CN104286872B - Natural enteric maca preparation and production method thereof - Google Patents
Natural enteric maca preparation and production method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a natural enteric maca preparation and a production method thereof. The natural enteric maca preparation is prepared from the following raw materials in parts by weight: 30-70 parts of maca powder, 5-8 parts of bletilla striata powder, 2-5 parts of konjac flour, 2-6 parts of yam powder, 6-12 parts of arrowroot powder and 5-10 parts of gordon euryale seed powder. The production method of the invention sequentially comprises the following steps: preparing maca extract, bletilla striata extract, konjak extract, Chinese yam extract, kudzu root extract and gordon euryale seed extract, mixing the extracts to obtain a mixed solution, homogenizing, and carrying out spray drying to obtain mixed powder; tabletting to obtain enteric maca tablets; or directly packaging the mixed powder to obtain enteric-coated maca powder; or filling the mixed powder into hard capsules. The maca health-care tea is scientific and unique in formula, does not affect the quality of the original maca product, is beneficial to human health and is purely natural.
Description
Technical field
The present invention relates to a kind of maca enteric coated preparations and production method thereof, particularly relate to a kind of natural enteric maca preparation and production method thereof.
Background technology
Maca is the separate row Vegetable spp plateau plant introduced a fine variety from Peru, having antifatigue, improve sperm motility, improve climacteric metancholia and rheumatism symptom, improve the functions such as memory, it is warm in nature, returns stomach, lung, kidney channel, edible maca product often causes stomach energy, causes and has a stomach upset.
Enteric coated preparations, is in order to some is had stimulation to stomach, can injure the preparation of stomach lining, absorb the most under one's belt, and at little enteral solution absorption, it is to avoid stomach is had undesirable effect by preparation.Present enteric coated preparations is usually the mode using enteric coating, the concept of enteric coating (enteric coating) occurred as soon as before more than 130 years, its clothing film stomach juice-resistant, can be disintegrated rapidly and discharge content after entering intestines a part, thus play drug effect.The mechanism of action of enteric polymer is its different solubility in different pH media, i.e. keeps complete when low pH, and the dissolution discharge medicine when higher pH.Enteric coating belongs to delayed release dosage forms (delayed release forms), and its purpose is mainly: avoids medicine to be destroyed by enzyme in stomach or hydrochloric acid in gastric juice, makes interior bag thing at intestinal absorption；Avoid medicine that stomach lining is produced intense stimulus, cause the bad reactions such as Nausea and vomiting.
At present, the enteric material of existing more than 100 kinds is studied and uses, and mainly has shellac, PVAP (PVAP), crylic acid resin (polyacrylic
The kind such as resin), acrylic resin is current domestic and international wide variety of coating material.Effect is waited in order to anti-stick, enteric coating formula can add the materials such as talcum powder, titanium dioxide, monoglyceride, tween toward contact, although these materials add harmless on a small quantity, but to human body also without benefit, if maca product using the mode of enteric coating enter intestines release be unfavorable for health, product can not reach natural free of contamination degree.
Also disclose that now some maca preparations, if publication date is on 04 04th, 2007, in the Chinese patent of Publication No. CN1939387, disclose a kind of compound Sanchi preparation, this compound Sanchi preparation by 20～50% Radix Notoginseng powder, 25～60% pueraria root powder and 10～45% kudzu-vine root powder mix, it has treatment cerebral thrombus, cerebral hemorrhage and the function of prevention cardiovascular and cerebrovascular disease, and is not belonging to enteric coated preparations.And for example publication date is on 01 08th, 2014, in the Chinese patent of Publication No. CN103494209A, disclose a kind of Maca composite health care medicine, this Maca composite health care medicine is made up of pueraria root powder, testiset penis phocae, donkey-hide gelatin, oyster, the tuber of dwarf lilyturf, the root of three-nerved spicebush, matrimony vine, the fruit of Chinese magnoliavine, activated calcium powder, and this Maca composite health care medicine is also not belonging to enteric coated preparations.For another example publication date is on 02 12nd, 2014, in the Chinese patent of Publication No. CN103566046A, disclose a kind of Chinese medicine preparation containing maca, this Chinese medicine preparation containing maca contains following raw material: maca, ginseng, the fruit of Chinese wolfberry, Chinese cassia tree, hawthorn, cassia seed and lotus leaf, wherein, on the basis of the maca of 100 weight portions, the content of each raw material is respectively: ginseng 20-40 weight portion, fruit of Chinese wolfberry 20-40 weight portion, Chinese cassia tree 10-20 weight portion, hawthorn 5-10 weight portion, cassia seed 5-10 weight portion, lotus leaf 5-10 weight portion, this Chinese medicine preparation is also not belonging to enteric coated preparations.
