CN104287698B - Flexibility for cervical region pulse detection can attach sensor and preparation method thereof - Google Patents
Flexibility for cervical region pulse detection can attach sensor and preparation method thereof Download PDFInfo
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- CN104287698B CN104287698B CN201410471365.2A CN201410471365A CN104287698B CN 104287698 B CN104287698 B CN 104287698B CN 201410471365 A CN201410471365 A CN 201410471365A CN 104287698 B CN104287698 B CN 104287698B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6804—Garments; Clothes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6822—Neck
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Abstract
The present invention relates to wearable flexible sensor; specifically a kind of flexibility for cervical region pulse detection can attach sensor; comprise fabric substrate, sensitive layer, electrode layer, barrier layer and protective layer; barrier layer is arranged in fabric substrate; sensitive layer is arranged on barrier layer; sensitive layer has highly sensitive three-dimensional cavernous structure, and electrode layer is between sensitive layer and protective layer, protective layer used in being attached to skin surface corresponding to neck pulse.Because sensitive material has good stability and biocompatibility, be therefore easy to form stable entirety on medicated clothing or clothing component.The frivolous softness of sensor of the present invention, various shape can be processed to, can attach, be worn on skin surface, have that cost is low, technique is simple, highly sensitive, wearing comfort, the advantage such as can to wash, can realize the physiological parameter of neck pulse detection of dynamic continuously for a long time.Present invention also offers the preparation method of the sensor, the method is simple to operation.
Description
Technical field
The present invention relates to wearable flexible sensor, the flexibility especially for cervical region pulse detection can attach sensor and preparation method thereof.
Background technology
Neck pulse signal contains important physiological parameter.Medical research shows, periphery chemical receptor of carotid body plays an important role in the signal change procedures such as mediation low arterial blood oxygen, hypercapnia and acidosis.Under morbid state, as in the patient of hypertension, sleep disordered breathing (comprising obstructive sleep apnea) and congestive heart failure and animal disease model, activity and the reflex sensitivity thereof of chemoreceptor all significantly improve.Carotid body maintains the blood oxidation stability of body under physiological situation, under pathological condition, take part in advancing of disease.The cell of carotid body and molecular Regulation Mechanism can be used for explaining the pathological process of numerous disease, so the real-time monitoring of cervical region pulse is extremely important in clinic study.
For realizing the early discovery of disease, early diagnosis and early treatment, the important physiological parameters such as the electrocardio to patient, blood pressure and blood oxygen are needed to carry out dynamic monitoring continuously for a long time.Conventional monitoring methods has multiple, and such as from electrocardiosignal, extraction, angiography etc. have wound method, these method complicated operations, the large-scale technical equipment that costly, needs are very accurate; Can be used for the electric sphygmomanometer of pulses measure, its each measurement all needs one to pressurize and the process of decompression, adds decompression process and has that sense of discomfort exists, display pulse waveform that can not be complete, cause measurement result misalignment; For another example external large-scale sphygmoscopy instrument (the tremulous pulse detector as Japan), is all used in larger medical mechanism, can not meet the daily demand of monitoring of ordinary people whenever and wherever possible; And for example in Holter (Holter) method, use silver chloride viscosity electrode, silver chloride viscosity electrode easily causes skin allergy, and dewaters gradually and mummification along with electrodes conduct gelinite, and the signal to noise ratio of signal significantly declines.Up to the present, also do not have a good product can very easily for the real-time monitoring of human body physiological parameter.
Summary of the invention
The present invention is directed to the deficiency that prior art exists, provide a kind of flexibility for cervical region pulse detection to attach sensor.To solve, the detecting instrument complicated operation, the cost that exist in prior art are high, the problem such as very flexible, testing result misalignment.
Flexibility for cervical region pulse detection provided by the invention can attach sensor; comprise fabric substrate, sensitive layer, electrode layer, barrier layer and protective layer; described barrier layer is arranged in fabric substrate; fabric substrate be on medicated clothing just on the region of neck pulse or clothing component just to the region of neck pulse; described sensitive layer is arranged on barrier layer; described electrode layer is between sensitive layer and protective layer, described protective layer used in being attached to skin surface corresponding to neck pulse.
Described medicated clothing comprises the soft textile such as such as T-shirt, vest, tights, and in wearing process, described medicated clothing has the skin surface just right with neck pulse and to contact region; Described clothing component comprises the neck ornament etc. that such as scarf, muffler, knot, flexible fabric fabric are made, and in donning process, described clothing component has the region that the skin surface just right with neck pulse contacts.
Concrete, described sensitive layer has three-dimensional cavernous structure; Described barrier layer and protective layer are flexible macromolecule polymer; Described electrode layer comprises at least two electrodes of drawing from sensitive layer surface, and described electrode is drawn from sensitive layer surface.
