CN104288713A - 一种治疗子宫肌瘤的外用中药药物 - Google Patents
一种治疗子宫肌瘤的外用中药药物 Download PDFInfo
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- CN104288713A CN104288713A CN201410646943.1A CN201410646943A CN104288713A CN 104288713 A CN104288713 A CN 104288713A CN 201410646943 A CN201410646943 A CN 201410646943A CN 104288713 A CN104288713 A CN 104288713A
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Abstract
一种治疗子宫肌瘤的外用中药药物,由以下原料制成:白芷10g、醋制三棱45g、乳香4g、没药5g、滑石粉15g、全蝎6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、丹参30g、益母草20g、白鲜皮18g、桂枝9g、荆芥10g、白薇6g、丝瓜络10g、三七10g、千年健30g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、半枝莲30g、穿心莲10g、紫背天葵15g、乌药30g、荔枝核45g、杜仲15g、桃仁30g、冰片0.9g、牛黄0.9g、珍珠3g、煅石膏45g、蟾酥0.03g、吴茱萸3g、海马18g、五倍子15g、炉甘石9g、木香30g、牙皂5g、阿魏45g、土鳖虫6g、蜈蚣6g、败酱草30g、甘草9g、鲜土豆120g。本发明标本兼治、众药综治、疗效好。
Description
技术领域
本发明涉及一种以中草药为原料制备的外用中药药物,具体地说是一种用于治疗子宫肌瘤的外用中药药物。
背景技术
子宫肌瘤是女性生殖器官中最常见的一种良性肿瘤,多见于育龄期妇女,也是人体中最常见的肿瘤之一,又称为子宫纤维肌瘤、子宫纤维瘤。子宫肌瘤确切的发病原因尚不清楚。该病主要表现为子宫增大、质硬、表面不平、按肌瘤生长部位可分为浆膜下肌瘤、肌壁间肌瘤、黏膜下肌瘤、宫颈肌瘤、宽韧带肌瘤。主要表现为经期延长或不规则出血,严重者可出现继发贫血,下腹可触及包块,以粘膜下肌瘤的表现最为严重。当肌瘤小于2个月妊娠子宫大小,尤其近绝经期或全身情况不能手术者,通常采用雄激素对抗雌激素,使子宫内膜萎缩,但较常见的不良反应为:女性为闭经,突破性出血和不规则阴道出血,并可有乳房缩小、声音嘶哑、毛发增多等;无论男女,均可出现粉刺、皮肤或毛发的油脂增多、下肢水肿或体重增加。同时由于雌激素效能低下:(1)可使妇女出现阴道灼热、干燥及瘙痒、出血或发生真菌性阴道炎;(2)皮肤发红、情绪或精神状态的改变、神经质或多汗;(3)有时可出现肌痉挛性疼痛等肌肉中毒症状。
发明内容
本发明的目的是提供一种标本兼治、众药综治、疗效好的治疗子宫肌瘤的外用中药药物。
为实现上述目的,本发明采用的技术方案为:
一种治疗子宫肌瘤的外用中药药物,其特征是,由以下重量配比的中药原料,按照以下制备工艺制成:
白芷10g、醋制三棱45g、乳香4g、没药5g、滑石粉15g、全蝎6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、丹参30g、益母草20g、白鲜皮18g、桂枝9g、荆芥10g、白薇6g、丝瓜络10g、 三七10g、千年健30g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、半枝莲30g、穿心莲10g、紫背天葵15g、乌药30g、荔枝核45g、杜仲15g、桃仁30g、冰片0.9g、牛黄0.9g、珍珠3g、煅石膏45g、蟾酥0.03g 、吴茱萸3g、海马18g、五倍子15g、炉甘石9g、木香30g、牙皂5g、阿魏45g、土鳖虫6g、蜈蚣6g、败酱草30g、甘草9g、鲜土豆120g;
