CN104338037A - Chinese medicinal capsule for treating insomnia - Google Patents
Chinese medicinal capsule for treating insomnia Download PDFInfo
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- CN104338037A CN104338037A CN201410595892.4A CN201410595892A CN104338037A CN 104338037 A CN104338037 A CN 104338037A CN 201410595892 A CN201410595892 A CN 201410595892A CN 104338037 A CN104338037 A CN 104338037A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention relates to a Chinese medicinal capsule for treating insomnia, and aims to effectively solve the administration problem in the treatment of insomnia. According to the technical scheme, the Chinese medicinal capsule is prepared from the following raw medicinal materials by weight: 8-12g of dangshen, 17-23g of large-head atractylodes rhizome, 25-35g of astragalus, 8-12g of Chinese angelica, 13-17g of poria with hostwood, 8-12g of thinleaf milkwort root-bark, 13-17g of lily, 25-35g of fried spina date seed, 13-17g of costus root, 8-12g of pinellia tuber, 13-17g of officinal magnolia bark, 25-35g of silktree albizzia bark, 10-14g of oriental waterplantain rhizome, 13-17g of blighted wheat, 7-11g of safflower, 5-7g of grassleaf sweetflag and 8-12g of liquoric root. The Chinese medicinal capsule is prepared by smashing the raw medicinal materials into fine powder of 100-120 meshes, and loading the fine powder into a capsule. The Chinese medicinal capsule is scientific in formula; according to the principle of formulating prescription of monarch, minister, assistant and guide, the raw medicinal materials support one another, and dialectical therapy is performed; the Chinese medicinal capsule has the effects of tranquilizing, allaying excitement and invigorating health effectively, is used for treating insomnia, is convenient to take, has a good curative effect, and is an innovation of insomnia treating medicaments.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese medicinal capsule of Cure for insomnia.
Background technology
Sleep is that human body maintains healthy requisite physiological process, and nowadays people's rhythm of life is more and more faster, and operating pressure increases gradually, and insomniac's number rapidly increases, and has had a strong impact on physical and mental health and the quality of life of people.The diagnostic criteria of Primary insomnia in " mental disorder diagnostic and statistical manual " (the 4th edition) of formulating according to Americanism science club.Main suit has difficulty in going to sleep and maintains dyskoimesis, onset at least 1 month; Sleep disordered eliminating is caused by narcolepsy, the obstacle such as sleep disorder, biorhythm sleep disorder relevant to breathing; The sleep disordered obstacle causing worries or the aspect such as society, occupation; Sleep disorder is got rid of by major depression, extensively caused by anxiety; Sleep disorder is got rid of caused by the psychological application of various physical disease, ethanol or medicine.
CSRS provides 5,000,000 parts of sleep disorder questionnaires in China in World Sleep Day in 2003, and survey result shows, and the ratio that respondent group exists sleep disorder is 38.4%.Insomnia also known as being insomnia, being often referred to and can not obtaining normal sleep in traditional medicine, or difficulty falling asleep and easily waking up for a kind of disease of feature.The pathogenesis of insomnia is a lot, and many and feelings will, diet, excessive thinking, overstrain, the factors such as physical weakness are relevant, but pathogenesis belongs to imbalance of YIN and YANG generally, overabundance of YANG leading to deficiency of YIN.In clinical practice, Cure for insomnia is main mainly with Western medicine, and because of its instant effect, but most of calm class medicine has dependency and drug resistance, and have hangover phenomenon, side effect is larger.Therefore Cure for insomnia becomes modern medicine and compares stubborn problem, and Chinese medicine has unique distinction in disease, though the existing Chinese medicine having treatment of insomnia patients, but for various reasons, it uses and curative effect unsatisfactory, and therefore, the improvement and bring new ideas on Cure for insomnia (disease) medicine is imperative.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicinal capsule of Cure for insomnia, effectively can solve the medication problem of Cure for insomnia (disease).
The technical scheme that the present invention solves is, this Chinese medicinal capsule is by weighing scale: Radix Codonopsis 8-12g, Rhizoma Atractylodis Macrocephalae 17-23g, Radix Astragali 25-35g, Radix Angelicae Sinensis 8-12g, Poria cum Radix Pini 13-17g, Radix Polygalae 8-12g, Bulbus Lilii 13-17g, Semen Ziziphi Spinosae (parched) 25-35g, Radix Aucklandiae (Radix Vladimiriae) 13-17g, Rhizoma Pinelliae 8-12g, Cortex Magnoliae Officinalis 13-17g, Cortex Albiziae 25-35g, Rhizoma Alismatis 10-14g, Fructus Tritici Levis 13-17g, Flos Carthami 7-11g, Rhizoma Acori Graminei 5-7g and Radix Glycyrrhizae 8-12g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, was distributed into capsule.
