CN104288366A - 鸡用保肝护肾口服液及其制备方法 - Google Patents

鸡用保肝护肾口服液及其制备方法 Download PDF

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CN104288366A
CN104288366A CN201410531745.0A CN201410531745A CN104288366A CN 104288366 A CN104288366 A CN 104288366A CN 201410531745 A CN201410531745 A CN 201410531745A CN 104288366 A CN104288366 A CN 104288366A
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liver
oral liquid
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kidney
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陈庆忠
安同伟
曹桂敏
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Tianjin Rebate Science and Technology Development Co Ltd
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Abstract

本发明涉及一种鸡用保肝护肾口服液，其口服液的组分及其重量份数比分别为：水飞蓟素2-6份；牛磺酸1-5份；丁香2-6份；茴香1-5份；川楝子3-7份；白芍1-5份；地锦草4-8份；列当4-8份；肉苁蓉4-8份；肉桂1-5份；合欢皮1-5份；灯心草1-5份。本发明配方组成科学合理，工艺简单，使用方便，成本较低，本口服液通过稳定修复受损的肝细胞保证肝脏正常的制造和解毒功能，通过扶正祛邪、补血活血、提升免疫力来保护肝脏和肾脏。

Description

鸡用保肝护肾口服液及其制备方法
技术领域
本发明属于兽药领域，尤其是一种鸡用保肝护肾口服液及其制备方法。
背景技术
随着肉鸡规模化、集约化、专业化、自动化发展和药物超量长时间使用，鸡的肝肾病发生率越来越高，危害愈来愈重，已成为鸡病中严重的问题。鸡肝肾病综合征是多种原因引起的肾脏机能障碍的总称。主要表现精神沉郁，羽毛蓬乱，低头嗜睡，饮水增多，排白色或水样稀便，解剖可见肾脏苍白或出血或尿酸盐沉积，肝脏腹水、肝脏萎缩、肝脏出血、肝脏淤血、肝脏有白色、黄色坏死灶等，轻则使雏鸡发育受阻，成鸡生产性能下降，重则导致大量死亡，造成严重经济损失。
发明内容
本发明的目的在于提供一种鸡用保肝护肾口服液，该组合物配方组成科学合理，工艺简单，使用方便，成本较低，本口服液通过稳定修复受损的肝细胞保证肝脏正常的制造和解毒功能，通过扶正祛邪、补血活血、提升免疫力来保护肝脏和肾脏。
本发明的另一个目的在于提供一种鸡用保肝护肾口服液的制备方法。
本发明主要通过以下技术方案实现的：
一种鸡用保肝护肾口服液，其口服液的组分及其重量份数比分别为：
而且，该口服液的组分及其最优重量份数比分别为：
一种鸡用保肝护肾口服液的制备方法，其制备方法步骤为：
(1)按配比重量称取丁香、茴香、川楝子、白芍、地锦草、列当、肉苁蓉、肉桂、合欢皮、灯心草，经洗净润药烘干后投入中药提取罐内，加1:1投料量的纯化水，在室温下浸泡24小时后，再继续加热至水沸腾煎煮10小时，将提取液0.45um过滤后吸入配液罐内储罐；
(2)中药提取罐内再加入1倍投料量的纯化水，加热至沸腾煎煮2小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并；
(3)将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa，蒸发器15分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次；
(4)提取液浓缩至原生药1ml将提取液吸入醇沉罐内，室内自然冷却，备用；
(5)将上清液储罐中的提取液过滤后吸入醇醇沉罐，自然醇沉36小时收取上清液，弃去残渣，直至原生药1ml；
(6)加入0.3％硫柳汞钠和5％的苯甲酸钠，用0.22um聚醚砜滤芯过滤；
(7)在称量区称取水飞蓟素、牛磺酸，向配液罐内缓慢加入水飞蓟素、牛磺酸，再加入80℃的注射水，加至200L，调节药液PH值：4.5-6.5，搅拌15分钟以上，用0.22um聚醚砜滤芯过滤，药液通过管道直接进入灌装机；
(8)打开灌装机进行灌装，灌装到医用瓶内，即可得到一种鸡用保肝护肾口服液。
本发明的优点及有益效果是：
1.口服液通过稳定肝脏细胞、修复受损的肝细胞、防治肝硬化、保证肝脏的制造和解毒功能，通过抑制PG合成，对抗缓激肽，抑制白细胞趋化和稳定溶酶体，阻止炎性物质合成和促进尿酸盐分解，对肾脏疾病、药物或毒素所致的肾炎，肾肿有很好的疗效。
2.中药成分毒扶正解毒、补血活血、提升免疫力、保肝护肾，长期应用安全可靠。
具体实施方式
本发明通过以下实施例进一步详述。需要说明的是：下述实施例是说明性的，不是限定性的，不能以下述实施例来限定本发明的保护范围。
实施例1
一种鸡用保肝护肾口服液，该口服液组分的重量分别为：水飞蓟素4kg、牛磺酸3kg、丁香4kg、茴香3kg、川楝子5kg、白芍3kg、地锦草6kg、列当6kg、肉苁蓉6kg、肉桂3kg、合欢花3kg、灯心草3kg。
一种鸡用保肝护肾口服液的制备方法，该口服液制备工艺步骤如下：
(1)安国市万联中药饮片有限公司采购购筛选净药材，在称重区按配比重量称取丁香、茴香、川楝子、白芍、地锦草、列当、肉苁蓉、肉桂、合欢皮、灯心草，经洗净润药烘干后投入中药提取罐内，加1:1投料量的纯化水，在室温下浸泡24小时后，再继续加热至水沸腾煎煮10小时，将提取液0.45um过滤后吸入配液罐内储罐。
(2)中药提取罐内再加入1倍投料量的纯化水，加热至沸腾煎煮2小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并。
(3)将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa为宜，蒸发器15分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次。
(4)提取液浓缩至原生药1ml相当于原生药1g将提取液吸入醇沉罐内，室内自然冷却，备用。
(5)将上清液储罐中的提取液过滤后吸入醇沉罐，自然醇沉36小时收取上清液，弃去残渣，直至原生药1ml相当于原生药2g。
(6)加入0.3％硫柳汞钠和5％的苯甲酸钠，用0.22um聚醚砜滤芯过滤。
(7)在称量区称取水飞蓟素、牛磺酸，向配液罐内缓慢加入水飞蓟素、牛磺酸，再加入80℃的注射水，加至200L，调节药液PH值：4.5-6.5，搅拌15分钟以上，用0.22um聚醚砜滤芯过滤，药液通过管道直接进入灌装机。
(8)打开灌装机进行灌装，灌装到医用瓶内，用纯化水清洗医用瓶，灌装，即可得到一种保肝护肾的口服液。
实施例2
一种鸡用保肝护肾口服液，该口服液组分的重量分别为：水飞蓟素2kg、牛磺酸1kg、丁香2kg、茴香1kg、川楝子3kg、白芍1kg、地锦草4kg、列当4kg、肉苁蓉4kg、肉桂1kg、合欢皮1kg、灯心草1kg。
其制备工艺的步骤同实施例1。
实施例3
一种鸡用保肝护肾口服液，该口服液组分的重量分别为：水飞蓟素3kg、牛磺酸2kg、丁香3kg、茴香2kg、川楝子4kg、白芍2kg、地锦草5kg、列当5kg、肉苁蓉5kg、肉桂2kg、合欢皮2kg、灯心草2kg。
其制备工艺的步骤同实施例1。
实施例4
一种鸡用保肝护肾口服液，该口服液组分的重量分别为：水飞蓟素5kg、牛磺酸4kg、丁香5kg、茴香4kg、川楝子6kg、白芍4kg、地锦草7kg、列当7kg、肉苁蓉7kg、肉桂4kg、合欢皮4kg、灯心草4kg。
其制备工艺的步骤同实施例1。
实施例5
一种鸡用保肝护肾口服液，该口服液组分的重量分别为：水飞蓟素6kg、牛磺酸5kg、丁香6kg、茴香5kg、川楝子7kg、白芍5kg、地锦草8kg、列当8kg、肉苁蓉8kg、肉桂5kg、合欢皮5kg、灯心草5kg。
其制备工艺的步骤同实施例1。
临床试验
1.口服液在商品肉鸡上的临床试验，病鸡表现为精神状态差，采食量下降，消化不良性腹泻，鸡体瘦弱，生长缓慢，尿液褐色，解剖肝脏腹水，萎缩，出血，肾脏肿大等。
2.试验时间：2014.02.28日，试验鸡群，某养殖厂商品艾维茵肉鸡，100只，分为4组，对照组，试验组，常规治疗I组，常规治疗II组每组15只，用法用量：治疗口服一次量每1kg体重，鸡2ml，一日一次，仅用一次。
对照组：为空白组，不使用任何药物治疗。
本发明实验组：为口服治疗组。1kg体重2ml
常规治疗I组：为市售药物治疗组，肝胆利康散，1kg体重2g。按使用说明书使用；
常规治疗II组：为市售药物治疗组l肝肾舒，1kg体重1g。按使用说明书使用；
试验结果如下：
试验表明：
综上所述，本发明口服液对商品肉鸡保肝护肾见效快，疗效好。

