CN107647869A

CN107647869A - Repeatable wearable breathing detection instrument based on graphene electronic nose

Info

Publication number: CN107647869A
Application number: CN201711063327.3A
Authority: CN
Inventors: 张佩刚
Original assignee: Shanghai Shushuang Material Technology Co Ltd
Current assignee: Shanghai Shushuang Material Technology Co Ltd
Priority date: 2017-11-02
Filing date: 2017-11-02
Publication date: 2018-02-02

Abstract

The present invention relates to a kind of repeatable wearable breathing detection instrument based on graphene electronic nose, and including breath collection devices, elasticity is worn, air filter box is entered on a left side, air filter box and one-way ventilating valve are entered in the right side.Employ the detector of this kind of structure, graphene sensor analysis can not only be utilized to judge unusual odor caused by the breathing of user, and its cell mutation and the dilation matrices in oral cavity are converted into the change of electricity, the detection to the abnormal conditions and breathing situation of user's health is realized, and can be used for clinically big data sample analysis.Simultaneously, the accumulation of low cost, high flux, big-sample data is advantageous to find new disease biomarkers, the detector provides the user with a kind of portable, noninvasive, quick, sensitive, accurate, cheap, repeatable wearable detection device, to external monitor air, internally disease of the detection including early-stage cancer, the accurate health data perceived with storage user, has wider application.

Description

Repeatable wearable breathing detection instrument based on graphene electronic nose

Technical field

The present invention relates to wearable medical instruments field, more particularly to human body respiration and saliva detection, in particular to A kind of repeatable wearable breathing detection instrument based on graphene electronic nose.

Background technology

Disease continually disturbs our joy of life and health, and cancer has severely impacted our quality of life With the existence time limit.There is the detection method of conventional disease and tumour relative complex invasive, somewhat expensive, delay treatment etc. to lack at present Point, it is late period when making a definite diagnosis to cause most of cancer patients, loses operation or best occasion for the treatment, prognosis are very poor.Therefore, Early discovery, early treatment are most important links in treatment of cancer.

Implication is heard, debates disease.Scientist finds that " hepatopathy, nephrosis, diabetes, pulmonary tuberculosis, intestines and stomach sense a long time ago Dye, and asthmatic patient can distribute the smell of uniqueness from oral cavity, have now been found that thousands of kinds of chemical compositions result in that A little special breath odors with disease warning function.As fingerprint, everyone respiratory characteristic is also unique.This meaning Taste to be detected by exhaling, and increasing health problem can be just diagnosed at the initial stage of disease.

According to American scientist, the blood sugar level that some dogs can smell their owners declines and proposes early warning.Through Abnormal response can be made to the smell sample of tumor patient by crossing the dog of training.Its rate of accuracy reached is to 90% or so (this and patient Related gene in exhaled gas in volatile organic compound and gas condensate is relevant).Israel researcher reports Claim, benign and malignant tubercle can be distinguished to the studies have shown that breast rail of 72 patients, accuracy rate is up to 88%, breathing inspection Particular type and the stage of lung cancer can also be assessed by surveying.

Modern medicine shows that disease can change the metabolism of human body, and this change causes cell in a certain organ to produce VOC (VOCs) composition difference is given birth to.And these VOCs can pass through blood circulation of human body Lung is arrived at, during gas exchanges, these VOCs can be excreted by human lung.The U.S. Cleveland clinic Alan Jay Lerner research institute Pulmonary Vascular director Rye De Deweike is represented " simply by the presence of volatile component, if can be with The thing for carrying out blood testing is all hopeful to come out by breath test.”

Compared with blood testing, breathing detection is not ached, and faster, testing cost is lower for output result, and is easy to repeat to examine Survey, or even can be carried out detecting when patient is sunk into sleep or takes exercises.Some breathing detections even can accomplish that blood testing is all done Less than thing.Breathing diagnosis is as a kind of non-invasive diagnosis method with fine development prospect, in countries in the world by increasingly More attention.Some experts wish：Breathing detection can be used in combination with CT scan, to reduce unnecessary biopsy Number.It is most effective, best in current high-tech clinical diagnosis instrument (including invasive colonoscopy) that this is included in it Means.The breathing detection of helicobacter pylori is applied among clinic already, and nitric oxide is as asthma anti-inflammatory therapy effect Testing index also has already been through the FDA certifications (SikoffP.E., 2004) in the U.S..

Recently, the Research Team of Shanghai Communications University achieves certain breakthrough in this respect, and their experimental demonstrations are exhaled Detection and the application of saliva detection.It is revealed that have developed the sensor of stomach cancer, and Technical comparing are detected by exhaling Lung cancer and the breathing detection of other tumours are studied by further by maturation, team.Although similar research is also many with achievement, All it is concentrated mainly in single sensor component performance mostly.Making with the sensor with performance brilliance with accurate tracker Chemical substance in body has achieved great progress with health detection aspect, scientists.However, they develop it is various The sensor of various kinds, although for theoretically very well, it is functionally also very outstanding in individual event.But it is currently not to be in laboratory In the stage, ready-made functional application product is exactly there is no, now the more Integrated Solution without integrated application, so can not also open at present Open up industrialized production and promote the use of in a wider context.

With the rapid development of society people propose higher pursuit to health and quality of the life, market compels to be essential Want small volume, light weight, low in energy consumption, consistency of performance is good, integrated, intelligent and energy high-volume market comprehensive detection production The appearance of product.Health detection of today is worn class product with intelligence and emerged in an endless stream, and health and longevity are the problem of people are most deeply concerned, Disease and cancer are the most worried worry of the mankind.Oral cavity and nasal cavity are the most important doors of human body, and continue human longevity Vitals.Its application technology is also with rapid changepl. never-ending changes and improvements, not only attracts the eyeball of people, also leads the direction of personal consumption.

Therefore, if being supplied to a kind of portable, noninvasive, quick, sensitive, accurate, cheap, high flux of popular offer, can weighing Multiple wearable detection device, it is believed that be bound to be liked that it manufactures simple and effective by healthy population is paid high attention to deeply Again economy and durability, suitable for large-scale promotion application.

The content of the invention

The purpose of the present invention is the shortcomings that overcoming above-mentioned prior art, there is provided one kind can realize that detection includes early stage The repeatable wearable breathing detection instrument based on graphene electronic nose of disease including cancer.

To achieve these goals, the breathing detection instrument of the invention based on graphene electronic nose has following form：

The repeatable wearable breathing detection instrument based on graphene electronic nose, it is mainly characterized by, described detector Including breath collection devices, elasticity is worn, air filter box is entered on a left side, air filter box and one-way ventilating valve are entered in the right side；Described Breath collection Device to record graphene array in real time resistance variations situation, air filter box is entered on a described left side and the right side enter air filter box respectively with institute The both ends that the elasticity stated is worn correspondingly are connected, the both ends that described elasticity is worn respectively with described breathing detection instrument main body Both sides are correspondingly connected；Described one-way ventilating valve is arranged at the surface of described breath collection devices；

Described repeatable wearable breathing detection instrument also includes detection module, display module, control module；Described inspection Survey the male part that module is connected with described display module and control module and is arranged at described breath collection devices respectively The top of position and the middle part at indent position, described display module are connected with described control module and described in being arranged at The middle part at the evagination position of breath collection devices.