The three-dimensional cavernous structure of described sensitive layer prepares formation by the following method,
1) supersound process is carried out after material with carbon element and volatile solvent being mixed in proportion, obtain slurry mixture, add flexible macromolecule polymer in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described material with carbon element and volatile solvent is than being 1:1 ~ 1:5, and the mass ratio of the described flexible macromolecule polymer that adds in mixture and material with carbon element is 1:0.5 ~ 1:3;
2) sensitive material to be coated on barrier layer and to be cured polymerization, volatile solvent in sensitive material is volatilized, and then forming three-dimensional cavernous structure, the aperture of described three-dimensional cavernous structure is 0.2 ~ 20 μm, and the spacing between Kong Yukong is 10 ~ 200 μm.
Particularly, the thickness of described barrier layer is greater than 1 μm, and the thickness of sensitive layer is greater than 1 μm, and the thickness of protective layer is 1 μm ~ 500 μm.Above scope comprises endpoint value.
Because sensitive material has good stability and biocompatibility, be therefore easy to form stable entirety on medicated clothing or clothing component.
Above-mentioned electrode by pasting, the mode of printing or physics cutting draws from sensitive layer surface, the material of electrode be selected from conductive non-woven fabrics, enamel-covered wire, with the one in the flat copper foil belt of pressure-sensitive adhesive and pliable and tough ultra-thin Copper Foil.
Correspondingly, the flexibility that present invention also offers for cervical region pulse detection can attach the preparation method of sensor, comprises the following steps:
S1, to fabric just to clean the region of neck pulse and dry;
S2, region surface on fabric after step S1 process apply one deck flexible macromolecule polymeric liquid, are then cured, itself and fabric are combined together, obtains barrier layer;
S3, at barrier layer surface-coated one deck sensitive material, be then cured polymerization, the volatile solvent in sensitive material volatilized, and then forms three-dimensional cavernous structure, obtain sensitive layer; ;
S4, prepare electrode layer on sensitive layer surface, described electrode layer comprises at least two electrodes of drawing from sensitive layer surface;
S5, at electrode layer and sensitive layer surface-coated one deck flexible macromolecule polymeric liquid, to be then cured, to form protective layer on the surface of electrode layer and sensitive layer.
Particularly, described sensitive material prepares by the following method: carry out supersound process after material with carbon element and volatile solvent being mixed in proportion, obtain slurry mixture, add flexible macromolecule polymer in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described material with carbon element and volatile solvent is than being 1:1 ~ 1:5, and sonication treatment time is 1min ~ 240min, and the flexible macromolecule polymer added in mixture and the mass ratio of material with carbon element are 1:0.5 ~ 1:3;
Described flexible macromolecule polymeric liquid is by remaking evacuation process by the quality of 1:10 than mix and blend by initiator and reactant and prepare.
Described fabric is medicated clothing or clothing component; Adopt ethanol just to clean the region of neck pulse on fabric in described step S1, described barrier layer to be arranged in this ethanol purge district and to be less than the area in this ethanol purge district, and described sensitive layer to be arranged on barrier layer and to be less than the area of barrier layer; Coating method in described step S2, S3 and S4 is printing, brushes or spin coating.
The solidification temperature of described step S2 is 70 DEG C ~ 80 DEG C, and hardening time is 1.5h ~ 2.5h; The solidification temperature of step S3 is 70 DEG C ~ 80 DEG C, and hardening time is 0.5h ~ 1.5h; The solidification temperature of step S5 is 70 DEG C ~ 80 DEG C, and hardening time is 1.5 ~ 2.5h.
Electrode in described step S4 by pasting, the mode of printing or physics cutting draws from sensitive layer surface, the material of electrode be selected from conductive non-woven fabrics, enamel-covered wire, with the one in the flat copper foil belt of pressure-sensitive adhesive and pliable and tough ultra-thin Copper Foil.
Material with carbon element of the present invention is selected from Graphene, redox graphene, graphene oxide, CNT; Described volatile solvent is ethanol, dichloromethane, ethyl acetate, acetone or carbon tetrachloride; Described flexible macromolecule polymer is polydimethylsiloxane (PDMS), ethylene-vinyl acetate copolymer, polyvinyl alcohol, polyethylene terephthalate or polyimides or polyethylene.
Because sensitive material can be responded to the lateral pressure that blood vessel wall produces when human pulse is beated, therefore, above-mentioned flexibility can attach the physiological parameter that sensor is applicable to human body cervical region pulse.Flexibility can be attached sensor and be attached at skin surface corresponding to cervical region pulse, physiological signal is gathered by sensitive layer, after the signal processing circuit process such as filtering, amplification, A/D conversion, with wireless transmission methods such as bluetooths, the signal after process is emitted on receiving terminal (as smart mobile phone, Pad etc.) display instrument, clearly can shows the parameter such as pulse wave, pulse frequency of user in real time.
