CN104304798A - Novel milk cow forage zinc-source additive adopting super-high chelation strength organic zinc - Google Patents
Novel milk cow forage zinc-source additive adopting super-high chelation strength organic zinc Download PDFInfo
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Abstract
The invention relates to a novel milk cow forage zinc-source additive adopting super-high chelation strength organic zinc, in particular to an application of the super-high chelation strength organic zinc in the novel zinc-source additive of the milk cow forage. Compared with the conventional zinc-source additive (mainly inorganic zinc sulfate and zinc dioxide), the novel super-high chelation strength organic zinc provided by the invention has the advantages that the existing form of the zinc is more similar to the existing form of the zinc element in a milk cow body, and the bioactivity is higher. Therefore, the health condition of the milk cow can be obviously improved due to the selection of the novel super-high chelation strength organic zinc in the preparation process of a milk cow total mixed ration, the milk production performance and the milk quality of the milk cow are improved, and the efficient and sustainable development of dairy industry is powerfully promoted.
Description
Technical field
The present invention relates to a kind of purposes of novel organic zinc product, be specifically related to a kind of in milk cow total mixed diet (TMR) process for preparation, select the organic zinc of the strong chelating intensity of polar biased as new zinc source additive, to meet the demand of milk cow to zinc, prevent the application of scarce zinc.
Background technology
Zinc be animal must one of trace element, the physiological function that the immunity function with enhancing development and body, the integrality etc. safeguarding cell membrane are important, take part in the links of vital movement, is thus called as " biological element ".Large quantity research shows, supplements zinc, effectively can prevent the appearance (Liang Jianguang, 2006) of high yield cow zinc dificiency in cow concentrate.Traditionally, the zinc added in milk cow diet, provides with inorganic salts (as zinc sulfate and zinc oxide) form.The zinc of inorganic form, as zinc sulfate and zinc oxide etc., can destroy the vitamin in feed and other active materials, and BA is lower.Therefore, the Stability Analysis of Structures of new generation succeeded in developing in recent years and have the organic zinc of higher biological activity, from once occurring the concern enjoying nutritionist.
Health and the various nutriment of normal need of production of livestock and poultry are supplied in a suitable form.Much research finds, trace element is main in vivo to play a role with organic double compound instead of with the form of free inorganic ions, so there is the great interest (Luo Xugang etc., 2004) namely causing Animal nutrition circle personage in organic trace element product one.Lot of experiments proves, adding organic zinc to high yield cow can significantly improve milk production of cow, reduces mammitis and intra-mammary infections rate, thus obviously reduces somatic number in milk, and do not reduce butterfat and milk protein levels (Liang Jianguang, 2006).This laboratory, on summary forefathers Research foundation, in the rumen bypass characteristic of the organic zinc of different chelating intensity with do a lot of work on the BA of milk cow, and achieves a series of achievement in research.As with the rumen bypass rate of Measures compare different shape zinc of isolated fermentation and the impact on rumen microbial protein amount, find that the stability of organic zinc in cud will be better than inorganic zinc sulfate greatly, namely organic zinc has good rumen bypass characteristic, and best with polar biased strong chelating intensity organic zinc; The dry matter degradability of organic zinc Rumen Fermentation in Vitro, volatile fatty acid (VFA) content, amount of bacteria and bacterioprotein content are all significantly higher than zinc sulfate, are best equally with the strong chelating intensity organic zinc of polar biased.Different shape zinc source is on the impact of milk production of cow and milk quality with the Measures compare of practical feeding, find in milk cow total mixed diet, add the output of milk that polar biased strong chelating intensity organic zinc can significantly improve milk cow, reduce somatic number in milk, its reason may be because after adding polar biased strong chelating intensity organic zinc, significantly improve milk cow blood plasma Zn content, Serum alkaline phosphatase activity and foot-and-mouth disease antibody titre, add the synthetic quantity of rumen bacteria albumen, enhance the immunity function of milk cow, improve the health status of milk cow, because of thus improve Milk Production and milk quality (Liang Jianguang, 2006, Wang etc., 2013).Above recent studies on achievement shows, the chelating intensity of organic zinc is the principal element affecting its rumen bypass rate and BA, namely on milk cow, not the BA of the organic zinc product of any chelating intensity is all significantly higher than inorganic zinc sulfate, only has the organic zinc product of the strong chelating intensity of polar biased just to have this advantage.But owing to causing feed manufacturer blindly to select organic zinc product as zinc source to prepare milk cow total mixed diet to the understanding deficiency of this rule in actual production, cause additive effect undesirable, do not reach the target strengthening milk cow health and improve the output of milk and milk quality.
