CN104338073A - Traditional Chinese medicinal preparation for treating dilated cardiomyopathy and preparation method of fluid extract thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal preparation, and in particular relates to a traditional Chinese medicinal preparation for treating dilated cardiomyopathy and a preparation method of a fluid extract thereof. The traditional Chinese medicinal granule is prepared from the following traditional Chinese medicinal raw materials: 5-8 parts of semen lepidii, 10-15 parts of astragalus membranaceus, 5-8 parts of rhizoma anemarrhenae, 7-10 parts of ginseng, 10-15 parts of selfheal, 5-8 parts of ligusticum wallichii, 5-8 parts of chrysanthemum, 5-8 parts of cassia twig, 5-8 parts of rehmannia root, 10-15 parts of poria cocos, 3-5 parts of angelica, 5-8 parts of radix curcumae, 8-10 parts of jujube, 5-8 parts of fritillaria cirrhosa and 5-8 parts of folium mori. The preparation method of the fluid extract comprises the following steps: grinding raw materials into fine powder; thinning the fine powder through 60% ethanol which serves as a solvent with addition of water, through a percolation method, collecting primary filtrate and storing the primary filtrate in a bottle A, and keeping percolating until the filtrate is observed by naked eyes to be colorless; collecting filtrate, concentrating at 40-60 DEG C under reduced pressure to obtain thick paste, and mixing with the primary filtrate in the bottle A to obtain mixed liquid; thinning the mixed liquid through 60% ethanol, keeping for 30h, and reserving supernatant liquid to obtain fluid extract of the traditional Chinese medicine. The traditional Chinese medicinal preparation disclosed by the invention has the advantages that the traditional Chinese medicinal composition, prepared from natural traditional Chinese medicines, can achieve a purpose of treating both symptoms and root causes.

Description

The Chinese medicine preparation for the treatment of dilated cardiomyopathy and fluid extract preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation and fluid extract preparation thereof for the treatment of dilated cardiomyopathy.

Background technology

Dilated cardiomyopathy (Dilated Cardiomyopathy, DCM) refers to left and right ventricles or bilateral chamber enlargement, and with myocardial hypertrophy.Normal generation congestive heart failure, therefore be also called congestive cardiomyopathy in the past.Dilated cardiomyopathy is modal one in cardiomyopathy, accounts for myocardiac 70-80%.Common sympton is that ventricular systolic function goes down, arrhythmia, heart failure etc.The state of an illness is that Progressive symmetric erythrokeratodermia increases the weight of, and death can betide any stage of disease.In clinical manifestation, each age all can fall ill, but in the majority with the middle age.

Dilated cardiomyopathy increases gradually in worldwide, and the cause of disease is not exclusively clear so far, without specific treatment method, invalid and case fatality rate is high.Drug therapy remains dilated cardiomyopathy and improves symptoms of heart failure, controls the general optimum selection of prognosis.But the use of in some cases, traditional anti heart failure treatment and beta-blocker, angiotensin converting enzyme inhibitor (ACEI) does not still reach good effect.

Dilated cardiomyopathy be cause at present the most commonly encountered diseases of heart failure because of, clinically with cardiac dilatation, heart failure, thromboembolism, arrhythmia, sudden death for feature.Pathological change is that myocardial cell reduces, remaining cardiac myocyte hypertrophy, interstitial collagen hypertrophy, and locular wall is thinning, and the chambers of the heart expands.Due to its etiology unknown, without specific treatment method, poor prognosis, invalid and case fatality rate is high, heart transplantation spends huge and need use the problems such as a large amount of immunosuppressant, and medical personnel is attempting using different medicines to improve clinical symptoms and the long-term prognosis of dilated cardiomyopathy constantly.

