CN102492925A - Medical anti-microbial silver-plated dressing and preparation method thereof - Google Patents
Medical anti-microbial silver-plated dressing and preparation method thereof Download PDFInfo
- Publication number
- CN102492925A CN102492925A CN2011104153375A CN201110415337A CN102492925A CN 102492925 A CN102492925 A CN 102492925A CN 2011104153375 A CN2011104153375 A CN 2011104153375A CN 201110415337 A CN201110415337 A CN 201110415337A CN 102492925 A CN102492925 A CN 102492925A
- Authority
- CN
- China
- Prior art keywords
- dressing
- silver
- sputtering
- plating
- medical dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Abstract
The invention discloses a medical anti-microbial silver-plated dressing and a preparation method thereof. The preparation method of the medical anti-microbial silver-plated dressing includes steps of mixing calcium alginate fibers and cellulose fibers to prepare a dressing substrate and preparing a silver-particle plated layer on the surface of the dressing substrate by means of vacuum sputtering. The medical anti-microbial silver-plated dressing has broad-spectrum anti-microbial performance, is simple and easy in preparation method and low in cost.
Description
Technical field
The present invention relates to a kind of antibacterial silver-plating medical dressing and preparation method thereof.
Background technology
Medical dressing is skin injury that causes because of wound or disease in order to assisting therapy and disease such as fester; Particularly play good effect the long-term bedfast patient of nursing; Along with countries in the world population occurs to aging direction development trend; People's overnutrition and the corresponding disease brought in addition grow with each passing day to the demand of medical dressing.The effect of medical dressing mainly is to play to isolate human body skin damnification place and periphery environment, thereby avoids cutaneous lesion to receive the bacterium in the environment and cause infection.Simultaneously, medical dressing is also tackled the body fluid that oozes out because of skin injury and is had adsorptive power, to guarantee the drying of wound.Medical dressing and antibacterial medical dressing that present medical dressing comprises common medical dressing, has the high-absorbable ability, common medical dressing are that adopting through the skimming treatment cotton fibre is the material of main part formation; High general calcium alginate fiber and the cellulosic fibre blending composition that adopt of medical dressing that absorb with high water-retaining capacity; Antibacterial medical dressing is on the basis of above-mentioned two kinds of medical dressing, adds antimicrobial component and makes this medical dressing obtain antibacterial ability.The antibiotic method of bibliographical information comprises at present: organic antibacterial agent is immersed with the medical dressing for preparing in (1), has acquired antibacterial effect; (2) be to utilize nano silver particles, combine with medical dressing that play antibacterial effect, medical dressing is sneaked into antibacterial fiber in (3), acquires antibacterial effect through tackiness agent or other modes.Usually the antibacterial fiber that is adopted is a silver plated fiber.
There is problem targetedly in most of organic antibacterial agent kind, for the various bacteria population, use many antiseptic-germicide kinds, and it combines the complete processing complicacy with medical dressing, and utilization ratio is lower; Though nano-silver ionic has broad spectrum antibacterial, its processing difficulties, cost is higher.Silver-plated antibacterial fiber all has better anti-bacterial effect, can be after medical dressing carries out blending processing jointly, production technique is simple, but owing to can only adopt blending technology, so will reach antibacterial effect, the large usage quantity of silver plated fiber often.See only need have antibacterial effect and get final product with the auxiliary material surface of skin exposure from medical dressing anti-microbial effect mechanism.
Summary of the invention
The purpose of this invention is to provide a kind of antibacterial silver-plating medical dressing and preparation method thereof.
Antibacterial silver-plating medical dressing provided by the present invention is to prepare according to the method that comprises the steps: calcium alginate fiber and cellulosic fibre are mixed with the dressing base material; Adopt vacuum sputtering to prepare silver particles coating, obtain the antibacterial silver-plating medical dressing at said dressing substrate surface.
Concrete preparation method comprises the steps:
1) calcium alginate fiber and cellulosic fibre are prepared formation dressing base material by a certain percentage;
2) adopt aqueous sodium hydroxide solution, water, absolute ethyl alcohol to wash the removal finish successively said dressing base material, dehydration is inserted after the drying and is carried out silver-platedly in the vacuum sputtering device, obtains said antibacterial silver-plating medical dressing.
