CN104288450A - Method for preparing pain killer liniment containing short-pedicel aconite root - Google Patents
Method for preparing pain killer liniment containing short-pedicel aconite root Download PDFInfo
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Abstract
The invention relates to a method for preparing a pain killer liniment containing short-pedicel aconite root, belonging to the technical field of traditional Chinese medicine external preparations. The method comprises the following steps: mixing short-pedicel aconite root, Radix Aconiti Kusenzoffii, radix aconite and red flower to be uniform, thereby obtaining a mixture I; adding the mixture I into ethanol, leaching, and merging the leaching solution, thereby obtaining a first leaching solution; adding water to yunnan craibiodendron leaf, and performing heating extraction, thereby obtaining a second leaching solution; respectively grinding frankincense, Forrest Silkvine Stem or Root, Ligusticum wallichii, Psammosilene tunicoides, Paris polyphylla, monkshood, Caesalpinia cucullata and borneol into granules, and mixing to be uniform, thereby obtaining a mixture II; adding the mixture II into ethanol, leaching, and merging the leaching solution, thereby obtaining a third leaching solution; merging the first leaching solution, the second leaching solution and the third leaching solution, and adjusting the mass concentration of ethanol, thereby obtaining the product. According to the pain killer liniment provided by the invention, the yunnan craibiodendron leaf is singly extracted by using water, so that the phenomenon that the stability of the major component, namely the short-pedicel aconite root, is influenced by impurities in the yunnan craibiodendron leaf can be avoided.
Description
Technical field
The present invention relates to a kind of preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), belong to Chinese medicine for external application technical field.
Background technology
Physical distress has had influence on routine work and the quality of life of people.Pain is a kind of disease in fact, should actively science pain relieving, correctly carries out Drug therapy, avoids mistake in understanding.
Externally-used pain-relieving anti-inflammatory agent acts directly on local, in guarantee good therapeutic effect situation, can reduce the stomach discomfort eaten analgesic and bring.Domestic and international multiple pain therapy guide is pointed out, is the first selection in the local pains such as externally-used pain-relieving anti-inflammatory agent takes on lumbago and backache at neck, and acute turning round is pulled, the osteoarthritis such as hands, knee joint treatment, should be considered to use before use oral medicine.Externally-used pain-relieving medicine, can ease pain by effective antiinflammatory, adds quick-recovery.With warm water cleaning or immersion diseased region before coating, find out the most obvious pressure pain point of lesion, expand 2 ~ 3 centimetres of coatings as center towards periphery, massage a few minutes gently, to promote drug absorption.
Data analysis according to SFDA south medication economics institute: the marketing scale of 2008 annual externally-used pain-relieving plaster hospital market is at home about 5.51 hundred million yuan, comparatively increases by more than 45.51% same period last year; The marketing scale of retail market is 21.27 hundred million yuan, accounts for the market share of whole pain-stopping plaster 79.41%, and maintains the impetus increased fast.The overall market scale of 2008 annual China externally-used pain-relieving plaster medication reaches 26.78 hundred million yuan, accounts for the market share of whole externally-used pain-relieving medicine 53.65%, with same period last year than growth by 25.95%, higher than the rate of increase of externally-used pain-relieving medicine 14.13%.The sales volume of China's externally-used pain-relieving plaster kept the impetus of growth fast in recent years, estimated that China's externally-used pain-relieving plaster market scale will keep growth fast in following 3 to five years, and its annual rate of growth is estimated to remain between 15 % ~ 25%.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) liniment anodyne, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain.For traumatic injury (soft tissue sprain, contusion etc.) and various arthralgia.Be recorded in the 20th of the Quality of Chinese Traditional Proprietary Medicine standard of Ministry of Public Health (WS3-B-4006-98), but the method also exists Principle component extraction, and yield is low, the problem that stability is bad.
Summary of the invention
The object of the invention is: it is low that solution Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) quick-acting antalgesic liniment also exists Principle component extraction yield, the problem that stability is bad.Its preparation method is improved, proposes a kind of preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).
