CN104316445A - Optical fiber DNA molecule sensor based on inclined raster and manufacturing method and application thereof - Google Patents
Optical fiber DNA molecule sensor based on inclined raster and manufacturing method and application thereof Download PDFInfo
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- CN104316445A CN104316445A CN201410668891.8A CN201410668891A CN104316445A CN 104316445 A CN104316445 A CN 104316445A CN 201410668891 A CN201410668891 A CN 201410668891A CN 104316445 A CN104316445 A CN 104316445A
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- oblique raster
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Abstract
An optical fiber DNA molecule sensor based on an inclined raster comprises a silica optical fiber serving as transmission media, an inclined raster part inscribed on the silica optical fiber and a source DNA molecule probe decorated through the existing silanization technology at the inclined optical raster part, namely ssDNA, wherein a wideband light source used for providing light signals is arranged at one end of the silica optical fiber, a spectrograph is arranged at the other end of the silica optical fiber to detect the spectral change of the wideband light source after the wideband light source passes through the silica optical fiber and the inclined raster part, and the silica optical fiber comprises a wrapping layer and a fiber core. The inclined raster serves as a sensing element, and the optical fiber DNA molecule sensor has the advantages of being high in flexibility, small in size, resistant to corrosion, low in thermo-sensitive intersectionality, resistant to electromagnetic interference and the like.
Description
Technical field
The present invention relates to a kind of optical fiber DNA molecular sensor based on oblique raster and preparation method thereof and application, belong to the technical field of sensor.
Background technology
Optical fiber technology have highly sensitive, electromagnetism interference, resist chemical, size are little and the feature such as quick response.Therefore, types of fiber biology sensor is a kind of sensor of extensively research both at home and abroad at present.Compared with traditional fiber grating, oblique raster solves the limitation of conventional Bragg fiber grating in strength of fluid measurement in sensor field, and long-period fiber grating sensor volume is large and the shortcoming such as refractive index temperature cross sensitivity.Oblique raster as a kind of novel sensing arrangement, have concurrently cheap, make simple, easy maintenance, high reliability, therefore enjoy the concern of researcher based on the sensor of oblique raster.DNA molecular sensor based on optical fiber technology has very important application in various fields such as environmental monitoring, clinical examination, food inspection.But mainly there is following problem in the domestic and international research for types of fiber DNA molecular sensor at present:
1) both at home and abroad the optical fiber DNA molecular sensor of report is most based on special optical fiber or interferometer structure, exist expensive, build the problems such as complicated, refractive index temperature cross sensitivity and poor stability;
2) research about oblique raster is more, and the research being applied to DNA molecular sensory field is less.
Summary of the invention
For existing technical deficiency, the invention provides a kind of optical fiber DNA molecular sensor based on oblique raster.
The present invention also provides a kind of preparation method of above-mentioned DNA molecular sensor.
The present invention also provides a kind of method utilizing above-mentioned DNA sensor to measure liquid dna molecular conecentration.The present invention has highly sensitive, and volume is little, corrosion-resistant, the advantages such as low temperature-sensitive intercrossing and electromagnetism interference.
Technical scheme of the present invention is as follows:
A kind of optical fiber DNA molecular sensor based on oblique raster, comprise as the silica fibre of transmission medium and the oblique raster part inscribed on silica fibre, and at the source DNA molecular probe that described oblique raster part utilizes existing silyation technigue to modify, i.e. ssDNA; Be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre; Described silica fibre comprises covering and fibre core.
Preferred according to the present invention, described oblique raster part includes grating, and the angle ξ of described grating and described optical fiber radial direction is 2-10 °; Described oblique raster part along fiber axis to length be 1-2cm; The screen periods of described oblique raster part is: ∧
gthen, following phase-matching condition is met:
λ
Bragg＝2n
eff，core∧/cosξ；
Wherein, ∧=∧
gcos ξ; In formula, ξ is the angle of inclination of grating, i.e. the angle of described grating and described optical fiber radial direction;
N
eff, corewith
be the effective refractive index of fiber core guided mode and the i-th rank cladding mode respectively, ∧ is the cycle of the grating when ξ=0; ∧
git is the screen periods of oblique raster; λ
braggfor the bragg reflection wavelength of grating;
the resonance wavelength of the i-th rank cladding mode.
Preferred according to the present invention, the angle ξ of described grating and described optical fiber radial direction is 2 °, 4 ° or 10 °.