Said method also comprises obtaining the step that the antibacterial silver-plating medical dressing is cut, sterilizes, packed.
Wherein, the mass ratio of calcium alginate fiber and cellulosic fibre can be 10 in the step 1): 90-90: 10.Used cellulosic fibre is selected from any one or a few in cotton fibre, flaxen fiber and the viscose fiber.
Said dressing base material specifically can prepare by following three kinds of methods:
1) mix, divide comb, acupuncture to be prepared from alginate calcium bulk fibre and Mierocrystalline cellulose bulk fibre.
2) with the alginate calcium bulk fibre after minute combing into net, carry out composite acupuncture with the Mierocrystalline cellulose spunlace non-woven cloth and be prepared from.
3) with the alginate calcium bulk fibre after minute combing into net, carry out composite acupuncture with the Mierocrystalline cellulose woven fabrics and be prepared from.
Step 2) vacuum sputtering described in specifically can be magnetron sputtering method and/or radio frequency sputtering method.
Wherein, the sputtering target material that is adopted is argent and/or silver alloys; Sputter gas is a pure argon; In sputter procedure, substrate (being the dressing base material) temperature is a room temperature, target temperature≤80 ℃, and the base vacuum degree is less than (2-6) * 10
-4Pa; Operating pressure during sputter is 0.1-5Pa, and sputtering power is 30-50W, and sputtering time is no less than 1min; Keeping the distance between substrate and the target during sputter is 30mm-170mm.
Above-mentioned silver alloys as sputtering target material specifically can be yellow gold, and wherein silver content is no less than 50%.
The thickness of silvering can be controlled through the control sputtering time among the present invention, and general thickness is 10nm-100nm.
Beneficial effect of the present invention:
The present invention is mixed with medical dressing surface sputtering one deck nanometer silver through the method for vacuum sputtering at calcium alginate fiber and cellulosic fibre; When the body fluid that guarantees skin injury place exosmosed has the good adsorption effect, has good broad-spectrum antimicrobial effect.Because nano silver plating only is in the medical dressing surface, can directly act on skin injury place, compared with prior art antimicrobial efficiency and the utilization ratio that improves silver can be gone up largely, thereby the consumption of silver can be reduced significantly, reduce cost.
Embodiment
Through specific embodiment method of the present invention is described below, but the present invention is not limited thereto.
Experimental technique described in the following embodiment like no specified otherwise, is ordinary method; Said reagent and material like no specified otherwise, all can obtain from commercial sources.
Embodiment 1, preparation antibacterial silver-plating medical dressing
(1) the alginate calcium bulk fibre is mixed in 20: 80 ratio of mass ratio with the cotton fibre bulk fibre,, prepare the dressing base material through dividing comb, acupuncture.
(2) formed dressing base material being immersed mass concentration is that (solid-liquid ratio of dressing base material and sodium hydroxide solution is 1kg: 1L), remove the fiber surface finish in 5% sodium hydroxide solution; Then successively water (solid-liquid ratio is 1kg: 3L), (solid-liquid ratio is 1kg: 1L) carry out drip washing, flush away remains in sodium hydroxide and finish and the dehydration in the dressing base material to absolute ethyl alcohol, after drying, inserts in the vacuum magnetic-control sputtering device.
(3) sputtering chamber in the magnetic control sputtering device is vacuumized, make its vacuum tightness less than 2 * 10
-4Pa, and the filling pure argon is a sputter gas; Adopt fine silver as magnetic control spattering target, base reservoir temperature is a room temperature, and silver-colored target temperature is 80 ℃; Operating pressure during sputter is 0.1Pa; Keeping the distance between substrate and the target is 30mm, and sputtering power is 30W, sputtering time 1min; Form silver particles coating at said dressing substrate surface, obtain the dressing after silver-plated.
(4) dressing after silver-plated is cut successively, sterilizes, packed, obtain the antibacterial silver-plating medical dressing.