制备工艺为:将所述的中草药的根茎、果实、种子经过清洗,烘干工艺,在无菌、无尘的条件下:
(1)将醋制三棱45g、全蝎6g、蜈蚣6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、益母草20g、丹参30g、白鲜皮18g、桂枝9g、荆芥10g、千年健30g、荔枝核45g、杜仲15g、桃仁30g、五倍子15g、海马18g、甘草9g、木香30g、阿魏45g、败酱草30g加冷水浸泡20-30min,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎沸后10分钟,漉出煎液;然后合并两次煎液浓缩至300ml装入无菌瓶内备用;
(2)将白芷10g、乳香4g、没药5g、蟾酥0.03g、三七10g、吴茱萸3g、白薇6g、丝瓜络10g、紫背天葵15 g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、乌药30g、穿心莲10g、牙皂5g、土鳖虫6g、半枝莲30g粉碎成细粉过筛采用环氧乙烷灭菌备用;
(3)将炉甘石9g、冰片0.9g、牛黄0.9g、珍珠3g、滑石粉15g、煅石膏45g研成细粉采用环氧乙烷灭菌备用;
(4)鲜土豆20g;
(5)用时取工艺(1)中的备用品50ml,取工艺(2)中的30g溶解混匀,再取工艺(3)中的15g加入工艺(1)和工艺(2)的汇合物中搅拌成膏状,最后再加入捣成泥状的工艺(4)中的原料,搅拌均匀制成最终药膏。
本发明将中药膏外敷于相关腧穴(子宫穴、曲泉穴、曲骨穴,横骨穴、太溪穴、水泉穴、关元、气海、中极)、脐孔及下腹部包块处,每日两次,并每次按摩腧穴20分钟。其治疗利用了中医穴位贴敷、按摩的治疗机理:中医认为,经络属于脏腑,外络于肢节,沟通内外,贯穿上下,将人体各部的组织器官联系成一个有机整体,运行气血,营养全身,使人体各部的功能活动能保持协调和相对平衡。中药膏外敷腧穴,并加以按摩:一方面可对人体的穴位产生刺激,激发经络的功能,调和气血,改善血液循环,促进和调整机体的免疫机能,调动人体内在的抗病能力,调整机体与外在环境的平衡,并调节人体的动态平衡;另一方面通过药物的渗透和按摩的促进渗透作用,药物通过皮肤进入血液循环,从而缓解症状,治愈疾病,并且中药贴敷还具有以下优点:1.小剂量的药物,可产生较强的治疗效果,2.中药膏外敷治疗简、便、灵、验、安全。
本发明具有活血化瘀、通络、消肿止痛、抗肿瘤及镇痛的作用,从子宫肌瘤发病的根源入手,全面提高免疫功能、调和气血、抗炎、抗肿瘤,活血散瘀、消肿止痛的作用。
本发明的有益效果:
1、标本兼治。它突破传统的治疗局限,该药在治疗子宫肌瘤的同时,能最大限度地调和气血,改善血液循环,促进和调整机体的免疫机能,调动人体内在的抗病能力,调整机体与外在环境的平衡,并调节人体的动态平衡,从整体上改善身体机能,达到治愈疾病的目的。
2、众药综治打破常规利用多种药物联合活血化瘀、通络镇痛、消肿、抗肿瘤,有效抑制肿瘤的复制,使肿瘤迅速消退;并疏通病变部位的经络,促进新陈代谢,恢复子宫的正常功能。迅速减轻月经量过多;腹痛、腰痛、下腹坠胀等症状;通过药物对穴位刺激激发经络的功能,调和气血,改善血液循环,促进和调整机体的免疫机能,促进垂体-性腺的功能,有效降低应用雄激素引起的副作用;促进雌激素的分泌,可有效减轻应用雄激素产生的副作用;调动人体内在的抗病能力,调整机体与外在环境的平衡,人体内部的动态平衡;对人体机能整体调治,从而缓解症状,治愈疾病。
具体实施方式
下面结合具体实施例对本发明作进一步说明:
对于子宫肌瘤患者的治疗,要首先尽快解决月经量过多,经期延长,腹痛、腰痛、下腹坠胀,抑制肿瘤的进一步生长,阻断病情的进一步恶化;促进子宫功能的恢复;同时又要从整体调整身体机能,调和气血,改善血液循环,提高全身的免疫力, 促进垂体-性腺的功能,以达到最终肌瘤缩小,治愈疾病的目的。
实施例
本发明一种治疗粘膜下子宫肌瘤外用中药药物,由以下重量配比的中药原料,按照以下制备工艺制成:
