CN104337842B - A kind of American cockroach medicinal material and preparation method thereof - Google Patents
A kind of American cockroach medicinal material and preparation method thereof Download PDFInfo
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- CN104337842B CN104337842B CN201410354006.9A CN201410354006A CN104337842B CN 104337842 B CN104337842 B CN 104337842B CN 201410354006 A CN201410354006 A CN 201410354006A CN 104337842 B CN104337842 B CN 104337842B
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Abstract
The present invention provides a kind of preparation methods of American cockroach medicinal material, it is that American cockroach after being put to death using non-heated method, is collected polypide, dry to get American cockroach medicinal material.The present invention also provides American cockroach medicinal materials prepared by this method.The present invention carries out the preparation of American cockroach medicinal material using electric shocking method, smother play, the cold water non-heated mode such as method of being drowned, compared with dead method being scalded with traditional boiling water, extract and free aminoacid content are significantly raised in medicinal material, show that the preparation method of medicinal material of the present invention is significantly better than traditional handicraft.
Description
Technical field
The present invention relates to a kind of American cockroach medicinal materials and preparation method thereof.
Background technology
American cockroach P erip laneta am ericana are Insecta Pterigota Blattaria Blattidae Periplaneta elder brother
Worm is commonly called as " cockroach ", be used as medicine first recorded in《Sheng Nong's herbal classic》.It is numerous studies have shown that chemical composition master in American cockroach
It is divided into two major classes.The first kind is that be big Lian have volatile pheromone component to pheromones to release in vitro, includes mainly
Sex pheromone and aggregation pheromone.Second class be amino acid and various insect neuropeptides, be present in its body chemistry at
Point.
Wherein, amino acid is to constitute organism protein and the related most basic substance with vital movement, is in biology
The base unit for constituting protein molecule in vivo has close relationship with the vital movement of biology.It has spy in antibody
Different physiological function is one of indispensable nutritional ingredient in organism.Amino acid is mainly used to prepare compound in medicine
Amino acid transfusion also serves as medicine and is used for synthetic polypeptide medicaments.Amino acid as drug has 100 kinds, wherein
The amino acid that amino acid including constituting protein has 20 kinds and constitutes nonprotein has more than 100 kinds.
The compound preparation being made of a variety of amino acid occupies in modern PN solution and " essential food " therapy
Very important status, to maintaining the nutrition of urgent patient, rescue patient vitals to have a positive effect, becoming can not in modern medical service
One of few medical kind.
American cockroach medicinal material tradition concocting method used at present is that adult bombay canary boiling water scalds extremely, dries or dries.
However, the tradition concocting method currently also rarely has research if appropriate for American cockroach medicinal material.
Invention content
With free aminoacid content, extract content in American cockroach medicinal material etc. for index in the present invention, to different processings
Method carries out comparative evaluation, to screen best concocting method.
The present invention provides the preparation methods of American cockroach medicinal material, it is to put to death American cockroach using non-heated method
Afterwards, polypide is collected, it is dry to get American cockroach medicinal material.
Wherein, the non-heated method is that electric shocking method, smother play or cold water are drowned method.
Further, the electric shocking method is that American cockroach is placed in high-voltage fence, under 2000~3000v voltages
Extremely.
Further, the smother play is that American cockroach is placed in vacuum bag, and vacuumizing makes its death by suffocation.
Further, the cold water method of being drowned is that American cockroach is placed in stainless steel to shine in net, will shine net and is immersed in cold water
Middle execution.
Wherein, the drying is low temperature drying, dries or air-dry to moisture≤10%.
The present invention studies have shown that later stage drying temperature at 60 DEG C, the quality of American cockroach medicinal material prepared by the present invention
Better than traditional processing procedure.Therefore, the low temperature drying that the present invention uses, the low temperature drying can continue to use traditional American cockroach
Drying temperature in concocting method --- it 60 DEG C, can be also dried when less than 60 DEG C.
The present invention also provides American cockroach medicinal materials prepared by the above method.
Wherein, it is calculated with anhydrous American cockroach medicinal material, ethanol soluble extractives content is in 26%w/w or more, free amine group
Acid content is in 2.0%w/w or more.
Further, it is calculated with anhydrous American cockroach medicinal material, ethanol soluble extractives content is 26-30%w/w, free ammonia
Base acid content is 2.0-3.0%w/w.
Further, it is calculated with anhydrous American cockroach medicinal material, ethanol soluble extractives content is 26-29%w/w, is dissociated
Amino acid content is 2.3-2.6%w/w.