Summary of the invention
The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of polar biased strong chelating intensity organic zinc is provided to be used as milk cow forage new zinc source additive, improve Milk Production and the milk quality of milk cow, reach simultaneously and strengthen milk cow health and promote its object of efficiently giving milk.
The technology of the present invention solution: a kind of polar biased strong chelating intensity organic zinc is used as the new zinc source additive of milk cow forage, and described polar biased strong chelating intensity Q f value scope is 900-1000.
Described novel organic zinc specifically comprises polar biased strong chelating intensity single amino acid chelates of zinc, polar biased strong chelating intensity compound amino acid chelates of zinc and polar biased strong chelating intensity zinc albuminate.
Described feed is milk cow total mixed diet (TMR).
The present invention's advantage is compared with prior art: the means discussion that the present invention's practical feeding and isolated fermentation the combine BA of different shape zinc on milk cow, find to add the output of milk that polar biased strong chelating intensity organic zinc can significantly improve milk cow, reduce somatic number in milk, improve immunologic function and the health status of milk cow, and as compared to weak and medium chelating intensity organic zinc, polar biased strong chelating intensity organic zinc more can improve dry matter degradability in cud effectively, VFA content, amount of bacteria and bacterioprotein content, namely the highest with the BA of polar biased strong chelating intensity organic zinc on milk cow.Based on the result of the test of above science, present invention finds chelating intensity is the principal element affecting organic zinc product BA, and only have the BA of polar biased strong chelating intensity organic zinc the highest, and invented strong for polar biased chelating intensity organic zinc as milk cow forage new zinc source additive, be applied to the method for application in milk cow total mixed diet (TMR) process for preparation, greatly can strengthen the efficiency utilization of milk cow to zinc in TMR daily ration, improve milk production of cow and milk quality, effectively promote the development of dairy.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described in detail, the chelating strength detection method provided only in order to illustrate the present invention, instead of in order to limit the scope of the invention.
Test one: different chelating intensity organic zinc is on the impact of milk production of cow, milk quality and immunologic function
1. test objective
Different shape zinc source (organic zinc source that three kinds of chelating intensity is different and the inorganic zinc sulfate) impact on milk production of cow, milk quality is added by observation, analyze Zn products chelating intensity and its correlation between milk cow Biological acdtivity in vivo, the new and effective organic zinc source being suitable for chelating intensity for science development and application in Cow product provides scientific experimentation foundation.
2. materials and methods
Employing completely randomized experiment designs, and observes feed weak, medium, polar biased strong chelating intensity organic zinc and inorganic zinc sulfate to the impact of the indexs such as milk production of cow, milk quality and immune performance.The 4 kinds of zinc sources selected comprise inorganic zinc sulfate (ZnSO
47H
2o) and 3 kinds of chelating intensity are respectively weak, medium, (organic zinc is 3 kinds of organic zinc-manganese sources of screening after this laboratory adopts polarography to analyze organic zinc source chelating intensity to the organic zinc source that polar biased is strong, assay method is according to agricultural industry criteria " feed addictive manganese amino acid and albumen manganese network (chela) close the mensuration of intensity ", with reference to Holwerda (1995) to the confining method of organic trace element product, the organic zinc that chelating strength detection value Qf is less than 10 is weak chelating intensity organic zinc, be medium chelating intensity between 10 and 100, be strong chelating intensity between 100 and 1000, more than 1000 is extremely strong chelating intensity).This analyzes the sample measured, (stability constant Qf value is 6.55 to comprise weak chelating intensity compound amino acid zinc source, Zn content is 11.9%, be designated as Zn-AA W), (stability constant Qf value is 30.7 in medium chelating intensity zinc albuminate source, Zn content is 13.3%, be designated as Zn-Pro M), polar biased strong chelating intensity zinc albuminate source (stability constant Qf value is 944, and Zn content is 18.6%, is designated as Zn-Pro S).
2.1 experimental design and process
Test adopts completely randomized design.Establish 5 processed group altogether, based on process 1, diet does not add external source zinc control group, process 2 is add zinc 40mg/kg processed group with zinc sulfate form on control group basis, process 3 is add zinc 40mg/kg processed group with above-mentioned weak chelating intensity organic zinc form on control group basis, process 4 is add zinc 40mg/kg processed group with above-mentioned medium chelating intensity organic zinc form on control group basis, and process 5 is add zinc 40mg/kg processed group with polar biased strong chelating intensity organic zinc form on control group basis.