Due to above technical scheme, beneficial effect of the present invention is:
1, the present invention by better simply mode at fabric face integrated induction device, and make sensitive layer to be formed three-dimensional cavernous structure by process cleverly, this three-dimensional cavernous structure makes the minimum detection limit of sensitive layer to pressure reach 0.8Pa, and the pressure that human pulse produces blood vessel wall when beating is 8 ~ 18.7KPa, therefore, have when the present invention being used for human body cervical region pulse that accuracy of detection is high, testing result significant advantage accurately.
2, the present invention is provided with protective layer on electrode layer and sensitive layer; this protective layer selects the material non-stimulated to human body skin nonhazardous to make; and this material has the Young's modulus close with human body skin; therefore when being attached to skin surface; skin allergy can not be caused or cause sense of discomfort, being applicable to wearing use for a long time.
3, by better simply mode, protective layer, electrode layer, sensitive layer and barrier layer are integrated in fabric face securely; thickness due to protective layer, electrode layer, sensitive layer and barrier layer is all micron-sized; therefore integrated after make fabric texture pliable and tough frivolous, be applicable to dress.
4, fabric is made up of numerous yarn, has stable structure relation.Barrier material is solidificated in fabric face by coating heating by the present invention; make to combine together between barrier layer and fabric difficult drop-off; and protective layer, electrode layer, there is between sensitive layer and barrier layer good stability and biocompatibility, thus this flexibility can attach that sensor construction is stable, difficult drop-off.
In sum, flexibility of the present invention can attach sensor and has that cost is low, technique is simple, highly sensitive, wearing comfort, the advantage such as can to wash.Can realize the important physiological parameter of neck pulse continuous detection of dynamic for a long time.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
The structural representation of Fig. 1 to be the present invention for the flexibility of cervical region pulse detection can attach sensor;
Fig. 2 is the SEM figure of the sensitive layer described in the embodiment of the present invention one;
Fig. 3 is the SEM figure of sensitive layer described in embodiments of the invention two;
Fig. 4 is the SEM figure of sensitive layer described in embodiments of the invention three;
The schematic flow sheet of Fig. 5 to be the present invention for the flexibility of cervical region pulse detection can attach preparation method of sensor;
Fig. 6 is the cervical region pulse waveform figure utilizing flexibility of the present invention can attach sensor to detect.
In figure: 1-fabric substrate, 2-barrier layer, 3-sensitive layer, 4-electrode layer, 5-protective layer.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under the prerequisite of not making creative work, all belongs to the scope of protection of the invention.
Embodiment one
Refer to Fig. 1; wearable flexibility of the present invention can attach sensor; comprise fabric substrate 1, sensitive layer 3, electrode layer 4, barrier layer 2 and protective layer 5; described barrier layer 2 is arranged in fabric substrate 1; described sensitive layer 3 is arranged on barrier layer 2, and described electrode layer 4 is between sensitive layer 3 and protective layer 5.
Described fabric substrate 1 is just to the region of neck pulse on medicated clothing; Described sensitive layer 3 has three-dimensional cavernous structure, and the thickness of sensitive layer 3 is 60 μm; Described barrier layer 2 and protective layer 5 are polydimethylsiloxane (PDMS), and the thickness of barrier layer 2 is 15 μm, and the thickness of protective layer 5 is 10 μm; Described electrode layer 4 is two electrodes of being drawn from sensitive layer 3 surface by bonding method, and the material of electrode is 10 μm of thick pliable and tough ultra-thin Copper Foils.
Polydimethylsiloxane (PDMS) has good stability and biocompatibility; be easy on medicated clothing, form stable entirety; simultaneously; polydimethylsiloxane (PDMS) is to skin nonhazardous and stimulation; when it can be used as protective layer to be attached to skin surface; can not cause allergic reaction, be applicable to very much the physiological parameter for real-time human body cervical region pulse.
Fig. 2 is the SEM figure that the above-mentioned flexibility for cervical region pulse detection can attach the sensitive layer of sensor, and the three-dimensional cavernous structure of high-visible sensitive layer in figure, the aperture of described three-dimensional cavernous structure is 0.2 ~ 20 μm, and the spacing between Kong Yukong is 10 ~ 200 μm.Described three-dimensional cavernous structure prepares formation by the following method,
1) supersound process is carried out after Graphene and acetone being mixed in proportion, obtain slurry mixture, add polydimethylsiloxane (PDMS) in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described Graphene and acetone is than being 1:2, and the described polydimethylsiloxane (PDMS) added in mixture is 1:0.5 with the mass ratio of Graphene;
2) sensitive material to be coated on barrier layer and to be cured polymerization, the acetone in sensitive material being volatilized, and then forms three-dimensional cavernous structure.
