CN104288325A - 一种治疗早发性象皮肿的中药及其制备方法 - Google Patents

一种治疗早发性象皮肿的中药及其制备方法 Download PDF

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CN104288325A
CN104288325A CN201410576413.4A CN201410576413A CN104288325A CN 104288325 A CN104288325 A CN 104288325A CN 201410576413 A CN201410576413 A CN 201410576413A CN 104288325 A CN104288325 A CN 104288325A
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CN104288325B (zh
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张守良
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Zhuhai Hengqin Maikairui Pharmaceutical Technology Co.,Ltd.
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HARBIN JINYU TECHNOLOGY DEVELOPMENT Co Ltd
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Abstract

一种治疗早发性象皮肿的中药及其制备方法，按以下重量份数比制备而成,牵牛子2-6份、一枝黄花6-11份、千金子3-6份、牛膝5-10份、生地4-9份、山橙6-12份、桑椹子5-10份、水蛭3-5份、大戟7-10份、丝瓜络7-12份、桃仁5-10份、水瓜5-10份、井栏荽7-13份、金钱草6-12份、女贞子5-10份、蛇王草3-7份、地肤子5-10份、川楝子4-8份、大黄4-8份、商陆2-5份。本发明所述方法包括爆炒、浸泡等过程。本发明制得的药物能够安全有效治早发性象皮肿。本发明所述方法简单适用。