白芷10g、醋制三棱45g、乳香4g、没药5g、滑石粉15g、全蝎6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、丹参30g、益母草20g、白鲜皮18g、桂枝9g、荆芥10g、白薇6g、丝瓜络10g、 三七10g、千年健30g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、半枝莲30g、穿心莲10g、紫背天葵15g、乌药30g、荔枝核45g、杜仲15g、桃仁30g、冰片0.9g、牛黄0.9g、珍珠3g、煅石膏45g、蟾酥0.03g 、吴茱萸3g、海马18g、五倍子15g、炉甘石9g、木香30g、牙皂5g、阿魏45g、土鳖虫6g、蜈蚣6g、败酱草30g、甘草9g、鲜土豆120g。
制备工艺:本发明采用上等纯天然中草药的根茎、果实、种子经过清洗,烘干等工艺,在无菌、无尘的条件下:
(1)将醋制三棱45g、全蝎6g、蜈蚣6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、益母草20g、丹参30g、白鲜皮18g、桂枝9g、荆芥10g、千年健30g、荔枝核45g、杜仲15g、桃仁30g、五倍子15g、海马18g、甘草9g、木香30g、阿魏45g、败酱草30g加冷水浸泡20-30min,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎沸后10分钟,漉出煎液;然后合并两次煎液浓缩至300ml装入无菌瓶内备用;
(2)将白芷10g、乳香4g、没药5g、蟾酥0.03g、三七10g、吴茱萸3g、白薇6g、丝瓜络10g、紫背天葵15 g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、乌药30g、穿心莲10g、牙皂5g、土鳖虫6g、半枝莲30g粉碎成最细粉过筛采用环氧乙烷灭菌备用;
(3)将炉甘石9g、冰片0.9g、牛黄0.9g、珍珠3g、滑石粉15g、煅石膏45g研成最细粉采用环氧乙烷灭菌备用;
(4)鲜土豆20g;
(5)用时取(1)中的备用品50ml,取(2)中的30g溶解混匀,再取(3)中的15g加入(1)和(2)的汇合物中搅拌成膏状,最后再加入捣成泥状的(4),搅拌均匀为最终药膏。
本发明的使用方法:
用时取(1)中的备用品50ml,取(2)中的30g溶解混匀,再取(3)中的15g加入(1)和(2)的汇合物中搅拌成膏状,最后再加入捣成泥状的(4),搅拌均匀成最终药膏。将药膏涂予相关腧穴(子宫穴、曲泉穴、曲骨穴,横骨穴、太溪穴、水泉穴、关元、气海、中极)、脐孔及下腹部包块处,外敷保鲜膜并按摩腧穴20分钟,每日早晚各一次,20天为一疗程。
本发明药理分析
本发明原料中:醋制三棱、桃仁、木香、姜黄、土鳖虫—破血行气,消积、逐瘀止痛;乳香、没药—活血止痛,消肿生肌;冰片、牛黄、蟾酥、大黄、牙皂、阿魏、鲜土豆、白鲜皮—清热解毒,消肿止痛;滑石粉、炉甘石、煅石膏、珍珠—清热、收湿敛疮;白薇、绞股蓝、穿心莲、防己、白花蛇舌草、甘草—健脾益气,清热解毒,疗疮痈,抗肿瘤。雷公藤、丝瓜络—活血通络,消肿止痛;川芎、 紫背天葵、 红花、丹参、益母草—活血祛瘀止痛,调节免疫抗肿瘤;桂枝、荆芥—温通经脉,通阳化气,止痛,止血;紫竹根、三七、黄药子、半枝莲、儿茶—软坚散结,化瘀止血,活血定痛。天花粉、败酱草、白芷—消肿排脓;吴茱萸、乌药、荔枝核—温肾散寒,行气止痛;杜仲、千年健、海马、五倍子、全蝎、当归、蜈蚣—补肝肾,强筋骨,活血散结,消肿止痛。
1、破血行气,消积、逐瘀止痛:将药物醋制三棱、桃仁、木香、姜黄、土鳖虫涂于子宫穴、曲泉穴、曲骨穴,横骨穴、太溪穴、水泉穴、关元、气海、中极等腧穴,脐孔及下腹部包块处其中的活性因子能迅速起到破血行气,消积、逐瘀止痛的作用,以达到散结消肿,止痛。这五种药物还具有很好的杀菌,抗病毒加速受损部位新陈代谢,抗血栓形成,促进血液流动,抗癌、抗基因突变、促进病变部位迅速恢复。