Adopt the method for GB/T20944 regulation; The antibacterial silver-plating medical dressing is carried out the anti-microbial property test; The result shows that prepared antibacterial silver-plating medical dressing material is 99% to streptococcus aureus (strain number ATCC6538) bacteriostasis rate; Candida albicans (strain number ATCC10231) bacteriostasis rate 99%, intestinal bacteria (strain number 8099) bacteriostasis rate 99%.
Adopt the A solution (142mmol sodium-chlor and 25mmol calcium chloride solution) of defined in the British Pharmacopoeia; Through the antibacterial silver-plating medical dressing being carried out the test of liquid adsorption performance, the result shows: prepared antibacterial silver-plating medical dressing material to the adsorptive power of A solution is: the amount of every gram dry weight antibacterial silver-plating medical dressing absorption A solution reaches 31.6 grams.
Embodiment 2, preparation antibacterial silver-plating medical dressing
(1) utilizes carding equipment, the alginate calcium bulk fibre is carried out branch comb into net, be tiled in viscose fiber spunlace non-woven cloth surface, utilize acupuncture apparatus to carry out the compound dressing base material that is prepared into of acupuncture; Wherein, the mass ratio of alginate calcium bulk fibre and viscose fiber spunlace non-woven cloth is 10: 90.
Step (2), (3), (4) are with embodiment 1; There is following variation in its processing parameter: vacuumizing the vacuum tightness that guarantees in the sputtering chamber is 6.0 * 10
-4Pa; Base reservoir temperature is a room temperature; Feed the working gas argon gas, the pressure when guaranteeing sputter is 5Pa; Target material is a yellow gold, and wherein, silver content is 50%, and the distance between adjustment substrate and the target is 170mm, and sputtering power is 50W, sputtering time 2min.
Adopt the method for GB/T20944 regulation; The antibacterial silver-plating medical dressing is carried out the anti-microbial property test; The result shows that prepared antibacterial silver-plating medical dressing material is 99% to streptococcus aureus (strain number ATCC6538) bacteriostasis rate; Candida albicans (strain number ATCC10231) bacteriostasis rate 98%, intestinal bacteria (strain number 8099) bacteriostasis rate 98%.
Adopt the A solution (142mmol sodium-chlor and 25mmol calcium chloride solution) of defined in the British Pharmacopoeia; Through the antibacterial silver-plating medical dressing being carried out the test of liquid adsorption performance, the result shows: prepared antibacterial silver-plating medical dressing material to the adsorptive power of A solution is: the amount of every gram dry weight antibacterial silver-plating medical dressing absorption A solution reaches 23.6 grams.
Embodiment 3, preparation antibacterial silver-plating medical dressing
(1) utilize carding equipment, the alginate calcium bulk fibre is carried out branch comb into net, be tiled in specifications parameter and be: ((the cotton fabric surface of root/10cm) utilizes acupuncture apparatus to carry out the compound dressing base material that is prepared into of acupuncture for root/10cm) * 210 in 13tex * 13tex * 185; Wherein, the mass ratio of alginate calcium bulk fibre and cotton fabric is 90: 10.
Step (2), (3), (4) are with embodiment 1; There is following variation in its processing parameter: vacuumizing the vacuum tightness that guarantees in the sputtering chamber is 3.0 * 10
-4Pa; Base reservoir temperature is a room temperature; Feed the working gas argon gas, the pressure when guaranteeing sputter is 2Pa; Target material is a fine silver, and the distance between adjustment substrate and the target is 100mm, and sputtering power is 40W, sputtering time 1.5min.
Adopt the method for GB/T20944 regulation; The antibacterial silver-plating medical dressing is carried out the anti-microbial property test; The result shows that prepared antibacterial silver-plating medical dressing material is 99% to streptococcus aureus (strain number ATCC6538) bacteriostasis rate; Candida albicans (strain number ATCC10231) bacteriostasis rate 99%, intestinal bacteria (strain number 8099) bacteriostasis rate 99%.
Adopt the A solution (142mmol sodium-chlor and 25mmol calcium chloride solution) of defined in the British Pharmacopoeia; Through the antibacterial silver-plating medical dressing being carried out the test of liquid adsorption performance, the result shows: prepared antibacterial silver-plating medical dressing material to the adsorptive power of A solution is: the amount of every gram dry weight antibacterial silver-plating medical dressing absorption A solution reaches 47.3 grams.