Preferred according to the present invention, the single-mode fiber SMF28 that the internal diameter of described silica fibre is 9 μm, external diameter is 125 μm.
Preferred according to the present invention, the broadband scanning LASER Light Source SM125 of described wideband light source to be wavelength be 1510nm-1590nm.
Preferred according to the present invention, described spectrometer is the MS9710C spectroanalysis instrument of Amway Company.This analyser can test the spectral characteristic of the wavelength coverage from 600nm to 1750nm, and ultimate resolution reaches 0.05nm.
A preparation method for above-mentioned DNA molecular sensor, comprises step as follows:
1) making of oblique raster part comprises step a-c:
A. optical fiber carries hydrogen process; Silica fibre is put into high pressure high-purity hydrogen and improve fiber core refractive index, for grating writing is ready;
B. oblique raster is carved into: adopt U-V writing to be carved into oblique raster part in conjunction with rotatable phase mask plate method on described silica fibre surface; Use KrF excimer laser, adjustment laser pulse exports energy and frequency; Rotatable phase mask plate, to reach the angle of inclination of expection;
C. annealing in process: again the silica fibre being carved with oblique raster part will be put into temperature-controlled cabinet annealing in process; Finally take out grating, observe its reflection and transmission spectrogram to determine the physical size of oblique raster;
2) steps d-f is comprised at the surface graft DNA molecular probe of oblique raster part:
D. activating pretreatment is carried out to oblique raster part surface, carry out silicone hydroxyl;
E. the oblique raster part silane reagent of silicone hydroxyl carries out silanization treatment, makes oblique raster part surface band last layer terminal amino group;
F. the functional groups amino of oblique raster part surface and ssDNA target molecule interact, and form DNA molecular probe;
3) be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre, namely obtains DNA molecular sensor.
Utilize a method for above-mentioned DNA molecular sensor measurement liquid dna molecular conecentration, comprise step as follows:
1) wavelength is the broadband scanning LASER Light Source SM125 of 1510nm-1590nm, is that to be coupled to one section of internal-and external diameter be in the single-mode fiber SMF28 of 9/125 μm for the optical patchcord input of APC type, and transmits in single-mode fiber under the constraint of covering through interface; This single-mode fiber utilize Ultra-Violet Laser mask plate inscribe the oblique raster part that fabrication techniques one segment length is 1cm, after light arrives described oblique raster part, the light meeting cladding mode radiation condition will be coupled in covering, with external environment generation energy exchange, cause being optical coupling out oblique raster;
2) calibrate: the liquid choosing known DNA molecular concentration, micro fluidic device is utilized to be entered by described liquid drain in described oblique raster part, and then utilize described DNA molecular sensor to measure it, detected speed and the size of resonance wavelength movement by described spectrometer, described DNA molecular concentration and relation physical quantity being detected are recorded in calibration;
3) after calibration, utilizing described DNA molecular sensor to measure DNA molecular concentration in testing liquid in real time, by detecting speed and the size of resonance wavelength movement, measuring the concentration of DNA molecular.In oblique raster part, utilize silyation technigue ssDNA molecule in its finishing, when oblique raster is partially filled certain density target dna (dsDNA) point period of the day from 11 p.m. to 1 a.m, ssDNA and dsDNA can match formation double-spiral structure, and then cause the refractive index of its oblique raster part to increase, the effective refractive index of cladding mode can change, thus causes the drift of the resonance wavelength of cladding mode coupled mode; The dsDNA of variable concentrations can cause the drift of resonance wavelength in various degree.
Advantage of the present invention:
(1) the present invention adopts oblique raster as senser element, and have highly sensitive, volume is little, corrosion-resistant, the advantages such as low temperature-sensitive intercrossing and electromagnetism interference.
(2) the present invention utilizes Ultra-Violet Laser mask plate to inscribe method on single-mode fiber, makes oblique raster structure, and utilizes silyation technigue to modify ssNDA molecule at optical fiber surface; Construct the bio-sensing probe with good stability and recyclability.
(3) the present invention makes testing liquid by oblique raster region by simple and easy microfluidic device, can realize the Real-Time Monitoring to liquid DNA concentration to be measured.
(4) sensing arrangement based on oblique raster of the present invention's making, has good temperature stability, and extremely responsive to DNA molecular, realizes the high specific to DNA and high-sensitivity detection.