Chinese medicine composition of the present invention is the modern Chinese medicine of development under veins disease theories instructs, Chinese pathology mechanism that its is pioneering uses traditional Chinese medical science veins disease theories to inquire into chronic heart failure and treatment, propose insufficiency of heart-QI weary, transport blood unable be the pathogenesis that occurs of congestive heart failure this; Channels stasis blocking is the key link of morbidity, and body fluid does not follow venation and runs, and it is outer and be that heresy that water is wet is sent out as edema to ooze out arteries and veins, blood stasis diseases caused by retention of fluid obstruction of collateral, and with the passing of time knot is polymerized to shape and causes heart network network to cease into the long-pending result being its development and increasing the weight of.In recent years the early stage neuroendocrine system proposed with modern medicine activates and causes hemodynamic responses, and then causes remodeling ventricle to be that the new ideas of fundamental mechanism that development occurs heart failure match.Chinese medicine composition of the present invention is by heart tonifying, diuresis, expansion blood vessel and suppress hypertensin system to improve hemodynamics alleviation symptoms of heart failure, alleviate left ventricular remodeling, reaches the effect for the treatment of both the principal and secondary aspects of a disease.

The syndrome of dilated cardiomyopathy is more, as with heart failure, hydrothorax, arrhythmia, cardiac sudden death and arterial thrombosis etc.So far, also there is no the medicine effectively treating dilated cardiomyopathy, only rely on and take cardiac tonic, diuresis source medicine or expand the preparation Western medicine symptom management such as blood vessel, but the multipair kidney of this type of Western medicine of long-term taking can cause very large burden, and can not thoroughly cure, if take into account pedestrian's work operation on heart or cardiac transplantation, the risk of its operation is larger, costly, and not general family can bear.

Chinese medicine is thought, dilated cardiomyopathy is " palpitation with fear ", " edema " or " the syndrome of dyspnea " etc., and multi-source accumulates from overworking, in being invaded by exogenous pathogen, aqueous vapor, thus causes the blood stasis of blood stagnant, need take treating both the principal and secondary aspects of a disease.

Summary of the invention

According to above the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy and preparation method thereof, it is for the inherent pathogenic factor of dilated cardiomyopathy, distinguish disease treating, with strong points, curative effect is fast, cost is low, and have no side effect, can reach and play good prevention effect, there is wide potential applicability in clinical practice.

Technical solution of the present invention is as follows: a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy, according to weight parts, is prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 5-8 part, Radix Astragali 10-15 part, Rhizoma Anemarrhenae 5-8 part, Radix Ginseng 7-10 part, Spica Prunellae 10-15 part, Rhizoma Chuanxiong 5-8 part, Flos Chrysanthemi 5-8 part, Ramulus Cinnamomi 5-8 part, Radix Rehmanniae 5-8 part, Poria 10-15 part, Radix Angelicae Sinensis 3-5 part, Radix Curcumae 5-8 part, Fructus Jujubae 8-10 part, Bulbus Fritillariae Cirrhosae 5-8 part, Folium Mori 5-8 part.

Treat a Chinese medicine preparation for dilated cardiomyopathy, according to weight parts, preferably prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 7 parts, the Radix Astragali 12 parts, the Rhizoma Anemarrhenae 7 parts, Radix Ginseng 8 parts, Spica Prunellae 12 parts, Rhizoma Chuanxiong 7 parts, Flos Chrysanthemi 7 parts, Ramulus Cinnamomi 6 parts, Radix Rehmanniae 7 parts, 12 parts, Poria, Radix Angelicae Sinensis 4 parts, Radix Curcumae 6 parts, Fructus Jujubae 9 parts, Bulbus Fritillariae Cirrhosae 6 parts, 6 parts, Folium Mori.

Treat a preparation method for the Chinese medicine fluid extract of dilated cardiomyopathy, step is as follows:

(1) raw mill is become fine powder, dilute after adding water with 60% ethanol as solvent, adopt percolation, collect just filtrate and enter a bottle A, continue diafiltration, until filtrate perusal is colourless stopping;

(2) collect filtrate, be evaporated to paste at 40-60 DEG C, after adding the first filtrate mixing in bottle A, obtain mixed liquor;

(3) use the above-mentioned mixed liquor of the ethanol dilution of 60% again, leave standstill 30 hours, after filtration, obtain the fluid extract that supernatant liquid is this Chinese medicine.

The mass ratio of raw materials quality and water is preferably 1:1.

Pharmacology analysis:

Semen Lepidii (Semen Descurainiae): nature and flavor are pungent, bitter cold; Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Cure mainly the dyspnea and cough with excessive sputum that sputum stops up lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.