Technical scheme:
A preparation method for liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), comprises the steps:
1st step, by weight, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30 ~ 50 parts, Radix Aconiti 10 ~ 15 parts, Radix Aconiti Kusnezoffii 16 ~ 20 parts, 20 ~ 30 parts, Flos Carthami, after mix homogeneously, obtain mixture I, add the ethanol of 3 ~ 5 times of weight of mixture I, lixiviate 1 ~ 3 time, merge lixiviating solution, obtain the first lixiviating solution;
10 ~ 15 parts, 2nd step, depletion leaf, adds water, and heating extraction obtains the second lixiviating solution;
3rd step, get Olibanum 4 ~ 6 parts, Caulis et Radix Periplocae Forrestii 5 ~ 10 parts, Rhizoma Chuanxiong 3 ~ 6 parts, Radix Psammosilenes 5 ~ 15 parts, Rhizoma Paridis 3 ~ 5 parts, Radix Aconiti Lateralis Preparata 2 ~ 4 parts, Radix Zanthoxyli Spinifolii 6 ~ 12 parts, Borneolum Syntheticum 20 ~ 25 parts, be ground into the granule of diameter 1 ~ 3 cm respectively, after mix homogeneously, obtain mixtures II, add 3 ~ 5 times of w ethanol of mixtures II, lixiviate 1 ~ 3 time, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
In the 1st described step, the time of lixiviate is 10 ~ 30 days.
In the 1st described step, the mass concentration of described ethanol is 60 ~ 70%.
In the 2nd described step, the weight of water is 3 ~ 5 times of the weight of Folium Craibiodendri Yunnanensis.
In the 2nd described step, extraction time is 2 ~ 4 h.
In the 3rd described step, the time of lixiviate is 10 ~ 20 days.
In the 3rd described step, the mass concentration of described ethanol is 50 ~ 60%.
beneficial effect
In liniment anodyne provided by the invention, Folium Craibiodendri Yunnanensis is used water extraction separately, impurity effect wherein can be avoided to the stability of main constituent bullatine A.
Detailed description of the invention
embodiment 1
A preparation method for liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), comprises the steps:
1st step, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30Kg, Radix Aconiti 10Kg, Radix Aconiti Kusnezoffii 16Kg, Flos Carthami 20Kg, after mix homogeneously, obtain mixture I, add the ethanol of 3 times of weight of mixture I, the mass concentration of described ethanol is 60%, lixiviate 1 time, and the time of lixiviate is 10 days, merge lixiviating solution, obtain the first lixiviating solution;
2nd step, depletion leaf 10Kg, add water, heating extraction, and the weight of water is 3 times of the weight of Folium Craibiodendri Yunnanensis, and extraction time is 2h, obtains the second lixiviating solution;
3rd step, get Olibanum 4Kg, Caulis et Radix Periplocae Forrestii 5Kg, Rhizoma Chuanxiong 3Kg, Radix Psammosilenes 5Kg, Rhizoma Paridis 3Kg, Radix Aconiti Lateralis Preparata 2Kg, Radix Zanthoxyli Spinifolii 6Kg, Borneolum Syntheticum 20Kg, be ground into the granule of diameter 1cm respectively, after mix homogeneously, obtain mixtures II, add 3 times of w ethanol of mixtures II, the mass concentration of described ethanol is 50%, lixiviate 1 ~ 3 time, the time of lixiviate is 10 days, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
embodiment 2
A preparation method for liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), comprises the steps:
1st step, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50Kg, Radix Aconiti 15Kg, Radix Aconiti Kusnezoffii 20Kg, Flos Carthami 30Kg, after mix homogeneously, obtain mixture I, add the ethanol of 5 times of weight of mixture I, the mass concentration of described ethanol is 70%, lixiviate 3 times, and the time of lixiviate is 30 days, merge lixiviating solution, obtain the first lixiviating solution;
2nd step, depletion leaf 15Kg, add water, heating extraction, and the weight of water is 5 times of the weight of Folium Craibiodendri Yunnanensis, and extraction time is 4 h, obtains the second lixiviating solution;
3rd step, get Olibanum 6Kg, Caulis et Radix Periplocae Forrestii 10Kg, Rhizoma Chuanxiong 6Kg, Radix Psammosilenes 15Kg, Rhizoma Paridis 5Kg, Radix Aconiti Lateralis Preparata 4Kg, Radix Zanthoxyli Spinifolii 12Kg, Borneolum Syntheticum 25Kg, be ground into the granule of diameter 3 cm respectively, after mix homogeneously, obtain mixtures II, add 5 times of w ethanol of mixtures II, the mass concentration of described ethanol is 60%, lixiviate 3 times, the time of lixiviate is 20 days, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