2. 活血止痛,消肿生肌:药物中的乳香、没药涂于子宫穴、曲泉穴、曲骨穴,横骨穴、太溪穴、水泉穴、关元、气海、中极等腧穴,脐孔及下腹部包块处,其中的活性因子能迅速起到活血止痛,消肿生肌的作用,这两种药物还具有多种抗菌素,所含的树脂、树胶、挥发油具有较强的镇痛作用。
3.清热解毒,消肿止痛:药物中的冰片、牛黄、蟾酥、大黄、牙皂、阿魏、鲜土豆、白鲜皮均有很好的清热解毒,消肿止痛的作用,能促进神经胶质细胞的分裂和生长,通过影响神经内分泌功能,进而调节机体的生理病理活动,以达到消肿、抗肿瘤、止痛的作用。
4. 清热、收湿敛疮:药物中的滑石粉、炉甘石、煅石膏、珍珠具有很好的清热,收湿敛疮的作用其中的活性成分,能吸着大量化学刺激物或毒物而起到收敛、消炎、止痒及保护创面作用,并能抑制局部葡萄球菌的生长。
5. 健脾益气,清热解毒,疗疮痈,抗肿瘤:药物中的白薇、绞股蓝、穿心莲、防己、白花蛇舌草、甘草具有健脾益气,清热解毒的作用,其中的三萜类、皂苷、氨基酸、黄酮、糖和多种无机元素,具有抗疲劳、抗缺氧、免疫调节、疗疮痈,抗肿瘤等作用。
6.活血通络,消肿止痛:药物中的雷公藤、丝瓜络通过腧穴,脐孔的刺激及药物的吸收,而充分起到活血通络,消肿止痛的作用,现代研究表明其中的生物碱、二萜、三萜和苷类等多种化合物有抗炎、镇痛、抗肿瘤、抗生育作用,有促进肾上腺合成皮质激素样作用。
7. 活血祛瘀止痛,调节免疫抗肿瘤;药物中的川芎、 紫背天葵、 红花、丹参、益母草具有很强的活血祛瘀止痛的作用,其中的生物碱,非生物碱有兴奋子宫的作用,还含有20多种具有镇静、解痉,免疫调节,抗放射,抗肿瘤的有效成分。
8. 温通经脉,通阳化气,镇痛,抗炎,止血:药物中的桂枝、荆芥均有温通经脉,通阳化气的作用,其中的桂皮醛,酮类,烯类成分具有很强的镇痛,抗炎,止血的作用。
9. 软坚散结,化瘀止血,活血定痛:药物中的紫竹根、三七、黄药子、半枝莲、儿茶可使子宫肌瘤软化缩小,有效减轻月经量多,子宫出血,腰部酸痛,下腹胀痛等症状。
10. 清热解毒、消肿排脓:药物中的天花粉、败酱草、白芷的有效成分如天花粉蛋白、癸酰乙醛、癸醛、月桂醛及甲壬酮等成分具有很强的清热解毒、消肿排脓的作用、据现代研究表明二者具有很强的抗菌、抗病毒、抗炎作用,还能增强机体的免疫力。
11. 温肾散寒,行气止痛;药物中的吴茱萸、乌药、荔枝核能起温肾散寒,行气止痛的作用,其中的碱次碱内酯通过中枢神经系统,而起到镇痛作用,通过温肾散寒提高机体的免疫力,并提高抗肿瘤,抑制肿瘤生长的能力。从而达到治愈疾病的目的。
12. 补肝肾,强筋骨,活血、散结、消肿止痛。药物中的杜仲、千年健、海马、五倍子、全蝎、当归、蜈蚣能有效滋补肝肾,强筋骨并能活血、散结、消肿止痛使子宫肌瘤缩小。
本发明药效学统计:
1.一般临床资料:选取我院妇产科2012年1月至2014年6月收治的124例子宫肌瘤患者,年龄20-81岁 ,随机分为2组:对照组62例,年龄20-79岁,平均49岁;实验组64例,年龄23-81岁,平均43岁、两组患者在年龄,营养状况等方面比较,差异无统计学意义(P>0.05)。
2.使用方法:对照组患者给予:甲睾酮5mg舌下含服,每天2次,每个疗程用药20天,实验组在甲睾酮5mg舌下含服,每天2次的基础上;将调好的药膏涂于相关腧穴(子宫穴、曲泉穴、曲骨穴,横骨穴、太溪穴、水泉穴、关元、气海、中极)、脐孔及下腹部包块处,外敷保鲜膜并按摩腧穴20分钟,每日早晚各一次, 20天为一疗程。
3.评价指标:1.比较两组患者第一个疗程后子宫肌瘤患者阴道流血,腹痛、腰酸、下腹坠胀症状变化情况、有效率2.比较两组患者第一个疗程后患者的治愈率。
4.统计学方法:应用SPSS13.0统计分析软件进行数据分析,两组间疗效比较采用x2检验p﹤0.05为差异有统计学意义。
表1 两组患者阴道流血、腹痛、腰酸、下腹坠胀症状消失、减轻比较(例)
注:χ2=5.905 p<0.05
表2 两组患者治愈率比较(%)
注:χ2=3.92 p<0.05