The breath collection devices of the repeatable wearable breathing detection instrument based on graphene electronic nose are and face shape The solid figure structure to match, and be evagination indent shell shape, it is additionally provided with one layer of circle in the middle part of described breath collection devices The silica gel dividing layer active clapboard of arcuation, one end of described silica gel dividing layer active clapboard in arc-shaped and with described breathing Harvester is tightly connected in plug-in type, and the other end of described silica gel dividing layer active clapboard is arranged to spill arcuation.

The detection module of the repeatable wearable breathing detection instrument based on graphene electronic nose includes：

Environment measuring submodule, it is arranged at the top of described display module；

Brain electro-detection submodule, it is arranged in top and two earholes of described environment measuring submodule；

Breath detection sub-module, it is arranged at the top of the plate face of described silica gel dividing layer active clapboard；

Implication detection sub-module, it is arranged at the bottom of the plate face of described silica gel dividing layer active clapboard；

Weight disease detection sub-module, it is arranged at the external arc periphery of described one-way ventilating valve；

Physiological detection submodule, it is arranged at the inner surface of described one-way ventilating valve；

Saliva detection sub-module, it is arranged at the bottom of described breath collection devices；

Pulse detection submodule, it is arranged at the bottom of described saliva detection sub-module.

The detection module of the repeatable wearable breathing detection instrument based on graphene electronic nose is following any sensing Device and any combination with lower sensor：

Graphene gas sensor, graphene rubber sensor, grapheme foam sensor, graphene fiber sensor, Graphene sensor；

Wherein, described graphene sensor be include gas sensing unit, pressure-responsive unit, wet sensitive sensing unit with And light sensor cellular array.

The display module of the repeatable wearable breathing detection instrument based on graphene electronic nose includes display screen submodule, Described display screen submodule is following any display screen unit：

Saran paper display screen unit, AMOLED touch display screens unit, OLED touch display screens unit, graphene answer transformation Power senses display screen unit.

The display screen submodule of the repeatable wearable breathing detection instrument based on graphene electronic nose is consolidated including display screen Order member, display screen mobile unit and display screen rotary unit.

The control module of the repeatable wearable breathing detection instrument based on graphene electronic nose include brain wave submodule, Microcomputer submodule and power supply submodule, described microcomputer submodule is arranged at the inner surface of described breath collection devices, described Brain wave submodule be provided with TGAT chips, the TGAT chips are arranged at described microcomputer submodule, described power supply Module is arranged at the back side of described display module.

The microcomputer submodule of the repeatable wearable breathing detection instrument based on graphene electronic nose is following any list Member and any combination with lower unit：

Microcomputer unit, wireless signal transmitting element, NE, positioning unit；

Wherein, described microcomputer unit includes data message analyzing and processing subelement, learning software speech play subelement And GPRS subelements.

The power supply submodule of the repeatable wearable breathing detection instrument based on graphene electronic nose includes friction susceptance rice Generator and power supply unit, wherein, said supply unit is following any battery unit：

It is graphene solid-state thin-film battery unit, Na-CO2 battery units, porous nickel fluoride film battery unit, ultra-thin soft Property battery FLCB battery units, paper battery unit, solar battery cell, solid rechargeable cell.

The repeatable wearable breathing detection instrument based on graphene electronic nose in the invention is employed, stone can not only be utilized Black alkene biosensor analysis judges unusual odor caused by the breathing of user, and its cell mutation and the flexible of oral cavity should Power is converted into the change of electricity, realizes the detection to the abnormal conditions and breathing situation of user's health, and can be used for Clinically big data sample analysis, the additionally function with global location.Meanwhile low cost, high flux, big-sample data Accumulation is advantageous to find new disease biomarkers, and the detector provides the user with a kind of portable, noninvasive, quick, sensitive, accurate Really, inexpensively, high flux, repeatable wearable detection device, to external monitor air, internally detection is including early-stage cancer Disease, the accurate health data perceived with storage user, provide real-time physical function information to patient and provide most suitable Treatment recommendations, there is wider application.

Brief description of the drawings

Fig. 1 is the mankind in an embodiment of the repeatable wearable breathing detection instrument based on graphene electronic nose of the present invention The front view of breathing detection instrument.

Fig. 2 is the mankind in an embodiment of the repeatable wearable breathing detection instrument based on graphene electronic nose of the present invention The left view of breathing detection instrument.

Fig. 3 is animal in an embodiment of the repeatable wearable breathing detection instrument based on graphene electronic nose of the present invention The front view of breathing detection instrument.

Fig. 4 is animal in an embodiment of the repeatable wearable breathing detection instrument based on graphene electronic nose of the present invention The left view of breathing detection instrument.

Description of reference numerals：

1 breath collection devices

2 environment measuring arrays

3 display modules

4 control modules

5 breaths detect array

6 disposable mouth patches

7 active clapboards

8 enter air filter box

9 weight disease detection arrays

10 physiological detection arrays

11 unidirectional air outlet valves

12 salivas detect array

13 implications detect array

14 pulse detection arrays

15 press types-friction electric generator

16 extrusion pressing types-friction electric generator

17 bounce types-friction electric generator

18 flexure types-friction electric generator

19 bendings or rocking type-friction electric generator

20 elasticity are worn

21 brain wave earphones

22 brain wave sensors

Embodiment

In order to more clearly describe the technology contents of the present invention, carried out with reference to specific embodiment further Description.

The repeatable wearable breathing detection instrument based on graphene electronic nose of the present invention, it is mainly characterized by, described Detector includes breath collection devices, elasticity is worn, air filter box is entered on a left side, air filter box and one-way ventilating valve are entered in the right side；Described exhales Resistance variations situation of the harvester to record graphene array in real time is inhaled, air filter box is entered on a described left side and air filter box point is entered on the right side It is not corresponding with the both ends that described elasticity is worn to be connected, the both ends that described elasticity is worn respectively with described breathing detection instrument The both sides of main body are correspondingly connected；Described one-way ventilating valve is arranged at the surface of described breath collection devices；

Refer to shown in Fig. 1, it is the repeatable wearable breathing detection instrument based on graphene electronic nose of the invention The front view of human breathing detector in one embodiment, the breath collection devices are the evagination solid figure silicon of liquid silica gel cast Plastic structure.

Refer to shown in Fig. 2 and Fig. 4, it is respectively the repeatable wearable breathing based on graphene electronic nose of the present invention The left view of human breathing detector and of the invention are worn based on the repeatable of graphene electronic nose in one embodiment of detector The left view of animal breath detector in an embodiment of formula breathing detection instrument is worn, the control module includes computer module and electricity Source module, the computer module are separately positioned on the inner surface of the breath collection devices and the back of the body of display module with power module Face.