Claims (3)

1.一种鸡用保肝护肾口服液，其特征在于：该口服液的组分及其重量份数比分别为：
2.根据权利要求1所述的鸡用保肝护肾口服液，其特征在于：该口服液的组分及其最优重量份数比分别为：
3.一种如权利要求1所述的鸡用保肝护肾口服液的制备方法，其特征在于：该制备方法步骤为：
(1)按配比重量称取丁香、茴香、川楝子、白芍、地锦草、列当、肉苁蓉、肉桂、合欢皮、灯心草，经洗净润药烘干后投入中药提取罐内，加1:1投料量的纯化水，在室温下浸泡24小时后，再继续加热至水沸腾煎煮10小时，将提取液0.45um过滤后吸入配液罐内储罐；
(2)中药提取罐内再加入1倍投料量的纯化水，加热至沸腾煎煮2小时将提取液过滤后吸入配液罐内储罐，和第一次提取液合并；
(3)将提取液进行浓缩，将配液罐加热以蒸汽压力0.09Mpa，蒸发器15分钟排放冷凝水一次，每两小时排放加热器的冷凝汽一次；
(4)提取液浓缩至原生药1ml将提取液吸入醇沉罐内，室内自然冷却，备用；
(5)将上清液储罐中的提取液过滤后吸入醇醇沉罐，自然醇沉36小时收取上清液，弃去残渣，直至原生药1ml；
(6)加入0.3％硫柳汞钠和5％的苯甲酸钠，用0.22um聚醚砜滤芯过滤；
(7)在称量区称取水飞蓟素、牛磺酸，向配液罐内缓慢加入水飞蓟素、牛磺酸，再加入80℃的注射水，加至200L，调节药液PH值：4.5-6.5，搅拌15分钟以上，用0.22um聚醚砜滤芯过滤，药液通过管道直接进入灌装机；
(8)打开灌装机进行灌装，灌装到医用瓶内，即可得到一种鸡用保肝护肾口服液。
CN201410531745.0A 2014-10-10 2014-10-10 鸡用保肝护肾口服液及其制备方法 Pending CN104288366A (zh)

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