In sum, there is presently no a kind of scientific formulation, uniqueness, neither affect the quality of original maca product, the most beneficially health, pure natural, without resin, the natural enteric maca preparation of glue class synthetic membrane's clothing material and production method thereof.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency present in prior art, and a kind of scientific formulation, uniqueness are provided, neither affect the quality of original maca product, be conducive to again health, pure natural, without resin, the natural enteric maca preparation of glue class synthetic membrane's clothing material and production method thereof.
The present invention solves the problems referred to above and be the technical scheme is that the feature of this natural enteric maca preparation is: said preparation is made up of the raw material of following parts by weight: pueraria root powder 30～70 parts, bletilla striata powder 5～8 parts, konjaku flour 2～5 parts, yam flour 2～6 parts, kudzuvine root starch 6～12 parts, gorgon euryale seed powder 5～10 parts.So that the compatibility science of natural enteric maca preparation of the present invention, uniqueness, each raw material cooperative compensating, preparation is made to have good antifatigue, improve sperm motility, improve climacteric metancholia and rheumatism symptom, improve the functions such as memory, and stomach energy will not be caused after edible, do not result in and have a stomach upset.
As preferably, the ethanol solution that pueraria root powder of the present invention uses volumn concentration to be 70% extracts, and the ethanol solution that described bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts.
A kind of production method of natural enteric maca preparation, its feature is: described production method is made up of the raw material of following parts by weight: pueraria root powder 30～70 parts, bletilla striata powder 5～8 parts, konjaku flour 2～5 parts, yam flour 2～6 parts, kudzuvine root starch 6～12 parts, gorgon euryale seed powder 5～10 parts；This production method comprises the steps of successively:
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and obtains maca extract；The ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, and respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract；Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are all in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10%～12%；
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure；
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder；
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet；Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis；Or by filling for mixed-powder one-tenth hard shell capsules.
So that production method is the simplest in the present invention, convenient to operate, production process is energy-conservation, green, environmental protection, on the premise of without resin, glue class synthetic membrane's clothing material, it is made for the enteric coated preparations of beneficially health, pure natural, overcomes the technology prejudice of those skilled in the art.
As preferably, the present invention is used for extracting 4-6 times that weight is pueraria root powder weight of the ethanol solution of pueraria root powder, for 4-6 times that extracts that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting 4-6 times that weight is konjaku flour weight of the ethanol solution of konjaku flour, for extracting 4-6 times that weight is yam flour weight of the ethanol solution of yam flour, for extracting 4-6 times that weight is kudzuvine root starch weight of the ethanol solution of kudzuvine root starch, for extracting 4-6 times that weight is gorgon euryale seed powder weight of the ethanol solution of gorgon euryale seed powder.
As preferably, in step of the present invention (1), the ultrasonic extraction of ethanol solution that pueraria root powder uses volumn concentration to be 70% three times, obtain maca extract.
As preferably, in step of the present invention (1), the ultrasonic extraction of ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% three times, respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.
As preferably, the present invention is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder.