Accompanying drawing explanation
Fig. 1 is the structural representation of DNA molecular sensor of the present invention;
Fig. 2 is the schematic diagram that the present invention carries out that on prepared oblique raster silanization treatment fixes ssNDA molecular process;
Fig. 3 is the fundamental diagram of DNA molecular sensor of the present invention;
Fig. 4 is the spectral characterization figure of DNA molecular sensor of the present invention, oblique raster part;
Fig. 5 be a kind of optical fiber DNA molecular sensor application based on oblique raster of the present invention when DNA molecular detects, the spectrum test figure of resonance wavelength movement.
Embodiment
Below in conjunction with accompanying drawing and embodiment, the invention will be further described, but be not limited thereto.
Embodiment 1,
As shown in Figure 1,3.
A kind of optical fiber DNA molecular sensor based on oblique raster, comprise as the silica fibre of transmission medium and the oblique raster part inscribed on silica fibre, and at the source DNA molecular probe that described oblique raster part utilizes existing silyation technigue to modify, i.e. ssDNA; Be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre; Described silica fibre comprises covering and fibre core.
Described oblique raster part includes grating, and the angle ξ of described grating and described optical fiber radial direction is 2 °, 4 ° or 10 °.
; Described oblique raster part along fiber axis to length be 1cm; The screen periods of described oblique raster part is: ∧
gthen, following phase-matching condition is met:
λ
Bragg＝2n
eff，core∧/cosξ；
Wherein, ∧=∧
gcos ξ; In formula, ξ is the angle of inclination of grating, i.e. the angle of described grating and described optical fiber radial direction; n
eff, corewith
be the effective refractive index of fiber core guided mode and the i-th rank cladding mode respectively, ∧ is the cycle of the grating when ξ=0; ∧
git is the screen periods of oblique raster; λ
braggfor the bragg reflection wavelength of grating,
the resonance wavelength of the i-th rank cladding mode.
Embodiment 2,
As described in Example 1 based on an optical fiber DNA molecular sensor for oblique raster, its difference is, the single-mode fiber SMF28 that the internal diameter of described silica fibre is 9 μm, external diameter is 125 μm.The broadband scanning LASER Light Source SM125 of described wideband light source to be wavelength be 1510nm-1590nm.Described spectrometer is the MS9710C spectroanalysis instrument of Amway Company.This analyser can test the spectral characteristic of the wavelength coverage from 600nm to 1750nm, and ultimate resolution reaches 0.05nm.
Embodiment 3,
As shown in Figure 2.
A preparation method for DNA molecular sensor as described in embodiment 1,2, comprises step as follows:
1) making of oblique raster part comprises step a-c:
A. optical fiber carries hydrogen process; Silica fibre is put into high pressure high-purity hydrogen and improve fiber core refractive index, for grating writing is ready;
B. oblique raster is carved into: adopt U-V writing to be carved into oblique raster part in conjunction with rotatable phase mask plate method on described silica fibre surface; Use KrF excimer laser, adjustment laser pulse exports energy and frequency; Rotatable phase mask plate, to reach the angle of inclination of expection;
C. annealing in process: again the silica fibre being carved with oblique raster part will be put into temperature-controlled cabinet annealing in process; Finally take out grating, observe its reflection and transmission spectrogram to determine the physical size of oblique raster;
2) steps d-f is comprised at the surface graft DNA molecular probe of oblique raster part:
D. activating pretreatment is carried out to oblique raster part surface, carry out silicone hydroxyl;
E. the oblique raster part silane reagent of silicone hydroxyl carries out silanization treatment, makes oblique raster part surface band last layer terminal amino group;
F. the functional groups amino of oblique raster part surface and ssDNA target molecule interact, and form DNA molecular probe;
3) be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre, namely obtains DNA molecular sensor.
