CN104306647A - 治疗膝关节骨性关节炎的中药贴 - Google Patents

治疗膝关节骨性关节炎的中药贴 Download PDF

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CN104306647A
CN104306647A CN201410547925.8A CN201410547925A CN104306647A CN 104306647 A CN104306647 A CN 104306647A CN 201410547925 A CN201410547925 A CN 201410547925A CN 104306647 A CN104306647 A CN 104306647A
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雷敬卫
丁晓医
刘宜军
方星元
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Henan University of Traditional Chinese Medicine HUTCM
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Abstract

本发明涉及治疗膝关节骨性关节炎的中药，可有效解决膝关节骨性关节炎的用药问题，其解决的技术方案是，包括纱布和中药液，所述中药液由以下重量计的原料药物：狗脊25-35g、血竭50-70g、透骨草25-35g、木瓜18-22g、伸筋草25-35g、杜仲25-35g、川芎25-35g、制乳香18-22g、制没药18-22g、蜈蚣13-17g、地龙10-14g、红花25-35g、冰片13-17g、三七18-22g和自然铜8-12g制成，将纱布浸入中药液，切块，用塑料薄膜包裹保湿，成中药贴，本发明有效地改善微循环，促进了炎症的吸收，缩短了病程，操作简便易行，疗效确切，病人依从性高，是治疗膝关节骨性关节炎药物上的创新。

Description

治疗膝关节骨性关节炎的中药贴
技术领域
本发明涉及临床上治疗疼痛疾病的药物制剂，特别是一种治疗膝关节骨性关节炎的中药贴。
背景技术
    膝关节骨性关节炎（knee osteoarthritis，KOA）是一种老年常见疾病，该病发病率女性多于男性，其病理特点为关节软骨变性破坏、软骨下骨硬化、关节边缘骨质增生、滑膜增生、关节囊和韧带挛缩或松弛等，临床表现为正常负重所致膝关节面塌陷变形，以关节肿痛、僵硬、活动障碍为主，伴有继发性滑膜炎的症状群。在我国人群中KOA的患病率为9.56％，症状多出现在40岁以后，女性发病率高于男性，60岁以上发病率达78.5％，随着老龄化社会的到来，已成为影响老年人生活质量的主要疾病之一。不仅给患者带来痛苦，而且给社会带来巨大的经济负担。膝关节骨关节炎的治疗大体可以分为非药物治疗、药物治疗与手术治疗三大类，具体治疗方法应根据患者的年龄和疾病程度来选择。早期骨关节炎的治疗目的是缓解疼痛，延缓病变发展，应尽量采用无创治疗；晚期骨关节炎的治疗目的则是缓解或消除疼痛，增加关节活动范围，重建关节稳定性。非药物治疗主要作用是增加局部血液循环、减轻炎症反应，解除肌肉痉挛，包括热疗、水疗、超声波、针灸、按摩、牵引等。急性膝痛多用冷敷、超声波治疗；亚急性膝痛多采用温水浴、蜡疗；慢性膝痛常用超短波、热疗、针灸、按摩等。药物的选择原则是炎症明显时，以消炎为主，镇痛为辅；炎症不明显时，以镇痛为主，消炎为辅。目前没有任何药物可以使骨关节炎的病程逆转和停止，但药物对消除症状有明显疗效。因此，治疗膝关节骨性关节炎药物上的改进是目前亟需解决的问题。
发明内容
针对上述情况，为解决现有技术之缺陷，本发明之目的就是提供一种治疗膝关节骨性关节炎的中药贴，可有效解决膝关节骨性关节炎的用药问题。
    本发明解决的技术方案是，包括纱布和中药液，其特征在于，所述中药液由以下重量计的原料药物：狗脊25-35g、血竭50-70g、透骨草25-35g、木瓜18-22g、伸筋草25-35g、杜仲25-35g、川芎25-35g、制乳香18-22g、制没药18-22g、蜈蚣13-17g、地龙10-14g、红花25-35g、冰片13-17g、三七18-22g和自然铜8-12g制成，将上述原料药物混合在一起，粉碎过40-60目筛，成细粉，用体积浓度为50-70%的酒精1800-2200ml浸泡，在5-38℃，浸泡14-28天（夏季14天、春秋季节21天、冬季28天），过滤，得中药液，将纱布浸入中药液，切块，用塑料薄膜包裹保湿，成中药贴。
本发明有效地改善微循环，促进了炎症的吸收，缩短了病程，操作简便易行，疗效确切，病人依从性高，是治疗膝关节骨性关节炎药物上的创新。
具体实施方式
以下结合实施例对本发明的具体实施方式作进一步详细说明。
实施例1
该中药贴由以下重量计的原料药物：狗脊25g、血竭50g、透骨草25g、木瓜18g、伸筋草25g、杜仲25g、川芎25g、制乳香18g、制没药18g、蜈蚣13g、地龙10g、红花25g、冰片13g、三七18g和自然铜8g制成，将上述原料药物混合在一起，粉碎过40目筛，成粗粉，用体积浓度为50%的酒精2200ml浸泡，在5-38℃，浸泡14-28天（夏季14天、春秋季节21天、冬季28天），过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
实施例2
该中药贴由以下重量计的原料药物：狗脊30g、血竭60g、透骨草30g、木瓜20g、伸筋草30g、杜仲30g、川芎30g、制乳香20g、制没药20g、蜈蚣15g、地龙12g、红花30g、冰片15g、三七20g和自然铜10g制成，将上述原料药物混合在一起，粉碎过40目筛，成粗粉，用体积浓度为60%的酒精2000ml浸泡，在5-38℃，浸泡14-28天（夏季14天、春秋季节21天、冬季28天），过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
实施例3
该中药贴由以下重量计的原料药物：狗脊35g、血竭70g、透骨草35g、木瓜22g、伸筋草35g、杜仲35g、川芎35g、制乳香22g、制没药22g、蜈蚣17g、地龙14g、红花35g、冰片17g、三七22g和自然铜12g制成，将上述原料药物混合在一起，粉碎过60目筛，成细粉，用体积浓度为70%的酒精2200ml浸泡，在5-38℃，浸泡14-28天（夏季14天、春秋季节21天、冬季28天），过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
本发明结合红外线照射及中药贴外敷可以起到活血化瘀，通络止痛、消肿之功效，经临床反复试验，均取得了相同或相似的有益技术效果，相关实验资料如下：
1、选择病例的标准
1.1 一般资料
    2009年3月~2013年3月运用本发明治疗膝关节骨性关节炎患者315例病人，其中男性160例，女性155例，年龄最小40岁，最大81岁，平均年龄58.6岁，病程最短3周，最长31年。单膝130例，双膝185例。
1.2诊断标准
参照中华医学会骨科学分会《骨关节诊治指南》（2007年版）。
①前月里有大多数时间有膝痛。
②X线片示关节边缘骨赘。
③关节液检查符合骨性关节炎。
④年龄大于40岁。
⑤晨僵小于30分钟。
⑥关节活动时有骨摩擦音。
   满足①+②条，或①+③+⑤+⑥条，或①+④+⑤+⑥条者可诊断膝关节骨性关节炎。
1.3 纳入标准
①符合膝关节骨性关节炎诊断标准者。
②年龄在40-65岁。
③病程在3个月-8年之间。
④能按计划坚持治疗，并配合本课题研究者。
1.4 排除标准
①合并有心脑血管、肝、肾和造血系统等严重危及生命的原发性疾病以及精神病患者。
②同时服用糖皮质激素类药、止痛药等可能影响疗效的药物。
③并发病影响到膝关节者，如骨结核、骨肿瘤、膝关节急性外伤、感染、牛皮癣、风湿热、免疫疾病及梅毒性神经病等。
④膝关节红、肿、热、痛者及因红、肿、热、痛者而引起之积液严重肿胀者。
2、治疗方案
 使用时，撕开塑料薄膜，用微波炉加热中药贴后，贴敷于患者塌渍部位皮肤上，然后用TDP灯照射，时间为25min，每天一次，10次为一疗程。塌渍后（治疗后）用温水清洁皮肤后适当涂抹润肤油。
3疗效标准及结果：
   治愈：膝痛、肿胀完全消失，行走及上下楼梯无不适感。
   有效：膝痛时发时止，行走时仍有轻度疼痛，上下楼稍感不便，关节活动稍受限。
   无效：膝痛、肿胀及活动时疼痛无明显改善。
3.1治疗结果
    315例中，治愈123例（39.04%），有效172例（54.60%），无效20例（6.35%）。
4、结论
本发明在多年临床研究基础上结合TDP灯照射及中药贴外敷可以起到活血化瘀，通络止痛、消肿，有效地改善微循环，促进了炎症的吸收，缩短了病程，减轻了患者的经济负担。操作简便易行，疗效确切，病人依从性高，具有实际的临床意义。

