CN104338174A - Bleeding-stopping patch with composite structure and preparation method thereof - Google Patents
Bleeding-stopping patch with composite structure and preparation method thereof Download PDFInfo
- Publication number
- CN104338174A CN104338174A CN201310342513.6A CN201310342513A CN104338174A CN 104338174 A CN104338174 A CN 104338174A CN 201310342513 A CN201310342513 A CN 201310342513A CN 104338174 A CN104338174 A CN 104338174A
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- layer
- cloth
- calcium alginate
- nonwoven layer
- hemostatic plaster
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of medical apparatuses, and concretely relates to a bleeding-stopping patch with a composite structure and a preparation method thereof. The bleeding-stopping patch comprises a mixed non-woven fabric layer of hydrophobic fiber and hydrophilic fiber, a calcium alginate non-woven fabric layer, and a metal-ion or metal-nanoparticle layer disposed on the composite non-woven fabric layer through coating. The bleeding-stopping patch has the effects of stopping bleeding, relieving pain, diminishing inflammation, keeping a moisture environment for a wound, promoting healing of the wound and the like.
Description
Technical field
The present invention relates to medical apparatus and instruments, hemostatic plaster being specifically related to composite construction and preparation method thereof.
Background technology
In daily Minimally Invasive Surgery wound hemostasis nursery work, usually adopt the absorbent carbasus being soaked with medicinal liquid apply ointment or plaster on wound or embed in wound, play the effect such as environment, promotion wound healing that hemostasis, analgesia, antiinflammatory, maintenance wound are moistening.In the last few years, existing a lot of patent documentation and non-patent literature disclosed or reported and adopted calcium alginate henatischesis dressing, nano silver calcium alginate bleeding-stopping dressing.
The advantage of calcium alginate henatischesis dressing is, the sodium ion in the fiber in calcium alginate non-woven fabrics and wound transudate and blood exchanges, and discharge calcium ion, calcium ion can accelerate the formation of clot in blood capillary end.Along with absorbing increasing of sodium ion amount, calcium alginate converts water-soluble sodium alginate gradually to, thin layer of hydrogel is formed at wound surface, the moistening of teleneuron can be maintained, slow down the pain of patient, and also for the healing of wound surface creates a good microcirculation environment, impel wound to heal as early as possible.The liquid absorption of calcium alginate non-woven fabrics can reach the 10-20 of own wt doubly.But, though calcium alginate non-woven fabrics has certain hemostatic function, without antibacterial ability, and its cost is high, intensity is low, fragility greatly, not acid and alkali-resistance, affect its result of use.
Summary of the invention
The invention provides a kind of hemostatic plaster of composite construction, it can reach hemostasis, analgesia, antiinflammatory, maintenance wound humidity environment, impel the effects such as wound healing, and can treatment cost be reduced, improve practicality.
The hemostatic plaster of composite construction of the present invention, comprises composite non woven layer of cloth, and the metal ion be positioned on composite non woven layer of cloth surface or metal nano-particle layer.In one embodiment, described composite non woven layer of cloth comprises the hybrid nonwoven layer of cloth of hydrophobic fibre and hydrophilic fibre, and calcium alginate nonwoven layer, and described hybrid nonwoven layer of cloth and calcium alginate nonwoven layer are combined with each other by processing adhesion.In another embodiment, the material of described hybrid nonwoven layer of cloth is for washing sticky, bright and beautiful sticky or polyester-cotton blend.In another embodiment, described metal ion is zinc ion, copper ion or silver ion.In another embodiment, described metal nanoparticle is from nanometer silver paste.
The present invention also provides the preparation method of the hemostatic plaster of composite construction, comprise the following steps: that the hydrophobic fibres such as sticky for sticky for washing of 1-2 layer/brocade/polyester-cotton blend and hydrophilic fibre hybrid nonwoven layer of cloth, 1 layer of calcium alginate nonwoven layer are stacked together by (1), then by processing, its adhesion is combined with each other, makes composite non woven layer of cloth; (2) liquid of spray metal ion or nanometer silver paste on the surface (i.e. calcium alginate nonwoven layer) of above-mentioned composite non woven layer of cloth.In one embodiment, above-mentioned steps (1) mixes hydrophobic fibre and hydrophilic fibre by carding, then by non-woven fabrics that needle point method is made.Spraying technology is sub-micron grade by liquid refining, is then directly coated in calcium alginate nonwoven layer on the surface.Due to coating be miniaturization to the even nano level liquid of sub-micron grade, so can be formed sub-micron grade, nano grade membrane thickness and high accuracy formed thin film; And liquid is state after disperseing directly is coated with.
