CN104324012A - Pet active feed intake anthelmintic tablet - Google Patents

Abstract

The invention relates to a pet active feed intake anthelmintic tablet. The pet active feed intake anthelmintic tablet is prepared by taking beef as a phagostimulant, taking an anthelmintic as a raw material, adding starch and other auxiliary materials, mixing, pulping, granulating, drying and tabletting, wherein a beef extract and beef powder are added into beef, the using amount of the beef extract accounts for 20-100% of the total amount of pulping; and the beef powder accounts for 10-50% of the total amount of starch. The pet active feed intake anthelmintic tablet provided by the invention selects the beef with relatively low content of fat, good flavor and a wide range of sources as the phagostimulant to prepare the anthelmintic tablet, the feeding attraction rate can achieve 100% and the active feed intake effect is achieved.

Description

A kind of house pet initiatively searches for food anthelmintic sheet

Technical field

The present invention relates to a kind of house pet initiatively to search for food anthelmintic sheet.

Background technology

The tablet that tablet on current veterinary clinic is main conventional, the most frequently used school taste method is sugar-coat, and for the medicine of pungent road or bitter in the mouth, conventional means are fine ground rear gavage, spice or drinking-water.For the animal of Scale dependency, such administering mode is very convenient.But for the house pet such as dog, cat, the convenience of this administering mode is not as good as initiatively searching for food.Have bibliographical information, have the calcium tablet that house pet initiatively searches for food at present clinically, the medicine for zest tastes such as bitterness adopts the mode of clathrate or microcapsule to cover.But anthelmintic albendazole conventional clinically at present, fenbendazole, avilamycin, ivermectin are all without the tablet of initiatively searching for food.

Summary of the invention

Technical scheme of the present invention there is provided house pet and initiatively to search for food anthelmintic sheet.Present invention also offers the preparation method of this anthelmintic sheet.

The invention provides a kind of house pet initiatively to search for food anthelmintic sheet, it is using beef as phagostimulant, take anthelmintic as raw material, add starch and other adjuvant and be prepared into tablet through mixing, slurrying, granulation, oven dry, tabletting, wherein, beef adds with Carnis Bovis seu Bubali cream and beef powder, and wherein the consumption of Carnis Bovis seu Bubali cream accounts for the 20-100% of slurrying total amount; Beef powder accounts for the 10-50% of starch total amount.

Wherein, the consumption of described Carnis Bovis seu Bubali cream accounts for 60% of slurrying total amount; Beef powder accounts for 30% of starch total amount.

Wherein, described Carnis Bovis seu Bubali cream, the preparation method of beef powder are: get fresh beef and clean, boil after section, pull dried beef slices out and dry pulverizing in 80 DEG C, obtain beef powder; It is that the extractum shape of 1:1.2 saves backup that steamed beef soup is concentrated into density, obtains Carnis Bovis seu Bubali cream.

Wherein, described anthelmintic is one or more the mixing in albendazole, fenbendazole, avilamycin, ivermectin.

Present invention also offers the preparation method of described anthelmintic sheet, it comprises the steps:

A, get anthelmintic principal agent, starch and other adjuvant mixing;

B, get fresh beef clean, boil after section, pull out dried beef slices in 80 DEG C dry pulverize, obtain beef powder; It is that the extractum shape of 1:1.2 saves backup that steamed beef soup is concentrated into density, obtains Carnis Bovis seu Bubali cream;

C, slurrying;

D, soft material processed;

E, oven dry, tabletting, to obtain final product.

The present invention selects fatty less, raciness and the beef of wide material sources prepares expelling tablet as phagostimulant, increasing phagostimulant makes house pet initiatively search for food, the animal such as dog, cat likes the taste of meat corruption, and food calling rate can reach 100%, reaches the effect of initiatively searching for food.

Detailed description of the invention

1 material

1.1 medicines and reagent

Albendazole, fenbendazole, Changzhou Yabang Qihui Fine Chemicals Co., Ltd.; Starch, Pulvis Talci, dextrin, Chengdu Ke Lilong chemical reagent company limited; Acetonitrile (chromatographically pure), methanol (chromatographically pure), Fisher company; Other reagent are analytical pure, Chengdu Ke Long Chemical Co., Ltd.; Avilamycin, ivermectin reference substance, China Veterinary Drugs Supervisory Inst.; Beef is the edible fresh beef that food products market is enough bought.

1.2 instrument and equipment

Agilent-1260 high performance liquid chromatograph, Anjelen Sci. & Tech. Inc; UV-1800-PC type ultraviolet spectrophotometer, Shanghai Mei Puda Instrument Ltd.; ALC-201 type electronic balance, Sartorius AG; 201 type electric heating air blast thermostatic drying chambers, Chengdu electric oven factory; HX-1000A type high speed Universalpulverizer, Yongkang City, Jiangsu Province small stream bank five metals medical instrument factory; YK-80 type oscillating granulator, Chongqing, changzhou work drying equipment accessory company limited; T-AII single punch tablet machine, Wanhe Industry Manufacturing Co., Ltd., Liaocheng; RE-52CS type Rotary Evaporators, the sub-flourish biochemical instrument instrument factory in Shanghai.