The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation; Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.

The Rhizoma Anemarrhenae: have invigorate blood circulation, diuresis, stimulate the menstrual flow, grow sun, moisturize, Adjust-blood lipid, the function such as logical nine orifices, sharp joint, qi and blood invigorating, cure mainly the diseases such as stomachache, edema, postnatal blood stasis, traumatic injury.

Radix Ginseng: sweet in the mouth, micro-hardship is warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae.Weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.

Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian.This product bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain.

Rhizoma Chuanxiong: pungent loose temperature is led to, can blood circulation promoting and blood stasis dispelling, again can promoting the circulation of QI to relieve pain, are " the gas medicine in blood ", the sensible QI and blood effect of tool, therefore control the breast side of body, all pains of abdominal part of qi depression to blood stasis.Control the obstruction of qi in the chest and cardialgia of heart arteries and veins stasis blocking, control the hypochondriac pain of stagnation of QI due to depression of the liver, liver blood stasis, gather mass in the abdomen, the twinge of the breast side of body, control tumbling down damage, pain caused by ecchymoma.

Flos Chrysanthemi: wind and heat dispersing, suppressing the hyperactive liver improving eyesight, removing toxic substances and promoting subsidence of swelling, effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances, the disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.

Ramulus Cinnamomi: energy expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea is suffered from abdominal pain; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.

Radix Rehmanniae: clearing away heat and promoting production of body fluid, after cool, hemostasis; For hot blast impairment of YIN, crimson tongue excessive thirst, send out speckle dermexanthesis, haematemesis, epistaxis, laryngopharynx swelling and pain.Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid; For calentura excessive thirst, send out speckle dermexanthesis, yin asthenia generating intrinsic heat, haematemesis, epistaxis, diabetes, infectious hepatitis.

Poria: sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.

Radix Angelicae Sinensis: the pungent temperature of sweet in the mouth.Return liver heart spleen channel, can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving; Moisturize laxation.

Radix Curcumae: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice, for obnubilation, blood stasis internal resistance etc.Pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Containing volatile oil, wherein there are camphene, Camphora, curcumene; Also containing curcumin, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Still containing starch, fatty oil, rubber, weld, Eucarvone and phellandrene.

Fructus Jujubae: Fructus Jujubae is warm in nature, sweet in the mouth, has effect of vigorate qi and replenish the blood, invigorating the spleen and regulating the stomach, Eradicates wind, increases the serum transaminase for the treatment of anaphylactoid purpura, anemia, hypertension, acute, chronic hepatitis and liver cirrhosis patient and prevents transfusion reaction etc. all to have desirable effect; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger to press down cancer, anti-allergic effects; Material containing antifatigue effect in Fructus Jujubae, can strengthen the endurance of people; Fructus Jujubae also has and alleviates toxicant effect to liver injury; Flavone compound in Fructus Jujubae, has the effect of calm blood pressure lowering.

Bulbus Fritillariae Cirrhosae: this product bitter in the mouth, cold nature, returns lung meridian, has the merit of clearing heat, eliminating phlegm, relieving cough, can be used for treatment expectorant heat syndrome cough and breathes heavily, yellow thick card of coughing up phlegm; To hold concurrently again sugariness, therefore kind nourishing the lung to arrest cough, treatment lung has the card that scorching cough expectorant is few and sticky, and the deficiency syndrome such as deficiency of YIN cough caused by dryness chronic cough; Also have the merit of eliminating stagnation dissipating depression of QI, the uncomfortable in chest vexed card for the treatment of caused by combination of phlegm and heat, and the disease such as scrofula sucutaneous nodule.

Folium Mori: be used for the treatment of anemopyretic cold; Pathogenic wind-warm from the beginning of, fever and headache, perspiration and aversion to wind, cough chest pain; Or dryness of the lung dry cough without phlegm; Dry throat and mouth; Wind heat and liver-yang are disturbed; Conjunctival congestion and swelling pain; Can dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.

The invention has the advantages that: with natural Chinese medicine for raw material, utilize the comprehensive function treatment dilated cardiomyopathy of each taste medicine, each taste medicine Combination application, and control according to state of an illness plus-minus opinion, drug effect has synergism, to human non-toxic's side effect, and cheap, determined curative effect, reaches the object for the treatment of both the principal and secondary aspects of a disease.