Calcium alginate fibre of the present invention has very strong haemostatic effect, and water soluble metallic compound is as metal ion source.Be not bound by any theory restrictions, metal ion of the present invention, nano-Ag particles have adsorption to microorganism, microorganism is by after metal ion, nano-Ag particles absorption, play respiratory enzyme and just lose effect, and the cell wall of microorganism, cell membrane all can be damaged, microorganism will be dead rapidly, so its sterilizing ability is strong especially.Hydrophobic fibre is terylene such as, and basic composition material is polyethylene terephthalate, not containing hydrophilic radical, durable, good springiness.And hydrophilic fibre such as viscose glue, containing hydrophilic radical, such as hydroxyl, degree of crystallinity is lower, has good hygroscopicity, can be absorbed by the transudate of wound in time, dispels the potential place of bacterial growth.The use of hemostatic plaster can prevent the excessive of the invasion of extraneous antibacterial and interior boundary wound fluid and jeopardize other wound.
Hemostatic plaster of the present invention is used for Wicresoft's intervene operation puncture wound hemostasis, adopt the compound of calcium alginate non-woven fabrics and other non-woven fabrics, intensity is high, and different fibre composition respectively plays effect that is hydrophobic and water suction in other non-woven fabrics, in time the transudate of wound can be absorbed, dispel the potential place of bacterial growth, the excessive of the invasion of extraneous antibacterial and interior boundary wound fluid can be prevented simultaneously and jeopardize other wound.
Simultaneously, this compound calcium alginate hemostatic plaster owing to spraying with metal ion, nano-Ag particles in calcium alginate nonwoven layer, make it with hemostatic function, antibacterial functions, moisture-keeping functions, liquid suction function etc., glue owing to adopting calcium alginate non-woven fabrics and washing sticky/brocade again/polyester-cotton blend is non-woven fabric compounded, greatly can improve the use fastness of hemostatic plaster, become a kind of very excellent medical hemostatic paster.
Accompanying drawing explanation
In order to more clearly describe technical scheme of the present invention, briefly introduce below in conjunction with accompanying drawing.Obviously, these accompanying drawings are only some detailed description of the invention that the application records.The present invention includes but be not limited to these accompanying drawings.
Fig. 1 is hemostatic plaster of the present invention, wherein 1-calcium alginate nonwoven layer; 2-washs bonded non-woven fabrics layer; 3-silver compound.
Fig. 2 is hemostatic plaster of the present invention, wherein 1-calcium alginate nonwoven layer; 2-washs bonded non-woven fabrics layer; 3-nanometer silver.
Fig. 3 is hemostatic plaster of the present invention, wherein 1-calcium alginate nonwoven layer; 2-brocade bonded non-woven fabrics layer; 3-silver compound
Fig. 4 is hemostatic plaster of the present invention, wherein 1-calcium alginate nonwoven layer; 2-polyester-cotton blend nonwoven layer; 3-silver compound
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, preferred version of the present invention is described.These describe the feature and advantage just illustrating hemostatic plaster of the present invention, but not limit the scope of the invention.
Embodiment 1
According to Fig. 1, hemostatic plaster of the present invention comprises 1-2 layer and washs bonded non-woven fabrics (2) and 1 layer of calcium alginate non-woven fabrics (1), is reinforced together by layer 2-3 non-woven fabrics by pinprick reinforcement method.Pinprick reinforcement method adopts miniature needing machine, and its primary structure comprises needle plate, trawl board, dials web plate, and Needle Board density is determined according to the needle handle diameter of pricker, and needling density is determined according to reinforced fibers length, fineness and reinforcing fastness.Then spray silver compound solution (3) on the surface in calcium alginate nonwoven layer, silver ion is adsorbed on calcium alginate fibre.
