CN113790832A - Intelligent pulse monitoring wrist patch based on flexible pressure sensor and manufacturing method thereof - Google Patents
Intelligent pulse monitoring wrist patch based on flexible pressure sensor and manufacturing method thereof Download PDFInfo
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- CN113790832A CN113790832A CN202111071615.XA CN202111071615A CN113790832A CN 113790832 A CN113790832 A CN 113790832A CN 202111071615 A CN202111071615 A CN 202111071615A CN 113790832 A CN113790832 A CN 113790832A
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L1/00—Measuring force or stress, in general
- G01L1/16—Measuring force or stress, in general using properties of piezoelectric devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4854—Diagnosis based on concepts of traditional oriental medicine
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- A—HUMAN NECESSITIES
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
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- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00134—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems comprising flexible or deformable structures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00134—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems comprising flexible or deformable structures
- B81C1/00166—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Abstract
The invention provides an intelligent pulse monitoring wrist patch based on a flexible pressure sensor, which consists of a waterproof patch and the flexible pressure sensor. The invention also provides an intelligent pulse monitoring wrist patch based on the flexible pressure sensor and a manufacturing method thereof. The invention provides an intelligent pulse monitoring wrist patch based on a flexible pressure sensor and a manufacturing method thereof, wherein a flexible sensing technology is combined with a disposable band-aid, the flexible pressure sensor is high in sensitivity and accurate in pulse monitoring information, and is combined with a waterproof patch to form the intelligent wrist patch, so that the intelligent wrist patch is light, thin, soft, simple in process, strong in biocompatibility and stability, and suitable for long-time monitoring of human pulse signals.
Description
Technical Field
The invention belongs to the technical field of flexible wearable devices, and particularly relates to an intelligent pulse monitoring wrist patch based on a flexible pressure sensor and a manufacturing method thereof.
Background
In recent years, with the rise of high and new technologies such as internet, super computing, big data, brain science and the like, human beings enter an intelligent era, and an intelligent wearable technology is a new technology with comprehensive cross of multiple disciplines and becomes a key point of the research of experts at home and abroad. While scientific technology is continuously improved, the economic society is rapidly developed, people are increasingly oriented to good life, and people are more and more concerned about health problems while pursuing high-quality life. Relevant medical research shows that sub-health state and potential diseases can be discovered as soon as possible by health monitoring in daily life, and timely prevention and treatment can be achieved. Among the physiological parameters monitored, the pulse measurement is important data for measuring the health of the human body and for performing pathological analysis.
In the theory of traditional Chinese medicine, "pulse feeling" plays an important role in four traditional disease diagnosis methods of "inspection, auscultation, inquiry and cutting", but the pulse feeling technology lacks scientific standards and objective descriptions due to the complexity in the inheritance and development, so that both domestic and foreign research is dedicated to how to realize the objectification of pulse feeling, and through continuous research and study, certain achievements are obtained, and various types of pulse condition monitoring equipment are developed successively. However, most of the medical pulse diagnosis devices at the present stage have the problems of large size and inconvenience for carrying, and users usually need to connect a heavy hub for monitoring, so that the medical pulse diagnosis devices have certain limitations in the aspects of real-time measurement and the like. Some household pulse diagnosis equipment sold in the market has low accuracy and cannot meet the requirement of long-term health monitoring. Meanwhile, most of the pulse diagnosis instruments are rigid, and flexible pulse monitoring equipment is not available.
The intelligent pulse monitoring wrist patch has the advantages of being soft, light, thin, portable, simple in process and the like, can overcome the problems of large size, inconvenience in use, limited measurement and the like of the conventional pulse diagnosis equipment, utilizes the flexible pressure sensor which is contained/provided/prepared in the intelligent wrist patch, has high sensitivity, strong stability and strong biocompatibility, directly obtains pulse information, can greatly reduce the operation difficulty of the conventional pulse monitoring, and improves the measurement precision and user experience of the pulse monitoring.