Criterion of therapeutical effect:

All patients before the treatment, all carry out cardiac functional grading by NYHA (heart failure) cardiac function point system afterwards.

Effective: clinical symptoms and sign are significantly improved, and left ventricle obviously reduces, cardiac function improves more than II level;

Effective: clinical symptoms and sign are improved, left ventricle relative decrease, and cardiac function improves more than I level;

Invalid: clinical symptoms and sign are without improvement, and cardiac function improves less than I level.

Below enumerate several model case:

Case 1: Zhang, man, 32 years old, in the past healthy, daily physical work can be born.But before being admitted to hospital 45 days in fatigue afterwards suddenly out of breath, sleeping, two lower limb ankle joint edema can not be equalled; Palpation is shown in distension of jugular vein, 1.5cm under hepatomegaly rib; Auscultation heart rate 97 beats/min, companion's third heart sound gallop; Electrocardiogram display ST-T ripple changes, with atrial fibrillation; Doppler ultrasound detects left atrium and left ventricle dilation, and mitral incompetence.Clinical definite is dilated cardiomyopathy, and opened metoprolol and perindopril tablets (acertil), metoprolol eats 6.25ml once, 2 times on the one, but feels still uncomfortable in chest, and heart beating is uncomfortable.Use the Chinese medicine composition of this kind of orally taken for curing dilated cardiomyopathy instead, make uncomfortable in chest, out of breath, edema be relieved to gradually and disappear completely.Whole process is after treating 40 days, and check electrocardiogram shows ST-T ripple and replys normal and atrial fibrillation disappearance, and doppler ultrasound detects and shows that the left atrium of expansion and left ventricle form are also obviously recovered.Continue after leaving hospital to take medicine, continuous follow up 2 months, does not recur again.

Case 2:

Appoint certain, female, 45 years old, housewife.Readme cardiopalmus, out of breath, sometimes have a sleepless night, night is often watchful, can not put down sleeping, needs pillow with two medicated pillows, closely thinks over the past half year " climacteric syndrome " always, be several outpatient services and made up the prescription by " climacteric syndrome " symptomatic treatment, its poor effect.This time medical inspection, pareordia is heard and III level systolic murmur, increased heart rate and premature beat; Electrocardiogram display sinus tachycardia, atrial premature beat and ST-T ripple change widely; Doppler ultrasound detects left ventricle dilation and slight mitral orifice reflux, and clinical correction is diagnosed as dilated cardiomyopathy, with congestive heart failure.Apply the Chinese medicine composition of this treatment dilated cardiomyopathy, exhort that patient goes home every day 3 times, serveing on 2 months is a course for the treatment of.Patient is to be treated to be followed up a case by regular visits to after two months, and the above-mentioned clinical manifestation of primary disease disappears completely.

Case 3: Liu, man, 30 years old, company clerk.The year before, because flu is delayed, enter county hospital and be in hospital, sensation of oppression over the chest with shortness of breath when being admitted to hospital, can not put down sleeping, and color ultrasound shows, cardiac dilatation, and ejection fraction is 30, hydrothorax, and main left room expands, and conclusion was DCM (dilated cardiomyopathy) at that time, after rotatably district hospital again, conclusion is identical.When starting most to treat, take Western medicine digoxin, captopril, SHUANGKE and spironolactone, but only maintain one and a half months to be in hospital again, and the symptom having abdomen to rise more, suffer from diarrhoea, and very easily catch a cold, Western medicine causes physical function disorderly, takes the Chinese medicine composition of this invention, exhort that patient goes home decoction every day 3 doses, serveing on 24 doses is a course for the treatment of.Patient is to be treated to be followed up a case by regular visits to after two months, and the above-mentioned clinical manifestation of primary disease disappears completely.

Collect 120 routine outpatient service dilated cardiomyopathies, be divided into treatment group and matched group at random, often organize 60 examples; Man 60 example, female 60 example; Age 35-55 year, average 40 years old; The course of disease is the longest 1.5 years, the shortest 6 weeks, on average about 2 months.Each group of patient age symptom is formed without significant difference; Treatment group patient takes invention formulation and treats, and 3 times on the one, serve on 2 months.

