CN104324024A - 心房纤颤的治疗 - Google Patents
心房纤颤的治疗 Download PDFInfo
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- CN104324024A CN104324024A CN201410474946.1A CN201410474946A CN104324024A CN 104324024 A CN104324024 A CN 104324024A CN 201410474946 A CN201410474946 A CN 201410474946A CN 104324024 A CN104324024 A CN 104324024A
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
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- 235000011164 potassium chloride Nutrition 0.000 description 1
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- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- CYSFLMHPYSPWKH-UHFFFAOYSA-N potassium;2-acetyloxyethyl(trimethyl)azanium Chemical compound [K+].CC(=O)OCC[N+](C)(C)C CYSFLMHPYSPWKH-UHFFFAOYSA-N 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000036593 pulmonary vascular resistance Effects 0.000 description 1
- 238000000306 qrs interval Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical group OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229940126121 sodium channel inhibitor Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229940071103 sulfosalicylate Drugs 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000000213 tachycardiac effect Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 239000000541 tocopherol-rich extract Substances 0.000 description 1
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- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US26192509P | 2009-11-17 | 2009-11-17 | |
US61/261,925 | 2009-11-17 |
Related Parent Applications (1)
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CN2010800519070A Division CN102665714A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
Publications (1)
Publication Number | Publication Date |
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CN104324024A true CN104324024A (zh) | 2015-02-04 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN201510364466.4A Pending CN105362264A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
CN201410474946.1A Pending CN104324024A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
CN2010800519070A Pending CN102665714A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
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CN201510364466.4A Pending CN105362264A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
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CN2010800519070A Pending CN102665714A (zh) | 2009-11-17 | 2010-11-16 | 心房纤颤的治疗 |
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US (1) | US8541464B2 (zh) |
EP (2) | EP2501381B1 (zh) |
JP (2) | JP6116908B2 (zh) |
CN (3) | CN105362264A (zh) |
DK (2) | DK3311810T3 (zh) |
ES (2) | ES2929185T3 (zh) |
HK (1) | HK1254495A1 (zh) |
HU (2) | HUE060876T2 (zh) |
PL (2) | PL2501381T3 (zh) |
RS (1) | RS63699B1 (zh) |
WO (1) | WO2011062906A2 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6116907B2 (ja) * | 2009-11-17 | 2017-04-19 | フヤ バイオサイエンス インターナショナル エルエルシー | サルカルディン及びその塩の緩速点滴 |
DK3311810T3 (da) * | 2009-11-17 | 2022-10-24 | Huyabio Int Llc | Anvendelse af sulcardin til behandling af atrieflimmer |
SG2013035662A (en) | 2013-05-08 | 2014-12-30 | Menicon Singapore Pte Ltd | Systems and methods for printing on a contact lens |
WO2020123824A1 (en) | 2018-12-13 | 2020-06-18 | Huya Bioscience International, Llc | Sulcardine administration for treatment of acute atrial fibrillation |