Claims (10)
1. a method for preparing the antibacterial silver-plating medical dressing comprises the steps:
1) calcium alginate fiber and cellulosic fibre are mixed with the dressing base material;
2) adopt vacuum sputtering to prepare silver particles coating, obtain the antibacterial silver-plating medical dressing at said dressing substrate surface.
2. method according to claim 1 is characterized in that: the mass ratio of calcium alginate fiber described in the step 1) and cellulosic fibre is 10: 90-90: 10.
3. method according to claim 1 and 2 is characterized in that: cellulosic fibre described in the step 1) is selected from following at least a: cotton fibre, flaxen fiber and viscose fiber.
4. according to each described method among the claim 1-3, it is characterized in that: the base material of dressing described in the step 1) is according to following 1)-3) in any one method prepare:
1) mix, divide comb, acupuncture to be prepared from alginate calcium bulk fibre and Mierocrystalline cellulose bulk fibre;
2) with the alginate calcium bulk fibre after minute combing into net, carry out composite acupuncture with the Mierocrystalline cellulose spunlace non-woven cloth and be prepared from;
3) with the alginate calcium bulk fibre after minute combing into net, carry out composite acupuncture with the Mierocrystalline cellulose woven fabrics and be prepared from.
5. according to each described method among the claim 1-4, it is characterized in that: step 2) described in vacuum sputtering be magnetron sputtering method and/or radio frequency sputtering method.
6. method according to claim 5 is characterized in that: the processing condition of said vacuum sputtering are following: the sputtering target material that is adopted is argent and/or silver alloys, and sputter gas is a pure argon; In the sputter procedure, the temperature of dressing base material is a room temperature, target temperature≤80 ℃, and the base vacuum degree is less than (2-6) * 10
-4Pa; Operating pressure during sputter is 0.1-5Pa, and sputtering power is 30-50W, and sputtering time is no less than 1min; Keeping the distance between substrate and the target during sputter is 30mm-170mm.
7. method according to claim 6 is characterized in that: said silver alloys is a yellow gold, and wherein the mass content of silver is no less than 50%.
8. according to each described method among the claim 1-7, it is characterized in that: step 2) described in the thickness of silver particles coating be 10nm-100nm.
9. according to each described method among the claim 1-8; It is characterized in that: said method also is included in step 2) preceding said dressing base material is carried out following processed steps: adopt aqueous sodium hydroxide solution, water, absolute ethyl alcohol to wash successively said dressing base material, and then dehydration, drying;
And/or the step that said antibacterial silver-plating medical dressing is cut, sterilized and packs.
10. the antibacterial silver-plating medical dressing that each said method prepares among the claim 1-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104153375A CN102492925A (en) | 2011-12-13 | 2011-12-13 | Medical anti-microbial silver-plated dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104153375A CN102492925A (en) | 2011-12-13 | 2011-12-13 | Medical anti-microbial silver-plated dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102492925A true CN102492925A (en) | 2012-06-13 |
Family
ID=46184786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104153375A Pending CN102492925A (en) | 2011-12-13 | 2011-12-13 | Medical anti-microbial silver-plated dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102492925A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338173A (en) * | 2013-08-06 | 2015-02-11 | 许春晖 | Preparation method and application of quick absorption saturation gelation seaweed hemostatic dressing |