Through verification experimental verification, the above-mentioned minimum detection limit of sensitive layer to pressure with three-dimensional cavernous structure reaches 0.8Pa, and the pressure that human pulse produces blood vessel wall when beating is 8 ~ 18.7KPa, therefore, have when the present invention being used for human body cervical region pulse that accuracy of detection is high, testing result significant advantage accurately.
Because sensitive material can be responded to the lateral pressure that blood vessel wall produces when human pulse is beated, therefore, above-mentioned flexibility can attach the physiological parameter that sensor is applicable to human body cervical region pulse.Flexibility can be attached sensor and be attached at skin surface corresponding to cervical region pulse, physiological signal is gathered by sensitive layer, after the signal processing circuit process such as filtering, amplification, A/D conversion, with wireless transmission methods such as bluetooths, the signal after process is emitted on receiving terminal (as smart mobile phone, Pad etc.) display instrument, clearly can show the parameter such as pulse wave, frequency of user in real time, as shown in Figure 6.
See Fig. 5, correspondingly, present invention also offers the preparation method that a kind of above-mentioned flexibility for cervical region pulse detection can attach sensor, the method is simply easy to operation, comprises the following steps:
The preparation of S1, polydimethylsiloxane (PDMS) and sensitive material:
1, take initiator 1g, reactant 10g mix and blend makes it react 10min, then vacuum filtration 10min, obtained polydimethylsiloxane (PDMS) liquid.
2, get 1g Graphene and the mixing of 2g acetone, then by mixture supersound process 15min, make graphene dispersion form muddy liquid in acetone.
3, in the obtained mixture of step 2, add 2g polydimethylsiloxane (PDMS) liquid, and stir 1.5h, obtain thick sensitive material.
The surface treatment of S2, fabric:
User is tried on through washing dry clothes, just makes a check mark to the rectangular region that carotid area is 25mm × 35mm on the collar of clothes, with ethanol, the surface in this region is clean and dry, obtained fabric substrate.
Above-mentioned clothes is preferably quality softness, frivolous, non-stimulated to skin clothing fabric, as cotton and cotton fabric, silk fabrics, fiber crops and linen look fabric and hair and wool fabrics.
The preparation of S3, barrier layer:
1, polydimethylsiloxane (PDMS) liquid that one deck area is 15mm × 25mm, thickness is 15 μm is evenly coated with in the central area of above-mentioned fabrics substrate;
2, spin coating had the clothes of polydimethylsiloxane (PDMS) liquid to insert in baking oven, be heating and curing 2h at the temperature of 80 DEG C, and polydimethylsiloxane (PDMS) liquid and fabric are combined together.
Fabric is made up of numerous yarn, has stable structure relation.By polydimethylsiloxane (PDMS) liquid is carried out applying and drying and processing, make it be cemented in fabric face and form rock-steady structure, difficult drop-off.
The preparation of S4, sensitive layer:
1, central area spin coating one deck area of above-mentioned barrier layer be 10mm × 20mm, thickness is the sensitive material of 60 μm;
2, spin coating had the clothes of sensitive material to insert in baking oven, be heating and curing 1h at the temperature of 70 DEG C, makes sensitive material solidify polymerization; Along with the volatilization of acetone in this process, will in polydimethylsiloxane (PDMS), form vent and then introduce gas phase, realize gas-solid biphase existence in material, sensitive layer is formed the three-dimensional cavernous structure being similar to ants ' nest shape, make sensitive layer have higher sensitivity.
The preparation of S5, electrode layer:
Utilize conductive silver glue to paste two 10 μm thick pliable and tough ultra-thin Copper Foils, as electrode on above-mentioned sensitive layer surface.
The preparation of S6, protective layer:
1, brush at electrode layer and sensitive layer surface polydimethylsiloxane (PDMS) liquid that a layer thickness is 10 μm,
2, brushing had the clothes of polydimethylsiloxane (PDMS) liquid to insert in baking oven, be heating and curing 1.5h at the temperature of 70 DEG C, and electrode layer, sensitive layer, barrier layer and fabric are combined together.
With it above-mentioned medicated clothing is through; the protective layer on medicated clothing is made to be attached at skin surface corresponding to carotid artery; cervical region pulse physiological signal is gathered by sensitive layer; after filtering, the signal processing circuit processing signals such as amplification, A/D conversion; recycling wireless or wire transmission technology is transmitted on terminal (as smart mobile phone, panel computer, notebook computer, oscillograph and other dependence test instruments) display instrument by the signal after process, can clearly see cervical region pulse waveform figure in real time.Utilize the present invention's flexibility to attach cervical region pulse waveform figure that sensor detects as shown in Figure 6.