Claims (4)

1.一种治疗膝关节骨性关节炎的中药贴，包括纱布和中药液，其特征在于，所述中药液由以下重量计的原料药物：狗脊25-35g、血竭50-70g、透骨草25-35g、木瓜18-22g、伸筋草25-35g、杜仲25-35g、川芎25-35g、制乳香18-22g、制没药18-22g、蜈蚣13-17g、地龙10-14g、红花25-35g、冰片13-17g、三七18-22g和自然铜8-12g制成，将上述原料药物混合在一起，粉碎过40-60目筛，成细粉，用体积浓度为50-70%的酒精1800-2200ml浸泡，在5-38℃，浸泡14-28天，过滤，得中药液，将中药液浸入纱布，切块，用塑料薄膜包裹保湿，成中药贴。
2.根据权利要求1所述的治疗膝关节骨性关节炎的中药贴，其特征在于，该中药贴由以下重量计的原料药物：狗脊25g、血竭50g、透骨草25g、木瓜18g、伸筋草25g、杜仲25g、川芎25g、制乳香18g、制没药18g、蜈蚣13g、地龙10g、红花25g、冰片13g、三七18g和自然铜8g制成，将上述原料药物混合在一起，粉碎过40目筛，成粗粉，用体积浓度为50%的酒精2200ml浸泡，在5-38℃，浸泡14-28天，过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
3.根据权利要求1所述的治疗膝关节骨性关节炎的中药贴，其特征在于，该中药贴由以下重量计的原料药物：狗脊30g、血竭60g、透骨草30g、木瓜20g、伸筋草30g、杜仲30g、川芎30g、制乳香20g、制没药20g、蜈蚣15g、地龙12g、红花30g、冰片15g、三七20g和自然铜10g制成，将上述原料药物混合在一起，粉碎过40目筛，成粗粉，用体积浓度为60%的酒精2000ml浸泡，在5-38℃，浸泡14-28天，过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
4.根据权利要求1所述的治疗膝关节骨性关节炎的中药贴，其特征在于，该中药贴由以下重量计的原料药物：狗脊35g、血竭70g、透骨草35g、木瓜22g、伸筋草35g、杜仲35g、川芎35g、制乳香22g、制没药22g、蜈蚣17g、地龙14g、红花35g、冰片17g、三七22g和自然铜12g制成，将上述原料药物混合在一起，粉碎过60目筛，成细粉，用体积浓度为70%的酒精1800ml浸泡，在5-38℃，浸泡14-28天，过滤，得药液，将药液浸润纱布，切块，用塑料薄膜包裹保湿，成中药贴。
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