CN112638903B (zh) * | 2019-01-29 | 2022-08-26 | 沪亚生物国际有限公司 | 舒欣啶盐 |
CN112516136B (zh) * | 2019-09-17 | 2024-03-01 | 中国科学院上海药物研究所 | 硫酸舒欣啶在制备抗心衰产品中的应用 |
AU2021288056A1 (en) | 2020-06-12 | 2023-02-09 | Huyabio International, Llc | Sulcardine administration for treatment of acute atrial fibrillation |
CN114984004B (zh) * | 2022-05-25 | 2023-09-12 | 扬州中宝药业股份有限公司 | 硫酸舒欣啶在制备抗脓毒症药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1299813A (zh) * | 1999-12-10 | 2001-06-20 | 中国科学院上海药物研究所 | N-取代苄基或苯基芳香磺酰胺化合物及其用途 |
CN1939298A (zh) * | 2005-09-29 | 2007-04-04 | 中国科学院上海药物研究所 | 硫酸舒欣啶固体和靶向制剂及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6116907B2 (ja) * | 2009-11-17 | 2017-04-19 | フヤ バイオサイエンス インターナショナル エルエルシー | サルカルディン及びその塩の緩速点滴 |
DK3311810T3 (da) * | 2009-11-17 | 2022-10-24 | Huyabio Int Llc | Anvendelse af sulcardin til behandling af atrieflimmer |
-
2010
- 2010-11-16 DK DK17182709.0T patent/DK3311810T3/da active
- 2010-11-16 US US13/509,752 patent/US8541464B2/en active Active
- 2010-11-16 WO PCT/US2010/056857 patent/WO2011062906A2/en active Application Filing
- 2010-11-16 EP EP10832058.1A patent/EP2501381B1/en active Active
- 2010-11-16 PL PL10832058T patent/PL2501381T3/pl unknown
- 2010-11-16 CN CN201510364466.4A patent/CN105362264A/zh active Pending
- 2010-11-16 EP EP17182709.0A patent/EP3311810B1/en active Active
- 2010-11-16 CN CN201410474946.1A patent/CN104324024A/zh active Pending
- 2010-11-16 ES ES17182709T patent/ES2929185T3/es active Active
- 2010-11-16 HU HUE17182709A patent/HUE060876T2/hu unknown
- 2010-11-16 RS RS20220986A patent/RS63699B1/sr unknown
- 2010-11-16 CN CN2010800519070A patent/CN102665714A/zh active Pending
- 2010-11-16 HU HUE10832058A patent/HUE034007T2/en unknown
- 2010-11-16 JP JP2012539071A patent/JP6116908B2/ja active Active
- 2010-11-16 DK DK10832058.1T patent/DK2501381T3/da active
- 2010-11-16 PL PL17182709.0T patent/PL3311810T3/pl unknown
- 2010-11-16 ES ES10832058.1T patent/ES2644818T3/es active Active
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2015
- 2015-09-01 JP JP2015171604A patent/JP2016028054A/ja active Pending
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2018
- 2018-10-25 HK HK18113704.0A patent/HK1254495A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1299813A (zh) * | 1999-12-10 | 2001-06-20 | 中国科学院上海药物研究所 | N-取代苄基或苯基芳香磺酰胺化合物及其用途 |
CN1939298A (zh) * | 2005-09-29 | 2007-04-04 | 中国科学院上海药物研究所 | 硫酸舒欣啶固体和靶向制剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2501381A4 (en) | 2013-06-12 |
ES2644818T3 (es) | 2017-11-30 |
JP2013511473A (ja) | 2013-04-04 |
HK1254495A1 (zh) | 2019-07-19 |
PL3311810T3 (pl) | 2022-12-05 |
WO2011062906A9 (en) | 2011-10-06 |
JP2016028054A (ja) | 2016-02-25 |
HUE060876T2 (hu) | 2023-04-28 |
PL2501381T3 (pl) | 2018-02-28 |
DK3311810T3 (da) | 2022-10-24 |
WO2011062906A2 (en) | 2011-05-26 |
CN105362264A (zh) | 2016-03-02 |
US20120309810A1 (en) | 2012-12-06 |
JP6116908B2 (ja) | 2017-04-19 |
EP3311810A1 (en) | 2018-04-25 |
ES2929185T3 (es) | 2022-11-25 |
EP2501381A2 (en) | 2012-09-26 |
EP3311810B1 (en) | 2022-07-27 |
EP2501381B1 (en) | 2017-07-26 |
DK2501381T3 (da) | 2017-11-06 |
WO2011062906A8 (en) | 2012-02-09 |
RS63699B1 (sr) | 2022-11-30 |
US8541464B2 (en) | 2013-09-24 |
HUE034007T2 (en) | 2018-01-29 |
CN102665714A (zh) | 2012-09-12 |
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