Scientific formula of the present invention, according to monarch, minister, the principles of formulating prescriptions of helping, making, supporting that mutually dialectical treatment has effect of tranquillizing and allaying excitement, health invigorating, is effective to Cure for insomnia, taking convenience, good effect, is the innovation on medicament for treating insomnia.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
The present invention can be provided by following examples in concrete enforcement.
Embodiment 1
The present invention is in concrete enforcement, by weighing scale: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 30g, Radix Angelicae Sinensis 10g, Poria cum Radix Pini 15g, Radix Polygalae 10g, Bulbus Lilii 15g, Semen Ziziphi Spinosae (parched) 30g, Radix Aucklandiae (Radix Vladimiriae) 15g, Rhizoma Pinelliae 10g, Cortex Magnoliae Officinalis 15g, Cortex Albiziae 30g, Rhizoma Alismatis 12g, Fructus Tritici Levis 15g, Flos Carthami 9g, Rhizoma Acori Graminei 6g and Radix Glycyrrhizae 10g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
Embodiment 2
The present invention is in concrete enforcement, also can by weighing scale: Radix Codonopsis 8.5g, Rhizoma Atractylodis Macrocephalae 22g, Radix Astragali 26g, Radix Angelicae Sinensis 11.5g, Poria cum Radix Pini 14g, Radix Polygalae 11.5g, Bulbus Lilii 14g, Semen Ziziphi Spinosae (parched) 34g, Radix Aucklandiae (Radix Vladimiriae) 14g, Rhizoma Pinelliae 11.5g, Cortex Magnoliae Officinalis 14g, Cortex Albiziae 34g, Rhizoma Alismatis 10.5g, Fructus Tritici Levis 16g, Flos Carthami 7.5g, Rhizoma Acori Graminei 6.5g and Radix Glycyrrhizae 8.5g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
Embodiment 3
The present invention is in concrete enforcement, also can by weighing scale: Radix Codonopsis 11.5g, Rhizoma Atractylodis Macrocephalae 18g, Radix Astragali 34g, Radix Angelicae Sinensis 8.5g, Poria cum Radix Pini 16g, Radix Polygalae 8.5g, Bulbus Lilii 16g, Semen Ziziphi Spinosae (parched) 26g, Radix Aucklandiae (Radix Vladimiriae) 16g, Rhizoma Pinelliae 8.5g, Cortex Magnoliae Officinalis 16g, Cortex Albiziae 26g, Rhizoma Alismatis 13g, Fructus Tritici Levis 14g, Flos Carthami 10.5g, Rhizoma Acori Graminei 5.5g and Radix Glycyrrhizae 11.5g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
Embodiment 4
The present invention is in concrete enforcement, also can by weighing scale: Radix Codonopsis 9-11g, Rhizoma Atractylodis Macrocephalae 19-21g, Radix Astragali 28-32g, Radix Angelicae Sinensis 9-11g, Poria cum Radix Pini 14.5-15.5g, Radix Polygalae 9-11g, Bulbus Lilii 14.5-15.5g, Semen Ziziphi Spinosae (parched) 28-32g, Radix Aucklandiae (Radix Vladimiriae) 14.5-15.5g, Rhizoma Pinelliae 9-11g, Cortex Magnoliae Officinalis 14.5-15.5g, Cortex Albiziae 28-32g, Rhizoma Alismatis 11-13g, Fructus Tritici Levis 14.5-15.5g, Flos Carthami 8.5-9.5g, Rhizoma Acori Graminei 5.5-6.5g and Radix Glycyrrhizae 9-11g make fine powder material medicine being ground into 100-120 mesh sieve as material medicine, be distributed into capsule, every 0.5g.
Scientific combination between medicine of the present invention, supports mutually, has effect of tranquillizing and allaying excitement, health invigorating, is effective to Cure for insomnia (disease), and through clinical trial, achieve very satisfied Advantageous Effects, interrelated data is as follows:
One, the standard of case is selected
Clinical main manifestations of having a sleepless night be the length of one's sleep degree of depth deficiency and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy then be insomnia all night, insomnia is one of common clinical disease, though do not belong to critical illness, hinder people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.All persons that has above-mentioned symptom, all as the standard selecting case.