2.2 experimental animals and diet
Select 30 average parity two tires, the healthy holstein cow of giving milk in peak period that body weight is close with the output of milk, be divided into 5 processed group at random, often organize 6 cow heads, raise in same cowshed.Milk cow TMR expects that basic components sees the following form 1, TMR material meets 25kg of giving milk NRC (2001) day, body weight 680kg, the lactating cow nutritional need of butterfat percnetage 3%, wherein concentrate supplement consists of: corn 44%, dregs of beans 15%, the dish dregs of rice 10%, wheat bran 27%, calcium monohydrogen phosphate 2%, salt 1% and additive 1% (non-zincification).The composition (every kilogram) of 1% additive: V
a6.25g, V
d41.0g, V
e18.1g, FeSO
47H
2o 20.5g, CuSO
45H
2o 14.5g, MnSO
45H
2o 20.6g, CoCO
30.07g, Ca (IO
3)
20.31g, Na
2seO
30.22g and zeolite powder 878g.The ZnSO that will add
4, weak chelating intensity organic zinc source, medium chelating intensity organic zinc source and strong chelating intensity organic zinc source first mix with zeolite powder, then mix thoroughly with fine fodder, every day is added at twice.Every day observes cow disease, and records the output of milk and the feed intake of every cow head.By test arrangement and epidemic prevention regulation, aftosa Attenuate vaccine immunity (every ox 3ml) is carried out to milk cow.Experimental period is 70 days, wherein 15 days preliminary trial periods (period whole Cow-feeding not zincification TMR material), just trying 55 days phases.
Table 1:TMR material formula
1
1to feed basis.
2add in every kilogram of TMR: V
a4000IU, V
d2000IU, V
e30.0IU, Cu (CuSO
45H
2o) 11.0mg, Mn (MnSO
4.H
2o) 14.0mg, Fe (FeSO
47H
2o) 80.0mg, I (KI) 0.60mg, Se (Na
3seO
3) 0.30mg, CoCO
30.11mg.
3measured value.
2.3 sample collections and analysis
According to the arrangement of examination face, the milk sample specified according to Dairy Herd Impovement (DHI) gathers way, just gathers milk sample at the end of the examination phase, for mensuration milk composition, microorganism and somatic number.Random multipoint acquisition diet biased sample, for constituent contents such as mensuration zinc; Just trying the 27th day phase and 55 days respectively from milk bovine jugular vein collection blood 20ml, wherein 10ml anticoagulant heparin, blood plasma is got for indexs such as concentration of element and alkaline phosphatase activities such as analysed for plasma zinc after centrifugal, second half 10ml whole blood then not anti-freezing, centrifuging and taking serum measures for the antibody titer of aftosa attenuated vaccine.
The content of the wherein mineral element such as zinc, copper, iron will be analyzed on ICAP-9000 plasma emission instrument after testing sample diet and blood plasma red fuming nitric acid (RFNA) and perchloric acid wet digestion method; By somatic cell counting instrument lateral body cell number; The antibody titer of aftosa attenuated vaccine is surveyed with indirect hemagglutination method.
2.4 statistical analysis
By GLM program in SAS software, variance analysis is carried out to all test datas, significant difference person, compare the significance of difference between average with LSD method, using 0.05 as significance test standard.
3. result
3.1 zinc sources are on the impact of milk production of cow, milk quality
The impact of zinc source on milk production of cow the results are shown in table 2.As can be seen from Table 2, Different Zinc Source significantly affects the output of milk (P<0.01) of milk cow, but all has no significant effect (P>0.05) somatic number in feed intake, butterfat percnetage, protein ratio, Ruzhong solid content and milk.Compared with control group, polar biased strong chelating intensity organic zinc source group and weak chelating organic zinc source group significantly improve the output of milk (P<0.05) of milk cow, but medium chelating intensity organic zinc source group and inorganic zinc sulfate group do not make significant difference to the output of milk, and the output of milk of weak chelating intensity zinc source group is also significantly higher than medium chelating intensity groups (P<0.05), but there is no significant difference (P>0.05) between polar biased strong organic zinc source group and weak chelating intensity zinc source group.
Table 2: Different Zinc Source is on the impact of cow feeding amount, the output of milk and milk quality
a, b, crepresent in same column that there is significant difference (P<0.05) between different Superscript letters person.
din same column, data calculate after log10 conversion.
