CN104306859A - 一种治疗糜烂型脚气的软膏及其制备方法 - Google Patents

一种治疗糜烂型脚气的软膏及其制备方法 Download PDF

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CN104306859A
CN104306859A CN201410501820.9A CN201410501820A CN104306859A CN 104306859 A CN104306859 A CN 104306859A CN 201410501820 A CN201410501820 A CN 201410501820A CN 104306859 A CN104306859 A CN 104306859A
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Abstract

一种治疗糜烂型脚气的软膏及其制备方法。糜烂型脚气是最为多见的一种，好发于第三与第四，第四与第五趾间。初起趾间潮湿，浸渍发白，干涸脱屑后，剥去皮屑为湿润、潮红的糜烂面或伴有裂口，有奇痒，易继发感染。本发明治疗糜烂型脚气的软膏；由以下重量份数的原料制成：厚朴8～11份、半边莲6～9份、白蔻6～9份、石菖蒲8～11份、过江藤5～8份、络石藤5～8份、茅根5～8份、巴豆5～8份、七叶莲5～8份、米糠蜡12～15份、活性炭10～12份、丁香油35～40份。软膏配方中各组分协同发挥作用，药效明显。

Description

一种治疗糜烂型脚气的软膏及其制备方法
技术领域
本发明属于中药技术领域，具体为一种治疗糜烂型脚气的软膏及其制备方法。
背景技术
在所有的脚气类型中糜烂型脚气是最为多见的一种，好发于第三与第四，第四与第五趾间。初起趾间潮湿，浸渍发白，干涸脱屑后，剥去皮屑为湿润、潮红的糜烂面或伴有裂口，有奇痒，易继发感染。此型足癣的致病菌尤喜在潮湿、温暖的环境里生长繁衍。因而当其长期寄生于伴有多汗的趾间时，易致表皮层皲裂，并因湿润浸渍而发白。多见于足多汗或经常穿透气性差的雨鞋、胶鞋的人，角质贮水过多而浸渍发白。
治疗方法，包括外用硝酸咪康唑软膏， 复方酮康唑软膏或者足光散等药剂。
发明内容
本发明的目的是提供一种疗效突出、多种药物复合、工艺简单的治疗糜烂型脚气的软膏及其制备方法。
本发明治疗糜烂型脚气的软膏；由以下重量份数的原料制成：厚朴8～11份、半边莲6～9份、白蔻6～9份、石菖蒲8～11份、过江藤5～8份、络石藤5～8份、茅根5～8份、巴豆5～8份、七叶莲5～8份、米糠蜡12～15份、活性炭10～12份、丁香油35～40份。
作为优选，该治疗糜烂型脚气的软膏；由以下重量份数的原料制成：厚朴9份、半边莲8份、白蔻7份、石菖蒲9份、过江藤6份、络石藤6份、茅根6份、巴豆6份、七叶莲6份、米糠蜡12份、活性炭10份、丁香油38份。
制备该治疗糜烂型脚气软膏的方法，、包括以下步骤：
a、将所属重量分数的过江藤、络石藤、茅根、巴豆、七叶莲分别粉碎成100目的粉末，加入到所述重量份数的丁香油中，然后加热到100℃～110℃保持30～40分钟，过滤取其滤液；
b、将所述重量份数的厚朴、半边莲、白蔻、 石菖蒲，分别粉碎成200目以上的粉末；
c、将步骤a中混合物加热到78℃～82℃，然后加入所述重量份数的米糠蜡、活性炭，搅拌均匀后，再加入步骤b中的药粉，混合均匀后，冷却即得。
该治疗糜烂型脚气的软膏配方中，厚朴味辛、性温，具有行气化湿、温中止痛、降逆平喘的功效。半边莲具备利尿消肿，清热解毒等功效。白蔻理气宽中，燥寒湿，解酒毒。石菖蒲理气，活血，散风，去湿。过江藤行血散结，消积止痛。络石藤具有祛风除湿，通络止痛，清热凉血，解毒消肿的功效。茅根凉血止血，清热解毒。巴豆泻寒积，通关窍，逐痰，行水，杀虫。七叶莲舒筋活络，行气祛湿，散寒祛风，祛湿止泻。米糠蜡是一种坚硬，不发粘，熔点高天然蜡，其主要成分是脂肪醇和脂肪酸。活性炭又称活性炭黑。具有矿晶分子结构的颗粒，其孔多，孔隙大，呈晶体排列，针对车内甲醛、苯系、氨、TVOC、异味、细菌螨虫等有害物质的消毒净化功能尤为显著。丁香油治胃寒痛胀、呃逆、吐泻、痹痛，疝痛，口臭，牙痛。软膏配方中各组分协同发挥作用，药效明显。
有关临床资料如下：
1．一般资料：
糜烂型脚气患者共866例，其中男651例，女215例；年龄13～68岁，平均40.1岁；病程1周～3年。随机平均分为治疗组和对照组。
2．诊断标准：
糜烂型脚气主要表现为第三和第四趾间，甚至可波及全趾间皮肤浸软，部分趾间皮肤皲裂，有时露出红色糜烂面，有臭味。可引起丹毒、癣菌病等合并症。皮疹夏重冬轻。
3.治疗方法：
治疗组接受本发明实施例1中软膏临床治疗，洗脚后涂到患处，每日三次，7天为一疗程,对照组接受硝酸咪康唑软膏临床治疗，洗脚后涂到患处，每日三次，七天为一疗程,两个疗程后观察疗效。
4．疗效判定标准：
痊愈: 皮损消退, 自觉症状消失, 抽查真菌镜检阴性。有效: 皮损消退40%以上, 自觉症状明显减轻。无效: 皮损消退小于40%, 自觉症状无明显好转, 真菌镜检阳性。
 
