CN104288226A - Compound nasal drops - Google Patents

Compound nasal drops Download PDF

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Publication number
CN104288226A
CN104288226A CN201410553472.XA CN201410553472A CN104288226A CN 104288226 A CN104288226 A CN 104288226A CN 201410553472 A CN201410553472 A CN 201410553472A CN 104288226 A CN104288226 A CN 104288226A
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Prior art keywords
parts
herba
liver oil
cod
compound
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CN201410553472.XA
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Chinese (zh)
Inventor
刘巴宁
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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Priority to CN201410553472.XA priority Critical patent/CN104288226A/en
Publication of CN104288226A publication Critical patent/CN104288226A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the technical field of the medicine and specifically relates to compound nasal drops. The compound nasal drops are prepared from the following raw materials in parts by weight: 15-35 parts of seal cod-liver oil, 8-12 parts of ephedra, 7-9 parts of siberian cocklebur, 3-7 parts of mint, 4-7 parts of beautiful sweetgum fruit, 2-7 parts of honeysuckle, 1-2 parts of sodium chloride, 0.3-0.7 parts of borneol and a proper amount of water. The compound nasal drops have the effects of diminishing inflammation and nourishing and moisturizing the epithelial cells of the nasal mucosa by scientifically combining the cod-liver oil and natural Chinese herbs and by virtue of the synergistic effect of the medicinal materials; besides, the compound nasal drops do not cause any side effect and allergic reaction.

