CN104306798A - Traditional Chinese medicine dispersible tablet for treating viral pneumonia and preparing method thereof - Google Patents
Traditional Chinese medicine dispersible tablet for treating viral pneumonia and preparing method thereof Download PDFInfo
- Publication number
- CN104306798A CN104306798A CN201410688636.XA CN201410688636A CN104306798A CN 104306798 A CN104306798 A CN 104306798A CN 201410688636 A CN201410688636 A CN 201410688636A CN 104306798 A CN104306798 A CN 104306798A
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- China
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- chinese medicine
- disintegrating agent
- viral pneumonia
- traditional chinese
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a traditional Chinese medicine dispersible tablet for treating viral pneumonia and a preparing method thereof. The traditional Chinese medicine dispersible tablet for treating viral pneumonia is composed of traditional Chinese herb extracts, a filling agent, an inner adding disintegrating agent, an outer adding disintegrating agent, corrigent, a wetting agent and a lubricating agent. The traditional Chinese medicine dispersible tablet for treating viral pneumonia has the effects of dispelling wind, clearing heat and relieving a cough and asthma, and is used for treating viral pneumonia. The traditional Chinese medicine is prepared into the dispersible tablet, solubleness can be improved, dispersibility is good, the dissolution rate is high, bioavailability is good, and the dispersible tablet can be distributed in the body quickly, is stable in quality, good in taste and convenient to take, can be swallowed or chewed or sucked or taken after being dispersed through water, and is more suitable for children, old people and patients who take medicine difficultly. The traditional Chinese medicine dispersible tablet has the advantages of being good in medicine stability, convenient to package, transport and store and the like, and the preparing method of the traditional Chinese medicine dispersible tablet is simple, easy, practical and suitable for industrial production.
Description
Technical field
the invention belongs to pharmaceutical technology sectors, be specifically related to a kind of viral pneumonia dispersible tablets of Chinese medicine and preparation method thereof.
Background technology
viral pneumonia is by upper respiratory tract infection, spreads caused pneumonia downwards.Primary disease all can occur throughout the year, but is more common in winter-spring season greatly, can break out or distribute popular.Clinical main manifestations is heating, headache, systemic pain, dry cough and lung infiltration etc.The age, immune functional state etc. of the virulence of the generation of viral pneumonia and virus, route of infection and host are relevant.General children's's sickness rate is higher than adult.
in acute respiratory infection, viral infection accounts for 90%, and viral infection, then based on upper respiratory tract, has common cold, pharyngolaryngitis, bronchitis, bronchiolitis, baby's herpangina and epidemic pleurodynia etc.Causing the virus of pneumonia rare, is wherein common with influenza virus,
viral pneumonia is caused by adenovirus, respiratory syncytial virus, influenza virus, parainfluenza virus, Coxsackie virus, echovirus etc., and premorbid has upper respiratory tract infection symptoms more, and numeration of leukocyte is normal or on the low side, and antibiotic therapy is invalid.
at present, there is no desirable antiviral drugs, therefore the treatment of viral pneumonia mainly symptomatic treatment, meanwhile, answer attention control complication, when nonjoinder bacteriological infection without the need to using antibiotic.And mostly the product on market is to make by traditional handicraft, traditional handicraft often adopts various crude drug to be ground into fine powder (more than 80 orders), take after mixing, and this traditional handicraft occupies sizable ratio at Chinese medicine pill, powder in solid kind preparation, traditional process technology makes its drug particle size many at 125 ~ 180 μm, be unfavorable for the abundant absorption of effective ingredient, and it is high to have production cost, utilization ratio of drug generally waits not enough.
Summary of the invention
the object of this invention is to provide a kind of viral pneumonia dispersible tablets of Chinese medicine and preparation method thereof of a kind of heat-clearing and toxic substances removing, relieving cough and relieving asthma.
in order to realize object of the present invention, the present invention is achieved by the following technical solutions: a kind of viral pneumonia dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 65%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 10%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 10%, lubricant 0.05 ~ 10%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Gypsum Fibrosum 130-170 part, Radix Glycyrrhizae 40-60 part, Rhizoma Osmundae 180-220 part, Cortex Moutan 80-120 part, Rhizoma Phragmitis 180-220 part, Radix Et Rhizoma Rhei 30-40 part, Ramulus Uncariae Cum Uncis 80-120 part, Radix Isatidis 130-170 part, Cortex Lycii 130-170 part, Herba Taraxaci 130-170 part.