Embodiment two
Wearable flexibility of the present invention can attach sensor; comprise fabric substrate 1, sensitive layer 3, electrode layer 4, barrier layer 2 and protective layer 5; described barrier layer 2 is arranged in fabric substrate 1, and described sensitive layer 3 is arranged on barrier layer 2, and described electrode layer 4 is between sensitive layer 3 and protective layer 5.
Described fabric substrate 1 is just to the region of neck pulse on medicated clothing; Described sensitive layer 3 has three-dimensional cavernous structure, and the thickness of sensitive layer 3 is 80 μm; Described barrier layer 2 and protective layer 5 are polyvinyl alcohol, and the thickness of barrier layer 2 is 30 μm, and the thickness of protective layer 5 is 500 μm; Described electrode layer 4 is four electrodes of being drawn from sensitive layer 3 surface by bonding method, the material of electrode be 20 μm thick and with the flat copper foil belt of pressure-sensitive adhesive.
Polyvinyl alcohol has good stability and biocompatibility; be easy on medicated clothing, form stable entirety; simultaneously; polyvinyl alcohol is to skin nonhazardous and stimulation; when it can be used as protective layer to be attached to skin surface; can not cause allergic reaction, be applicable to very much the physiological parameter for real-time human body cervical region pulse.
Fig. 3 is the SEM figure of above-mentioned sensitive layer, and the three-dimensional cavernous structure of high-visible sensitive layer in figure, the aperture of described three-dimensional cavernous structure is 0.5 ~ 15 μm, and the spacing between Kong Yukong is 50 ~ 180 μm.Described three-dimensional cavernous structure prepares formation by the following method,
1) supersound process is carried out after redox graphene and ethanol being mixed in proportion, obtain slurry mixture, add polydimethylsiloxane (PDMS) in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described redox graphene and ethanol is than being 1:1, and the described polydimethylsiloxane (PDMS) added in mixture is 1:2 with the mass ratio of redox graphene;
2) sensitive material to be coated on barrier layer and to be cured polymerization, the ethanol in sensitive material being volatilized, and then forms three-dimensional cavernous structure.
Through verification experimental verification, the above-mentioned minimum detection limit of sensitive layer to pressure with three-dimensional cavernous structure reaches 1.2Pa, and the pressure that human pulse produces blood vessel wall when beating is 8 ~ 18.7KPa, therefore, have when the present invention being used for human body cervical region pulse that accuracy of detection is high, testing result significant advantage accurately.
The above-mentioned flexibility for cervical region pulse detection can attach sensor and prepare by the following method.
The preparation of S1, polydimethylsiloxane (PDMS) and sensitive material:
1, take initiator 1g, reactant 10g mix and blend makes it react 10min, then vacuum filtration 10min, obtained polydimethylsiloxane (PDMS) liquid.
2, get 2g redox graphene and the mixing of 2g ethanol, then by mixture supersound process 100min, make redox graphene disperse to form muddy liquid in ethanol.
3, in the obtained mixture of step 2, add 1g polydimethylsiloxane (PDMS) liquid, and stir 1.5h, obtain thick sensitive material.
The surface treatment of S2, fabric:
User is tried on through washing dry clothes, just makes a check mark to the rectangular region that carotid area is 25mm × 35mm on clothes, with ethanol, the surface in this region is clean and dry, obtained fabric substrate.
Above-mentioned clothes is preferably quality softness, frivolous, non-stimulated to skin clothing fabric, as cotton and cotton fabric, silk fabrics, fiber crops and linen look fabric and hair and wool fabrics.
The preparation of S3, barrier layer:
1, the polyvinyl alcohol liquid that one deck area is 15mm × 25mm, thickness is 30 μm is evenly coated with in the central area of above-mentioned fabrics substrate;
2, spin coating had the clothes of polyvinyl alcohol liquid to insert in baking oven, be heating and curing 1.5h at the temperature of 70 DEG C, and polyvinyl alcohol liquid and fabric are combined together.
Fabric is made up of numerous yarn, has stable structure relation.By polyvinyl alcohol liquid is carried out applying and drying and processing, make it be cemented in fabric face and form rock-steady structure, difficult drop-off.
The preparation of S4, sensitive layer:
1, central area spin coating one deck area of above-mentioned barrier layer be 10mm × 20mm, thickness is the sensitive material of 80 μm;
2, spin coating had the clothes of sensitive material to insert in baking oven, be heating and curing 0.5h at the temperature of 80 DEG C, makes sensitive material solidify polymerization; Along with the volatilization of ethanol in this process, will in polydimethylsiloxane (PDMS), form vent and then introduce gas phase, realize gas-solid biphase existence in material, sensitive layer is formed the three-dimensional cavernous structure being similar to ants ' nest shape, make sensitive layer have higher sensitivity.