In an advantageous embodiment, the display screen of described display module is saran paper display screen, and the display screen is Display screen with Telescopic movable and rotation turn-over.

In an advantageous embodiment, described computer module is the Data Analysis Services with the atomic cake core of super low consumption Formed with information processing system, learning software and language play back system, and GPRS units, described computer module band bluetooth Wireless signal sending module and 4G/5G mixed-media network modules mixed-medias.

In another preferred embodiment, the power module is graphene solid-state thin-film battery.

Refer to shown in Fig. 3 and Fig. 4, it is respectively the repeatable wearable breathing based on graphene electronic nose of the present invention In another embodiment of detector, the front view of animal breath detector and the repeating based on graphene electronic nose of the present invention The left view of animal breath detector in one embodiment of wearable breathing detection instrument, the breath collection devices are liquid silica gel The cylinder solid figure silica gel structure of cast.

In another preferred embodiment, the detection module is following any sensor：

Graphene gas sensor, graphene sensor；Described graphene gas sensor is with graphene, doping egg White matter and DNA, described graphene sensor have the multiple functions such as air-sensitive, wet sensitive.

In another preferred embodiment, described display module is that graphene strains pressure sensing display screen, described aobvious It is fixed mode touch display screen to show module.

In another preferred embodiment, the control module includes computer module and power module, the computer module The anterior inner surface of the breath collection devices is separately positioned on power module.

In another preferred embodiment, described computer module is at the data analysis with the atomic cake core of super low consumption Reason and information processing system, learning software and language play back system, and GPRS units are formed, while and wireless with bluetooth Data wireless signal sending module, 4G/5G mixed-media network modules mixed-media and Big Dipper positioner.

In another preferred embodiment, the power module is " metal-air (Na-CO2) battery ".

In actual applications, detection module is made up of following material：

First, electrode (coiled material is made：PET, unit：mm)

Table 1

2nd, electrod-array is made：

Table 2

In above-mentioned practical application, biology sensor and device based on graphene are for a variety of biological micromolecules, protein (including virus and cancer markers etc.) and DNA etc. detection all show good sensitivity and selectivity, be to be used to build Efficiently, quickly, the ideal material of the biology sensor of Sensitive Detection.Compared with traditional sensors, graphene can significantly improve biography The sensitivity of sensor and shortening response and recovery time, reduce noise signal.Using by polymer gas sensitive and its all kinds of nothings Machine filler deposition to the sensor being prepared on interdigital microelectrode possess high sensitivity, can do work at room temperature, low-power consumption, just In detection, beneficial to array it is integrated, can directly perceive and amplify the change of boundary material, and by human body checking matter composition, concentration Etc. information be converted into exportable electric signal or it is other easily detectable signal device (selectivity, sensitivity, stability, repeatability, Anti-corrosion property).Film makes the quick side for preparing graphene film using continuous volume to volume CVD growth encapsulation transfer nondestructively peeling Method.

Electrode in the present invention makes (plane is micro- interdigital) using the quick bubbling transfer of PET volume to volume hot padding-electrochemistry Electrode.Wherein, production method is to realize graphene from copper foil growth substrate directly to industrial PET flexible transparent plastics substrate The lossless transfer of serialization, so as to be prepared for high-quality graphene/PET flexiplasts (PET) position interdigital electrode, meanwhile, by metal Nano wire (nano silver wire, copper nano-wire etc.) network is directly encapsulated between graphene and flexiplast (PET) substrate, and batch is made For graphene/metal nanometer line/PET composite-type flexible conductive film.This continuous volume to volume CVD growth-encapsulation turns The quick method for preparing graphene film of shifting-nondestructively peeling breaches many technical bottlenecks, and the spirit of sensor is also respectively increased Sensitivity and stability.This highly sensitive device is dirty for the early diagnosis of respiratory disease and environment to studying and making The detection of dye gas has important directive significance, realizes the company of high-quality graphene film and high-performance flexible transparency electrode Continuousization and large-scale production, there are the potentiality of industrialized production.

Wherein, bipolarity (the i.e. either electron withdrawing group of " environment, breath and implication detection array " based on graphene Or electron donating groups are adsorbed to the change that its changes of threshold and work function are led on graphene, can by its Electrode surface occurs redox reaction and produces corresponding current signal to detect target molecule).It can quickly transmit electricity Son, and can realize the selective enumeration method of biomolecule, thus are easy to be monitored in resistance type sensor.And graphene is rich Rich surface functional group modification target molecule, after gas molecule adheres to and departs from, graphene can recover its reset condition again Characteristic.

" environment, breath and the implication detection array " uses the discoloration sensor using graphene as the litmus paper class of carrier Film.There are stronger chemism and special characteristic electron using grapheme material the defects of doping, using multiple element Doping, the approach of surface structure design is modified and optimizes to grapheme material.This case will also have the selection of different air-sensitives Property multiple gas sensors composition array, using the cross sensitivity of its array, with reference to computer technology and pattern-recognition Technology exports response to it and analyzed and researched, and just can realize the improvement of sensor selectivity and the raising of measurement accuracy, Effectively lifting sensitive material to the responsiveness of gas (conveniently can delicately detect the gaseous organic pollutant in living environment), With substantially prompting user (when film runs into the toxic gas in air, pink can be become immediately, when having by color When poison gas bulk concentration is higher, the color of the thin membrane regions also just becomes deeper).This new material of graphene can with indoor environment and Detection target preferably contacts, and so as to improve detection sensitivity, can be also detected even if the pollution for having 0.01% in room air Out.