2 methods

2.1 beef prepare

The beef of purchase is cleaned, boils after section, pull dried beef slices out and pulverize for subsequent use in 80 DEG C of oven dry.It is that the extractum shape of 1:1.2 saves backup that steamed beef soup is concentrated into density.

2.2 preliminary process tests

Select the specification of the conventional anthelmintic sheet of States Pharmacopoeia specifications to draft production prescription, albendazole 0.2g sheet, fenbendazole 0.1g sheet, avilamycin 5mg sheet, ivermectin 5mg sheet, sheet with 1g, 2g compacting, adds beef powder or Carnis Bovis seu Bubali cream, in table 1 by different proportion heavily respectively.

2.2.1 mixing takes principal agent, starch (beef powder), Pulvis Talci etc. by the formula that " table 1 " specifies and is placed in mixer, start stirring 1 hour.

2.2.2 slurrying specifies by " table 1 ", and formula takes Carnis Bovis seu Bubali cream, dextrin is placed in stainless steel cask, adds the mixing of the regulation water yield, becomes pasty state, be incubated for subsequent use with steam heating to suspension.

2.2.3 " 2 " are inserted in " 1 " by soft material processed, remove mixer after being stirred to graininess while hot, and granule is by 10 object stainless steel sifts.

2.2.4 dry the granule that sieves in 80 DEG C of baking ovens, dry 12 hours (moisture less than 10%), remove and save backup.2.2.5 granule is placed in mixer by total mixing, and add magnesium stearate and the aluminium hydroxide of recipe quantity, mix homogeneously, saves backup

2.2.5 the size of regulation exchanged into by the mould of tablet machine by tabletting, and sheet recanalization, to regulation sheet weight, adds the granule of mixing in feed hopper, start tabletting, timesharing selective examination sheet weight.

2.3 assay

2.3.1 albendazole

Get albendazole tablet 20, porphyrize, precision takes in right amount, and (being about equivalent to albendazole 20mg) puts in 100ml measuring bottle, add glacial acetic acid 10ml, the ultrasonic albendazole that makes dissolves, and adds ethanol to scale, shake up, filter, precision measures subsequent filtrate 5ml, puts in 100ml measuring bottle, with ethanol dilution to scale, shake up, measure absorbance at 295nm wavelength place, by C with ultraviolet-visible spectrophotometer ₁₅h ₁₃n ₃o ₃the absorptance of S be 444, calculate and get final product.

2.3.2 fenbendazole

Get albendazole tablet 20, porphyrize, precision takes in right amount, and (being about equivalent to Fen Benda azoles 30mg) puts in 100ml measuring bottle, add methanol 90ml, the ultrasonic Fen Benda azoles that makes dissolves, and adds methanol to scale, shake up, filter, precision measures subsequent filtrate 5ml, puts in 100ml measuring bottle, with methanol dilution to scale, shake up, measure absorbance at 294nm wavelength place, by C with ultraviolet-visible spectrophotometer ₁₅h ₁₃n ₃o ₃the absorptance of S be 490, calculate and get final product.

2.3.3 avilamycin

Chromatographic condition octadecylsilane chemically bonded silica is filler, and methanol-water (85:15) is mobile phase, and determined wavelength is 245nm, avilamycin B _1aand B _1bseparating degree should conform with the regulations.

Algoscopy takes this product 20, porphyrize, and precision takes in right amount (being about equivalent to avilamycin 20mg), is placed in 100ml measuring bottle, adds methanol and make dissolving, and be diluted to scale, filters, gets subsequent filtrate as need testing solution.Go avilamycin reference substance 20mg to be placed in 100ml measuring bottle, add methanol and make dissolving, and be diluted to scale, in contrast product solution.Respectively get 10 μ l and inject hplc determination peak area, calculate content by external standard method.

2.3.3 ivermectin

Chromatographic condition octadecylsilane chemically bonded silica is filler, and acetonitrile-methanol-water (53:35:12) is mobile phase, and determined wavelength is 254mm.Number of theoretical plate calculates by H2B1a peak and is not less than 2000, and the separating degree of ivermectin H2B1a and H2B1b is not less than 3.0, and ivermectin H2B1b peak is about 0.8 of H2B1a peak retention time.

Algoscopy takes this product 20, porphyrize, and precision takes in right amount (being about equivalent to ivermectin 20mg), is placed in 100ml measuring bottle, adds methanol and make dissolving, and be diluted to scale, filters, gets subsequent filtrate as need testing solution.Go ivermectin reference substance 20mg to be placed in 100ml measuring bottle, add methanol and make dissolving, and be diluted to scale, in contrast product solution.Respectively get 20 μ l and inject hplc determination peak area, calculate content by external standard method.