| CN104338174A (en) * | 2013-08-07 | 2015-02-11 | 上海微创医疗器械（集团）有限公司 | Bleeding-stopping patch with composite structure and preparation method thereof |
| CN105463700A (en) * | 2015-12-18 | 2016-04-06 | 厦门百美特生物材料科技有限公司 | Spunlace alginate dressing |
| CN106362192A (en) * | 2016-08-25 | 2017-02-01 | 江苏省健尔康医用敷料有限公司 | Preparation method of alginate fiber medical gauze |
| CN106510947A (en) * | 2016-09-30 | 2017-03-22 | 天津宝兴威科技有限公司 | Nano silver sterile gauze |
| CN108686253A (en) * | 2018-06-21 | 2018-10-23 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of high-efficiency antimicrobial medical dressing |
| CN108708026A (en) * | 2018-05-09 | 2018-10-26 | 山东联润新材料科技有限公司 | A kind of antimicrobial yarn and its Yarn spinning method |
| CN109453413A (en) * | 2018-12-26 | 2019-03-12 | 青岛大学 | A kind of preparation method of the electroactive dressing containing micro cell |
| CN110699946A (en) * | 2017-05-15 | 2020-01-17 | 彭珍 | Preparation method of composite layer non-woven fabric |
| CN111759557A (en) * | 2020-07-29 | 2020-10-13 | 王紫萱 | Metal antibacterial heat-dissipation dressing device |
| CN111826949A (en) * | 2020-07-28 | 2020-10-27 | 深圳市菩安科技有限公司 | Antibacterial non-woven fabric and preparation method thereof |
| CN112048906A (en) * | 2019-12-05 | 2020-12-08 | 山东汇高智慧纺织科技有限公司 | Antibacterial silver-containing fiber with excellent biocompatibility and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6471982B1 (en) * | 1994-01-20 | 2002-10-29 | Bristol-Myers Squibb Company | Wound dressing |
| US20040244164A1 (en) * | 2001-10-12 | 2004-12-09 | Ferguson Paul John | Gel-forming fabric composite |
| CN101608246A (en) * | 2009-07-20 | 2009-12-23 | 西安工程大学 | A kind of method for preparing antibacterial silver-plating leather |
-
2011
- 2011-12-13 CN CN2011104153375A patent/CN102492925A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6471982B1 (en) * | 1994-01-20 | 2002-10-29 | Bristol-Myers Squibb Company | Wound dressing |
| US20040244164A1 (en) * | 2001-10-12 | 2004-12-09 | Ferguson Paul John | Gel-forming fabric composite |
| CN101608246A (en) * | 2009-07-20 | 2009-12-23 | 西安工程大学 | A kind of method for preparing antibacterial silver-plating leather |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338173A (en) * | 2013-08-06 | 2015-02-11 | 许春晖 | Preparation method and application of quick absorption saturation gelation seaweed hemostatic dressing |
| CN104338174A (en) * | 2013-08-07 | 2015-02-11 | 上海微创医疗器械（集团）有限公司 | Bleeding-stopping patch with composite structure and preparation method thereof |
| WO2015018349A1 (en) * | 2013-08-07 | 2015-02-12 | 上海微创医疗器械（集团）有限公司 | Hemostatic plaster having a composite structure and preparation method therefor |
| CN104338174B (en) * | 2013-08-07 | 2017-05-03 | 上海微创医疗器械（集团）有限公司 | Bleeding-stopping patch with composite structure and preparation method thereof |
| CN105463700A (en) * | 2015-12-18 | 2016-04-06 | 厦门百美特生物材料科技有限公司 | Spunlace alginate dressing |
| CN106362192B (en) * | 2016-08-25 | 2019-10-25 | 江苏省健尔康医用敷料有限公司 | A kind of preparation method of alginate fibre hospital gauze |
| CN106362192A (en) * | 2016-08-25 | 2017-02-01 | 江苏省健尔康医用敷料有限公司 | Preparation method of alginate fiber medical gauze |
| CN106510947A (en) * | 2016-09-30 | 2017-03-22 | 天津宝兴威科技有限公司 | Nano silver sterile gauze |
| CN110846887A (en) * | 2017-05-15 | 2020-02-28 | 彭珍 | Preparation method of composite layer non-woven fabric |
| CN110846885A (en) * | 2017-05-15 | 2020-02-28 | 彭珍 | Preparation method of composite layer non-woven fabric |
| CN110699946A (en) * | 2017-05-15 | 2020-01-17 | 彭珍 | Preparation method of composite layer non-woven fabric |
| CN110846884A (en) * | 2017-05-15 | 2020-02-28 | 彭珍 | Composite layer nonwoven fabric product |
| CN110846886A (en) * | 2017-05-15 | 2020-02-28 | 彭珍 | Preparation method of composite layer non-woven fabric |
| CN108708026A (en) * | 2018-05-09 | 2018-10-26 | 山东联润新材料科技有限公司 | A kind of antimicrobial yarn and its Yarn spinning method |