The change of myocardial viability groups of grains and treatment of control group left ventricular end-diastolic internal diameter

The change of myocardial viability groups of grains and treatment of control group Left Ventricular Ejection Fraction

The change of ambition ratio before and after myocardial viability groups of grains and treatment of control group

The change of the cardiopalmus of TCM symptom score

The change of the asthma of TCM symptom score

The change of the cough of TCM symptom score

Comprehensive therapeutic effect analysis after myocardial viability groups of grains and treatment of control group:

Statistical result is as follows:

Group	N	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	60	5	54	1	98.3
Matched group	60	0	28	32	53.3

Result: in treatment group, in 60 routine patients, effective and healing accounts for 59 examples, accounts for 98.3%; Statistics total effective rate is 100%.

Show through above-mentioned patient clinical statistical result, the present invention is improved myocardium shrinkage function, immunity moderation function, significantly can improves the clinical symptoms of dilated cardiomyopathy, patients with heart failure, can be used safely in clinical.Compare with matched group, have curative effect obvious, the total effective rate for the treatment of CHF in Patients with Dilated is 98.3%, apparently higher than the total effective rate of 51.6% of matched group; Shown by clinical and patient's long-term taking, dilated cardiomyopathy can be made to obtain good therapeutic effect, obviously can improve clinical symptoms, the sign of dilated cardiomyopathy, and without obvious toxic-side effects.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to specific embodiment.

Embodiment 1:

Treat a Chinese medicine preparation for dilated cardiomyopathy, according to weight parts, prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 5 parts, the Radix Astragali 15 parts, the Rhizoma Anemarrhenae 5 parts, Radix Ginseng 10 parts, Spica Prunellae 10 parts, Rhizoma Chuanxiong 8 parts, Flos Chrysanthemi 5 parts, Ramulus Cinnamomi 8 parts, Radix Rehmanniae 5 parts, 15 parts, Poria, Radix Angelicae Sinensis 3 parts, Radix Curcumae 8 parts, Fructus Jujubae 8 parts, Bulbus Fritillariae Cirrhosae 8 parts, 5 parts, Folium Mori.

Embodiment 2:

Treat a Chinese medicine preparation for dilated cardiomyopathy, according to weight parts, prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 8 parts, the Radix Astragali 10 parts, the Rhizoma Anemarrhenae 8 parts, Radix Ginseng 7 parts, Spica Prunellae 15 parts, Rhizoma Chuanxiong 5 parts, Flos Chrysanthemi 8 parts, Ramulus Cinnamomi 5 parts, Radix Rehmanniae 8 parts, 10 parts, Poria, Radix Angelicae Sinensis 5 parts, Radix Curcumae 5 parts, Fructus Jujubae 10 parts, Bulbus Fritillariae Cirrhosae 5 parts, 8 parts, Folium Mori.

Embodiment 3:

Treat a Chinese medicine preparation for dilated cardiomyopathy, according to weight parts, preferably prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 7 parts, the Radix Astragali 12 parts, the Rhizoma Anemarrhenae 7 parts, Radix Ginseng 8 parts, Spica Prunellae 12 parts, Rhizoma Chuanxiong 7 parts, Flos Chrysanthemi 7 parts, Ramulus Cinnamomi 6 parts, Radix Rehmanniae 7 parts, 12 parts, Poria, Radix Angelicae Sinensis 4 parts, Radix Curcumae 6 parts, Fructus Jujubae 9 parts, Bulbus Fritillariae Cirrhosae 6 parts, 6 parts, Folium Mori.

Embodiment 4:

Treat a preparation method for the Chinese medicine fluid extract of dilated cardiomyopathy, step is as follows:

(1) become fine powder to get 1000g the raw mill in embodiment 1, flood 30 hours with 60% ethanol as solvent, dilute after adding water, adopt percolation, collect just filtrate 870ml and enter a bottle A, continue diafiltration, stop until filtrate perusal is colourless or micro-yellow;

(2) collect filtrate, be evaporated to paste at 40 DEG C, after adding the first filtrate mixing in bottle A, obtain mixed liquor;

(3) use the above-mentioned mixed liquor of the ethanol dilution of 60% to 1000ml again, leave standstill more than 30 hours, after filtration, obtain the fluid extract that supernatant liquid is this Chinese medicine.