The present invention is compared with prior art, have the following advantages and effect: content of starch is higher, have the water-alcohol extraction protecting stomach function food and medicament dual-purpose Chinese medicine as coating agent 1. to use the bletilla striata, konjaku, Chinese yam, the root of kudzu vine and Gorgon fruit etc., to Maca extract mixing parcel, it is spray-dried, make natural intestine solubility preparation, it is to avoid the Maca extract spread effect to stomach.2. using the bletilla striata, konjaku, Chinese yam, the root of kudzu vine and Semen euryales extract as coating agent, both can play package action, in its extract, the nutritive value of Maca extract can be played humidification again by the function composition such as flavones, alkaloid, polysaccharide.3. the present invention can be directly produced pulvis, filling hard capsule or produce tablet, it is not necessary to add any additive and auxiliary material, it is ensured that product natural pollution-free.4. compatibility science, uniqueness, each raw material cooperative compensating, there is good antifatigue, improve sperm motility, improve climacteric metancholia and rheumatism symptom, improve the functions such as memory, and edible after will not cause stomach energy, do not result in and have a stomach upset.5., on the premise of without resin, glue class synthetic membrane's clothing material, it is made for the enteric coated preparations of beneficially health, pure natural, overcomes the technology prejudice of those skilled in the art.6. the technique of the production method of the present invention is the simplest, it is simple to operation, production process is energy-conservation, green, environmental protection.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, and following example are explanation of the invention and the invention is not limited in following example.
Embodiment 1.
In the present embodiment, the production method of natural enteric maca preparation comprises the steps of successively.
(1) weighing dry pueraria root powder 70 kilograms, add the edible ethanol solution 350 kilograms that volumn concentration is 70%, ultrasonic extraction three times, be i.e. initially charged the edible ethanol solution 350 kilograms that volumn concentration is 70%, ultrasonic extraction is once, it is thus achieved that maca extract is 1.；Being subsequently adding the edible ethanol solution 350 kilograms that volumn concentration is 70%, ultrasonic extraction is once, it is thus achieved that maca extract is 2.；Adding the edible ethanol solution 350 kilograms that volumn concentration is 70%, ultrasonic extraction is once, it is thus achieved that 3., said process is the process of ultrasonic extraction three times to maca extract.After ultrasonic extraction three times, mixing maca extract 1., maca extract 2. with maca extract 3., it is thus achieved that maca extract 1000 kilograms.
(2) 5 kilograms of dry bletilla striata powder, konjaku flour 5 kilograms, yam flour 5 kilograms, kudzuvine root starch 8 kilograms and gorgon euryale seed powder 5 kilograms are weighed, it is separately added into the edible ethanol solution that volumn concentration is 50% of five times of weight, ultrasonic extraction three times, i.e. it is separately added into the edible ethanol solution that volumn concentration is 50% of 25 kilograms, 25 kilograms, 25 kilograms, 40 kilograms and 25 kilograms, ultrasonic extraction once, respectively obtain bletilla striata extract 1., konjaku extract 1., Chinese yam extract 1., root of kudzu vine extract 1. with Gorgon fruit extract 1.；It is then respectively adding the edible ethanol solution that volumn concentration is 50% of 25 kilograms, 25 kilograms, 25 kilograms, 40 kilograms and 25 kilograms, ultrasonic extraction once, respectively obtain bletilla striata extract 2., konjaku extract 2., Chinese yam extract 2., root of kudzu vine extract 2. with Gorgon fruit extract 2.；It is separately added into the edible ethanol solution that volumn concentration is 50% of 25 kilograms, 25 kilograms, 25 kilograms, 40 kilograms and 25 kilograms again, ultrasonic extraction is once, obtain respectively bletilla striata extract 3., konjaku extract 3., Chinese yam extract 3., root of kudzu vine extract 3. with Gorgon fruit extract 3., said process is the process of ultrasonic extraction three times.After ultrasonic extraction three times, mixing bletilla striata extract 1., bletilla striata extract 2. with bletilla striata extract 3., it is thus achieved that bletilla striata extract 76 kilograms；Mixing konjaku extract 1., konjaku extract 2. with konjaku extract 3., it is thus achieved that konjaku extract 76 kilograms；Mixing Chinese yam extract 1., Chinese yam extract 2. with Chinese yam extract 3., it is thus achieved that Chinese yam extract 75 kilograms；Mixing root of kudzu vine extract 1., root of kudzu vine extract 2. with root of kudzu vine extract 3., it is thus achieved that root of kudzu vine extract 122 kilograms；Mixing Gorgon fruit extract 1., Gorgon fruit extract 2. with Gorgon fruit extract 3., it is thus achieved that Gorgon fruit extract 76 kilograms.