3.2 zinc sources are on the impact of blood plasma Zn content, alkaline phosphatase activities and plasma antibody titre
The results are shown in table 3.Table 3 is known, remarkable impact is not caused to blood plasma alkaline phosphatase activities in zinc source, when also not aligning 27 days examination phases, blood plasma Zn content brings remarkable impact (P>0.05), but the 55th day just significantly affects Zn content in blood plasma at the end of the examination phase.Compared with control group, zincification group significantly improves Zn content (P<0.05) in milk cow blood plasma, and the blood plasma Zn content of polar biased strong chelating intensity organic zinc group is significantly higher than medium chelating intensity organic zinc group (P<0.05), but medium, weak chelating intensity organic zinc group and inorganic zinc sulfate group difference are not significantly (P>0.05).When just trying 27 days phases, zinc source significantly affects the blood plasma foot-and-mouth disease antibody titre (P=0.003) of milk cow, compared with control group, strong and the weak chelating intensity organic zinc source group of polar biased significantly improves blood plasma foot-and-mouth disease antibody titre, but medium chelating intensity organic zinc source group, inorganic zinc sulfate group and control group are without significant difference.Just at the end of the examination phase, each processed group blood plasma foot-and-mouth disease antibody titre is all without significant difference.
Table 3: zinc source is on the impact of blood plasma Zn content, alkaline phosphatase activities and foot-and-mouth disease antibody titre
a, b, crepresent in same column that there is significant difference (P<0.05) between different Superscript letters person.
din same column, data calculate after log10 conversion.
Test two: external artificial lumen fermentation method evaluates different chelating intensity organic zinc source to the impact of lumen fermentation
1. test objective
Adopt artificial rumen simulation cultivation, the impact that different shape zinc source (organic zinc source that three kinds of chelating intensity is different and inorganic zinc sulfate) and zinc level ferment on artificial rumen is added by observation, analyze Zn products chelating intensity and its correlation on milk cow between BA, the new and effective organic zinc source being suitable for chelating intensity for science development and application in Cow product provides the test basis of science.
2. materials and methods
2.1 experimental design and process
Test employing 4 × 3 liang of factor completely randomized designs.4 kinds of zinc sources are respectively zinc sulfate and test the 3 kinds of chelating intensity selected and are respectively weak, medium and that polar biased is strong organic zinc source, 3 zinc Pitch-based sphere are respectively 0,10,20ug/ml, in 4, zinc source shares 1 control group, form 9 processed group altogether, each process 3 repetition, each repetition is 1 Rumen Fermentation in Vitro test tube.
2.2 tests prepare
3 healthy holstein cows that rumen fistula is housed are raised and same cowshed, in raising after 7 days, from the cud of 3 cow heads, extract 300ml rumen fluid respectively, after putting into the mixing of same vacuum flask, by 4 layers of filtered through gauze, the rumen fluid after filtering is injected lasting logical newborn CO
21L vial in, vial remains in the water of 39 DEG C for subsequent use, and with reference to Baumgardt (1993) preparation buffer solution, continue to pass into CO
2.After rumen fluid and buffer solution 1:1 ratio are mixed, add in each fermentation tube 0.5g not zincification to feed ox fine fodder be fermentation substrate, then add the zinc solution of 1ml Different Zinc Source, 1ml methionine solution, 1ml urea liquid and 50ml rumen fluid and nutrient solution mixed liquor.Add the final zinc concentration provided of Different Zinc Source be 0,10,20ug/ml.In fermentation tube add variable concentrations methionine and urea liquid and be used for equilibrium phase and answer processed group methionine and total nitrogen content to same level.
Fermentation tube is fully shaken up and is placed in 39 DEG C of water-baths, start shaking table, fermentation 24h.For correcting substrate dry matter degradability, separately establishing a blank, fermenting simultaneously.
The collection of 2.3 samples and preparation
After 24h cultivates, fermentation tube, with ice-cooled, then filter rumen fluid with Nylon Bag and is sub-packed in two 50ml centrifuge tubes, 1 pH measuring each sample immediately, and gets 1.5ml for ammonia nitrogen (NH
3-N) measure, 1.5ml surveys volatile fatty acid, and another gets 10ml with after centrifugal 15min at 20,000 turns 10 DEG C, and supernatant and sediment fraction are for survey Zn content, sediment fraction Simultaneously test amount of bacteria and bacterioprotein amount.Nylon Bag surveys its dry matter degradability after drying.
2.4 sample analysis
Use colorimetric method for determining ammonia-nitrogen content.
PH is measured by acidity.
Supernatant and sedimentary Zn content is measured with ICP-Intrepid plasma emission spectrometer.
The method reported with reference to Galyean (1997) measures VFA.
Put with reference to king the method (1990) reported and measure bacterioprotein amount.