It is with the American cockroach medicinal material the present invention also provides the preparation that above-mentioned American cockroach medicinal material is prepared
(such as American cockroach medicinal powder) or its extract are active constituent, in addition pharmaceutically common auxiliary material or complementary ingredient are prepared
Preparation.
Pharmaceutically acceptable auxiliary material of the present invention refers to the substance being included in addition to the active ingredient (s in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including phosphoric acid dioxy sodium and disodium hydrogen phosphate) etc.；Emulsifier include Tween-80, do not have sour sorb it is smooth,
Pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become the leading position of above-mentioned health products or pharmaceutical composition in treatment of diseases, and only play auxiliary effect, these are auxiliary
Assist effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.
The present invention carries out the preparation of American cockroach medicinal material using electric shocking method, smother play, the cold water non-heated mode such as method of being drowned,
Compared with scalding dead method with traditional boiling water, extract and free aminoacid content are significantly raised in medicinal material, show the system of medicinal material of the present invention
Preparation Method is significantly better than traditional handicraft.
Obviously, the above according to the present invention is not departing from this hair according to the ordinary technical knowledge and means of this field
Under the premise of bright above-mentioned basic fundamental thought, the modification, replacement or change of other diversified forms can also be made.
Below by way of the form of specific embodiment, the above of the present invention is described in further detail again.But no
The range that this should be interpreted as to the above-mentioned theme of the present invention is only limitted to embodiment below.It is all to be realized based on the above of the present invention
Technology all belong to the scope of the present invention.
Specific implementation mode
1 electric shocking method of embodiment prepares American cockroach medicinal material
By adult bombay canary, it is placed in high-voltage fence, is powered, the moment execution under 2000~3000v voltages is powered off, received
Collect polypide, is placed in heated-air circulation oven 60 DEG C of dryings to moisture≤10%.
2 smother play of embodiment prepares American cockroach medicinal material
Adult bombay canary is placed in vacuum bag, vacuumizing makes its death by suffocation, collects polypide, is placed in hot air circulation
60 DEG C of dryings are to moisture≤10% in baking oven.
3 cold water of embodiment be drowned method prepare American cockroach medicinal material
It is placed in adult bombay canary in stainless steel mesh, sieve is immersed in cold water, after its death, collects worm
Body is placed in heated-air circulation oven 60 DEG C of dryings to moisture≤10%.
The research of 4 American cockroach medicinal material preparation method of embodiment
1. American cockroach medicinal material processing
(1) electric shocking method
By adult bombay canary, it is placed in high-voltage fence, is powered, the moment execution under 2000~3000v voltages is powered off, received
Collect polypide, is placed in heated-air circulation oven 60 DEG C of dryings to moisture≤10%.
(2) smother play
Adult bombay canary is placed in vacuum bag, vacuumizing makes its death by suffocation, collects polypide, is placed in hot air circulation
60 DEG C of dryings are to moisture≤10% in baking oven.
(3) cold water is drowned method
It is placed in adult bombay canary in stainless steel mesh, sieve is immersed in cold water, after its death, collects worm
Body is placed in heated-air circulation oven 60 DEG C of dryings to moisture≤10%.
(4) boiling water scalds dead method
It is placed in adult bombay canary in the stainless-steel pan for filling boiling water, scalds extremely, collect polypide, is placed in hot air circulation baking
60 DEG C of dryings are to moisture≤10% in case.
2. determination of moisture
American cockroach medicinal material prepared by above method, is crushed with high speed disintegrator, crosses 40 mesh sieve, and determination of moisture is shone in sampling
Method (《Chinese Pharmacopoeia》Ⅸ the first methods of H of annex) measure moisture.
3. determination of extractives
According under ethanol soluble extractives measuring method item hot dipping (《Chinese Pharmacopoeia》Ⅹ A of annex) it measures, made with 50% ethyl alcohol
Solvent measures extract content.
4. Contents of Amino Acids
(1) sample preparation
Periplaneta Americana powder 10g is weighed, is set in 250ml flasks, adds 8 times of 65% alcohol reflux of amount extractions three times, 1.5 is small every time
When, merge extracting solution, filtering, filtrate decompression is concentrated into about 10ml, about 40ml boiling water, stirring and dissolving, standing is added to let cool, and divides and deoils
Layer, filtering, filtrate add distilled water to be settled to 50ml.