Two, diagnostic criteria
All have difficulty falling asleep, can not sleep soundly, the length of one's sleep reduce, early awakening, wake up after cannot fall asleep again, again and again wake from a nightmare with a start, self-induction is all being had nightmares whole night, slept after energy do not recover; Disease time is changeable, and short person's a couple of days can take a turn for the better, and elder's last for days is difficult to recover; Easily waken up with a start, have to sound sensitive, what have is responsive to light; The people of a lot of insomnia is fond of daydreams; Long insomnia can cause neurasthenia and depression, and the disease of neurastheniac can increase the weight of insomnia, can be diagnosed as and suffer from insomnia.
Three, therapeutic scheme
All making a definite diagnosis suffers from insomnia person, capsule of the present invention all can be adopted to treat, take 3 every day, early, middle and late each 1 time, each 8, every 0.5g, after meal warm water delivery service, within 15 days, be a course for the treatment of, 4 courses for the treatment of evaluate curative effect, treatments period fasting zest greasy food.And adopting matched group simultaneously, the oral existing mind tranquilizing tablet of matched group (composition: Semen Ziziphi Spinosae, Radix Polygalae, Poria cum Radix Pini, Radix Glycyrrhizae), every day 3 times, warm water swallows (taking by mind tranquilizing tablet operation instruction) after meal.
Four, efficacy assessment standard
" new Chinese medicine guideline of clinical investigations " (Cure for insomnia) promulgated according to health ministry 1993 judges: (1) clinical recovery: recover normal the length of one's sleep or Nighttime sleep more than 6 hours; sleep deep, energetic after waking up.(2) effective: sleep is clearly better, and increases by more than 3 hours the length of one's sleep, Depth of sleep increases.(3) effective: symptom alleviates, the length of one's sleep, comparatively front increase was less than 3 hours.(4) invalid: after treatment, insomnia is not improved or increases the weight of on the contrary.
Five, statistical procedures
By above-mentioned diagnostic criteria, contrast therapy is carried out to make a definite diagnosis 171 routine patients, all from out-patient, age 15-65 year, average 40 years old; Wherein man 51 example, female 35 example; Age reckling 15 years old, the maximum 65 years old; The course of disease is the shortest 5 months, the longest 4 years.Patient is divided into treatment group and matched group at random, treats by the above-mentioned therapeutic scheme provided, wherein, treatment group 86 example (man 51 example, female 35 example) adopts capsule for treating of the present invention; Matched group 85 example (man 51 example, female 34 example) gives mind tranquilizing tablet treatment, and 4 courses for the treatment of add up curative effect, and statistical disposition result is as follows:
Group | N(people) | Recovery from illness | Effective | Effectively | Invalid | Effective percentage |
Treatment group | 86 | 27(31.4%) | 36(41.9%) | 20(23.2%) | 3(3.5%) | 96.5% |
Matched group | 85 | 18(21.2%) | 24(28.2%) | 18(21.2%) | 25(29.4%) | 70.6% |
(magic list) p < 0.05 is checked through Ridit, illustrate to there is significant difference between two groups, prompting treatment group curative effect is better than matched group, and capsule of the present invention finds no untoward reaction in experimentation, show drug safety, stable curative effect is reliable.
Six, conclusion
Above-mentioned data shows, the present invention has effect of tranquillizing and allaying excitement, health invigorating, and be effective to Cure for insomnia (disease), curative effect is up to more than 96%, reliable and stable, have no side effect, taking convenience, abundant raw material, easy manufacture, have very strong actual application value, be the innovation on Cure for insomnia (disease) medicine, economic and social benefit is remarkable.
Claims (5)
1. the Chinese medicinal capsule of a Cure for insomnia, it is characterized in that, by weighing scale: Radix Codonopsis 8-12g, Rhizoma Atractylodis Macrocephalae 17-23g, Radix Astragali 25-35g, Radix Angelicae Sinensis 8-12g, Poria cum Radix Pini 13-17g, Radix Polygalae 8-12g, Bulbus Lilii 13-17g, Semen Ziziphi Spinosae (parched) 25-35g, Radix Aucklandiae (Radix Vladimiriae) 13-17g, Rhizoma Pinelliae 8-12g, Cortex Magnoliae Officinalis 13-17g, Cortex Albiziae 25-35g, Rhizoma Alismatis 10-14g, Fructus Tritici Levis 13-17g, Flos Carthami 7-11g, Rhizoma Acori Graminei 5-7g and Radix Glycyrrhizae 8-12g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, was distributed into capsule.