Description

Compound nose drop
Technical field
The present invention relates to technical field of pharmaceuticals, specifically a kind of compound nose drop.
Background technology
Rhinitis (Rhinitis) refers to the inflammation of nasal membrane and submucous tissue.Show as hyperemia or edema, patient often there will be nasal obstruction, and stream clear water tears, rhinocnesmus, throat is uncomfortable, the symptoms such as cough.The wash sample material of nasal secretions is called nasal mucus or nasal secretion, and its effect helps dust out, and antibacterial is to keep the health of pulmonary.Under normal circumstances, be drawn to throat after the nasal mucus of mixed cell and dust and finally enter gastric, because its secretory volume is little, generally can not attract much attention.When inflammation appears in intranasal, nasal cavity can secrete a large amount of nasal mucus, and can because of infection yellowing, can cough be caused when flowing through throat, can also flow out through prenaris when nasal mucus amount is very many.
The medicine for external use being used for the treatment of nose diseases at present mostly containing antibiotic and Claritin, life-time service the drug resistance of antibacterial can be caused to strengthen and patient to the dependence of Claritin.Therefore, this type of medicine is strictly prohibited life-time service bar none.Although oral antibiotic and Claritin also can the symptoms of reduction of patient, same exist the similar drug dependence problem with the former.Especially the side effect such as drowsiness grade that Claritin causes can bring serious potential safety hazard to being engaged in driving, mechanically actuated and work high above the ground contour risk post patient.
Summary of the invention
The object of the invention is for above-mentioned Problems existing, providing a kind of is the nasal drop of raw material with natural materials.
For achieving the above object, the technical solution used in the present invention is: a kind of compound nose drop, is made up of the raw material of following parts by weight: sea dog cod-liver oil 15 ~ 35 parts, 8 ~ 12 parts, Herba Ephedrae, Herba Xanthii 7 ~ 9 parts, Herba Menthae 3 ~ 7 parts, Fructus Liquidambaris 4 ~ 7 parts, Flos Lonicerae 2 ~ 7 parts, 1 ~ 2 part, sodium chloride, Borneolum Syntheticum 0.3 ~ 0.7 part, suitable quantity of water.
Further, be made up of the raw material of following parts by weight: sea dog cod-liver oil 17 ~ 31 parts, 9 ~ 11 parts, Herba Ephedrae, Herba Xanthii 7 ~ 9 parts, Herba Menthae 3 ~ 6 parts, Fructus Liquidambaris 4 ~ 6 parts, Flos Lonicerae 2 ~ 6 parts, 1 ~ 2 part, sodium chloride, Borneolum Syntheticum 0.3 ~ 0.7 part.
Further, be made up of the raw material of following parts by weight: sea dog cod-liver oil 25 parts, 10 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 6 parts, Fructus Liquidambaris 5 parts, Flos Lonicerae 5 parts, 1 part, sodium chloride, Borneolum Syntheticum 0.5 part.
A preparation method for compound nose drop, adds the water of gross weight 5 ~ 10 times, soaks 15 ~ 20 hours by Herba Ephedrae, Herba Xanthii, Herba Menthae, Fructus Liquidambaris, Flos Lonicerae, then boil 3 ~ 5 hours at 68 ~ 85 DEG C, filters to remove filtering residue and obtain filtrate; Borneolum Syntheticum and sodium chloride are dissolved in filtrate, mix homogeneously, then obtained product of the present invention after adding the mixing of sea dog liver oil.
Side of the present invention separates
Cod-liver oil is the oils and fats that the animal liverss such as Fish, whale, sea dog refine, transparent yellow liquid, slightly fishlike smell, and be usually used in treating nyctalopia, keratomalacia, rickets and malacopathia etc., to existing protective effects of epidermal tissue such as respiratory tract upper strata mucosas.
Herba Ephedrae, diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
Fructus Liquidambaris, expelling wind and removing dampness; Soothing the liver active; Diuretic, has one's ideas straightened out.
Fructus Xanthii, loose wind dehumidifying, clearing the nasal passage.
Flos Lonicerae, heat-clearing and toxic substances removing.
Herba Menthae, dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.
Borneolum Syntheticum, refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
Advantageous Effects of the present invention is: medicine of the present invention passes through cod-liver oil and natural Chinese medicinal herb scientific compatibility, by the synergism between medicine, there is antiinflammatory, effect that Nasal Epithelial Cells is moistened in nutrition, and product of the present invention can not produce any side effect and anaphylaxis.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of compound nose drop, is made up of the raw material of following parts by weight: sea dog cod-liver oil 15 parts, 12 parts, Herba Ephedrae, Herba Xanthii 7 parts, Herba Menthae 7 parts, Fructus Liquidambaris 4 parts, Flos Lonicerae 2 parts, 1 part, sodium chloride, Borneolum Syntheticum 0.3 part, suitable quantity of water.
A preparation method for compound nose drop, 12 parts, Herba Ephedrae, Herba Xanthii 7 parts, Herba Menthae 7 parts, Fructus Liquidambaris 4 parts, Flos Lonicerae 2 parts are added the water of medicine gross weight 5 times, soak at room temperature 15 hours, then boils 5 hours under 68 DEG C of conditions, filters to remove filtering residue and obtain filtrate; Borneolum Syntheticum 0.3 part and 1 part, sodium chloride are dissolved in filtrate, mix homogeneously, then obtained product of the present invention after adding the mixing of sea dog liver oil.
Embodiment 2
A kind of compound nose drop, is made up of the raw material of following parts by weight: sea dog cod-liver oil 35 parts, 12 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 7 parts, Fructus Liquidambaris 7 parts, Flos Lonicerae 7 parts, 2 parts, sodium chloride, Borneolum Syntheticum 0.7 part, suitable quantity of water.
A preparation method for compound nose drop, 12 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 7 parts, Fructus Liquidambaris 7 parts, Flos Lonicerae 7 parts are added the water of medicine gross weight 7 times, soak at room temperature 20 hours, then boils 4 hours, filters to remove filtering residue and obtain filtrate; Borneolum Syntheticum 0.7 part and 2 parts, sodium chloride are dissolved in filtrate, mix homogeneously, then obtained product of the present invention after adding sea dog liver oil 35 parts mixing.
Embodiment 3
A kind of compound nose drop, is made up of the raw material of following parts by weight: sea dog cod-liver oil 25 parts, 10 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 6 parts, Fructus Liquidambaris 5 parts, Flos Lonicerae 5 parts, 1 part, sodium chloride, Borneolum Syntheticum 0.5 part.
A preparation method for compound nose drop, 10 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 6 parts, Fructus Liquidambaris 5 parts, Flos Lonicerae 5 parts are added the water of medicine gross weight 10 times, soak at room temperature 20 hours, then boils 5 hours, filters to remove filtering residue and obtain filtrate; Borneolum Syntheticum 0.5 part and 1 part, sodium chloride are dissolved in filtrate, mix homogeneously, then obtained product of the present invention after adding the mixing of sea dog liver oil.
Clinical verification the foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, and any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. compound nose drop, it is characterized in that, be made up of the raw material of following parts by weight: sea dog cod-liver oil 15 ~ 35 parts, 8 ~ 12 parts, Herba Ephedrae, Herba Xanthii 7 ~ 9 parts, Herba Menthae 3 ~ 7 parts, Fructus Liquidambaris 4 ~ 7 parts, Flos Lonicerae 2 ~ 7 parts, 1 ~ 2 part, sodium chloride, Borneolum Syntheticum 0.3 ~ 0.7 part, suitable quantity of water.
2. compound nose drop according to claim 1, it is characterized in that, be made up of the raw material of following parts by weight: sea dog cod-liver oil 17 ~ 31 parts, 9 ~ 11 parts, Herba Ephedrae, Herba Xanthii 7 ~ 9 parts, Herba Menthae 3 ~ 6 parts, Fructus Liquidambaris 4 ~ 6 parts, Flos Lonicerae 2 ~ 6 parts, 1 ~ 2 part, sodium chloride, Borneolum Syntheticum 0.3 ~ 0.7 part.
3. compound nose drop according to claim 2, is characterized in that, be made up of the raw material of following parts by weight: sea dog cod-liver oil 25 parts, 10 parts, Herba Ephedrae, Herba Xanthii 9 parts, Herba Menthae 6 parts, Fructus Liquidambaris 5 parts, Flos Lonicerae 5 parts, 1 part, sodium chloride, Borneolum Syntheticum 0.5 part.
4. the preparation method of compound nose drop according to any one of claims 1 to 3, it is characterized in that, Herba Ephedrae, Herba Xanthii, Herba Menthae, Fructus Liquidambaris, Flos Lonicerae are added the water of gross weight 5 ~ 10 times, soak 15 ~ 20 hours, then boil 3 ~ 5 hours at 68 ~ 85 DEG C, filter and remove filtering residue and obtain filtrate; Borneolum Syntheticum and sodium chloride are dissolved in filtrate, mix homogeneously, then obtained product of the present invention after adding the mixing of sea dog liver oil.
CN201410553472.XA 2014-10-20 2014-10-20 Compound nasal drops Pending CN104288226A (en)