the optimum weight portion rate of described Chinese medicine extract Raw is: 150 parts, Gypsum Fibrosum, 50 parts, Radix Glycyrrhizae, Rhizoma Osmundae 200 parts, Cortex Moutan 100 parts, Rhizoma Phragmitis 200 parts, Radix Et Rhizoma Rhei 35 parts, Ramulus Uncariae Cum Uncis 100 parts, Radix Isatidis 150 parts, Cortex Lycii 150 parts, Herba Taraxaci 150 parts.
described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 65 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 10 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 10 part, lubricant 0.05 ~ 10 part.
described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 8 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts.
described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Gypsum Fibrosum of high-quality, Radix Glycyrrhizae, Rhizoma Osmundae, Cortex Moutan, Rhizoma Phragmitis, Radix Et Rhizoma Rhei, Ramulus Uncariae Cum Uncis, Radix Isatidis, Cortex Lycii, Herba Taraxaci raw material, clean and remove impurity;
step 2: extract: by above-mentioned Chinese medicine, decoct with water secondary, 8 times amount soak by water 2 hours for the first time, second time 8 times amount soak by water 1 hour, merge twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, be concentrated into relative density 1.2-1.3 by filtrate, then room temperature is chilled to, adding appropriate ethanol makes alcohol content reach 50%, and static 24 hours precipitations, extract supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.2-1.25, finally at 80 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
in said medicine: Gypsum Fibrosum life expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst.Control calentura high fever not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, and hyperactivity of toxic heat, sends out speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.External treatment ulcer sores, bursts and does not close up, the burning hot wound of soup.Radix Glycyrrhizae and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Rhizoma Osmundae kills ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control anemopyretic cold.Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, cestode, artificial abortion, postpartum hemorrhage.Cortex Moutan clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis, the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Rhizoma Phragmitis heat clearing away, promotes the production of body fluid, relieving restlessness, preventing or arresting vomiting.Control calentura excessive thirst, gastropyretic vomiting, dysphagic, regurgitation, consumptive lung disease, lung abscess.And separate Fugu ocellatus ichthyotoxin.Radix Et Rhizoma Rhei purges heat poison, and removing mass is stagnant, clots absorbing blood.Control excess-heat constipation, delirium sends out holder, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spit blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinates, carbuncle and ulcer toxic swelling, furuncle, burn.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation., jaundice due to damp-heat not well for excess-heat constipation, stagnant stomachache, dysentery.Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control pediatric epilepsy scared Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia.Radix Isatidis heat clearing away, removing toxic substances, removing heat from blood.Control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.Cortex Lycii removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.Herba Taraxaci heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
beneficial effect of the present invention: a kind of viral pneumonia dispersible tablet of the present invention, has effect of wind and heat dispersing, relieving cough and relieving asthma, be used for the treatment of viral pneumonia.Its prepared composition discrete piece can be improved dissolubility, favorable dispersibility, and dissolution is high, and bioavailability is good, distribution in vivo is rapid, steady quality, and mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for child, old man and the patient of difficulty of swallowing, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group eats the present invention, eats the present invention every day once, within 15 days, be a course for the treatment of, another group matched group uses liver-protecting tablet, every group selection outpatient 235 example, wherein man 115 example, female 120 example, max age 75 years old, minimal ages 35 years old, every day uses once, within 15 days, be a course for the treatment of, clinical manifestation is that heating, headache, systemic pain, dry cough and lung infiltrate, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
detailed description of the invention:
embodiment 1
a kind of viral pneumonia dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 65%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 10%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 10%, lubricant 0.05 ~ 10%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Gypsum Fibrosum 130-170 part, Radix Glycyrrhizae 40-60 part, Rhizoma Osmundae 180-220 part, Cortex Moutan 80-120 part, Rhizoma Phragmitis 180-220 part, Radix Et Rhizoma Rhei 30-40 part, Ramulus Uncariae Cum Uncis 80-120 part, Radix Isatidis 130-170 part, Cortex Lycii 130-170 part, Herba Taraxaci 130-170 part.