Wherein, weight disease detection array is for a variety of biological micromolecules, protein (bag based on the biology sensor of graphene Include virus and cancer markers etc.) and DNA etc. detection all show good sensitivity and selectivity, foundation complementary nucleic acid is miscellaneous Hand over principle, amplified detection signal by " Infinite Cyclic digestion ", functionalization is carried out to graphene, makes tumour sensor；It is logical Cross and enhanced sensitivity is carried out to graphene with DNA, make gene sensor；By using antibody modification graphene, making (uses alpha-fetoprotein As model) thionine (TH) immunosensor；Two are pressed using by the biomass such as a large amount of protein, aglucon, nuclease probe molecule Structure is tieed up, respectively according to the sequence being pre-designed, is sprayed to high-density by precise nozzle and is fixed on specially treated PET loads On body, probe dot matrix is formed.(sample molecule that a variety of biomass in exhalation implication are adhered to graphenic surface and mark is carried out Hybridization reaction, we are with regard to that can obtain the full details of various biomolecules).According to the characteristic of probe, make its with it is to be checked in saliva Biomolecule carries out specific adsorption or reaction, and the monitoring analysis to hybridization signal obtains the quantity of sample molecule and sequence is believed Breath, by detect protein, with the presence of tumor-related gene, analysing protein with the defects of tumour Associated Memory and its expression Function, realize the seizure to cmicroRNA.The purpose for reaching diagnosing tumor and parting (applies also for finding tumour correlation The research of gene and tumour Associated Memory express spectra)." the weight disease detection array ", can also use one kind without enzymatic amplification protein The method (washing away unnecessary enzyme without a set of complicated system) of signal.This new method utilizes molecule chain reaction, only exists Just triggered strongly in the presence of target protein.This transduction mechanism is to utilize DNA nanometer technologies, by this mechanism egg White matter signal is converted into the nucleic acid output of amplification.The recognition unit wherein combined with nucleic acid forms catalytic composite, in multicomponent Hybridization/transposition reaction is driven in nucleic acid substrate, multiple target single stranded oligonucleotides are discharged in the form of amplification, pass through such side Method is come the target protein of detection needed for identifying.The surface of most animals cell carries quiet negative electrical charge, sialic acid on glycoprotein Carboxyl is the main reason for its is negatively charged.Because cancer cell is more active, the negative charge density of its surface institute band can be higher.It is right The gas of patient's exhalation is detected, and can rapidly realize diagnosis, and graphene device carries out electricity to the sample of mutant cell The detection of signal, it is to realize the detection to mutant cell by electrical signal using the graphene molecules device of lattice.When " cancer During the surface of cell " contact " graphene chip ", it can make it that the electric charge of graphene chip surface rearranges (because cancer is thin Born of the same parents' hyperactive, the surface of graphene chip can be caused to discharge more protons and higher negative electrical charge occur).Finally with special Computer software to result carry out accurately and rapidly analyze and explain, so as to realize the measurement and screening to protein.Pass through The antibody of prepare with scale is fabricated to micro-array chip, there is strong, easy to operate, quick and detection sensitivity height of comparativity etc. Feature, it is suitable for the high flux screening analysis of lot of antibodies in prepare with scale antibody.

Wherein, physiological detection array is to have great surface than, high carrier mobility, high sensitive based on graphene The characteristics such as degree, high signal to noise ratio.Sensitivity is used as using a kind of specialty fibers structure similar to compression spring, and by the use of graphene Conductive material, it is prepared for a kind of flexible fiber sensor that can sense stretching, bending and torsional deflection.This fiber sensing The elongation strain detection range of device is up to 100%, and induction sensitivity is up to 0.2%.Also have simultaneously extremely excellent to bending Deformation and the actual induction of torsional deformation.90 degree are up to the detection range of angle of bend, induction sensitivity reaches 2 degree.It is right In clockwise and anticlockwise torsional deflection, the fiber sensor can also make a distinction and the sensing of torsion degree.

The present invention is vertically arranged several flexible fibers in a upright framework, is held for gathering on the fiber The blow gas pressure received (its miniature deformation amount can cause the change of resistance).By in the array both ends on-load voltage, and detect The variable quantity of its voltage is the deformation quantity that can obtain the fiber, by calculating modulus of elasticity and the deformation drag of the fiber, i.e., Its relative pressure is can obtain, therefore, when user blows, you can accurately obtain on air blowing number, the size of blowing force, side To etc. data.

Wherein, saliva detection array is that will generate hydrogen peroxide based on glucose oxidase and glucose response, and peroxide Changing hydrogen can interact with doped graphene and produce electric signal, the proportional spy of the content of the electric signal and glucose Property, the sensor of making glucolase base.The structure of " saliva detect array ", it is that circular arc is made using PET film is flat The split pattern of flat clam shell, it is arranged on the bottom of breath collection devices 1.Usually down doubling is closely sealed, in use, lifting upper strata The edge of concave circular arcs opens to mouth lifting (is fitted with micro- interdigital detecting electrode, the chip on the foldable plane of the clam shell Surface be also fitted with one layer of " the water imbibition melt spraying non-woven fabrics film of disposable 10 grams m, " used time can quickly absorb with Even scattered saliva, disposably abandoned after use), micro- interdigital detecting electrode of " saliva detects array ", is gone back using chemistry Chloroplatinic acid and graphite oxide are reduced and obtain Pt/RG mixture by former method simultaneously, and platinum is effectively secured into graphene carrier On, Pt/RG/GCE electrodes are prepared afterwards, and glucose oxidase is then fixed to PET film material with the mode of electropolymerization Pt/RG/GCE electrode surfaces prepare glucose biological sensor, other materials in saliva, such as dopamine, uric acid and Vitamin C Acid, it is also possible to influence size of current.To prevent from disturbing, can be coated between the enzyme layer of outermost and gate electrode with reference to polyaniline (PANI) and perfluorinated sulfonic acid (Nafion)-graphene film duplicature.Meanwhile this duplicature can help fixing glucose oxidation Enzyme improves its test performance to glucose on gate electrode.In addition, need to only coordinate corresponding enzyme, saliva can be tested Other levels of substance such as uric acid in liquid.For example, biology sensor and uricase (UOx), polyaniline (PANI) and perfluor sulphur Sour (Nafion)-graphene film duplicature combines, and the array just only can have reaction to uric acid, and other have an opportunity to disturb As a result material can be blocked.

In actual applications, it is only 1% of solubility in blood containing sugar in normal person (diabetic is considerably higher) saliva To 10%.And the error of blood clinical inspection is in 10%-20% or so, the error of saliva test is in 5%-10% at present, relatively As a result it is more accurate.Quick and highly sensitive blood sugar test is required diagnosis, for example, it is glycosuria to lack insulin and excessive blood glucose The two big causes of disease of disease, both of which can be detected by measuring blood glucose.

Wherein, pulse detection array is to have light weight, softness, contact area big, durable based on graphene piezoelectric foam The characteristics of property is good, and piezoelectric response dynamic range is big, measures heart rate using contact piezoelectric foam, can reduce interference signal, adopt It is with CVD growing three-dimensional graphene, it is compound with PDMS, PDMS is filled up completely with the sky of three-dimensional graphene framework in a mold Chamber, the new force-sensitive material with flexible extensible is made, for prepare flexible shock sensor (have economy, technique it is simple, Easy to operate, test simple to install, practical, the advantages that can be easily made various sizes and shape)." the pulse detection battle array Row " make the graphene flexible shock sensor of denture fixing device shape structure using pouring technology, are placed under device for detecting respiratory 1 Portion's (at arteries on lower forehead both sides), for measuring heart rate (each heartbeat of human body, the arterial blood on forehead both sides of user Pipe also has small vibration simultaneously).By to faint pressure change caused by body surface, and the analysis of pulse change, The accurate detection of human body difference physiological status can tentatively be realized, its three-dimensional grapheme piezoelectric foam be compounded to form with PDMS it is soft After property conducting base, the still electrical conductivity with 10S/cm.As long as there are slight deformation or pressure, the contact on its surface Resistance value on shock sensor can sharply increase and (can recover its original pattern and resistance value rapidly after stress release), its spirit Sensitivity has the sensitivity for being up to thousands of times higher than conventional resistive foil gauge hundreds of.And the change of these electrodes is captured, then pass through Algorithm can restore the frequency of heart rate bounce.The detection method is expected to obtain in terms of health evaluation and disease diagnosis early stage Obtain extensive use.The application can also change to the electrode being collected into, and by algorithm process, while detect " pressure sensation, the pain sensation, the sense of heat And the sense of cold ", " pressure sensation " is when frontal artery skin of the grapheme foam array contact at human body bottom, in human body Body surface there are potential difference between much putting, and soft pulse is enough to disturb the electric current for flowing through graphene, and produce resistance survey Result is measured, the data such as heart rate, pulse, muscle and skin of user is then collected into, accurately result is drawn after. " pain sensation " meeting " being produced when the power of unit area is stronger ", can be calculated with area divided by the pressure of detection." the temperature Feel and the sense of cold " aspect, grapheme foam can slightly deform with temperature change, detection therefore caused current values change It can find out.