(3) respectively by 1000 kilograms of maca extracts, 76 kilograms of bletilla striata extracts, 76 kilograms of konjaku extracts, 75 kilograms of Chinese yam extracts, 122 kilograms of root of kudzu vine extracts and 76 kilograms of Gorgon fruit extracts in 35 DEG C of temperature, under 10KPa pressure, it is concentrated in vacuo, the volumn concentration being concentrated into ethanol is 10%, and 425 kilograms of maca of acquisition extract concentrates respectively, 42 kilograms of bletilla striatas are extracted concentrate, 42 kilograms of konjakus extraction concentrates, 41 kilograms of Chinese yams extraction concentrates, 74 kilograms of roots of kudzu vine extraction concentrates and 42 kilograms of Gorgon fruits and extract concentrates.
(4) 425 kilograms of maca in step (3) are extracted concentrate, 42 kilograms of bletilla striatas are extracted concentrate, 42 kilograms of konjakus extraction concentrates, 41 kilograms of Chinese yams extraction concentrates, 74 kilograms of root of kudzu vine extraction concentrates and 42 kilograms of Gorgon fruits and extract concentrate mixing, obtain 666 kilograms of mixed liquors, mixed liquor is joined in homogenizer, prior to homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(5) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder 23 kilograms.
(6) carry out filling by being spray-dried the mixed-powder obtained, it is thus achieved that natural enteric maca hard shell capsules.
Embodiment 2.
In the present embodiment, the production method of natural enteric maca preparation comprises the steps of successively.
(1) weigh dry pueraria root powder 500 kilograms, add the edible ethanol solution 2500 kilograms that volumn concentration is 70%, ultrasonic extraction three times, it is thus achieved that maca extract 7400 kilograms.
(2) 80 kilograms of dry bletilla striata powder, konjaku flour 50 kilograms, yam flour 60 kilograms, kudzuvine root starch 100 kilograms and gorgon euryale seed powder 100 kilograms are weighed, it is separately added into the edible ethanol solution that volumn concentration is 50% of five times of weight, ultrasonic extraction three times, obtain bletilla striata extract 1230 kilograms respectively, konjaku extract 760 kilograms, Chinese yam extract 920 kilograms, root of kudzu vine extract 1520 kilograms, Gorgon fruit extract 1520 kilograms.
(3) bletilla striata extract in step (2), konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, under the vacuum of 10KPa pressure, the volumn concentration being concentrated into ethanol is 10%, and 3000 kilograms of maca of acquisition extract concentrates respectively, 740 kilograms of bletilla striatas are extracted concentrate, 460 kilograms of konjakus extraction concentrates, 370 kilograms of Chinese yams extraction concentrates, 900 kilograms of roots of kudzu vine extraction concentrates and 900 kilograms of Gorgon fruits and extract concentrates.
(4) 3000 kilograms of maca in step (3) are extracted concentrate, 740 kilograms of bletilla striatas are extracted concentrate, 460 kilograms of konjakus extraction concentrates, 370 kilograms of Chinese yams extraction concentrates, 900 kilograms of root of kudzu vine extraction concentrates and 900 kilograms of Gorgon fruits and extract concentrate mixing, obtain 6370 kilograms of mixed liquors, join in homogenizer, prior to homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(5) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder 160 kilograms.
(6) the mixed-powder direct tablet compressing obtained will be spray-dried, it is thus achieved that natural enteric Maca tablet.