Embodiment 2
Similar with the method for embodiment 1, as shown in Figure 2, in hemostatic plaster of the present invention, nonwoven layer adopts terylene, viscose glue hybrid nonwoven cloth and calcium alginate non-woven fabric compounded, and coating adopts nanometer silver.
Embodiment 3
Similar with the method for embodiment 1, as shown in Figure 3, hemostatic plaster nonwoven layer of the present invention adopts chinlon, viscose rayon hybrid nonwoven cloth and calcium alginate non-woven fabric compounded, and coating adopts silver compound.
Embodiment 4
Similar with the method for embodiment 1, as shown in Figure 4, hemostatic plaster nonwoven layer of the present invention adopts terylene, cotton fiber hybrid nonwoven cloth and calcium alginate non-woven fabric compounded, and coating adopts silver compound.
The explanation of above embodiment just understands core concept of the present invention for helping.Should be understood that; for the ordinary skill in the art; under the premise without departing from the principles of the invention, some improvement and modification can also be carried out to hemostatic plaster of the present invention and preparation method thereof, but these improve and modification also falls in the scope of the claims in the present invention request protection.
Reference material:
Patent documentation:
Application number 201110039947.X, denomination of invention: a kind of preparation method of medical calcium alginate filler strips;
Application number 201010017663.6, denomination of invention " a kind of preparation method of compound calcium alginate dressing ";
Application number 201010017666.X, denomination of invention " a kind of preparation method of biological calcium alginate antimicrobial dressing ";
Application number 201020022437.2, denomination of invention " a kind of preparation method of compound calcium alginate antiseptic dressing ";
Application number 200610053877.2, denomination of invention " nano silver calcium alginate antibacterial dressing ";
Application number 200510039299.2, denomination of invention " calcium alginate henatischesis dressing of a kind of superabsorbent and preparation method thereof ";
Application number 201110332357.6, denomination of invention " preparation method of a kind of carrying silver ion calcium alginate fibre or year silver-colored medical adhesive-bonded fabric ";
Application number 96242391.2, denomination of invention " Application containing calcium alginate ";
Application number 96113181, denomination of invention " calcium alginate is applied ointment or plaster and the manufacture method of calcium alginate fibre non-woven fabrics "; And
Non-patent literature:
" nano-silver biological effect study progress ", Southeast China University's journal (natural science edition), on November 20th, 2009;
" the anti-microbial property research of silver ion anti-bacterial fibre ", hosiery industry, on April 28th, 2008; And
" comparative study that two kinds of different medical dressing infect abdominal operation incision ", Jilin University's Master's thesis, on October 1st, 2011.
Claims (8)
1. a hemostatic plaster for composite construction, comprises composite non woven layer of cloth, and the metal ion be positioned on composite non woven layer of cloth surface or metal nano-particle layer.
2. the hemostatic plaster of the composite construction of claim 1, described composite non woven layer of cloth comprises the hybrid nonwoven layer of cloth of hydrophobic fibre and hydrophilic fibre, and calcium alginate nonwoven layer, described hybrid nonwoven layer of cloth and calcium alginate nonwoven layer are combined with each other by processing adhesion.
3. the hemostatic plaster of the composite construction of claim 2, wherein the material of hybrid nonwoven layer of cloth is for washing sticky, bright and beautiful sticky or polyester-cotton blend.
4. the hemostatic plaster of the composite construction of any one of claim 1-3, wherein metal ion is zinc ion, copper ion or silver ion.
5. the hemostatic plaster of the composite construction of any one of claim 1-3, wherein metal nanoparticle is from nanometer silver paste.
6. the preparation method of the hemostatic plaster of the composite construction of any one of claim 1-5, comprises the following steps:
(1) hydrophobic fibre of 1-2 layer and hydrophilic fibre hybrid nonwoven layer of cloth, 1 layer of calcium alginate nonwoven layer are stacked together, then by processing, its adhesion are combined with each other, make composite non woven layer of cloth;
(2) at the liquid of calcium alginate nonwoven layer spray metal ion or the nanometer silver paste on the surface of above-mentioned composite non woven layer of cloth.
7. the preparation method of claim 6, wherein step (1) mixes hydrophobic fibre and hydrophilic fibre by carding, then by nonwoven layer that needle point method is made.
