal preparation for nourishing liver and kidney, supplementing qi, engendering blood, promoting blood circulation, removing obstruction in channels and relieving pain |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115590906A (en) * | 2022-10-12 | 2023-01-13 | 四川御鼎堂中药饮片有限公司（Cn） | Traditional Chinese medicine decoction pieces and preparation method thereof |
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Effective date of registration: 20190813 Address after: 201507 No. 958 Langong Road, Jinshan Industrial Zone, Shanghai Patentee after: Shanghai Jincheng Suzhi Pharmaceutical Co., Ltd. Address before: 322300 Panan City, Jinhua Province, the new city of Zhejiang Lingfeng Road, No. 2 Patentee before: PAN'AN DAODI PANYAO CHINESE MEDICINE INSTITUTE |