Embodiment 3.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 30～70 parts, bletilla striata powder 5～8 parts, konjaku flour 2～5 parts, yam flour 2～6 parts, kudzuvine root starch 6～12 parts, gorgon euryale seed powder 5～10 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and obtains maca extract；The ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, and respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract；Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are all in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10%～12%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.First use elevated pressures (40MPa) homogeneous three times, the large particulate matters such as the residual dietary fiber in mixed liquor, fat globule, polysaccharide are broken into small particle, again with relatively low pressure (4.5MPa) homogeneous once, prevent fine particle adhesion in mixed liquor agglomerating, affect product characteristics.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet；Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis；Or by filling for mixed-powder one-tenth hard shell capsules.Thus prepare natural enteric maca preparation, the scientific formulation of this natural enteric maca preparation, uniqueness, neither affect the quality of original maca product, the most beneficially health, and edible after will not cause stomach energy, do not result in and have a stomach upset.
Under normal circumstances, in step (1), it is used for extracting 4-6 times that weight is pueraria root powder weight of the ethanol solution of pueraria root powder, preferably 5 times；For 4-6 times that extracts that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, preferably 5 times；For extracting 4-6 times that weight is konjaku flour weight of the ethanol solution of konjaku flour, preferably 5 times；For extracting 4-6 times that weight is yam flour weight of the ethanol solution of yam flour, preferably 5 times；For extracting 4-6 times that weight is kudzuvine root starch weight of the ethanol solution of kudzuvine root starch, preferably 5 times；For extracting 4-6 times that weight is gorgon euryale seed powder weight of the ethanol solution of gorgon euryale seed powder, preferably 5 times.In step (1), the ultrasonic extraction of ethanol solution that pueraria root powder uses volumn concentration to be 70% three times, obtain maca extract, the ultrasonic extraction of ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% three times, respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.
Embodiment 4.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 40 parts, 8 parts of bletilla striata powder, konjaku flour 3 parts, yam flour 4 parts, kudzuvine root starch 7 parts, gorgon euryale seed powder 6 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 5.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 45 parts, 5 parts of bletilla striata powder, konjaku flour 4.5 parts, yam flour 6 parts, kudzuvine root starch 9 parts, gorgon euryale seed powder 10 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 12%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 6.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 30 parts, 6.5 parts of bletilla striata powder, konjaku flour 4 parts, yam flour 3 parts, kudzuvine root starch 12 parts, gorgon euryale seed powder 7 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 11%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 7.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 50 parts, 6 parts of bletilla striata powder, konjaku flour 2 parts, yam flour 3.5 parts, kudzuvine root starch 11 parts, gorgon euryale seed powder 8 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 4 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 4 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 4 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 4 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 4 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 4 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10.5%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 8.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 55 parts, 5.5 parts of bletilla striata powder, konjaku flour 3.5 parts, yam flour 2 parts, kudzuvine root starch 8 parts, gorgon euryale seed powder 8.5 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 6 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 6 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 6 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 6 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 6 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 6 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 11.5%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 9.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 70 parts, 7 parts of bletilla striata powder, konjaku flour 2.5 parts, yam flour 5 parts, kudzuvine root starch 10 parts, gorgon euryale seed powder 5 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Embodiment 10.
In the present embodiment, the production method of natural enteric maca preparation is made up of the raw material of following parts by weight: pueraria root powder 60 parts, 7.5 parts of bletilla striata powder, konjaku flour 5 parts, yam flour 4.5 parts, kudzuvine root starch 6 parts, gorgon euryale seed powder 9 parts.This production method comprises the steps of successively.
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and is used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, and ultrasonic extraction three times obtains maca extract.Bletilla striata powder, konjaku flour, yam flour, the ethanol solution that kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder, the most ultrasonic extraction three times, respectively obtain bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are placed in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 12%.
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure.
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder.
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet.Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis.Or by filling for mixed-powder one-tenth hard shell capsules.