Disclosure of Invention
Aiming at the problems of large volume, inconvenience in use, limited measurement and the like of the conventional pulse diagnosis equipment, the invention provides the intelligent pulse monitoring wrist patch based on the flexible pressure sensor and the manufacturing method thereof.
The invention provides an intelligent pulse monitoring wrist patch based on a flexible pressure sensor, which comprises:
the waterproof sticker is pasted on the wrist of a user with pulse to be monitored;
the flexible pressure sensor is arranged on the lower surface of the waterproof sticker;
and the data acquisition device is electrically connected with the flexible pressure sensor, and receives the pressure value signal sent by the flexible pressure sensor and converts the pressure value signal into a pulse oscillogram for display.
Preferably, in the intelligent pulse monitoring wrist patch based on the flexible pressure sensor, the flexible pressure sensor sequentially comprises from top to bottom:
a single-sided self-adhesive non-woven fabric layer;
the pressure sensitive layer is a mixed nano composite film with a one-dimensional cubic surface microstructure prepared by adopting a mixed solution template method and taking a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate;
and the flexible electrode layer is an interdigital electrode prepared by printing conductive silver paste on a high-density fabric by a screen printing technology.
The flexible pressure sensor is of a sandwich layered structure, and the pressure sensitive layer deforms through pulse beating, so that the pulse information of a human body is acquired in real time.
The invention also provides a manufacturing method of the intelligent pulse monitoring wrist patch based on the flexible pressure sensor, which comprises the following steps:
printing a pre-designed interdigital electrode pattern on a nylon screen printing template through a screen printing technology to obtain a flexible electrode layer;
the method comprises the following steps of (1) preparing a mixed nano composite film with a one-dimensional cubic surface microstructure by using a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate and adopting a mixed solution template method to prepare a pressure sensitive layer;
after the electrode interface is connected with a lead by using a conductive copper adhesive tape, a flexible pressure sensor is assembled by adopting a packaging mode that the lower layer is a flexible electrode layer, the middle layer is a pressure sensitive layer and the upper layer is a sandwich structure with a single-sided self-adhesive non-woven lining;
and (4) cutting the waterproof patch, and arranging the flexible pressure sensor in the middle of the lower surface of the waterproof patch to obtain the intelligent pulse monitoring wrist patch.
Preferably, in the manufacturing method of the intelligent pulse monitoring wrist patch based on the flexible pressure sensor, the manufacturing method of the pressure sensitive layer includes the following steps:
mixing the carbon nano tube with N, N-dimethylformamide solution, and carrying out primary ultrasonic treatment;
adding a mixed solution of silver nanowires and an N, N-dimethylformamide solution, and carrying out secondary ultrasonic treatment;
then adding polyurethane resin into the mixed solution, and carrying out magnetic stirring to obtain a uniform solution of the sensitive layer;
placing the uniformly mixed solution in a vacuum drying box for vacuumizing;
and then casting the uniform mixed solution in a micrometer structure mold for drying, taking out and cooling to obtain the pressure sensitive layer film.
Compared with the prior art, the invention has the following advantages:
the pressure sensitive layer is prepared by taking a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate and adopting a mixed solution template method to prepare a mixed nano composite film with a one-dimensional cubic surface microstructure.