2.4 disintegration check item

With disintegration tester, this product is checked, open disintegration tester, by water temp. heating to 37 DEG C ± 1 DEG C, hanging basket is hung on metal rack by the stainless steel shaft of upper end, immerse in 1000ml beaker, 2.5cm at the bottom of distance cup when regulating hanging basket position that hanging basket is declined, when height of water level makes hanging basket rise, in underwater, screen cloth ensures that tablet does not go out the water surface, when water in the cup temperature 37 DEG C, a slice tablet is respectively put in 6 each pipes of hanging basket, put into baffle plate, minute is set 15 minutes, it is 30-32 beat/min that hanging basket moves up and down frequency, move up and down distance for 55mm ± 2mm, start disintegration tester to start to measure, after prompt time reaches 15 minutes, take out hanging basket, tablet should all by screen cloth or do not pass through screen cloth on a small quantity, on a small quantity should be not softening by screen cloth person, be judged to and conform with the regulations.If there have a slice to be judged in 6 to be against regulation, then separately get 6 and redeterminate.

2.5 initiatively search for food test

Often kind of a tablet gets 40,40 house pets of feeding (each 20 of dog, cat), every house pet 1, and record is initiatively searched for food situation.

2.6, according to the experimental result under " 2.5 " item, select the addition of Carnis Bovis seu Bubali cream and beef powder optimum, are then combined by two kinds of additions and are prepared into tablet, to ensure the active edibility of tablet, and rearrange test of initiatively searching for food.

3 results

3.1 each components of distributing according to " table 1 " prepare various dried beef slices, checked, show that content and the disintegration of each all conform with the regulations, the results are shown in Table 2 by assay and disintegration.

The various tablet indicator-specific statistics of table 2

3.2 initiatively search for food test

Often kind of a tablet gets 40, to feed 40 house pets (each 20 of dog, cat), every house pet 1, record situation of initiatively searching for food, find that the percentage ratio 2g sheet of initiatively searching for food all obviously increases after more than 60% higher than beef powder, Carnis Bovis seu Bubali cream addition higher than 1g sheet, Carnis Bovis seu Bubali cream, beef powder addition is all obviously increasing, in table 3 after more than 30%.

Table 3 is initiatively searched for food test

3.3 process optimization tests

Can obtain according to result " 3.2 ", Carnis Bovis seu Bubali cream addition all obviously increases after more than 60%, beef powder addition is all obviously increasing after more than 30%, and disintegration and content all can reach standards of pharmacopoeia, therefore, Carnis Bovis seu Bubali cream (60% of preparation volume of slurry) and beef powder (assuming that starch weight 30%) are added simultaneously, lay particular stress on as 2g, and carried out content, the detection of disintegration and test (with reference to method under " 2.5 ") of initiatively searching for food, can reach result content and disintegration pharmacopeia mark, percentage ratio of initiatively searching for food is 100%.In table 4.

4 conclusions

Shown by test, prepare albendazole 0.2g sheet, fenbendazole 0.1g sheet, avilamycin 5mg sheet, ivermectin 5mg sheet, with beef as phagostimulant, need to add Carnis Bovis seu Bubali cream and account for 60% (density is 1.2) of slurrying total amount and beef powder accounts for 30% of starch total amount, its food calling rate is 100%, reaches the effect of initiatively searching for food.

Claims (5)

1. a house pet initiatively searches for food anthelmintic sheet, it is characterized in that: it is using beef as phagostimulant, take anthelmintic as raw material, add starch and other adjuvant and be prepared into tablet through mixing, slurrying, granulation, oven dry, tabletting, wherein, beef adds with Carnis Bovis seu Bubali cream and beef powder, and wherein the consumption of Carnis Bovis seu Bubali cream accounts for the 20-100% of slurrying total amount; Beef powder accounts for the 10-50% of starch total amount.

2. anthelmintic sheet according to claim 1, is characterized in that: the consumption of described Carnis Bovis seu Bubali cream accounts for 60% of slurrying total amount; Beef powder accounts for 30% of starch total amount.

3. anthelmintic sheet according to claim 1 and 2, is characterized in that: described Carnis Bovis seu Bubali cream, the preparation method of beef powder are: get fresh beef and clean, boil after section, pulls dried beef slices out and dries pulverizing in 80 DEG C, obtain beef powder; It is that the extractum shape of 1:1.2 saves backup that steamed beef soup is concentrated into density, obtains Carnis Bovis seu Bubali cream.

4. anthelmintic sheet according to claim 1 and 2, is characterized in that: described anthelmintic is one or more the mixing in albendazole, fenbendazole, avilamycin, ivermectin.

5. the preparation method of the anthelmintic sheet described in claim 1-4 any one, it comprises the steps:

A, get anthelmintic, starch and other adjuvant mixing;

B, get fresh beef clean, boil after section, pull out dried beef slices in 80 DEG C dry pulverize, obtain beef powder; It is that the extractum shape of 1:1.2 saves backup that steamed beef soup is concentrated into density, obtains Carnis Bovis seu Bubali cream;

C, slurrying;

D, soft material processed;

E, oven dry, tabletting, to obtain final product.