The preparation of S5, electrode layer:
On above-mentioned sensitive layer surface by bonding method draw four 20 μm thick and with the flat copper foil belt of pressure-sensitive adhesive as electrode.
The preparation of S6, protective layer:
1, brush at electrode layer and sensitive layer surface the polyvinyl alcohol liquid that a layer thickness is 500 μm,
2, have the clothes of polyvinyl alcohol liquid to insert in baking oven brushing, be heating and curing 2.5h at the temperature of 80 DEG C, and electrode layer, sensitive layer, barrier layer and fabric are combined together.
With it above-mentioned medicated clothing is through; the protective layer on medicated clothing is made to be attached on skin corresponding to carotid artery; cervical region pulse physiological signal is gathered by sensitive layer; after filtering, the signal processing circuit processing signals such as amplification, A/D conversion; recycling wireless or wire transmission technology is transmitted on terminal (as smart mobile phone, panel computer, notebook computer, oscillograph and other dependence test instruments) display instrument by the signal after process, can clearly see cervical region pulse waveform figure in real time.
Embodiment three
Wearable flexibility of the present invention can attach sensor; comprise fabric substrate 1, sensitive layer 3, electrode layer 4, barrier layer 2 and protective layer 5; described barrier layer 2 is arranged in fabric substrate 1, and described sensitive layer 3 is arranged on barrier layer 2, and described electrode layer 4 is between sensitive layer 3 and protective layer 5.
Described fabric substrate 1 is just to the region of neck pulse on scarf; Described sensitive layer 3 has three-dimensional cavernous structure, and the thickness of sensitive layer 3 is 100 μm; Described barrier layer 2 and protective layer 5 are ethylene-vinyl acetate copolymer, and the thickness of barrier layer 2 is 50 μm, and the thickness of protective layer 5 is 300 μm; Described electrode layer 4 is two electrodes of being drawn from sensitive layer 3 surface by physics cutting mode.
Ethylene-vinyl acetate copolymer has good stability and biocompatibility; be easy on scarf, form stable entirety; simultaneously; ethylene-vinyl acetate copolymer is to skin nonhazardous and stimulation; when it can be used as protective layer to be attached to skin surface; can not cause allergic reaction, be applicable to very much the physiological parameter for real-time human body cervical region pulse.
Fig. 4 is the SEM figure of above-mentioned sensitive layer, and the three-dimensional cavernous structure of high-visible sensitive layer in figure, the aperture of described three-dimensional cavernous structure is 2 ~ 20 μm, and the spacing between Kong Yukong is 10 ~ 100 μm.Described three-dimensional cavernous structure prepares formation by the following method,
1) supersound process is carried out after Graphene and dichloromethane being mixed in proportion, obtain slurry mixture, add polydimethylsiloxane (PDMS) in the mixture, thick sensitive material is obtained after stirring, the mixed proportion of described Graphene and dichloromethane is 1:5, and the described polydimethylsiloxane (PDMS) added in mixture is 1:3 with the mass ratio of Graphene;
2) sensitive material to be coated on barrier layer and to be cured polymerization, the volatile solvent in sensitive material being volatilized, and then forms three-dimensional cavernous structure.
Through verification experimental verification, the above-mentioned minimum detection limit of sensitive layer to pressure with three-dimensional cavernous structure reaches 5.4Pa, and the pressure that human pulse produces blood vessel wall when beating is 8 ~ 18.7KPa, therefore, have when the present invention being used for human body cervical region pulse that accuracy of detection is high, testing result significant advantage accurately.
The above-mentioned flexibility for cervical region pulse detection can attach sensor and prepare by the following method.
The preparation of S1, polydimethylsiloxane (PDMS) liquid and sensitive material:
1, take initiator 1g, reactant 10g mix and blend makes it react 10min, then vacuum filtration 10min, obtained polydimethylsiloxane (PDMS) liquid.
2, get 3g Graphene and the mixing of 15g dichloromethane, then by mixture supersound process 200min, make graphene dispersion in dichloromethane, form muddy liquid.
3, in the obtained mixture of step 2, add 1g polydimethylsiloxane (PDMS) liquid, and stir 1h, obtain thick sensitive material.
The surface treatment of S2, fabric:
User examination is enclosed through washing dry scarf, just makes a check mark to the square region that the area of cervical region pulse is 30mm × 30mm on scarf, with ethanol, the surface in this region is clean and dry, obtained fabric substrate.