The waterproof sticker has certain viscosity, so that the pulse detection device can be detached and replaced at any time, and the flexible pressure sensor can be well fixed, so that the pulse signal can be stably monitored; the waterproof patch is a transparent flexible film consisting of PET, poly-amino acid and medical grade acrylic adhesive, has an antibacterial effect and a waterproof function, is integrated with the flexible pressure sensor, enables the intelligent wrist patch to be naturally attached to the skin, is comfortable to wear, light, thin, breathable and strong in biocompatibility, is suitable for long-time monitoring of human pulse signals, and greatly improves user experience;
the preparation method combining the flexible sensing technology and the waterproof patch is simple in process and low in cost, and the intelligent wrist patch has the characteristics of portability, softness, wearability, strong biocompatibility and the like, and can realize real-time monitoring of human pulse signals;
different from the traditional mechanical rigid pulse diagnosis instrument, the device has the characteristics of portability, high accuracy and flexibility and wearability on the premise of objectification of pulse diagnosis, and is expected to replace the pulse diagnosis instrument which is heavy, inconvenient to use and poor in accuracy;
for many diseases needing long-term detection, the device can replace the traditional pulse diagnosis method to carry out objective medical diagnosis, help patients to carry out medical diagnosis at home, greatly improve user experience and further promote the development of traditional Chinese medicine pulse diagnosis modernization.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a flow chart of one embodiment of a method for manufacturing an intelligent pulse monitoring wrist patch based on a flexible pressure sensor according to the present invention;
FIG. 2 is a flowchart of a method for manufacturing a pressure sensitive layer in an embodiment of a method for manufacturing an intelligent pulse monitoring wrist patch based on a flexible pressure sensor according to the present invention;
fig. 3 is a diagram of human body pulse signals collected by the intelligent pulse monitoring wrist patch based on the flexible pressure sensor provided by the invention.
Detailed Description
The present invention is further described in detail below with reference to the attached drawings so that those skilled in the art can implement the invention by referring to the description text.
It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.
The invention provides an intelligent pulse monitoring wrist patch based on a flexible pressure sensor, which comprises:
the waterproof sticker is pasted on the wrist of a user with pulse to be monitored;
the flexible pressure sensor is arranged on the lower surface of the waterproof sticker;
and the data acquisition device is electrically connected with the flexible pressure sensor, and receives the pressure value signal sent by the flexible pressure sensor and converts the pressure value signal into a pulse oscillogram for display.
In an embodiment of the intelligent pulse monitoring wrist patch based on the flexible pressure sensor provided by the invention, the flexible pressure sensor sequentially comprises from top to bottom:
a single-sided self-adhesive non-woven fabric layer;
the pressure sensitive layer is a mixed nano composite film with a one-dimensional cubic surface microstructure prepared by adopting a mixed solution template method and taking a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate;
and the flexible electrode layer is an interdigital electrode prepared by printing conductive silver paste on a high-density fabric by a screen printing technology.
The resistance change is controlled through the pressure change of the pressure sensitive layer, the sensor has the characteristics of high sensitivity, good stability and accurate test data, and the pulse information of the human body can be acquired in real time.
As shown in fig. 1, the invention further provides a method for manufacturing the intelligent pulse monitoring wrist patch based on the flexible pressure sensor, which comprises the following steps:
printing a pre-designed interdigital electrode pattern on a nylon screen printing template through a screen printing technology to obtain a flexible electrode layer;
the method comprises the following steps of (1) preparing a mixed nano composite film with a one-dimensional cubic surface microstructure by using a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate and adopting a mixed solution template method to prepare a pressure sensitive layer;
after the electrode interface is connected with a lead by using a conductive copper adhesive tape, a flexible pressure sensor is assembled by adopting a packaging mode that the lower layer is a flexible electrode layer, the middle layer is a pressure sensitive layer and the upper layer is a sandwich structure with a single-sided self-adhesive non-woven lining;
and (4) cutting the waterproof patch, and arranging the flexible pressure sensor in the middle of the lower surface of the waterproof patch to obtain the intelligent pulse monitoring wrist patch.
As shown in fig. 2, in an embodiment of the method for manufacturing the intelligent pulse monitoring wrist patch based on the flexible pressure sensor, the method for manufacturing the pressure sensitive layer includes the following steps:
mixing the carbon nano tube with N, N-dimethylformamide solution, and carrying out primary ultrasonic treatment;
adding a mixed solution of silver nanowires and an N, N-dimethylformamide solution, and carrying out secondary ultrasonic treatment;
then adding polyurethane resin into the mixed solution, and carrying out magnetic stirring to obtain a uniform solution of the sensitive layer;
placing the uniformly mixed solution in a vacuum drying box for vacuumizing;
and then casting the uniform mixed solution in a micrometer structure mold for drying, taking out and cooling to obtain the pressure sensitive layer film.