In actual applications, the tissue around heart and body fluid can be conductive, therefore can regard human body as and have for one Length and width, the volume conductor in thick three-dimensional space.Heart cans be compared to power supply, and the summation of countless Single Cardiac Cell changes can pass Lead and reflect body surface.There is potential difference between body surface is much put, it is to wait electricity also to have between many points without potential difference 's.Changed by the electrode being collected into, by algorithm process, many numerical value can be restored, wherein heart rate number can be restored Value.The heart rate value monitored can be passed into mobile phone, flat board etc. with indigo plant in real time with reference to the rhythm of the heart scheme of Bluetooth technology The portable equipment of the function of tooth 4.0, heart rate data and lead state collect real-time display on App, and by analysis Heart rate data shows ecg wave form figure.

Functionally see, the detection module in technical scheme is similar to biological permissive cell, and control module is similar In the brain of biology, remainder is then similar to signal transduction system.The effect of detection module can imitate to a certain extent The olfactory function of the mankind, to realize the collection of specific gas and saliva.Graphene electronic nose array non-invasively gathers each of human body Item vital sign parameter, processor carry out supple-settlement to the signal collected, can calculate the information such as body temperature, heart rate, blood pressure. And by WIFE modules by information back-up to built-in mobile phone, apparatus such as computer.In health exception, system can just be sent out Go out alarm signal.

In actual applications, the display module uses with Telescopic movable and rotated the saran paper display screen of turn-over.

(1) it is easy to read：Saran paper display screen carrys out display pattern by reflection environment light, and it has as paper printing Effect.Compared with traditional transmissive liquid crystal display screen, saran paper display does not need backlight, is easy to read, even in sunlight Beneath, saran paper is still clear visual.In addition, saran paper display shows soft, not dazzling, flicker free, and visible angle is several 180 ° are reached.Therefore, saran paper display screen is especially suitable for reading.

(2) it is frivolous flexible：Compared with common liquid crystals display screen, saran paper either has substantially on thickness or weight Advantage, to find out its cause, except because in structure it is fairly simple outer, it is thin based on soft plastics also to have benefited from saran hard copy body The material of film；Meanwhile this also creates its born flexible, flexible feature；In addition, it can also arbitrarily cut as needed Into variously-shaped.These advantages of saran paper, him is set not limited substantially by shape of product, size and structure in application System, it neatly " can be almost pasted " on the surface of any product.It meets the needs of current flexible display technologies development.

(3) power and energy saving：Good hand in terms of saran paper display screen or power and energy saving, mainly there is the original of two aspects Cause.First, it need not backlight this power consumption rich and influential family -- this part generally consumes common liquid crystals display screen more than 60% Electric power；Secondly, saran paper has a distinguished characteristic -- bistability.Bistability is meant, when display still image When, saran paper can not power consumption completely, in other words, as even if disconnecting all power supplys, saran paper display screen still can Enough retain last painting face.It means that we need not be needed continuously as conventional liquid crystal for match Human relations paper display maintains the supply of power supply, but only just needs to provide the electric power of a wee bit when display picture is switched. It can be appreciated that saran paper display is than conventional liquid crystal power saving much.

Just take an electronic reading screen using saran paper technology to go ahead, in the condition of normal use, charged to it Once, can continue to read more than two weeks.And if the liquid crystal display of a same size, same battery capacity Under, often it is merely able to support the use of several hours.

Using the implicit digital display screen of OLED Vacuum Depositions, electricity and the electric current and voltage of input and output can be accurately shown. (graphene touch-screen) can also produce electric signal according to detecting touch, and show position and the pressure of detecting object simultaneously Size, but also more traditional pressure sensor with more transparency and consumption lower power consumption.

It is somebody's turn to do " control module ", is made up of respectively " computer module " and " power module ".It is somebody's turn to do " computer module ", based on described Breathing detection instrument is wearable product, so have selected the wearable type wireless patch of Freescale.This integrated monitoring work Have measurable heart rate, breathing pattern and other vital signs.The paster is applied to clinical and personal health care application.Patch-type Medical and health-care products can increase the mobility and comfortableness of patient, and vital sign data can be wirelessly uploaded into high in the clouds, be used for Analysis or long-term keeping records in real time.Freescale microcontroller provides high throughput and the desirable combination of low-power consumption, suitably Body-worn medical electronic device design.Its with wired and wave point, including USB,802.15.4、Technology Solution and touch-screen user interface design.

Simultaneously, it is contemplated that the comfort level of wearing, while do not influence the processing to vital sign data again.System board uses Flexible polyimides (or polyester film) is the circuit board of base material, can bear repeatedly bending, folding and winding, heat dispersion It is good.Low-power consumption bluetooth signal communication of the node of composition with main frame by 2.4GHz, main frame are adopted using smart mobile phone operation information Collect the APP of display.Multiple nodes can utilize application layer protocol and main frame composition star network.Moreover, it is related in the application The single mode BLE of bluetooth 4.0 (Bluetooth Low Energy), its power consumption is lower, and the usage time of battery can be made longer, into This lower and transmission range is farther.Specially towards the wireless solution all being had higher requirements to cost and power consumption.

Wherein, " the brain wave TGAM units " in the present invention includes TGAT chips, and the chip is one highly integrated One chip eeg sensor, three Neurosky eSense parameters can be exported, analog-to-digital conversion, detection contact can be carried out Bad abnormality, filter out an electric noise and current interference.

The brain wave detection unit is fitted in the forehead. centre of user using a sensor probe, is reconfigured at two in addition Individual earplug is connected with TGAT chips, and common combination is used for monitoring the brain activity of people.It can safety measurement people brain telecommunications Number, monitoring people is counting, concentration level when memory and pattern arrangement are applied.MindWave Mobile are removed and are adapted to PC and Mac Outside, can also be connected with iPhone, iPad and Android.As a Wearable equipment, it can pass through bluetooth wireless connection The terminal devices such as mobile phone, tablet personal computer, laptop computer, desktop computer or intelligent television.Coordinate corresponding application software can Realize the interactive manipulation of consciousness force.It is deep by users with powerful training soft ware that references external advanced brain-computer interface technology Like.It can allow this detector, mobile phone or tablet personal computer to recognize your brain states immediately, for example whether be absorbed in, be nervous, Loosen or fatigue etc..And the brain signal detected is changed into data signal and is sent to the required department understood and information storage Ground.