embodiment 3
A preparation method for liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), comprises the steps:
1st step, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40Kg, Radix Aconiti 12Kg, Radix Aconiti Kusnezoffii 18Kg, Flos Carthami 25Kg, after mix homogeneously, obtain mixture I, add the ethanol of 4 times of weight of mixture I, the mass concentration of described ethanol is 65%, lixiviate 2 times, and the time of lixiviate is 20 days, merge lixiviating solution, obtain the first lixiviating solution;
2nd step, depletion leaf 12Kg, add water, heating extraction, and the weight of water is 4 times of the weight of Folium Craibiodendri Yunnanensis, and extraction time is 3h, obtains the second lixiviating solution;
3rd step, get Olibanum 5Kg, Caulis et Radix Periplocae Forrestii 8Kg, Rhizoma Chuanxiong 5Kg, Radix Psammosilenes 10Kg, Rhizoma Paridis 4Kg, Radix Aconiti Lateralis Preparata 3Kg, Radix Zanthoxyli Spinifolii 10Kg, Borneolum Syntheticum 22Kg, be ground into the granule of diameter 2 cm respectively, after mix homogeneously, obtain mixtures II, add 4 times of w ethanol of mixtures II, the mass concentration of described ethanol is 40%, lixiviate 2 times, the time of lixiviate is 15 days, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
reference examples 1
Be with the difference of embodiment 3: what Folium Craibiodendri Yunnanensis adopted is alcohol extraction.
A preparation method for liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), comprises the steps:
1st step, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40Kg, Radix Aconiti 12Kg, Radix Aconiti Kusnezoffii 18Kg, Flos Carthami 25Kg, after mix homogeneously, obtain mixture I, add the ethanol of 4 times of weight of mixture I, the mass concentration of described ethanol is 65%, lixiviate 2 times, and the time of lixiviate is 20 days, merge lixiviating solution, obtain the first lixiviating solution;
2nd step, depletion leaf 12Kg, add the alcoholic solution of 70%, heating extraction, and the weight of alcoholic solution is 4 times of the weight of Folium Craibiodendri Yunnanensis, and extraction time is 3h, obtains the second lixiviating solution;
3rd step, get Olibanum 5Kg, Caulis et Radix Periplocae Forrestii 8Kg, Rhizoma Chuanxiong 5Kg, Radix Psammosilenes 10Kg, Rhizoma Paridis 4Kg, Radix Aconiti Lateralis Preparata 3Kg, Radix Zanthoxyli Spinifolii 10Kg, Borneolum Syntheticum 22Kg, be ground into the granule of diameter 2 cm respectively, after mix homogeneously, obtain mixtures II, add 4 times of w ethanol of mixtures II, the mass concentration of described ethanol is 40%, lixiviate 2 times, the time of lixiviate is 15 days, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
assay
The preparation of reference substance solution: precision takes the bullatine A reference substance 5mg being dried to constant weight at 80 DEG C, put in 100ml measuring bottle, be diluted to scale with 0.0001mol/L dissolve with hydrochloric acid solution, shake up, obtain (containing bullatine A 50 μ g in every 1ml).
The preparation of need testing solution: precision measures this product 5ml, puts in water-bath and steams near dry, add 0.1mol/L hydrochloric acid solution 0.1ml and water 5ml, be stirred to dissolve, move in 100ml measuring bottle, add water to scale, shake up, filter, to obtain final product with dry filter paper.
Algoscopy: precision measures reference substance solution and each 2ml of need testing solution, put respectively in separatory funnel, respectively add bromocresol green solution and (get bromocresol green 50mg and Potassium Hydrogen Phthalate 1.021g, add 0.2mol/L sodium hydroxide solution 6.0ml and make dissolving, add water to 100ml, shake up, filter, to obtain final product) 2.0ml, precision adds chloroform 10ml, jolting extracts 2 minutes, leaves standstill and makes layering, divides the chloroform solution getting clarification, according to spectrophotography, measure trap respectively at the wavelength place of 416nm, meter, to obtain final product.