Embodiment 5:

Treat a preparation method for the Chinese medicine fluid extract of dilated cardiomyopathy, step is as follows:

(1) become fine powder to get 1000g the raw mill in embodiment 2, flood 30 hours with 60% ethanol as solvent, dilute after adding water, adopt percolation, collect just filtrate 900ml and enter a bottle A, continue diafiltration, stop until filtrate perusal is colourless or micro-yellow;

(2) collect filtrate, be evaporated to paste at 60 DEG C, after adding the first filtrate mixing in bottle A, obtain mixed liquor;

(3) use the above-mentioned mixed liquor of the ethanol dilution of 60% to 1000ml again, leave standstill more than 30 hours, after filtration, obtain the fluid extract that supernatant liquid is this Chinese medicine.

Embodiment 6:

Treat a preparation method for the Chinese medicine fluid extract of dilated cardiomyopathy, step is as follows:

(1) become fine powder to get 1000g the raw mill in embodiment 3, flood 30 hours with 60% ethanol as solvent, dilute after adding water, adopt percolation, collect just filtrate 880ml and enter a bottle A, continue diafiltration, stop until filtrate perusal is colourless or micro-yellow;

(2) collect filtrate, be evaporated to paste at 60 DEG C, after adding the first filtrate mixing in bottle A, obtain mixed liquor;

(3) use the above-mentioned mixed liquor of the ethanol dilution of 60% to 1000ml again, leave standstill more than 30 hours, after filtration, obtain the fluid extract that supernatant liquid is this Chinese medicine.

Claims (4)

1. treat a Chinese medicine preparation for dilated cardiomyopathy, it is characterized in that: according to weight parts, prepared by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 5-8 part, Radix Astragali 10-15 part, Rhizoma Anemarrhenae 5-8 part, Radix Ginseng 7-10 part, Spica Prunellae 10-15 part, Rhizoma Chuanxiong 5-8 part, Flos Chrysanthemi 5-8 part, Ramulus Cinnamomi 5-8 part, Radix Rehmanniae 5-8 part, Poria 10-15 part, Radix Angelicae Sinensis 3-5 part, Radix Curcumae 5-8 part, Fructus Jujubae 8-10 part, Bulbus Fritillariae Cirrhosae 5-8 part, Folium Mori 5-8 part.

2. a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy according to claim 1, is characterized in that: according to weight parts, formulated by following raw material of Chinese medicine: Semen Lepidii (Semen Descurainiae) 7 parts, the Radix Astragali 12 parts, the Rhizoma Anemarrhenae 7 parts, Radix Ginseng 8 parts, Spica Prunellae 12 parts, Rhizoma Chuanxiong 7 parts, Flos Chrysanthemi 7 parts, Ramulus Cinnamomi 6 parts, Radix Rehmanniae 7 parts, 12 parts, Poria, Radix Angelicae Sinensis 4 parts, Radix Curcumae 6 parts, Fructus Jujubae 9 parts, Bulbus Fritillariae Cirrhosae 6 parts, 6 parts, Folium Mori.

3. a preparation method for the Chinese medicine fluid extract for the treatment of dilated cardiomyopathy according to claim 1, it is characterized in that, step is as follows:

(1) raw mill is become fine powder, dilute after adding water with 60% ethanol as solvent, adopt percolation, collect just filtrate and enter a bottle A, continue diafiltration, until filtrate perusal is colourless stopping;

(2) collect filtrate, be evaporated to paste at 40-60 DEG C, after adding the first filtrate mixing in bottle A, obtain mixed liquor;

(3) use the above-mentioned mixed liquor of the ethanol dilution of 60% again, leave standstill 30 hours, after filtration, obtain the fluid extract that supernatant liquid is this Chinese medicine.

4. a preparation method for the Chinese medicine fluid extract of dilated cardiomyopathy according to claim 3, is characterized in that the mass ratio of described raw materials quality and water is 1:1.