Priority Applications (1)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106334034A (en) * 2016-10-13 2017-01-18 中国热带农业科学院热带生物技术研究所 Traditional Chinese medicine compositon, nose drop containing same and application thereof
CN106474323A (en) * 2016-12-22 2017-03-08 赣州安宏环保科技有限公司 The crystallization of rhinitis influenza Chinese medicine is smoked to treat piece and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101579359A (en) * 2009-06-24 2009-11-18 遵义医学院附属医院 Compound cod-liver oil nasal drops and preparation method
CN104398579A (en) * 2014-11-03 2015-03-11 郝杰 Nasal drops and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101579359A (en) * 2009-06-24 2009-11-18 遵义医学院附属医院 Compound cod-liver oil nasal drops and preparation method
CN104398579A (en) * 2014-11-03 2015-03-11 郝杰 Nasal drops and preparation method thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
凌艳君: "薄冰滴鼻剂治疗慢性鼻炎83例临床观察", 《湖南中医杂志》 *
刘新民等主编: "《临床药物学》", 31 January 2008, 军事医学科学出版社 *
南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 *
周秋丽等主编: "《现代中药基础研究与临床》", 30 June 2012, 天津科技翻译出版公司 *
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程海冬等主编: "《五官科护士分层培训》", 30 April 2014, 湖北科学技术出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106334034A (en) * 2016-10-13 2017-01-18 中国热带农业科学院热带生物技术研究所 Traditional Chinese medicine compositon, nose drop containing same and application thereof
CN106474323A (en) * 2016-12-22 2017-03-08 赣州安宏环保科技有限公司 The crystallization of rhinitis influenza Chinese medicine is smoked to treat piece and preparation method thereof

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Application publication date: 20150121