2. the Chinese medicinal capsule of Cure for insomnia according to claim 1, it is characterized in that, by weighing scale: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 30g, Radix Angelicae Sinensis 10g, Poria cum Radix Pini 15g, Radix Polygalae 10g, Bulbus Lilii 15g, Semen Ziziphi Spinosae (parched) 30g, Radix Aucklandiae (Radix Vladimiriae) 15g, Rhizoma Pinelliae 10g, Cortex Magnoliae Officinalis 15g, Cortex Albiziae 30g, Rhizoma Alismatis 12g, Fructus Tritici Levis 15g, Flos Carthami 9g, Rhizoma Acori Graminei 6g and Radix Glycyrrhizae 10g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
3. the Chinese medicinal capsule of Cure for insomnia according to claim 1, it is characterized in that, by weighing scale: Radix Codonopsis 8.5g, Rhizoma Atractylodis Macrocephalae 22g, Radix Astragali 26g, Radix Angelicae Sinensis 11.5g, Poria cum Radix Pini 14g, Radix Polygalae 11.5g, Bulbus Lilii 14g, Semen Ziziphi Spinosae (parched) 34g, Radix Aucklandiae (Radix Vladimiriae) 14g, Rhizoma Pinelliae 11.5g, Cortex Magnoliae Officinalis 14g, Cortex Albiziae 34g, Rhizoma Alismatis 10.5g, Fructus Tritici Levis 16g, Flos Carthami 7.5g, Rhizoma Acori Graminei 6.5g and Radix Glycyrrhizae 8.5g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
4. the Chinese medicinal capsule of Cure for insomnia according to claim 1, it is characterized in that, by weighing scale: Radix Codonopsis 11.5g, Rhizoma Atractylodis Macrocephalae 18g, Radix Astragali 34g, Radix Angelicae Sinensis 8.5g, Poria cum Radix Pini 16g, Radix Polygalae 8.5g, Bulbus Lilii 16g, Semen Ziziphi Spinosae (parched) 26g, Radix Aucklandiae (Radix Vladimiriae) 16g, Rhizoma Pinelliae 8.5g, Cortex Magnoliae Officinalis 16g, Cortex Albiziae 26g, Rhizoma Alismatis 13g, Fructus Tritici Levis 14g, Flos Carthami 10.5g, Rhizoma Acori Graminei 5.5g and Radix Glycyrrhizae 11.5g make as material medicine, material medicine was ground into the fine powder of 100-120 mesh sieve, be distributed into capsule, every 0.5g.
5. the Chinese medicinal capsule of Cure for insomnia according to claim 1, it is characterized in that, by weighing scale: Radix Codonopsis 9-11g, Rhizoma Atractylodis Macrocephalae 19-21g, Radix Astragali 28-32g, Radix Angelicae Sinensis 9-11g, Poria cum Radix Pini 14.5-15.5g, Radix Polygalae 9-11g, Bulbus Lilii 14.5-15.5g, Semen Ziziphi Spinosae (parched) 28-32g, Radix Aucklandiae (Radix Vladimiriae) 14.5-15.5g, Rhizoma Pinelliae 9-11g, Cortex Magnoliae Officinalis 14.5-15.5g, Cortex Albiziae 28-32g, Rhizoma Alismatis 11-13g, Fructus Tritici Levis 14.5-15.5g, Flos Carthami 8.5-9.5g, Rhizoma Acori Graminei 5.5-6.5g and Radix Glycyrrhizae 9-11g makes fine powder material medicine being ground into 100-120 mesh sieve as material medicine, be distributed into capsule, every 0.5g.
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CN101129568A (en) * | 2007-08-08 | 2008-02-27 | 江国潮 | Orally taken traditional Chinese medicine for treating heart-spleen deficiency type anhypnia |
WO2008113118A1 (en) * | 2007-03-16 | 2008-09-25 | Medcina Group Pty Ltd | Compositions and methods for treating male infertility |
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WO2008113118A1 (en) * | 2007-03-16 | 2008-09-25 | Medcina Group Pty Ltd | Compositions and methods for treating male infertility |
CN101129568A (en) * | 2007-08-08 | 2008-02-27 | 江国潮 | Orally taken traditional Chinese medicine for treating heart-spleen deficiency type anhypnia |
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