| CN108708026B (en) * | 2018-05-09 | 2021-04-30 | 山东联润新材料科技有限公司 | Antibacterial yarn and spinning method thereof |
| CN108686253A (en) * | 2018-06-21 | 2018-10-23 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of high-efficiency antimicrobial medical dressing |
| CN109453413A (en) * | 2018-12-26 | 2019-03-12 | 青岛大学 | A kind of preparation method of the electroactive dressing containing micro cell |
| CN109453413B (en) * | 2018-12-26 | 2021-06-01 | 青岛大学 | Preparation method of electroactive dressing containing micro-battery |
| CN112048906A (en) * | 2019-12-05 | 2020-12-08 | 山东汇高智慧纺织科技有限公司 | Antibacterial silver-containing fiber with excellent biocompatibility and preparation method thereof |
| CN112048906B (en) * | 2019-12-05 | 2022-12-20 | 山东汇高智慧纺织科技集团有限公司 | Antibacterial silver-containing fiber with excellent biocompatibility and preparation method thereof |
| CN111826949A (en) * | 2020-07-28 | 2020-10-27 | 深圳市菩安科技有限公司 | Antibacterial non-woven fabric and preparation method thereof |
| CN111826949B (en) * | 2020-07-28 | 2021-08-03 | 深圳市菩安科技有限公司 | Antibacterial non-woven fabric and preparation method thereof |
| CN111759557A (en) * | 2020-07-29 | 2020-10-13 | 王紫萱 | Metal antibacterial heat-dissipation dressing device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102492925A (en) | Medical anti-microbial silver-plated dressing and preparation method thereof | |
| JP6903715B2 (en) | Manufacturing method of antibacterial wound dressing | |
| CA2510151C (en) | Wound dressings comprising metallic silver | |
| EP3402462B1 (en) | A nanobiocomposite formulation for wound healing and a process for the preparation thereof | |
| Wen et al. | In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing | |
| CA2490847C (en) | Antimicrobial, silver-containing wound dressing for continuous release | |
| KR101377569B1 (en) | Antimicrobial Wound Dressing and Preparing Method of the Same | |
| WO2015165400A1 (en) | Hygroscopic silver-containing product containing silver thiosulfate complex or silver-ammonia complex, and preparation method thereof | |
| CN101905031B (en) | Method for preparing flamazine/bacterial cellulose composite wound dressing | |
| CN107456321B (en) | A kind of nanometer silver antimicrobial sanitary napkin and its production method | |
| CN105664225A (en) | Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof | |
| CN103074777A (en) | Silver-loaded alginate fiber and preparation method thereof | |
| CN101141985B (en) | Antibacterial dressings manufacturing method for medical purpose and uses thereof | |
| CN101927030A (en) | Preparation method of biological dressing containing nano silver, zinc and bismuth | |
| CN109966540B (en) | Preparation method and application of nano chitin composite calcium alginate medical dressing | |
| Yang et al. | A facile, biosynthetic design strategy for high-performance multifunctional bacterial cellulose-based dressing | |
| CN105288698A (en) | Calcium alginate composite medical surgical dressing and preparation method thereof | |
| CN108969791B (en) | Composite wound dressing loaded with nano-silver and preparation method thereof | |
| Kim et al. | Thermal fabrication and characterization of Ag nanoparticle-activated carbon composites for functional wound-dressing additives | |
| Shi et al. | Studies of the properties of CHG-Loaded alginate fibers for medical application | |
| CN110124082A (en) | Swelling type medical bio gel filler based on Polysaccharide from Portulaca oleracea and chromocor extract | |
| CN111658815B (en) | Antibacterial alginate dressing and preparation method thereof | |
| CN110882409B (en) | Composite hydrophilic fiber dressing and preparation method thereof | |
| CN107670093A (en) | A kind of anti-sticky type antibacterial medical bandage | |
| US20200306289A1 (en) | Wound healing topical formulation and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120613 |