Above-mentioned scarf is preferably quality softness, frivolous, non-stimulated to skin soft fabric, as cotton and cotton fabric, silk fabrics, fiber crops and linen look fabric.
The preparation of S3, barrier layer:
1, the ethylene-vinyl acetate copolymer solution that one deck area is 20mm × 25mm, thickness is 50 μm is evenly coated with in the central area of above-mentioned fabrics substrate.
2, spin coating had the clothes of ethylene-vinyl acetate copolymer solution to insert in baking oven, be heating and curing 2.5h at the temperature of 70 DEG C, and ethylene-vinyl acetate copolymer solution and fabric are combined together.
The preparation of S4, sensitive layer:
1, central area spin coating one deck area of above-mentioned barrier layer be 15mm × 20mm, thickness is the sensitive material of 100 μm;
2, spin coating had the clothes of sensitive material to insert in baking oven, be heating and curing 1.5h at the temperature of 75 DEG C, and sensitive material is polymerized; Along with the volatilization of dichloromethane in this process, will in polydimethylsiloxane (PDMS), form vent and then introduce gas phase, realize gas-solid biphase existence in material, sensitive layer is formed the three-dimensional cavernous structure being similar to ants ' nest shape, make sensitive layer have higher sensitivity.
The preparation of S5, electrode layer:
Two wide electrodes for 2mm are drawn by physics cutting mode on above-mentioned sensitive layer surface.
The preparation of S6, protective layer:
1, brush at electrode layer and sensitive layer surface the ethylene-vinyl acetate copolymer solution that a layer thickness is 300 μm,
2, have the clothes of ethylene-vinyl acetate copolymer solution to insert in baking oven brushing, be heating and curing 2h at the temperature of 70 DEG C, and electrode layer, sensitive layer, barrier layer and fabric are combined together.
Above-mentioned scarf is trapped among on neck; the protective layer on scarf is made to be attached on skin corresponding to carotid artery; cervical region pulse physiological signal is gathered by sensitive layer; after filtering, the signal processing circuit processing signals such as amplification, A/D conversion; recycling wireless or wire transmission technology is transmitted on terminal (as smart mobile phone, panel computer, notebook computer, oscillograph and other dependence test instruments) display instrument by the signal after process, can clearly see cervical region pulse waveform figure in real time.
Beneficial effect of the present invention is: 1, the present invention by better simply mode at fabric face integrated induction device, and make sensitive layer to be formed three-dimensional cavernous structure by process cleverly, this three-dimensional cavernous structure makes the minimum detection limit of sensitive layer to pressure reach 0.8Pa, and the pressure that human pulse produces blood vessel wall when beating is 8 ~ 18.7KPa, therefore, have when the present invention being used for human body cervical region pulse that accuracy of detection is high, testing result advantage accurately.2, the present invention is provided with protective layer on electrode layer and sensitive layer; this protective layer selects the material non-stimulated to human body skin nonhazardous to make; and this material has the Young's modulus close with human body skin; therefore when being attached to skin surface; skin allergy can not be caused or cause sense of discomfort, being applicable to wearing use for a long time.3, by better simply mode, protective layer, electrode layer, sensitive layer and barrier layer are integrated in fabric face securely; thickness due to protective layer, electrode layer, sensitive layer and barrier layer is all micron-sized; therefore integrated after make fabric texture pliable and tough frivolous, be applicable to dress.Barrier layer of the present invention is solidificated in fabric face by coating baking; make to combine together between barrier layer and fabric difficult drop-off; and protective layer, electrode layer, there is between sensitive layer and barrier layer good stability and biocompatibility; thus this flexibility can attach that sensor construction is stable, difficult drop-off, can also wash after wearing.
In sum, flexibility of the present invention can attach sensor and has that cost is low, technique is simple, highly sensitive, wearing comfort, the advantage such as can to wash.Can realize wanting physiological parameter continuous detection of dynamic for a long time to body weight for humans.
Above disclosedly be only a kind of preferred embodiment of the present invention, certainly can not limit the interest field of the present invention with this, therefore according to the equivalent variations that the claims in the present invention are done, still belong to the scope that the present invention is contained.
