CN104274836A - Making method for improvement of drug palatability - Google Patents
Making method for improvement of drug palatability Download PDFInfo
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- CN104274836A CN104274836A CN201310281659.4A CN201310281659A CN104274836A CN 104274836 A CN104274836 A CN 104274836A CN 201310281659 A CN201310281659 A CN 201310281659A CN 104274836 A CN104274836 A CN 104274836A
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- raw material
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Abstract
The invention discloses a making method for improvement of drug palatability, and relates to a pharmaceutical excipient raw material component and a production process. The method is mainly as follows: raw material polyvinyl alcohol, hydroxypropyl methylcellulose and other main materials and ethyl cellulose and other auxiliary materials are prepared into a certain concentration water solution or alcohol solution according to a certain proportion, and the certain concentration water solution or alcohol solution is evenly sprayed onto the veterinary drug particle surface, and then is dried for using. The masking agent can effectively mask the veterinary drug bitter and pungent odor, improves the veterinary drug receiving condition of animals, is stable in traits and long in storage period, and can improve drug curative effect by control of drug dissolution parts.
Description
Technical field
The present invention relates to a kind of excipient substance, especially relate to the masking agent of a kind of veterinary drug bitterness, penetrating odor.
Background technology
Veterinary drug preparation often affects poultry because certain reason has strong bitterness and searches for food in application process, then affect larger on the feed intake of the more sensitive pig of olfactory sensation, also have medicine instability, zest large simultaneously, easily cause gastric ulcer after feed intake or cause vomiting, the easily shortcoming such as inactivation in the intestines and stomach, thus impact effect.
Veterinary drug such as polymyxin, florfenicol, taimulin, tylosin, grace tassor star, enrofloxacin have extremely strong bitterness, the palatability of pig can be affected, pharmaceutical granulation temperature influence is as ivermectin/tilmicosin, in feedstuff, add the impact such as light, oxygen, feed enzyme, mineral when medication or drinking-water add medication, thus drug effect reduces.
Summary of the invention
The object of the invention is to overcome and make up current veterinary drug deficiency in use, provide one can eliminate veterinary drug bitterness, penetrating odor masking agent.
Technical scheme of the present invention is: making this masking agent primary raw material used is: polyvinyl alcohol, hypromellose, ethyl cellulose, polyacrylic acid tree is cruel, Pulvis Talci and titanium dioxide, and the weight proportion between them is 100:100-150:0 ~ 100:0-150:100-150:50 ~ 100; Its processing technology is that the water of the raw material prepared in proportion and raw material gross weight 5 ~ 20 times is prepared into aqueous solution.
Can add adjuvant tween 80 and edible colorant when making this masking agent, the weight added is 50 ~ 80% and 10 ~ 50% of polyvinyl alcohol weight respectively.Also can be made into alcoholic solution with ethanol as solvent during making, the weight of ethanol is 5 ~ 15 times of raw material gross weight.Use during this masking agent and it is evenly sprayed onto veterinary drug particle surface, use after drying.
The invention has the beneficial effects as follows:
(1) various component ratio is suitable, and abundance is with low cost, safety non-toxic;
(2) preparation method is simply controlled, with short production cycle, is easy to realize standardized administration, is suitable for large-scale production.
(3) its composition and proportioning scientific and reasonable, the mechanical parameter of the dosage form of gained is reasonable, can not produce other side effect.
(4) this masking agent can cover poor taste and the abnormal smells from the patient of crude drug completely, and has certain protection against the tide and oxygen barrier effect, and combines firmly between adjuvant and crude drug, and closely, smooth appearance is attractive in appearance, ensure that the expiry date of medicine for parcel.
Detailed description of the invention
Requirement to several preparation raw material:
Polyvinyl alcohol: viscosity 10-30mPas; Hypromellose: methoxyl content 19.0-30.0% and hydroxypropyl content 4.0-12.0%; Ethyl cellulose: ethoxyl content 44.0 ~ 51.0%; Polyacrylic resin: relative density 0.810-0.820 and viscosity 50mPas; Pulvis Talci: fineness 325 order percent of pass 98%; Tween 80: relative density 1.06-1.09 and pH value 5-7.
embodiment 1
Take material polyethylene alcohol 100 kg, hypromellose and each 100 kg of Pulvis Talci, titanium dioxide 50 kg, title adjuvant tween 80 are 50 kg, edible colorant 10 kg, the water of raw material gross weight 5 ~ 20 times or the ethanol of 5 ~ 15 times is put into after all can being mixed by above-mentioned all raw materials, be prepared into aqueous solution or alcoholic solution, even spraying to veterinary drug particle surface, after oven dry.
embodiment 2
Take material polyethylene alcohol 100 kg, hypromellose and each 130 kg of Pulvis Talci, titanium dioxide 75 kg, ethyl cellulose 30 kg and polyacrylic resin 50 kg, claim adjuvant tween 80 to be that 65 kg and edible colorant 30 kg. processing technology are same as Example 1.
embodiment 3
Take each 150 tons of material polyethylene alcohol 100 tons, hypromellose and Pulvis Talci, titanium dioxide 100 kg, ethyl cellulose 100 kg and polyacrylic resin 150kg, claim adjuvant tween 80 to be that 80 kg and edible colorant 50 kg. processing technology are same as Example 1.
Claims (3)
1. improve a manufacture method for palatability of drugs, it is characterized in that:
(1) making this masking agent primary raw material used is: polyvinyl alcohol, hypromellose, ethyl cellulose, polyacrylic acid tree is cruel, Pulvis Talci and titanium dioxide, and the weight proportion between them is 100:100-150:0 ~ 100:0-150:100-150:50 ~ 100;
(2) its processing technology is that the water of the raw material prepared in proportion and raw material gross weight 5 ~ 20 times is prepared into aqueous solution.
2. the improvement palatability of drugs according to claim, is characterized in that: can add adjuvant tween 80 and edible colorant when making this masking agent, and the weight added is 50 ~ 80% and 10 ~ 50% of polyvinyl alcohol weight respectively.
3. the improvement palatability of drugs according to claim, is characterized in that: also can be made into alcoholic solution with ethanol as solvent during making, and the weight of ethanol is 5 ~ 15 times of raw material gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310281659.4A CN104274836A (en) | 2013-07-07 | 2013-07-07 | Making method for improvement of drug palatability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310281659.4A CN104274836A (en) | 2013-07-07 | 2013-07-07 | Making method for improvement of drug palatability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104274836A true CN104274836A (en) | 2015-01-14 |
Family
ID=52250496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310281659.4A Pending CN104274836A (en) | 2013-07-07 | 2013-07-07 | Making method for improvement of drug palatability |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104274836A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017056075A1 (en) | 2015-10-01 | 2017-04-06 | Solutex Na, Lcc | Process for the preparation and stabilization of emulsions with omega-3 by means of isometric crystalline networks of cellulose derivatives |
-
2013
- 2013-07-07 CN CN201310281659.4A patent/CN104274836A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017056075A1 (en) | 2015-10-01 | 2017-04-06 | Solutex Na, Lcc | Process for the preparation and stabilization of emulsions with omega-3 by means of isometric crystalline networks of cellulose derivatives |
| US10856564B2 (en) | 2015-10-01 | 2020-12-08 | Solutex Na, Lcc | Process for the preparation and stabilization of emulsions with Omega-3 by means of isometric crystalline networks of cellulose derivatives |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150114 |