Wherein, the principle of electric nano generator of being rubbed in the power module in the present invention is " triboelectrification and electrostatic induction The coupling of effect, at the same coordinate thin layer formula electrode (make various regular Model arrays with micro-machined method in film surface, Friction effect is strengthened with this so as to improve the delivery efficiency of nano generator.New " nano generator " is being extruded, bending or shaken It is dynamic lower to export and the voltage that to save AA batteries almost identical) design, realize effective output of electric current.”

This case is provided with " rub electric nano generator " of following 5 kinds of structures accordingly：

(15) press type；(16) extrusion pressing type；(17) bounce type；(18) flexure type；(19) bending or rocking type.

Referring specifically to shown in Fig. 1 and Fig. 2：

This case (15) press type " rub electric nano generator "：

Generator material：Dimethyl silicone polymer (PDMS) film and polyethylene terephthalate (PET).

Generator makes：From two kinds of high molecular polymer films for being coated with metal electrode and grid --- poly dimethyl silicon In the flexible substrate of oxygen alkane (PDMS) film and polyethylene terephthalate (PET) film with conducting nanoparticles (CNT, Nano silver wire etc.) planar shaped sensitive thin film generator device is made.

Generator power：According to surveying under only 0.13% mechanical deformation, the output voltage of individual devices reaches 3.3V, defeated Go out electric current 0.6 μ A, peak power density 10.4MW/cm3.

Generator is installed：The back side of graphene array is bonded in by the PET planes of the generator device, by silica gel, then Positive negative conductor is connected to the counter electrode of above-mentioned generator respectively, forms self-driven energy source device.

Generator application：Environment measuring array 2, display module 3, control module 4, breath detection array 6, saliva detection battle array Row 12.

Generator uses：Finger pressure, air blowing, ear-drum extruding and the energy of vibrations are collected, electric energy is converted into and realizes self-driven.

This case (16) extrusion pressing type " rub electric nano generator "：

Generator material：Stretchy nylon (or the common textile such as elastic terylene), and graphene elastomer cloth.

Generator makes：From the graphene elastomer cloth by inkjet printing metal electrode, with stretchy nylon (or bullet Property the common textile such as terylene) edge pressing after be used as inside and outside two electrodes, then using disposable elastic bamboo fibre (being used for mouth health) is fitted in the aspect of stretchy nylon layer by electrostatic interaction, then again by its three layers of elastic fabrics After the gas hole that size is collapsed with lip is excavated out at centre position, then its peripheral edge is fixed on breathing detection with velcro and filled The edge for putting inner side forms planar shaped generator device.

Generator power：There is its energy delivery efficiency of the generator device of micro structure array significantly larger than original according to measuring tool Without structure devices, output voltage is up to 18V, and peak point current reaches 0.7 μ A, and corresponding peak current density is about 0.13 μ A/ cm2。

Generator application：Display module 3, control module 4, brain wave earphone 21.

Generator uses：Muscular movement when mouth is blown and energy caused by brains shake are collected, causes stretchy nylon It is squeezed with graphene elastomer cloth this 2 kinds of materials and is realized self-driven with electrostatic induction with triboelectrification.

Bounce type " rub electric nano generator " in the present invention：

Generator material：Polyimides (Kapton) film and polyethylene terephthalate (PET).

Generator makes：From the two kinds of high molecular polymer for being coated with metal electrode films --- polyimides (Kapton) Conducting nanoparticles (CNT, nano silver wire are used in the flexible substrate of film and polyethylene terephthalate (PET) film Deng) planar shaped sensitive thin film shape generator device is made.

Generator application：Display module 3, control module 4, pulse detection array 13.

Generator uses：The energy that artery shakes reflection with mouth vibration, brains is collected, various shock energies are converted into electricity Can and realize self-driven.

Flexure type " rub electric nano generator " in the present invention：

Generator material：Electrically conductive graphite powder particles GPs；Dimethyl silicone polymer (PDMS)；Polyethylene terephthalate Ester (PET).

Generator makes：It is molded using culture dish, prepared by the method that is heating and curing.By " electrically conductive graphite powder particles GPs doping PDMS composite membranes (PDMS@GPs)【The aluminium film (AL foil) for being fixed on vibrator is Top electrode, is fixed on the poly- to benzene two of base The fat of formic acid second two (PET) is that bottom electrode substrate is assembled into sandwich structure】, and the flexible friction susceptance rice hair based on the composite membrane Motor (CFNG) device.”

Generator power：The peak power output of the CFNG can light 52 LEDs in parallel simultaneously up to 1.48mW.

Generator is installed：1.5 ㎝ outer-hexagonal plastic column, ㎝ (the double end external screw threads of diameter Ф 0.8 is grown from 4 polished rods The ㎝ of Ф 4), its one end external screw thread is separately fixed in the internal thread hole around breath collection devices check valve, then sent out this Four through-hole alignments installation on motor is safe, then the internal thread by 4 outer-hexagonal columns (its 1 end internal thread, 1 end external screw thread) Put fixation；Form its self-driven energy source device.

Generator application：Display module 3, control module 4, physiological detection array 12.

Generator uses：Under the blowing force effect after lip is gathered, the device surface can produce the mechanical shapes such as bending at once Become, cause phase mutual friction occurs between two layers of polymers film, realized self-driven so as to produce separation of charge and form electrical potential difference.

The installation of physiological detection array：Four through holes for being provided with plurality of flexible fiber frame are sleeved on above-mentioned generator On four threaded rods exposed, the corresponding electric of above-mentioned generator is connected respectively after tightening nut and fixing, then with positive negative conductor Pole.

Bending or rocking type " rub electric nano generator " in the present invention：

Generator material：Zinc oxide ZnO；Dimethyl silicone polymer (PDMS)；Polyethylene terephthalate (PET).

Generator makes：Surface and the internal porous ant all patterned are prepared using the method for hydrochloric acid etching oxidation zinc pore-forming Cave-shaped flexible and transparent PDMS composite membranes, and transparent graphene-conducting polymer transparency electrode of PET base is combined, prepare Flexible and transparent friction susceptance rice generator device.

Alternator data：Up to 7.8 μ A (1.95 μ A/c ㎡), voltage reaches 271V, maximum work output for maximum current output Rate is up to 0.39mW.

Generator application：Display module 3, control module 4, implication detection array 9, weight disease detection array 10.

Generator uses：The energy of crosswind, the vibration in oral cavity and the shake on head caused by blowing is collected, is converted Realized self-driven into electric energy.

" capacitor type " nano generator both may act as energy storage devices, and can serves as energy output equipment above.This case Each circuit module based on self-driven (all friction susceptance rice generator circuits interconnect) is used, configures setting supplemented by power supply Meter.