Description

一种治疗早发性象皮肿的中药及其制备方法
技术领域
本发明涉及一种中药及其制备方法,具体涉及一种治疗早发性象皮肿的中药及其制备方法。
背景技术
淋巴水肿是指机体某些部位淋巴液回流受阻引起的软组织液在体表反复感染后皮下纤维结缔组织增生，脂肪硬化，若为肢体则增粗，后期皮肤增厚、粗糙、坚韧如象皮，亦称“象皮肿”。早期患肢肿胀，抬高后可减轻。晚期患肢肿大明显，表面角化粗糙，呈橡皮样肿。少数可有皮肤裂开、溃疡或出现疣状赘生物。对于早发性象皮肿目前尚缺少安全有效的治疗药物。
发明内容
本发明的目的是提供一种治疗早发性象皮肿的中药及其制备方法，在原有的中医基础上,本发明提出了燥湿解毒、活血化瘀、温补脾肾、利水解毒水肿胀满新疗法,经过反复实验,确定了配伍比例,达到安全有效治愈早发性象皮肿的目的。制备方法简单实用。
所述目的是通过如下方案实现的：
一种治疗早发性象皮肿的中药，按以下重量份数比制备而成,牵牛子2-6份、一枝黄花6-11份、千金子3-6份、牛膝5-10份、生地4-9份、山橙6-12份、桑椹子5-10份、水蛭3-5份、大戟7-10份、丝瓜络7-12份、桃仁5-10份、水瓜5-10份、井栏荽7-13份、金钱草6-12份、女贞子5-10份、蛇王草3-7份、地肤子5-10份、川楝子4-8份、大黄4-8份、商陆2-5份。
优选方案1:
按以下重量份数比制备而成,牵牛子3份、一枝黄花11份、千金子3份、牛膝5份、生地6份、山橙12份、桑椹子10份、水蛭3份、大戟8份、丝瓜络9份、桃仁5份、水瓜10份、井栏荽13份、金钱草10份、女贞子5份、蛇王草5份、地肤子10份、川楝子4份、大黄4份、商陆5份。
优选方案2:
按以下重量份数比制备而成,牵牛子2份、一枝黄花9份、千金子6份、牛膝10份、生地4份、山橙6份、桑椹子8份、水蛭5份、大戟10份、丝瓜络7份、桃仁8份、水瓜8份、井栏荽7份、金钱草6份、女贞子8份、蛇王草7份、地肤子5份、川楝子8份、大黄5份、商陆2份。
优选方案3:
按以下重量份数比制备而成,牵牛子6份、一枝黄花6份、千金子4份、牛膝7份、生地9份、山橙9份、桑椹子5份、水蛭4份、大戟7份、丝瓜络12份、桃仁10份、水瓜5份、井栏荽10份、金钱草12份、女贞子10份、蛇王草3份、地肤子8份、川楝子6份、大黄8份、商陆3份。
制备方法:
(1)将水蛭、大戟、川楝子、大黄、牵牛子、商陆放入蒸锅里蒸8分钟,蒸锅里放入50度白酒,白酒与水的重量比为1:1。取出放入炒锅里加入醋炒3分钟,与醋的重量比为1:0.2。再加入黄酒爆炒,与黄酒的重量比为1:0.1,2分钟后取出,晾凉,研成细末备用；
(2)将一枝黄花、千金子、牛膝、山橙、桑椹子、丝瓜络、桃仁、水瓜、井栏荽、金钱草、女贞子、蛇王草、地肤子、生地清洗后用零下20-30摄氏度的水浸泡50分钟，取出自然晒干,研成细末备用；
(3)将(1)和(2)混合搅拌,制成胶囊。
药理说明:
牵牛子,功能：泻下去积，逐水退肿，杀虫。主治：热结便秘，水肿，蛔虫，绦虫。
一枝黄花,1.疏风清热：用治感冒发热，咳嗽，2．解毒消肿：用于疮疡肿痛，痈肿，黄疸，毒蛇咬伤等。外用跌打损伤。
千金子功能：泻水消肿，破血通经。
牛膝,活血祛瘀、补肝肾，强筋骨，利尿通淋，引血下行。生用祛瘀血，引血下行，利关节；熟用补肝肾，强筋骨。
生地：功效与作用：1、止血：动物实验证实，生地的提取物有促进血液凝固的作用，可见中医在止血方剂内应用生地是有根据的。2、强心、利尿：对衰弱的心脏，其强心作用较显著，主要作用于心肌。由于有强心、利尿作用，故有助于解热。3、降血糖：作用显著，能抑制实验性高血糖，也能使正常家免的血糖量下降。
山橙,功能：化气、止痛。
桑椹子,有利尿、镇咳、增强机体抵抗力的作用。
水蛭,功能：通经、破瘀、消肿。
主治：瘀血停滞、经闭、血块积聚、丹毒痈肿、跌打损伤等。
大戟,功能：攻积逐水、解毒。主治：水肿胀满、痰饮积聚，痈肿疮毒。
丝瓜络,功能：清热解毒、活血通络、利尿消肿。主治：筋骨酸痛、胸胁痛、乳汁不通、经闭、睾丸肿痛、便血、崩漏等症。
桃仁：功效与作用：破血行瘀，油燥滑肠。其作用为：镇痛、消炎、解毒、通便。又对小白鼠实验性结核病有疗效。
水瓜,性味：功能：利水、解热毒。
井栏荽：功能：清热、利水、祛湿。
金钱草：功能：平肝火、清气热、利水、通淋、祛黄、理肺热、化气、止咳。
女贞子：1.对因化疗或放疗引起的白血球下降有升高作用；2.煎剂对痢疾杆菌有抑制作用；3.有强心利尿作用。
蛇王草：功能：消肿、散毒、止痛、止痒。
地肤子：功效与作用：清湿热（利尿、抗皮肤真菌）。功能：清湿热，利小便。
川楝子,功能：清肝火，除湿热，止痛，杀虫。
大黄,功能：泻下通肠，行瘀破积、外敷清火消肿。主治：肠胃实热积滞，血分实热证，黄疸，水肿，瘀血积聚。外服痈肿疮毒，水火烫伤。
商陆性味：功能：逐水、利尿、消肿。主治：水肿胀满、小便不利。
一枝黄花、蛇王草、牵牛子、桃仁、川楝子有燥湿解毒功效。牛膝、山橙、丝瓜络、千金子、水蛭、大黄有活血化瘀、温补脾肾功效。生地、桑椹子、大戟、井栏荽、金钱草、女贞子、商陆、水瓜、地肤子有利水解毒水肿胀满功效。
本发明采用以上配方,在药物间的相互与协同作用下,能快速排除郁积滞留淋巴液,加快水钠排出，能够安全有效治早发性象皮肿。本发明所述方法简单，容易操作，利于推广应用。
具体实施方式
下面详细阐述本发明优选的实施方式。
治疗方法：
每个胶囊0.5克,一日三次，每次3克，连续服用10日为一个疗程，根据病情一般需治疗1-4个疗程，可达到较好治愈的效果。
实施例1:
一种治疗早发性象皮肿的中药，按以下重量份数比制备而成,牵牛子2-6份、一枝黄花6-11份、千金子3-6份、牛膝5-10份、生地4-9份、山橙6-12份、桑椹子5-10份、水蛭3-5份、大戟7-10份、丝瓜络7-12份、桃仁5-10份、水瓜5-10份、井栏荽7-13份、金钱草6-12份、女贞子5-10份、蛇王草3-7份、地肤子5-10份、川楝子4-8份、大黄4-8份、商陆2-5份。制备方法见实施例2。
病例：陆某，女，24岁，哈尔滨人。患病1年,服用本胶囊10天,皮皱减轻,接着服用10天,皮肤增厚变硬粗糙现象消失。
实施例2:
按以下重量份数比制备而成,牵牛子3份、一枝黄花11份、千金子3份、牛膝5份、生地6份、山橙12份、桑椹子10份、水蛭3份、大戟8份、丝瓜络9份、桃仁5份、水瓜10份、井栏荽13份、金钱草10份、女贞子5份、蛇王草5份、地肤子10份、川楝子4份、大黄4份、商陆5份。
制备方法:
(1)将水蛭、大戟、川楝子、大黄、牵牛子、商陆放入蒸锅里蒸8分钟,蒸锅里放入50度白酒,白酒与水的重量比为1:1。取出放入炒锅里加入醋炒3分钟,与醋的重量比为1:0.2。再加入黄酒爆炒,与黄酒的重量比为1:0.1,2分钟后取出,晾凉,研成细末备用；
(2)将一枝黄花、千金子、牛膝、山橙、桑椹子、丝瓜络、桃仁、水瓜、井栏荽、金钱草、女贞子、蛇王草、地肤子、生地清洗后用零下20-30摄氏度的水浸泡50分钟，取出自然晒干,研成细末备用；
(3)将(1)和(2)混合搅拌,制成胶囊。
典型病例：
病例：王某，女，25岁，山东人。患病4年,服用本胶囊30天,皮肤增厚变硬粗糙现象消失。
实施例3:
按以下重量份数比制备而成,牵牛子2份、一枝黄花9份、千金子6份、牛膝10份、生地4份、山橙6份、桑椹子8份、水蛭5份、大戟10份、丝瓜络7份、桃仁8份、水瓜8份、井栏荽7份、金钱草6份、女贞子8份、蛇王草7份、地肤子5份、川楝子8份、大黄5份、商陆2份。制备方法和实施例2相同。
实施例4:
按以下重量份数比制备而成,牵牛子6份、一枝黄花6份、千金子4份、牛膝7份、生地9份、山橙9份、桑椹子5份、水蛭4份、大戟7份、丝瓜络12份、桃仁10份、水瓜5份、井栏荽10份、金钱草12份、女贞子10份、蛇王草3份、地肤子8份、川楝子6份、大黄8份、商陆3份。制备方法和实施例2相同。
发明人2010年8月-2011年10月间共收集110例早发性象皮肿的女性门诊患者，年龄14-25岁，病程1-6年。随机分为：治疗组80例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性。
试验方法：
治疗组口服本发明的胶囊，早中晚各一次。疗程20天。
空白组口服安慰剂胶囊，早中晚各一次。疗程20天。
治疗组痊愈40人,临床症状全部消失，试验室检查正常,好转40人临床症状减轻，病情得到控制，实验室检查改善或正常。无效0人。
空白组痊愈0人,好转8人临床症状减轻，病情得到控制，实验室检查改善或正常。无效22人。
可见，本发明制得的药物能够安全有效治早发性象皮肿。
本实施方式只是对本专利的示例性说明而并不限定它的保护范围，本领域人员还可以对其进行局部改变，只要没有超出本专利的精神实质，都视为对本专利的等同替换，都在本专利的保护范围之内。