Embodiment 4,
Utilize a method for DNA molecular sensor measurement liquid dna molecular conecentration as described in embodiment 1-3, comprise step as follows:
1) wavelength is the broadband scanning LASER Light Source SM125 of 1510nm-1590nm, is that to be coupled to one section of internal-and external diameter be in the single-mode fiber SMF28 of 9/125 μm for the optical patchcord input of APC type, and transmits in single-mode fiber under the constraint of covering through interface; This single-mode fiber utilize Ultra-Violet Laser mask plate inscribe the oblique raster part that fabrication techniques one segment length is 1cm, after light arrives described oblique raster part, the light meeting cladding mode radiation condition will be coupled in covering, with external environment generation energy exchange, cause being optical coupling out oblique raster;
2) calibrate: the liquid choosing known DNA molecular concentration, micro fluidic device is utilized to be entered by described liquid drain in described oblique raster part, and then utilize described DNA molecular sensor to measure it, detected speed and the size of resonance wavelength movement by described spectrometer, described DNA molecular concentration and relation physical quantity being detected are recorded in calibration;
3) after calibration, utilizing described DNA molecular sensor to measure DNA molecular concentration in testing liquid in real time, by detecting speed and the size of resonance wavelength movement, measuring the concentration of DNA molecular.In oblique raster part, utilize silyation technigue ssDNA molecule in its finishing, when oblique raster is partially filled certain density target dna (dsDNA) point period of the day from 11 p.m. to 1 a.m, ssDNA and dsDNA can match formation double-spiral structure, and then cause the refractive index of its oblique raster part to increase, the effective refractive index of cladding mode can change, thus causes the drift of the resonance wavelength of cladding mode coupled mode; The dsDNA of variable concentrations can cause the drift of resonance wavelength in various degree.
Fig. 4 is a kind of optical fiber DNA molecular sensor based on oblique raster of the present invention, the spectral characterization figure of oblique raster.The prepared DNA probe based on oblique raster is directly docked with wideband light source and spectrometer, measures its transmitted spectrum.Have Fig. 4 known, the single transmission peaks of the rightmost side is that the Bragg reflection of oblique raster causes, and this pattern is also called the fibre core pattern of oblique raster.The a series of transmission peaks in left side is caused by covering coupled modes, is therefore also called the cladding mode of oblique raster.Peak value due to cladding mode is subject to the sensitive modulation of oblique raster surrounding environment refractive index, and along with the change of refractive index in general biological respinse, therefore, this structure is expected to there is important application in bio-sensing field.
Fig. 5 is detection method lab diagram described in the embodiment of the present invention 4, the relation curve that testing liquid DNA molecular concentration and spectral transmission peak change.Can find out, when DNA molecular concentration to be measured becomes large, spectrum projection peak is to the significantly movement of long wave direction.When oblique raster inclination angle is 4 °, in the process that DNA molecular concentration increases gradually, the resonant wavelength 1553,44nm of typical case's cladding mode is moved to 1553.57nm. and moves 0.13nm. and utilize the movement of this resonance wavelength effectively can measure DNA concentration.
By reference to the accompanying drawings the specific embodiment of the present invention is described although above-mentioned; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme of the present invention, those skilled in the art do not need to pay various amendment or distortion that creative work can make still within protection scope of the present invention.
Claims (8)
1. the optical fiber DNA molecular sensor based on oblique raster, it is characterized in that, described sensor comprises as the silica fibre of transmission medium and the oblique raster part inscribed on silica fibre, and at the source DNA molecular probe that described oblique raster part utilizes existing silyation technigue to modify, i.e. ssDNA; Be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre; Described silica fibre comprises covering and fibre core.
2. a kind of optical fiber DNA molecular sensor based on oblique raster according to claim 1, it is characterized in that, described oblique raster part includes grating, and the angle ξ of described grating and described optical fiber radial direction is 2-10 °; Described oblique raster part along fiber axis to length be 1-2cm; The screen periods of described oblique raster part is: ∧
g
Then, following phase-matching condition is met:
Wherein, ∧=∧
gcos ξ; In formula, ξ is the angle of inclination of grating, i.e. the angle of described grating and described optical fiber radial direction; n
eff, corewith
be the effective refractive index of fiber core guided mode and the i-th rank cladding mode respectively, ∧ is the cycle of the grating when ξ=0; ∧
git is the screen periods of oblique raster; λ
braggfor the bragg reflection wavelength of grating;
the resonance wavelength of the i-th rank cladding mode.
3. a kind of optical fiber DNA molecular sensor based on oblique raster according to claim 2, is characterized in that, the angle ξ of described grating and described optical fiber radial direction is 2 °, 4 ° or 10 °.
4. a kind of optical fiber DNA molecular sensor based on oblique raster according to claim 1, is characterized in that, the internal diameter of described silica fibre is 9 μm, single-mode fiber SMF28 that external diameter is 125 μm.