The following is a detailed description of the fabrication process:
firstly, manufacturing a flexible electrode layer
Designing an interdigital electrode pattern, drawing the interdigital electrode pattern through Corel DRAW software, customizing a nylon screen printing template according to the characteristics of printing paste conductive silver paste, and finally printing electrodes on high-density fabric to obtain a flexible electrode layer;
two manufacturing pressure sensitive layers
1) Weighing 0.047g of multi-walled carbon nanotubes (MWNTs), adding the multi-walled carbon nanotubes (MWNTs) into 4ml of N, N-Dimethylformamide (DMF) solution, wherein the mass fraction of the multi-walled carbon nanotubes (MWNTs) is 5%, and sealing and carrying out ultrasonic treatment for 30min by using a preservative film after mixing, wherein the ultrasonic frequency is 45Hz, so that the multi-walled carbon nanotubes are uniformly dispersed in the DMF solution;
2) adding 2.7ml of mixed solution of silver nanowires and N, N-Dimethylformamide (DMF) into an MWNTs/DMF solution which is subjected to ultrasonic treatment, wherein the mass fraction of the silver nanowires is 1%, sealing and performing ultrasonic treatment for 30min after mixing, and the ultrasonic frequency is 45Hz, so that the multi-walled carbon nanotubes and the silver nanowires are uniformly dispersed in the DMF solution;
3) adding 0.9g of polyurethane into the obtained carbon nanotube-silver nanowire/DMF solution, sealing and magnetically stirring for 90min to uniformly mix the multi-walled carbon nanotube and the silver nanowire with the polyurethane and the DMF solution to obtain a uniform mixed solution;
4) pricking a plurality of small holes on the sealed preservative film, placing the beaker filled with the uniformly mixed solution in a vacuum drying oven for vacuumizing, repeating the operation for 3 times each time for 15min, and finishing the preparation of the uniform solution of the pressure sensitive layer;
5) uniformly and slowly casting the prepared pressure sensitive layer solution into a micrometer structure die manufactured by a machine engraving method;
6) putting the die into an oven, drying at 85 ℃ for 60min, taking out the die after drying, and cooling to room temperature to obtain a pressure sensitive layer film with a micron structure on one surface, wherein the size of the film is 2cm x 2cm, and the thickness of the film is 108 +/-4.74 microns;
three-assembly flexible pressure sensor
Connecting the flexible electrode layer electrode interface with a lead by using a conductive copper adhesive tape, then placing a pressure sensitive layer on an interdigital electrode part of the flexible electrode layer, wherein one surface of the pressure sensitive layer with a micron structure is in contact with the flexible electrode layer, and finally covering the pressure sensitive layer by adopting a single-surface self-adhesive non-woven liner to finish the packaging of the flexible pressure sensor so as to obtain the flexible pressure sensor;
four-assembly intelligent pulse monitoring wrist patch
The method comprises the following steps of (1) configuring a flexible pressure sensor (a flexible electrode layer faces to the side, which can be pasted, of the waterproof paste) in the middle of the waterproof paste, and integrating the flexible pressure sensor and the waterproof paste to obtain the intelligent pulse monitoring wrist paste;
fix intelligent pulse detection wrist subsides in the wrist, data acquisition device is connected to the wire, gathers human pulse signal and conveys the pulse oscillogram that the computer obtained human pulse signal through flexible pressure sensor, as shown in figure 3.
According to the intelligent pulse monitoring wrist patch based on the flexible pressure sensor and the preparation method thereof, the prepared flexible pressure sensor is high in sensitivity, good in stability and accurate in test data, the prepared intelligent pulse monitoring wrist patch has the characteristics of portability, softness, thinness, high biocompatibility and the like, and can monitor human pulse signals in real time.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.