The every 1ml of this product contains total alkaloids with bullatine A (C
22h
33nO
2) meter, should be 0.59 ~ 0.81mg.
Above-mentioned sample is placed in Brown Glass Brown glass bottles and jars only, carries out long-term stable experiment, temperature 25 DEG C ± 2 DEG C, relative humidity, 60% ± 5%, samples detection level respectively at 0,12,24 the end of month.
Every 1ml of the sample in each embodiment of table 1 and reference examples containing total alkaloid content, unit mg
As can be seen from the table, in method provided by the invention, the content of active substance is high, and by Folium Craibiodendri Yunnanensis separately with after water extraction, impurity effect can be avoided to arrive main constituent, makes drug main composition in long-term stable experiment, occur degraded.
Claims (7)
1. a preparation method for the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), is characterized in that, comprise the steps:
1st step, by weight, get Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30 ~ 50 parts, Radix Aconiti 10 ~ 15 parts, Radix Aconiti Kusnezoffii 16 ~ 20 parts, 20 ~ 30 parts, Flos Carthami, after mix homogeneously, obtain mixture I, add the ethanol of 3 ~ 5 times of weight of mixture I, lixiviate 1 ~ 3 time, merge lixiviating solution, obtain the first lixiviating solution;
10 ~ 15 parts, 2nd step, depletion leaf, adds water, and heating extraction obtains the second lixiviating solution;
3rd step, get Olibanum 4 ~ 6 parts, Caulis et Radix Periplocae Forrestii 5 ~ 10 parts, Rhizoma Chuanxiong 3 ~ 6 parts, Radix Psammosilenes 5 ~ 15 parts, Rhizoma Paridis 3 ~ 5 parts, Radix Aconiti Lateralis Preparata 2 ~ 4 parts, Radix Zanthoxyli Spinifolii 6 ~ 12 parts, Borneolum Syntheticum 20 ~ 25 parts, be ground into the granule of diameter 1 ~ 3 cm respectively, after mix homogeneously, obtain mixtures II, add 3 ~ 5 times of w ethanol of mixtures II, lixiviate 1 ~ 3 time, merges lixiviating solution, obtains the 3rd lixiviating solution;
4th step, merge the first lixiviating solution, the second lixiviating solution, the 3rd lixiviating solution, and the mass concentration adjusting ethanol is 60%.
2. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, it is characterized in that: in the 1st described step, the time of lixiviate is 10 ~ 30 days.
3. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, it is characterized in that: in the 1st described step, the mass concentration of described ethanol is 60 ~ 70%.
4. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, it is characterized in that: in the 2nd described step, the weight of water is 3 ~ 5 times of the weight of Folium Craibiodendri Yunnanensis.
5. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, is characterized in that: in the 2nd described step, extraction time is 2 ~ 4 h.
6. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, it is characterized in that: in the 3rd described step, the time of lixiviate is 10 ~ 20 days.
7. the preparation method of the liniment anodyne containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) according to claim 1, it is characterized in that: in the 3rd described step, the mass concentration of described ethanol is 50 ~ 60%.
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Cited By (1)
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| CN105997855A (en) * | 2016-06-24 | 2016-10-12 | 贵州弘康药业有限公司 | Itching-relieving and pain-relieving pollen liniment and preparation method thereof |
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| CN1723928A (en) * | 2005-07-07 | 2006-01-25 | 云南省药物研究所 | External use medicinal composition for treating swelling paint |
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2014
- 2014-09-30 CN CN201410516874.2A patent/CN104288450A/en active Pending
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| CN1686197A (en) * | 2005-03-23 | 2005-10-26 | 云南省玉溪市维和制药有限公司 | External use medicinal preparation using aconiti brachypodi tuber, raw aconite etc. thirteen medicinal extracts |
| CN1723928A (en) * | 2005-07-07 | 2006-01-25 | 云南省药物研究所 | External use medicinal composition for treating swelling paint |
Non-Patent Citations (1)
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| 中华人民共和国卫生部药典委员会编: "《中华人民共和国卫生部药品标准 中药成方制剂（第二十册）》", 31 December 1998 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105997855A (en) * | 2016-06-24 | 2016-10-12 | 贵州弘康药业有限公司 | Itching-relieving and pain-relieving pollen liniment and preparation method thereof |
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Application publication date: 20150121 |