5. a kind of optical fiber DNA molecular sensor based on oblique raster according to claim 1, is characterized in that, the broadband scanning LASER Light Source SM125 of described wideband light source to be wavelength be 1510nm-1590nm.
6. a kind of optical fiber DNA molecular sensor based on oblique raster according to claim 1, it is characterized in that, described spectrometer is the MS9710C spectroanalysis instrument of Amway Company.This analyser can test the spectral characteristic of the wavelength coverage from 600nm to 1750nm, and ultimate resolution reaches 0.05nm.
7. the preparation method of DNA molecular sensor as described in claim 1-6 any one, comprises step as follows:
1) making of oblique raster part comprises step a-c:
A. optical fiber carries hydrogen process;
B. oblique raster is carved into: adopt U-V writing to be carved into oblique raster part in conjunction with rotatable phase mask plate method on described silica fibre surface;
C. annealing in process: again the silica fibre being carved with oblique raster part will be put into temperature-controlled cabinet annealing in process;
2) steps d-f is comprised at the surface graft DNA molecular probe of oblique raster part:
D. activating pretreatment is carried out to oblique raster part surface, carry out silicone hydroxyl;
E. the oblique raster part silane reagent of silicone hydroxyl carries out silanization treatment, makes oblique raster part surface band last layer terminal amino group;
F. the functional groups amino of oblique raster part surface and ssDNA target molecule interact, and form DNA molecular probe;
3) be provided with the wideband light source providing light signal in one end of described silica fibre, the other end is provided with spectrometer, to detect the spectrum change of described wideband light source after oblique raster part described in silica fibre, namely obtains DNA molecular sensor.
8. utilize a method for DNA molecular sensor measurement liquid dna molecular conecentration as described in claim 1-6 any one, comprise step as follows:
1) wavelength is the broadband scanning LASER Light Source SM125 of 1510nm-1590nm, is that to be coupled to one section of internal-and external diameter be in the single-mode fiber SMF28 of 9/125 μm for the optical patchcord input of APC type, and transmits in single-mode fiber under the constraint of covering through interface;
2) calibrate: the liquid choosing known DNA molecular concentration, micro fluidic device is utilized to be entered by described liquid drain in described oblique raster part, and then utilize described DNA molecular sensor to measure it, detected speed and the size of resonance wavelength movement by described spectrometer, described DNA molecular concentration and relation physical quantity being detected are recorded in calibration;
3) after calibration, utilizing described DNA molecular sensor to measure DNA molecular concentration in testing liquid in real time, by detecting speed and the size of resonance wavelength movement, measuring the concentration of DNA molecular.
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| CN114185129A (en) * | 2022-02-15 | 2022-03-15 | 深圳奥斯诺导航科技有限公司 | Method for writing inclined grating polarization filter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105136741A (en) * | 2015-04-30 | 2015-12-09 | 西北工业大学 | Graphene coated tilted fiber grating-based liquid refractive index sensor |
| CN105758827A (en) * | 2016-05-04 | 2016-07-13 | 中国计量大学 | Protein detection fiber optic sensor based on TFBG-SPR |
| CN106990248A (en) * | 2017-04-25 | 2017-07-28 | 重庆理工大学 | A kind of preparation method and detection method of the NDV immunosensors based on 81 ° of TFG |
| CN108872110A (en) * | 2018-07-04 | 2018-11-23 | 暨南大学 | A kind of high refractive index sensitivity optical fiber microfluidic sensor and preparation method thereof |
| CN108872110B (en) * | 2018-07-04 | 2020-12-11 | 暨南大学 | High-refractive-index-sensitivity optical fiber micro-flow sensor and preparation method thereof |
| CN112773328A (en) * | 2020-12-11 | 2021-05-11 | 北京信息科技大学 | Embolism patch detection optical fiber Raman probe based on tilted grating |
| CN112902862A (en) * | 2021-01-12 | 2021-06-04 | 河南渡盈光电科技有限公司 | Deflection sensor based on chirped fiber grating resonant cavity and manufacturing method thereof |
| CN113340854A (en) * | 2021-06-07 | 2021-09-03 | 西安石油大学 | Biochemical sensor based on reflection type inclined fiber grating probe and manufacturing method |
| CN114185129A (en) * | 2022-02-15 | 2022-03-15 | 深圳奥斯诺导航科技有限公司 | Method for writing inclined grating polarization filter |
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