Claims (4)
1. Intelligence pulse monitoring wrist subsides based on flexible pressure sensor, its characterized in that includes:
the waterproof sticker is pasted on the wrist of a user with pulse to be monitored;
the flexible pressure sensor is arranged on the lower surface of the waterproof sticker;
and the data acquisition device is electrically connected with the flexible pressure sensor, and receives the pressure value signal sent by the flexible pressure sensor and converts the pressure value signal into a pulse oscillogram for display.
2. The intelligent pulse monitoring wrist patch based on the flexible pressure sensor, according to claim 1, is characterized in that the flexible pressure sensor sequentially comprises from top to bottom:
a single-sided self-adhesive non-woven fabric layer;
the pressure sensitive layer is a mixed nano composite film with a one-dimensional cubic surface microstructure prepared by adopting a mixed solution template method and taking a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate;
and the flexible electrode layer is an interdigital electrode prepared by printing conductive silver paste on a high-density fabric by a screen printing technology.
3. The manufacturing method of the intelligent pulse monitoring wrist patch based on the flexible pressure sensor is characterized by comprising the following steps of:
printing a pre-designed interdigital electrode pattern on a nylon screen printing template through a screen printing technology to obtain a flexible electrode layer;
the method comprises the following steps of (1) preparing a mixed nano composite film with a one-dimensional cubic surface microstructure by using a multi-walled carbon nanotube and a silver nanowire as active materials and polyurethane as a flexible substrate and adopting a mixed solution template method to prepare a pressure sensitive layer;
after the electrode interface is connected with a lead by using a conductive copper adhesive tape, a flexible pressure sensor is assembled by adopting a packaging mode that the lower layer is a flexible electrode layer, the middle layer is a pressure sensitive layer and the upper layer is a sandwich structure with a single-sided self-adhesive non-woven lining;
and (4) cutting the waterproof patch, and arranging the flexible pressure sensor in the middle of the lower surface of the waterproof patch to obtain the intelligent pulse monitoring wrist patch.
4. The method for manufacturing the intelligent pulse monitoring wrist patch based on the flexible pressure sensor as claimed in claim 3, wherein the method for manufacturing the pressure sensitive layer comprises the following steps:
mixing the carbon nano tube with N, N-dimethylformamide solution, and carrying out primary ultrasonic treatment;
adding a mixed solution of silver nanowires and an N, N-dimethylformamide solution, and carrying out secondary ultrasonic treatment;
then adding polyurethane resin into the mixed solution, and carrying out magnetic stirring to obtain a uniform solution of the sensitive layer;
placing the uniformly mixed solution in a vacuum drying box for vacuumizing;
and then casting the uniform mixed solution in a micrometer structure mold for drying, taking out and cooling to obtain the pressure sensitive layer film.
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| CN202111071615.XA CN113790832A (en) | 2021-09-14 | 2021-09-14 | Intelligent pulse monitoring wrist patch based on flexible pressure sensor and manufacturing method thereof |
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| CN202111071615.XA CN113790832A (en) | 2021-09-14 | 2021-09-14 | Intelligent pulse monitoring wrist patch based on flexible pressure sensor and manufacturing method thereof |
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| CN104257359A (en) * | 2014-09-16 | 2015-01-07 | 苏州能斯达电子科技有限公司 | Wearable flexible sensor for monitoring wrist pulse and preparation method thereof |
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| CN106618521A (en) * | 2016-10-24 | 2017-05-10 | 合肥工业大学 | Wearable wrist integrated sensor based on PVDF piezoelectric film and preparation method of wearable wrist integrated sensor |
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2021
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| CN106618521A (en) * | 2016-10-24 | 2017-05-10 | 合肥工业大学 | Wearable wrist integrated sensor based on PVDF piezoelectric film and preparation method of wearable wrist integrated sensor |
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| CN110411616A (en) * | 2019-06-13 | 2019-11-05 | 东华大学 | Motor message and human pulse signal the monitoring preparation of pliable pressure sensor |
| CN111562039A (en) * | 2020-03-30 | 2020-08-21 | 重庆文理学院 | Textile material-based wearable pressure sensor and manufacturing method thereof |
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