Claims (10)
1. the flexibility for cervical region pulse detection can attach sensor, comprise fabric substrate (1), sensitive layer (3) and electrode layer (4), it is characterized in that, also comprise barrier layer (2) and protective layer (5), described barrier layer (2) is arranged in fabric substrate (1), fabric substrate (1) on medicated clothing just on the region of neck pulse or clothing component just to the region of neck pulse, described sensitive layer (3) is arranged on barrier layer (2), described electrode layer (4) is positioned between sensitive layer (3) and protective layer (5), described protective layer (3) is for being attached to skin surface corresponding to neck pulse,
Described sensitive layer (3) prepares formation by the following method,
1) supersound process is carried out after material with carbon element and volatile solvent being mixed in proportion, obtain slurry mixture, add flexible macromolecule polymer in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described material with carbon element and volatile solvent is than being 1:1 ~ 1:5, and the mass ratio of the described flexible macromolecule polymer that adds in mixture and material with carbon element is 1:0.5 ~ 1:3;
2) sensitive material to be coated on barrier layer and to be cured polymerization, the volatile solvent in sensitive material being volatilized, and then forms three-dimensional cavernous structure.
2. the flexibility for cervical region pulse detection according to claim 1 can attach sensor, it is characterized in that, described sensitive layer (3) has three-dimensional cavernous structure;
Described barrier layer (2) and protective layer (5) are flexible macromolecule polymer;
Described electrode layer (4) comprises at least two strip electrodes, and described electrode is drawn from sensitive layer (3) surface.
3. the flexibility for cervical region pulse detection according to claim 2 can attach sensor, it is characterized in that, the aperture of described three-dimensional cavernous structure is 0.2 ~ 20 μm, and the spacing between Kong Yukong is 10 ~ 200 μm.
4. the flexibility for cervical region pulse detection according to claim 2 can attach sensor, it is characterized in that, described electrode by pasting, the mode of printing or physics cutting draws from sensitive layer (3) surface, the material of electrode be selected from conductive non-woven fabrics, enamel-covered wire, with the one in the flat copper foil belt of pressure-sensitive adhesive and pliable and tough ultra-thin Copper Foil.
5. the flexibility for cervical region pulse detection according to claim 1-4 any one can attach sensor; it is characterized in that; the thickness of described barrier layer (2) is greater than 1 μm; the thickness of sensitive layer (3) is greater than 1 μm, and the thickness of protective layer (5) is 1 μm ~ 500 μm.
6. can attach the preparation method of sensor for the flexibility of cervical region pulse detection, it is characterized in that, comprise the following steps:
S1, to fabric just to clean the region of neck pulse and dry;
S2, region surface on fabric after step S1 process apply one deck flexible macromolecule polymeric liquid, are then cured, itself and fabric are combined together, obtains barrier layer;
S3, at barrier layer surface-coated one deck sensitive material, be then cured polymerization, the volatile solvent in sensitive material volatilized, and then forms three-dimensional cavernous structure, obtain sensitive layer;
S4, prepare electrode layer on sensitive layer surface, described electrode layer comprises at least two electrodes of drawing from sensitive layer surface;
S5, at electrode layer and sensitive layer surface-coated one deck flexible macromolecule polymeric liquid, to be then cured, to form protective layer on the surface of electrode layer and sensitive layer.
7. method according to claim 6, is characterized in that, described sensitive material prepares by the following method:
Supersound process is carried out after material with carbon element and volatile solvent being mixed in proportion, obtain slurry mixture, add flexible macromolecule polymer in the mixture, thick sensitive material is obtained after stirring, the mixing quality of described material with carbon element and volatile solvent is than being 1:1 ~ 1:5, sonication treatment time is 1min ~ 240min, and the flexible macromolecule polymer added in mixture and the mass ratio of material with carbon element are 1:0.5 ~ 1:3;
Described flexible macromolecule polymeric liquid is by remaking evacuation process by the quality of 1:10 than mix and blend by initiator and reactant and prepare.
8. method according to claim 6, is characterized in that, described fabric is medicated clothing or clothing component; Adopt ethanol just to clean the region of neck pulse on fabric in described step S1, described barrier layer to be arranged in this ethanol purge district and to be less than the area in this ethanol purge district, and described sensitive layer to be arranged on barrier layer and to be less than the area of barrier layer; Coating method in described step S2 and S3 is printing, brushes or spin coating.
9. the method according to claim 6-8 any one, is characterized in that, the solidification temperature of described step S2 is 70 DEG C ~ 80 DEG C, and hardening time is 1.5h ~ 2.5h; The solidification temperature of step S3 is 70 DEG C ~ 80 DEG C, and hardening time is 0.5h ~ 1.5h; The solidification temperature of step S5 is 70 DEG C ~ 80 DEG C, and hardening time is 1.5 ~ 2.5h.
10. method according to claim 9, it is characterized in that, electrode in described step S4 by pasting, the mode of printing or physics cutting draws from sensitive layer surface, the material of electrode be selected from conductive non-woven fabrics, enamel-covered wire, with the one in the flat copper foil belt of pressure-sensitive adhesive and pliable and tough ultra-thin Copper Foil.
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Inventor after: Xiong Zuoping Inventor before: Zhang Ting Inventor before: Xiong Zuoping |