(2) prepared by reference substance solution
Precision, which is weighed, to be dried at 105 DEG C to the alanine reference substance 50mg of constant weight, is set in 100ml measuring bottles, simultaneously with water dissolution
It is diluted to scale, is shaken up, precision measures 5ml, sets in 100ml measuring bottles, is diluted with water to scale, shakes up to get (containing third per 1ml
25 μ g of propylhomoserin).
(3) preparation of standard curve
Precision measures reference substance solution 0.0ml, 0.2ml, 0.4ml, 0.6ml, 0.8ml, 1.0ml, is respectively placed in 10ml tools
Fill in test tube in, add water to 1ml, add 0.2mol/L citrate buffers (pH value 5.0) 1.0ml, 1% ascorbic acid solution 0.1ml,
Ninhydrin ethylene glycol monomethyl ether test solution 3.0ml, shakes up, and sets in boiling water bath and heats 15 minutes, takes out, lets cool, then adds 80% ethyl alcohol
3.0ml shakes up, according to spectrophotometry (《Chinese Pharmacopoeia》V B of annex) experiment, absorbance is measured at 570nm wavelength, with extinction
Degree is ordinate, and a concentration of abscissa draws standard curve.
(4) total amino acid assay in sample
Precision measures sample 2.0ml, sets in 100ml measuring bottles, is diluted with water to scale, shakes up.Precision measures 1ml, sets
In 10ml tool plug test tubes, the method under sighting target directrix curve preparation " adds 0.2mol/L citrate buffers (pH value 5.0) certainly
1.0ml " rise, measure absorbance in accordance with the law, from standard curve read test solution in amino acid content, calculate to get.
One, result
The American cockroach determination of extractives result of different concocting methods is as follows：
Table 1
The American cockroach free aminoacid content of different concocting methods is as follows：
Table 2
Four, conclusion
American cockroach medicinal material processing is carried out using electric shocking method, smother play, the cold water non-heated mode such as method of being drowned, is boiled with tradition
The dead method of having one's hair waved compares, and extract and free aminoacid content are significantly raised in medicinal material.
Claims (6)
1. the preparation method of American cockroach medicinal material, it is characterised in that：It is by American cockroach, using non-heated method put to death after,
Polypide is collected, it is dry to get American cockroach medicinal material；
Wherein, the non-heated method is smother play, and the smother play is that American cockroach is placed in vacuum plant, and vacuumizing makes
Its death by suffocation.
2. preparation method according to claim 1, it is characterised in that：The drying be low temperature drying, dry or air-dry to
Moisture≤10%.
3. American cockroach medicinal material prepared by claims 1 or 2 the method.
4. American cockroach medicinal material according to claim 3, it is characterised in that：It is calculated with anhydrous American cockroach medicinal material, alcohol
Dissolubility extract content is in 26%w/w or more, and free aminoacid content is in 2.0%w/w or more.
5. American cockroach medicinal material according to claim 4, it is characterised in that：It is calculated with anhydrous American cockroach medicinal material, alcohol
Dissolubility extract content is 26%-30%w/w, free aminoacid content 2.0%-3.0%w/w.
6. American cockroach medicinal material according to claim 5, it is characterised in that：It is calculated with anhydrous American cockroach medicinal material, alcohol
Dissolubility extract content is 26%-29%w/w, free aminoacid content 2.3%-2.6%w/w.
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| CN201410354006.9A CN104337842B (en) | 2013-08-02 | 2014-07-23 | A kind of American cockroach medicinal material and preparation method thereof |
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| CN201410354006.9A CN104337842B (en) | 2013-08-02 | 2014-07-23 | A kind of American cockroach medicinal material and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1961893A (en) * | 2005-11-08 | 2007-05-16 | 肖小芹 | Method for preparing extract of adult bombay canary |
| CN102846667A (en) * | 2012-08-23 | 2013-01-02 | 耿福能 | Preparation method for nanometer Periplaneta americana through low temperature drying |
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2014
- 2014-07-23 CN CN201410354006.9A patent/CN104337842B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1961893A (en) * | 2005-11-08 | 2007-05-16 | 肖小芹 | Method for preparing extract of adult bombay canary |
| CN102846667A (en) * | 2012-08-23 | 2013-01-02 | 耿福能 | Preparation method for nanometer Periplaneta americana through low temperature drying |
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Effective date of registration: 20190107 Address after: 615000 Xichang Airport Road, Sichuan Province Patentee after: Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd. Address before: Room 206, Building 5, Gaopeng Avenue, Chengdu High-tech Zone, Sichuan 610041 Patentee before: Chengdu Baicao Heji Technology Co., Ltd. |