the optimum weight portion rate of described Chinese medicine extract Raw is: 150 parts, Gypsum Fibrosum, 50 parts, Radix Glycyrrhizae, Rhizoma Osmundae 200 parts, Cortex Moutan 100 parts, Rhizoma Phragmitis 200 parts, Radix Et Rhizoma Rhei 35 parts, Ramulus Uncariae Cum Uncis 100 parts, Radix Isatidis 150 parts, Cortex Lycii 150 parts, Herba Taraxaci 150 parts.
described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 65 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 10 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 10 part, lubricant 0.05 ~ 10 part.
described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 8 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts.
described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Gypsum Fibrosum of high-quality, Radix Glycyrrhizae, Rhizoma Osmundae, Cortex Moutan, Rhizoma Phragmitis, Radix Et Rhizoma Rhei, Ramulus Uncariae Cum Uncis, Radix Isatidis, Cortex Lycii, Herba Taraxaci raw material, clean and remove impurity;
step 2: extract: by ratio of weight and the number of copies, by above-mentioned Chinese medicine, decoct with water secondary, 8 times amount soak by water 2 hours for the first time, second time 8 times amount soak by water 1 hour, merges twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, filtrate is concentrated into relative density 1.2-1.3, is then chilled to room temperature, add appropriate ethanol and make alcohol content reach 50%, static 24 hours precipitations, extract supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.2-1.25, last at 80 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: by ratio of weight and the number of copies, extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant evenly, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
Claims (6)
1. a viral pneumonia dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 65%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 10%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 10%, lubricant 0.05 ~ 10%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Gypsum Fibrosum 130-170 part, Radix Glycyrrhizae 40-60 part, Rhizoma Osmundae 180-220 part, Cortex Moutan 80-120 part, Rhizoma Phragmitis 180-220 part, Radix Et Rhizoma Rhei 30-40 part, Ramulus Uncariae Cum Uncis 80-120 part, Radix Isatidis 130-170 part, Cortex Lycii 130-170 part, Herba Taraxaci 130-170 part.
2. a kind of viral pneumonia dispersible tablets of Chinese medicine according to claim 1, it is characterized in that: the optimum weight portion rate of described Chinese medicine extract Raw is: 150 parts, Gypsum Fibrosum, 50 parts, Radix Glycyrrhizae, Rhizoma Osmundae 200 parts, Cortex Moutan 100 parts, Rhizoma Phragmitis 200 parts, Radix Et Rhizoma Rhei 35 parts, Ramulus Uncariae Cum Uncis 100 parts, Radix Isatidis 150 parts, Cortex Lycii 150 parts, Herba Taraxaci 150 parts.
3. a kind of viral pneumonia dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 65 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 10 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 10 part, lubricant 0.05 ~ 10 part.
4. a kind of viral pneumonia dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 8 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts.
5. a kind of viral pneumonia dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
6. the preparation method of a kind of viral pneumonia dispersible tablets of Chinese medicine according to claim 1-5, is characterized in that: the concrete steps of its preparation method are:
Step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Gypsum Fibrosum of high-quality, Radix Glycyrrhizae, Rhizoma Osmundae, Cortex Moutan, Rhizoma Phragmitis, Radix Et Rhizoma Rhei, Ramulus Uncariae Cum Uncis, Radix Isatidis, Cortex Lycii, Herba Taraxaci raw material, clean and remove impurity;
Step 2: extract: by ratio of weight and the number of copies, by above-mentioned Chinese medicine, decoct with water secondary, 8 times amount soak by water 2 hours for the first time, second time 8 times amount soak by water 1 hour, merges twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, filtrate is concentrated into relative density 1.2-1.3, is then chilled to room temperature, add appropriate ethanol and make alcohol content reach 50%, static 24 hours precipitations, extract supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.2-1.25, last at 80 DEG C of drying under reduced pressure, obtain extract;
Step 3, preparation: by ratio of weight and the number of copies, extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant evenly, with tabletting machine, make tablet;
Step 4, packaging: according to tablet format, class wrapping, makes finished product.
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| CN1736443A (en) * | 2004-08-17 | 2006-02-22 | 王德英 | Chinese medicinal ointment for treating pneumonia |
| CN102145122A (en) * | 2010-02-08 | 2011-08-10 | 王德英 | Chinese medical plaster for treating pneumonia |
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Application publication date: 20150128 |