" metal-air cell ", it is the air electrode for being used as lithium carbon dioxide battery by graphene, is born with lithium metal Pole, by absorbing the carbon dioxide of characteristics of contaminated respiratory droplets in " device for detecting respiratory ", and the rechargeable battery to release energy.

The graphene solid-state thin-film battery Na-CO2 batteries are easier than other metals such as Li-CO2-carbon dioxide battery Realize reversible discharge and recharge reaction, absorbing carbon dioxide during electric discharge, release carbon dioxide during charging, thus be referred to as breathing sodium- Carbon dioxide battery.

Wherein, be the cross sensitivity problem that eliminates mixed gas in oral cavity, in technical scheme using 2 sections of softwares come Lift the accuracy of detection.

The mode identification method that software 1 is combined using " fuzzy diagnosis " with " BP neural network " in technical scheme High performance software algorithm (higher recognition correct rate, shorter recognition time can be provided, so as to making up to a certain extent Error caused by hardware and environmental uncertainty), use pattern recognition methods is simultaneously carried out excellent using Adaboost algorithm Change is handled, and can effectively realize the separation of fusion signal.The component analysis being combined by the identification technology, realizes multi-signal Collection, the algorithm for completing data analysis and signal extraction,

Software 2 uses heart rate drainage pattern in technical scheme, and the heart for obtaining wearer in real time is detected by artery Rate (and sending alarm signal in a certain critical point of heart rate), then by the information transfer of collection to control module 4；The control The information that sensor group obtains is changed and calculated by software systems again by module 4, and the result detected is included On the display screen of the detector, wearer is reminded to pay attention to, while the heart rate data of collection is sent into visitor by blue-tooth device On the mobile phone and network intelligence main control device at family.The development of the information processing technology and computer technology causes entering for gas sensor One step application is possibly realized.By gas sensor technology and mode identification technology, electronics described in technical scheme Nose array can not only solve the problems, such as the intrinsic poor selectivity of single gas sensitive device, can also obtain being far longer than the steady of discrete component Qualitative and sensitivity.

Detection module must also enter before algorithm realization is carried out to the various data being collected into technical scheme Row certain processing --- feature selecting and extraction.The pattern that the characteristic vector that feature recombination method obtains is input to design again is known It is final to realize classification in other system.Then again by fuzzy recognition method, BP neural network method and multivariate data statistics side The response signal of detection module can be converted into gas, the constituent concentration value of liquid composition by method etc., and then obtain to gas to be measured The intelligent interpretation device of taste qualitative analysis.In addition, in conjunction with relevant test circuits, side can realize to smell in real time, it is highly sensitive The detection of degree ground.Meanwhile high performance software algorithm can provide higher recognition correct rate, shorter time, so as to certain Error caused by hardware and environmental uncertainty is compensate in degree.Pass through exhaled gas, it may be determined that the spy in human body Gas componant and micro-concentrations are determined, so as to start to investigate certain disease.

In one embodiment, display screen power supply is first opened during measurement, voltage is added in the electrode of detection array, passes through Data acquisition equipment obtains resistance or current signal, the change of output signal reflect the resistance variations of sensitive thin film, thus may be used Detect the concentration of object gas.The GC/MC results of breath tester sample are analyzed by system and structure algorithm, with exclude and Differentiate " normal and canceration " pattern, really provide information for the design of sensor.

Breathing detection instrument is the detection product for aiming at personal physical examination research and development in technical scheme, and it is that a safety can Lean on, the convenient wear-type detector worn.Record the resistance variations situation of graphene array in real time by breath collection devices, it is rich Rich colorful video training software can allow the convenient study of users with operating with.It can be shown by touch display screen The health data of user, and can recognize heart rate, respiratory rate and skin temperature etc. immediately by mobile phone (or tablet personal computer) Data, also collect the information such as sub-health state and the early-stage cancer of user.Detected data can pass through bluetooth Mode is sent.

Wherein, after the APP software contexts on the blue-tooth device and mobile phone on the breathing detection instrument, detection data can also pass To the computer terminal of doctor.After the data that doctor collects according to breathing detection instrument complete the data analysis and diagnosis of specialty, pass through To the interactive acquisition of the expert more related general knowledge on disease, then feed back detailed disease treatment to user mobile phone and reported with suggesting Accuse, and by bluetooth and mobile phone pairing after, doctor can be realized by breathing detection instrument in technical scheme it is near it is long-range not It is interrupted the follow-up rehabilitation progress situation of tracking monitor patient, finds potential risks factor, dynamic evaluation curative effect of medication in time.

Wherein, data are also uploaded and are stored on network big data platform by the blue-tooth device on the breathing detection instrument simultaneously Health services system.The health data service system is by collecting, arranging, filtering, judging, analyzing, feeding back etc. to user Efficiency management, health control, personal preference life and work behavior etc. carry out statistics refinement, and provide intervention to a certain extent Property suggestion, allows big data to be preferably individual services.

Wherein, data are also uploaded and are stored into three of cooperative medical service under line by the blue-tooth device on the breathing detection instrument simultaneously First hospital.The height intercommunication such as personal health, medical product and medical service organ is mutual from being begun setting up small data, family data The ecosystem of connection, realize and individual health data is gathered anywhere or anytime.It is big that accumulation by data forms ripe medical treatment Data, data interconnection intercommunication, so as to provide accurate medical treatment, personalized health health care is instructed, realizes big data intelligent medical.It is described Blue-tooth device on breathing detection instrument is also upload the data on the mobile phone of user simultaneously, and user oneself can be allowed to be better understood from Itself.After it have collected mass data, the data of user, which can be put into existing data model, to be analyzed, carry out laterally and The comparison of longitudinal direction, to it is of the same age, compare with the average risk index of sex population, draw the health risk index of individual subscriber, If the body data of user occur larger exception may remind the user that do deeper into inspection, this is exactly that wearable device is big The important embodiment of data application.The individual health data of the breathing detection instrument configuration cloud, user oneself and household all may be used Quickly to upload to high in the clouds, permanent storage is carried out.High in the clouds storage establish data system, can allow user only by One account, it is possible to the health data of the whole family, carry out the management of multi-platform multiple terminals.Intuitively show user health situation And trend, help customer analysis changes in health, there is provided health analysis and health suggestion, reach preferably prevention and monitoring chronic disease Effect.And these data can also carry out high in the clouds with chart and share, it can quickly export when seeing a doctor, be doctor's Detailed reference is done in diagnosis.The breathing detection instrument connects APP and the hospital of user by blue-tooth device, forms an inspection The medical services closed loop ecological chain of survey-treatment-rehabilitation-monitoring.Along with a cell phone application application software specially designed, Intelligent medical detecting system with regard to complete set can be formed.The introducing of big data will make Intelligent worn device really turn into human body work( The extension of energy, its importance are bound to increasingly highlight.With grapheme material and booming, the electrochemical sensing of production technology Device will develop towards more miniaturization and portability direction.With the development of science and technology gas-detecting device will be lighter and will be easy to Carry, and will the great Shi Chinese boxings in disorder in screening or monitoring.