2.5 statistical analysis
Carry out variance analysis by the GLM program in SAS software to all test datas, the aobvious author of F inspection, comparing the significance of difference between average with LSD method, is statistical discrepancy level of significance test standard with 0.05.
3. result
Different Zinc Source and zinc level on the impact of external artificial lumen fermentation in table 4.As shown in Table 4, except to except ammonia-nitrogen content in zymotic fluid, zinc source and zinc level all significantly affects all the other indexs in zymotic fluid.These are subject in the index of significantly impact, and except Zn content in pH and solution, all the other indexs are all subject to zinc source and the mutual of zinc level affects.Compared with control group, the rumen fluid ph of zincification group significantly reduces (P<0.05), but between two kinds of zinc levels, difference does not reach the level of signifiance.
When zinc concentration in solution is increased to 10ug/ml from 0, the bacterial population of all zincification groups and bacterioprotein content all significantly increase (P<0.05), dry matter degradability and the general volatile content of fatty acid of zinc sulfate group do not change, but remarkable increase (P<0.05) all occurs the These parameters of organic zinc source group.But when zinc concentration in solution is increased to 20ug/ml from 10, the above-mentioned four-index of zincification group all significantly declines (P<0.05), no matter show which kind of zinc source, in solution, the zinc level of 20ug/ml all obviously exceeds needed for vitro Rumen bacterium.Compared with inorganic zinc source, organic zinc is activity higher (P<0.05) in raising vitro Rumen bacterium dry matter degradability, general volatile content of fatty acid and amount of bacteria, but there is no significant difference between organic zinc source in 3.When zinc concentration in solution is 10ug/ml, medium and bacterioprotein content that is polar biased strong chelating intensity organic zinc source group is significantly higher than weak chelating intensity organic zinc source group and zinc sulfate group (P<0.05), weak chelating intensity organic zinc source group and zinc sulfate group difference not remarkable.No matter add which kind of zinc source, bacterium Zn content all linearly increases (P<0.05) with the rising of Zn content in solution.
Table 4: Different Zinc Source and zinc Pitch-based sphere are on the impact of external artificial lumen fermentation
acalculate according to the value of 3 parallel fermentation tubes and obtain (n=3).
bcalculate according to the value of 6 parallel fermentation tubes and obtain (n=6).
ccalculate according to the value of 12 parallel fermentation tubes and obtain (n=12).
d, e, f, g, h, i, j, k, lrepresent in same column that there is significant difference (P<0.05) between different alphabetical subscript person.
a, B, Crepresent in same column that there is between different alphabetical subscript person significant difference (P<0.05) on zinc source or zinc level.
4. conclusion
Zinc source does not affect somatic number in the feed intake of milk cow, milk composition and milk.But in the fermentation of reinforcement rumen bacteria, promote milk cow health situation and improve in milk production of cow, the BA between Different Zinc Source is not just the same.Compared with other zinc sources, the BA of polar biased strong chelating intensity organic zinc is the highest, weak chelating intensity is taken second place, its mechanism may be by improving lumen fermentation and rumen bypass characteristic, and improve the activity of blood plasma Zn content and relevant enzyme, thus improve the health status of milk cow, and then improve the Milk Production of milk cow.Therefore, due to the existence of milk cow fermentation cud, only have polar biased strong chelating intensity organic zinc to be just conducive to most the optimum utilization of milk cow to wherein zinc.
Claims (3)
1. polar biased strong chelating intensity organic zinc is used as the new zinc source additive of milk cow forage, it is characterized in that: intensity Q f (the Quotient of formation) measured value of the coordinate bond formed between described Zn-ef ficiency and organic ligand between scope be 900 to 1000.
2. polar biased according to claim 1 strong chelating intensity organic zinc is used as the new zinc source additive of milk cow forage, it is characterized in that: described novel organic zinc specifically comprises polar biased strong chelating intensity single amino acid chelates of zinc, polar biased strong chelating intensity compound amino acid chelates of zinc and polar biased strong chelating intensity zinc albuminate.
3. polar biased according to claim 1 and 2 strong chelating intensity organic zinc is used as the new zinc source additive of milk cow forage, it is characterized in that: described feed is milk cow total mixed diet (TMR).
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| CN108077609A (en) * | 2018-01-16 | 2018-05-29 | 湖南农业大学 | A kind of ruminant domestic animal mixed feed and its application based on zinc-glycine chelate |
| CN111087318A (en) * | 2019-12-24 | 2020-05-01 | 长沙兴嘉生物工程股份有限公司 | Preparation method of zinc serine and application of zinc serine in field of animal feed |
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Application publication date: 20150128 |