Claims (5)

1.一种治疗早发性象皮肿的中药，其特征在于:按以下重量份数比制备而成,牵牛子2-6份、一枝黄花6-11份、千金子3-6份、牛膝5-10份、生地4-9份、山橙6-12份、桑椹子5-10份、水蛭3-5份、大戟7-10份、丝瓜络7-12份、桃仁5-10份、水瓜5-10份、井栏荽7-13份、金钱草6-12份、女贞子5-10份、蛇王草3-7份、地肤子5-10份、川楝子4-8份、大黄4-8份、商陆2-5份。
2.根据权利要求1所述的一种治疗早发性象皮肿的中药，其特征在于:按以下重量份数比制备而成,牵牛子3份、一枝黄花11份、千金子3份、牛膝5份、生地6份、山橙12份、桑椹子10份、水蛭3份、大戟8份、丝瓜络9份、桃仁5份、水瓜10份、井栏荽13份、金钱草10份、女贞子5份、蛇王草5份、地肤子10份、川楝子4份、大黄4份、商陆5份。
3.根据权利要求1所述的一种治疗早发性象皮肿的中药，其特征在于:按以下重量份数比制备而成,牵牛子2份、一枝黄花9份、千金子6份、牛膝10份、生地4份、山橙6份、桑椹子8份、水蛭5份、大戟10份、丝瓜络7份、桃仁8份、水瓜8份、井栏荽7份、金钱草6份、女贞子8份、蛇王草7份、地肤子5份、川楝子8份、大黄5份、商陆2份。
4.根据权利要求1所述的一种治疗早发性象皮肿的中药，其特征在于:按以下重量份数比制备而成,牵牛子6份、一枝黄花6份、千金子4份、牛膝7份、生地9份、山橙9份、桑椹子5份、水蛭4份、大戟7份、丝瓜络12份、桃仁10份、水瓜5份、井栏荽10份、金钱草12份、女贞子10份、蛇王草3份、地肤子8份、川楝子6份、大黄8份、商陆3份。
5.权利要求1-4所述的一种治疗早发性象皮肿的中药制备方法，其特征在于:(1)将水蛭、大戟、川楝子、大黄、牵牛子、商陆放入蒸锅里蒸8分钟,蒸锅里放入50度白酒,白酒与水的重量比为1:1，取出放入炒锅里加入醋炒3分钟,与醋的重量比为1:0.2；再加入黄酒爆炒,与黄酒的重量比为1:0.1,2分钟后取出,晾凉,研成细末备用；
(2)将一枝黄花、千金子、牛膝、山橙、桑椹子、丝瓜络、桃仁、水瓜、井栏荽、金钱草、女贞子、蛇王草、地肤子、生地清洗后用零下20-30摄氏度的水浸泡50分钟，取出自然晒干,研成细末备用；
(3)将(1)和(2)混合搅拌,制成胶囊。
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