8. the preparation method of claim 6 or 7, wherein spraying allows liquid is fine turns to sub-micron grade even nanoscale, is then directly coated in calcium alginate nonwoven layer on the surface.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310342513.6A CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
| PCT/CN2014/083847 WO2015018349A1 (en) | 2013-08-07 | 2014-08-07 | Hemostatic plaster having a composite structure and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310342513.6A CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104338174A true CN104338174A (en) | 2015-02-11 |
| CN104338174B CN104338174B (en) | 2017-05-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310342513.6A Active CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104338174B (en) |
| WO (1) | WO2015018349A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536030A (en) * | 2016-01-08 | 2016-05-04 | 山东明德生物医学工程有限公司 | Dressing chip with hemostasis and restoration promoting functions and preparation method thereof |
| CN105727346A (en) * | 2016-02-04 | 2016-07-06 | 中国科学院化学研究所 | Hemostatic fabric and preparation method and application thereof |
| CN114763631A (en) * | 2021-01-11 | 2022-07-19 | 哈尔滨汇隽医药科技有限公司 | Non-woven material for medical dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935268A (en) * | 2006-10-18 | 2007-03-28 | 上海川本卫生材料有限公司 | Nano silver calcium alginate antibacterial dressing |
| WO2008127287A2 (en) * | 2006-10-11 | 2008-10-23 | Biolife, L.L.C. | Materials and methods for wound treatment |
| CN102492925A (en) * | 2011-12-13 | 2012-06-13 | 中国人民解放军总后勤部军需装备研究所 | Medical anti-microbial silver-plated dressing and preparation method thereof |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
-
2013
- 2013-08-07 CN CN201310342513.6A patent/CN104338174B/en active Active
-
2014
- 2014-08-07 WO PCT/CN2014/083847 patent/WO2015018349A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008127287A2 (en) * | 2006-10-11 | 2008-10-23 | Biolife, L.L.C. | Materials and methods for wound treatment |
| CN1935268A (en) * | 2006-10-18 | 2007-03-28 | 上海川本卫生材料有限公司 | Nano silver calcium alginate antibacterial dressing |
| CN102492925A (en) * | 2011-12-13 | 2012-06-13 | 中国人民解放军总后勤部军需装备研究所 | Medical anti-microbial silver-plated dressing and preparation method thereof |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536030A (en) * | 2016-01-08 | 2016-05-04 | 山东明德生物医学工程有限公司 | Dressing chip with hemostasis and restoration promoting functions and preparation method thereof |
| CN105536030B (en) * | 2016-01-08 | 2018-09-18 | 山东明德生物医学工程有限公司 | A kind of hemostasis promotees to repair dressing chip and preparation method thereof |
| CN105727346A (en) * | 2016-02-04 | 2016-07-06 | 中国科学院化学研究所 | Hemostatic fabric and preparation method and application thereof |
| CN114763631A (en) * | 2021-01-11 | 2022-07-19 | 哈尔滨汇隽医药科技有限公司 | Non-woven material for medical dressing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104338174B (en) | 2017-05-03 |
| WO2015018349A1 (en) | 2015-02-12 |
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Effective date of registration: 20190529 Address after: Room 197, Building 1, 3339 Linggongtang Road, Nanhu District, Jiaxing City, Zhejiang Province, 314000 Patentee after: MAITONG MEDICAL TECHNOLOGY (JIAXING) Co.,Ltd. Address before: 201203, 501, Newton Road, Zhangjiang hi tech park, Shanghai, Pudong New Area Patentee before: SHANGHAI MICROPORT MEDICAL (GROUP) Co.,Ltd. |
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Address after: 314006 2nd floor, building 5, No.1303, Asia Pacific Road, Nanhu District, Jiaxing City, Zhejiang Province Patentee after: Zhejiang Maitong Intelligent Manufacturing Technology (Group) Co.,Ltd. Address before: Room 197, Building 1, 3339 Linggongtang Road, Nanhu District, Jiaxing City, Zhejiang Province, 314000 Patentee before: MAITONG MEDICAL TECHNOLOGY (JIAXING) Co.,Ltd. |
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