具体实施方式
下面给出的实施例拟对本发明作进一步说明，但不能理解为是对本发明保护范围的限制，本领域技术人员根据本发明内容对本发明的一些非本质的改进和调整，仍属于本发明的保护范围。
实施例1：
a、取过江藤6克、络石藤6克、茅根6克、巴豆6克、七叶莲6克分别粉碎成100目的粉末，加入到38克的丁香油中，然后加热到100℃～110℃保持30～40分钟，过滤取其滤液；
b、取厚朴9克、半边莲8克、 白蔻7克、石菖蒲9克，分别粉碎成200目以上的粉末；
c、将步骤a中混合物加热到78℃～82℃，然后加入米糠蜡12克、活性炭10克，搅拌均匀后，再加入步骤b中的药粉，混合均匀后，冷却即得。
实施例2：
a、取过江藤5克、络石藤5克、茅根5克、巴豆5克、七叶莲5克分别粉碎成100目的粉末，加入到35克的丁香油中，然后加热到100℃～110℃保持30～40分钟，过滤取其滤液；
b、取厚朴8克、半边莲6克、 白蔻6克、石菖蒲8克，分别粉碎成200目以上的粉末；
c、将步骤a中混合物加热到78℃～82℃，然后加入米糠蜡12克、活性炭10克，搅拌均匀后，再加入步骤b中的药粉，混合均匀后，冷却即得。
实施例3：
a、取过江藤8克、络石藤8克、茅根8克、巴豆8克、七叶莲8克分别粉碎成100目的粉末，加入到40克的丁香油中，然后加热到100℃～110℃保持30～40分钟，过滤取其滤液；
b、取厚朴11克、半边莲9克、 白蔻9克、石菖蒲11克，分别粉碎成200目以上的粉末；
c、将步骤a中混合物加热到78℃～82℃，然后加入米糠蜡15克、活性炭12克，搅拌均匀后，再加入步骤b中的药粉，混合均匀后，冷却即得。

Claims (3)

1.一种治疗糜烂型脚气的软膏；其特征在于由以下重量份数的原料：厚朴8～11份、半边莲6～9份、白蔻6～9份、 石菖蒲8～11份、 过江藤5～8份、络石藤5～8份、 茅根5～8份、 巴豆5～8份、 七叶莲5～8份、 米糠蜡12～15份、活性炭10～12份、丁香油35～40份。
2.根据权利要求1所述治疗糜烂型脚气的软膏；其特征在于由以下重量份数的原料制成：厚朴9份、半边莲8份、 白蔻7份、 石菖蒲9份、 过江藤6份、络石藤6份、 茅根6份、 巴豆6份、 七叶莲6份、 米糠蜡12份、活性炭10份、丁香油38。
3.一种制备权利要求1所述所述治疗糜烂型脚气软膏的方法，其特征在于包括以下步骤：
a、将所述重量份数的过江藤、络石藤、 茅根、 巴豆、 七叶莲分别粉碎成100目的粉末，加入到所述重量份数的丁香油中，然后加热到100℃～110℃保持30～40分钟，过滤取其滤液；
b、将所述重量份数的厚朴、半边莲、白蔻、 石菖蒲，分别粉碎成200目以上的粉末；
c、将步骤a中混合物加热到78℃～82℃，然后加入所述重量份数的米糠蜡、活性炭，搅拌均匀后，再加入步骤b中的药粉，混合均匀后，冷却即得。
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CN106344837A (zh) * 2016-11-14 2017-01-25 河南中医药大学 一种用于治疗脚气的中药组合物
CN107510803A (zh) * 2017-09-01 2017-12-26 广西叶茂生物科技有限公司 一种脚气清洗液

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