5. 结果:实验组患者阴道流血、腹痛、腰酸、下腹坠胀症状消失、减轻的人数明显高于对照组,有效率高,见表1;实验组患者治愈率高于对照组,见表2 。差异有统计学意义(P<0.05)。
本发明独特之处表现在:一是子宫肌瘤的药膏外敷起到了清热解毒,止痛消肿,活血化瘀,散寒通络的作用,可调节子宫的功能,使受损子宫迅速消肿,恢复原有功能;二是将中药膏外敷于相关腧穴每日两次,并每次按摩腧穴20分钟。利用了中医穴位贴敷、按摩治疗机理:中医认为,经络属于脏腑,外络于肢节,沟通内外,贯穿上下,将人体各部的组织器官联系成一个有机整体,运行气血,营养全身,使人体各部的功能活动能保持协调和相对平衡。中药膏外敷腧穴,并加以按摩:一方面可对人体的穴位产生刺激,激发经络的功能,调和气血,改善血液循环,促进和调整机体的免疫机能,调动人体内在的抗病能力,调整机体与外在环境的平衡,并调节人体的动态平衡;另一方面通过药物的渗透和按摩的促进渗透作用,药物通过皮肤进入血液循环,从而缓解症状,治愈疾病、并且中药贴敷还具有以下优点:1.小剂量的药物,可产生较强的治疗效果,2.中药膏外敷治疗简、便、灵、验、安全;三是通过药物和穴位的刺激可以促进垂体—性腺的功能,加速雌激素的分泌,可减轻仅用睾丸酮等雄激素的副作用,提高子宫肌瘤的治愈率。
上面所述的实施例仅是对本发明的优选实施方式进行描述,并非对本发明的构思和保护范围进行限定,在不脱离本发明设计构思的前提下,本领域中普通工程技术人员对本发明的技术方案作出的各种变型和改进,均应落入本发明的保护范围。
Claims (1)
1.一种治疗子宫肌瘤的外用中药药物,其特征是,由以下重量配比的中药原料,按照以下制备工艺制成:
白芷10g、醋制三棱45g、乳香4g、没药5g、滑石粉15g、全蝎6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、丹参30g、益母草20g、白鲜皮18g、桂枝9g、荆芥10g、白薇6g、丝瓜络10g、 三七10g、千年健30g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、半枝莲30g、穿心莲10g、紫背天葵15g、乌药30g、荔枝核45g、杜仲15g、桃仁30g、冰片0.9g、牛黄0.9g、珍珠3g、煅石膏45g、蟾酥0.03g 、吴茱萸3g、海马18g、五倍子15g、炉甘石9g、木香30g、牙皂5g、阿魏45g、土鳖虫6g、蜈蚣6g、败酱草30g、甘草9g、鲜土豆120g;
制备工艺为:将所述的中草药的根茎、果实、种子经过清洗,烘干工艺,在无菌、无尘的条件下:
(1)将醋制三棱45g、全蝎6g、蜈蚣6g、当归9g、绞股蓝30g、白花蛇舌草45g、雷公藤18g、防己18g、大黄18g、川芎30g、红花30g、益母草20g、丹参30g、白鲜皮18g、桂枝9g、荆芥10g、千年健30g、荔枝核45g、杜仲15g、桃仁30g、五倍子15g、海马18g、甘草9g、木香30g、阿魏45g、败酱草30g加冷水浸泡20-30min,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎沸后10分钟,漉出煎液;然后合并两次煎液浓缩至300ml装入无菌瓶内备用;
(2)将白芷10g、乳香4g、没药5g、蟾酥0.03g、三七10g、吴茱萸3g、白薇6g、丝瓜络10g、紫背天葵15 g、紫竹根3g、姜黄3g、黄药子3g、天花粉10g、儿茶3g、乌药30g、穿心莲10g、牙皂5g、土鳖虫6g、半枝莲30g粉碎成细粉过筛采用环氧乙烷灭菌备用;
(3)将炉甘石9g、冰片0.9g、牛黄0.9g、珍珠3g、滑石粉15g、煅石膏45g研成细粉采用环氧乙烷灭菌备用;
(4)鲜土豆20g;
(5)用时取工艺(1)中的备用品50ml,取工艺(2)中的30g溶解混匀,再取工艺(3)中的15g加入工艺(1)和工艺(2)的汇合物中搅拌成膏状,最后再加入捣成泥状的工艺(4)中的原料,搅拌均匀制成最终药膏。
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