Although the present invention is open as above with embodiment, but it is not limited to protection scope of the present invention, any technical staff being familiar with this technology, in the change made without departing from the spirit and scope of the invention and retouching, all should belong to protection scope of the present invention.
Claims (5)
1. the production method of a natural enteric maca preparation, it is characterised in that: the raw material used by described production method is made up of the material of following parts by weight: pueraria root powder 30～70 parts, bletilla striata powder 5～8 parts, konjaku flour 2～5 parts, yam flour 2～6 parts, kudzuvine root starch 6～12 parts, gorgon euryale seed powder 5～10 parts；This production method comprises the steps of successively:
(1) ethanol solution that pueraria root powder uses volumn concentration to be 70% extracts, and obtains maca extract；The ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% extracts, and respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract；Maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract are all in 35 DEG C of temperature, and 10KPa vacuum under pressure concentrates, and the volumn concentration being concentrated into ethanol is 10%～12%；
(2) maca extract, bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and the mixing of Gorgon fruit extract after concentrating, obtain mixed liquor, mixed liquor is added in homogenizer, first homogeneous three times under 40MPa pressure, then homogeneous is once under 4.5MPa pressure；
(3) mixed liquor after homogeneous is spray-dried under nitrogen protection, obtains mixed-powder；
(4) by mixed-powder compressing tablet, it is thus achieved that enteric Maca tablet；Or mixed-powder is directly packed, it is thus achieved that enteric maca pulvis；Or by filling for mixed-powder one-tenth hard shell capsules.
The production method of natural enteric maca preparation the most according to claim 1, it is characterized in that: be used for extracting 4-6 times that weight is pueraria root powder weight of the ethanol solution of pueraria root powder, for 4-6 times that extracts that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting 4-6 times that weight is konjaku flour weight of the ethanol solution of konjaku flour, for extracting 4-6 times that weight is yam flour weight of the ethanol solution of yam flour, for extracting 4-6 times that weight is kudzuvine root starch weight of the ethanol solution of kudzuvine root starch, for extracting 4-6 times that weight is gorgon euryale seed powder weight of the ethanol solution of gorgon euryale seed powder.
The production method of natural enteric maca preparation the most according to claim 1, it is characterised in that: in described step (1), the ultrasonic extraction of ethanol solution that pueraria root powder uses volumn concentration to be 70% three times, obtain maca extract.
The production method of natural enteric maca preparation the most according to claim 1, it is characterized in that: in described step (1), the ultrasonic extraction of ethanol solution that bletilla striata powder, konjaku flour, yam flour, kudzuvine root starch and gorgon euryale seed powder all use volumn concentration to be 50% three times, respectively obtains bletilla striata extract, konjaku extract, Chinese yam extract, root of kudzu vine extract and Gorgon fruit extract.
The production method of natural enteric maca preparation the most according to claim 2, it is characterized in that: be used for extracting weight is pueraria root powder weight 5 times of the ethanol solution of pueraria root powder, for 5 times that extract that the weight of the ethanol solution of bletilla striata powder is bletilla striata grain weight amount, for extracting weight is konjaku flour weight 5 times of the ethanol solution of konjaku flour, for extracting weight is yam flour weight 5 times of the ethanol solution of yam flour, for extracting weight is kudzuvine root starch weight 5 times of the ethanol solution of kudzuvine root starch, for extracting weight is gorgon euryale seed powder weight 5 times of the ethanol solution of gorgon euryale seed powder.
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| CN102824545A (en) * | 2012-08-22 | 2012-12-19 | 厦门鹰君药业有限公司 | Blood sugar-reduction traditional Chinese medicine composition |
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| CN102824545A (en) * | 2012-08-22 | 2012-12-19 | 厦门鹰君药业有限公司 | Blood sugar-reduction traditional Chinese medicine composition |
| CN103181951A (en) * | 2012-10-29 | 2013-07-03 | 赵言林 | Application of pseudo-ginseng and maca composition to treatment of dizziness, headache and hand-foot numbness |
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