In actual applications, for health industry as one of global maximum industry, global year gross expenditure accounts for GWP total values 1/10th or so, it is the new engine of global economic development.Aging population, sub-health state and Climate and Environment Variation are big strong Health industry creates wide development space.Shown according to global management advisory corporation Mai Kenxi report, if medical insurance field energy Enough substantially effectively to utilize big data resource, medical institutions and consumer can save up to 450,000,000,000 dollars of expense.China More than ten00000000 population, if we have 200,000,000 population with wearable device, the data that we can collect, it becomes possible to The whole Chinese a generation of prediction or the health status of people of future generation, or even our health, diet, life habit can be had influence on The change in the various directions such as used.

Using the strong graphene of adsorptivity, detection sensitivity is improved up to capturing cmocroRNA after 10 times.Again by comprehensive Analysis, can draw whether canceration occurWhich kind of cancerBy by the gas of exhalation and saliva and known mammary gland in database The feature of the cancers such as cancer, colon cancer is compared, it is possible to knows whether subject is in the holeFor all kinds of tumours Early diagnose, treat it is significant.Biology sensor and device based on graphene are for a variety of biological micromolecules, albumen Matter (including virus and cancer markers etc.) and DNA etc. detection all show good sensitivity and selectivity, be to be used for structure Build the ideal material of efficient, quick, Sensitive Detection biology sensor.

The repeatable wearable breathing detection instrument based on graphene electronic nose in the present invention is employed, stone can not only be utilized Black alkene biosensor analysis judges unusual odor caused by the breathing of user, and its cell mutation and the flexible of oral cavity should Power is converted into the change of electricity, realizes the detection to the abnormal conditions and breathing situation of user's health, and can be used for Clinically big data sample analysis, the additionally function with global location.Meanwhile low cost, high flux, big-sample data Accumulation is advantageous to find new disease biomarkers, and the detector provides the user with a kind of portable, noninvasive, quick, sensitive, accurate Really, inexpensively, high flux, repeatable wearable detection device, to external monitor air, internally detection is including early-stage cancer Disease, the accurate health data perceived with storage user, provide real-time physical function information to patient and provide most suitable Treatment recommendations, there is wider application.

In this description, the present invention is described with reference to its specific embodiment.But it is clear that it can still make Various modifications and alterations are without departing from the spirit and scope of the present invention.Therefore, specification and drawings are considered as illustrative It is and nonrestrictive.

Claims

A kind of 1. repeatable wearable breathing detection instrument based on graphene electronic nose, it is characterised in that described detector bag Include breath collection devices, elasticity is worn, air filter box is entered on a left side, air filter box and one-way ventilating valve are entered in the right side；Described Breath collection dress Put to the resistance variations situation of record graphene array in real time, air filter box is entered on a described left side and the right side enter air filter box respectively with it is described The both ends worn of elasticity be correspondingly connected, the both ends that described elasticity is worn respectively with described breathing detection instrument main body two Side is correspondingly connected；Described one-way ventilating valve is arranged at the surface of described breath collection devices；

Described repeatable wearable breathing detection instrument also includes detection module, display module, control module；Described detection mould Block is connected with described display module and control module and is arranged at the evagination position of described breath collection devices respectively Top and the middle part at indent position, described display module are connected with described control module and are arranged at described breathing The middle part at the evagination position of harvester.
2. the repeatable wearable breathing detection instrument according to claim 1 based on graphene electronic nose, it is characterised in that Described breath collection devices are the solid figure structure to match with face shape, and are evagination indent shell shape, and described exhales Inhale and the silica gel dividing layer active clapboard of one layer of arc-shaped be additionally provided with the middle part of harvester, described silica gel dividing layer activity every One end of plate in arc-shaped and being tightly connected with described breath collection devices in plug-in type, described silica gel dividing layer activity every The other end of plate is arranged to spill arcuation.
3. the repeatable wearable breathing detection instrument according to claim 1 based on graphene electronic nose, it is characterised in that Described detection module includes：

Environment measuring submodule, it is arranged at the top of described display module；

Brain electro-detection submodule, it is arranged in top and two earholes of described environment measuring submodule；

Breath detection sub-module, it is arranged at the top of the plate face of described silica gel dividing layer active clapboard；

Implication detection sub-module, it is arranged at the bottom of the plate face of described silica gel dividing layer active clapboard；

Weight disease detection sub-module, it is arranged at the external arc periphery of described one-way ventilating valve；

Physiological detection submodule, it is arranged at the inner surface of described one-way ventilating valve；

Saliva detection sub-module, it is arranged at the bottom of described breath collection devices；

Pulse detection submodule, it is arranged at the bottom of described saliva detection sub-module.
4. the repeatable wearable breathing detection instrument according to claim 1 based on graphene electronic nose, it is characterised in that Described detection module is following any sensor and any combination with lower sensor：

Graphene gas sensor, graphene rubber sensor, grapheme foam sensor, graphene fiber sensor, graphite Alkene sensor；

Wherein, described graphene sensor is to include gas sensing unit, pressure-responsive unit, wet sensitive sensing unit and light The array of quick sensing unit.
5. the repeatable wearable breathing detection instrument according to claim 1 based on graphene electronic nose, it is characterised in that Described display module includes display screen submodule, and described display screen submodule is following any display screen unit：

Saran paper display screen unit, AMOLED touch display screens unit, OLED touch display screens unit, graphene answer pressure changeable to pass Feel display screen unit.
6. the repeatable wearable breathing detection instrument according to claim 5 based on graphene electronic nose, it is characterised in that Described display screen submodule includes display screen fixed cell, display screen mobile unit and display screen rotary unit.
7. the repeatable wearable breathing detection instrument according to claim 1 based on graphene electronic nose, it is characterised in that Described control module includes brain wave submodule, microcomputer submodule and power supply submodule, and described microcomputer submodule is arranged at The inner surface of described breath collection devices, described brain wave submodule are provided with TGAT chips, and the TGAT chips are arranged at At described microcomputer submodule, described power supply submodule is arranged at the back side of described display module.
8. the repeatable wearable breathing detection instrument according to claim 7 based on graphene electronic nose, it is characterised in that Described microcomputer submodule is following any unit and any combination with lower unit：

Microcomputer unit, wireless signal transmitting element, NE, positioning unit；

Wherein, described microcomputer unit include data message analyzing and processing subelement, learning software speech play subelement and GPRS subelements.
9. the repeatable wearable breathing detection instrument according to claim 7 based on graphene electronic nose, it is characterised in that Described power supply submodule includes rub electric nano generator and power supply unit, wherein, said supply unit is following any Battery unit：

Graphene solid-state thin-film battery unit, Na-CO2 battery units, porous nickel fluoride film battery unit, ultrathin flexible electricity Pond FLCB battery units, paper battery unit, solar battery cell, solid rechargeable cell.