CN104273143B - A kind of macro tetrolide and the compositions of nimbin and application - Google Patents
A kind of macro tetrolide and the compositions of nimbin and application Download PDFInfo
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- CN104273143B CN104273143B CN201410543882.6A CN201410543882A CN104273143B CN 104273143 B CN104273143 B CN 104273143B CN 201410543882 A CN201410543882 A CN 201410543882A CN 104273143 B CN104273143 B CN 104273143B
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- nimbin
- macro tetrolide
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- tetrolide
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Abstract
The invention belongs to the technical field that agricultural chemical insecticide is compounding, a kind of macro tetrolide and the compositions of nimbin and application.Said composition effective ingredient is macro tetrolide and nimbin, wherein the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:1-15, the problem farthest alleviating current pest resistance to insecticide, thus decrease the consumption of pesticide, also alleviate the impact for environment.
Description
Technical field
The invention belongs to the technical field that agricultural chemical insecticide is compounding, a kind of macro tetrolide and the compositions of nimbin and application.
Background technology
Macro tetrolide
Being by the antibiotic produced by the mutation of streptomyces griseus Liuyang with macrolide structure, for low toxicity, low-residual, can prevent and treat the broad spectrum acaricides of the multiple mites of various crop, prevention effect is good.The tetranychid of various crop is had good action of contace poison, and without interior absorption, medicament has lipotropy, if to becoming demodicid mite to have efficiently, not killing Predatory Mites, evil demodicid mite is not likely to produce resistance, and mite killing spectrum is relatively extensively, the most effective to tetranychid, wart demodicid mite.Compound with some organophosphors or carbamate pesticide, have significant potentiation.Action of contace poison to evil demodicid mite, lasting period 7～14 days.
Physicochemical property: the mixture being made up of 5 components, four viable bacteria elements are main active component.Sterling is the crystallization of colourless prism-shaped, fusing point 112 DEG C～113 DEG C.It is soluble in benzene, ethyl acetate, chloroform, ether, acetone, dissolves in 50% solvent such as ethanol, normal hexane, water insoluble.To ultraviolet-sensitive, irradiating 2 days in the sun, decomposable asymmetric choice net 50% is with property percutaneous LDso > 2 000mg/kg.Character sterling is the crystallization of colourless prism-shaped.
Nimbin
Azadirachta Indica A. (lian) is the title of a kind of fast-growing deciduous tree, and seed and bark all can be used as medicine.
Azadirachta Indica A. is the preferable pesticide plant generally acknowledged in the world in 2013.Azadirachta Indica A. (Azadirachta
Indica A.Juss) it is Meliaceae Melia arbor, extensively plant in tropical and subtropical region.Originally a plague of locusts is investigated analysis, in the seed of Azadirachta Indica A. tree, leaves and bark, containing a kind of material nimbin, just because of its existence, make Azadirachta Indica A. tree have the magical function that worm is cured the disease.Show through modern study, the compositions such as the nimbin extracted from Azadirachta Indica A. fruit are wide spectrum recognized in the world, efficient, low toxicity, degradable, the insecticide of noresidue and do not have Drug resistance, to nearly all plant insect, indoor Cimex bedbug, flea, fly, mosquito etc. all have repelling and killing efficacy, and to people and animals and surrounding without any pollution, Azadirachta Indica A. also has medical function to numerous disease simultaneously, will have wider application in medicine.
Currently, with respect to the compounding of macro tetrolide and nimbin it is not yet reported that.
Summary of the invention
It is an object of the invention to provide a kind of has macro tetrolide and the Pesticidal combination of nimbin and application thereof, said composition effective ingredient is macro tetrolide and nimbin, wherein the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:1-15, the problem farthest alleviating current pest resistance to insecticide, thus decrease the consumption of pesticide, also alleviate the impact for environment.
The technical scheme is that
A kind of macro tetrolide and the compositions of nimbin, effective ingredient is macro tetrolide and nimbin, and wherein the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:1-15.
As preferably, the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:5-10.
As preferably, the total weight percentage of described effective ingredient is 15～60%.
The macro tetrolide of the present invention and the compositions of nimbin, add auxiliary agent and excipient, make various preparation, including wettable powder, suspending agent, water dispersible granules, aqueous emulsion or cream；It is preferably aqueous emulsion.
Described auxiliary agent and excipient include: solvent, emulsifying agent, antifreeze, defoamer, thickening agent, carrier or filler, dispersant.
The macro tetrolide of the present invention and the aqueous emulsion of nimbin, consisting of following component by weight percentage: macro tetrolide 2-10%, nimbin 10-50%, emulsifying agent 3-10%, solvent 2-6%, antifreezing agent 1-3%, defoamer 1-3%, thickening agent 0.5-2%, surplus is water.
Described solvent is selected from: one or more in solvent naphtha, ethyl acetate, acetone, butanol.
Described emulsifying agent is selected from: triethanolamine salt, agriculture breast 600#(phenyl phenol polyoxyethyl ether), peaceful breast 36#One or more in (phenethyl fluosite polyoxyethyl ether), sorbitan fatty acid ester polyoxyethylene ether.
Described antifreezing agent is selected from: one or more in Polyethylene Glycol, carbamide, ethylene glycol.
Described defoamer is selected from: one or more in polyethers, higher alcohol, mineral oil, silicone compound, CS-10 aliphatic alcohols compound.
Described thickening agent is selected from: one or more in bentonite, silicic acid, carboxymethyl cellulose polyvinyl alcohol.
Described carrier, filler are selected from: one or more in attapulgite, Kaolin, kieselguhr, bentonite.
Described dispersant is selected from: one or more in lignosulfonates, aliphatic amine polyoxyethylene ether, sodium tripolyphosphate, polycarboxylate (2700), diffusion agent N O, diffusant FO.
Described wetting agent is: one or more in DBSA, Bombyx mori L., lauryl alcohol polyvinylether sodium sulfate, sodium laurylsulfate, naphthalene sulfonate.
The macro tetrolide of the present invention and the compositions of nimbin, for preventing and treating the aleyrodid of crop, aphid, unguiculus demodicid mite, leafhopper, wart demodicid mite, be particularly suited for preventing and treating leafhopper.
The invention have the benefit that
Said composition is complex insecticidal composition, significantly enhances insecticidal effect, delays the generation of pest resistance to insecticide, and expands effective active preventing and treating spectrum, has speed fast, and the lasting period is long, and consumption is low, eco-friendly feature.The weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:1-15, serves good synergistic function by compounding, has effectively resisted the problem that pest resistance produces, reduces the consumption of pesticide.This complex composition is particularly suited for preventing and treating leafhopper, and it is had good effect.
Compound synergic research to the compositions of the present invention, test uses leafhopper.
The toxicity index of medicament and mixed co-toxicity coefficient (CTC value) is calculated according to the abundant method of Sun Yun.
Table 1
The different ratio relation toxicity test result to leafhopper
| Process | Co-toxicity coefficient |
| Macro tetrolide 1: nimbin 1 | 225.9 |
| Macro tetrolide 1: nimbin 5 | 627.1 |
| Macro tetrolide 1: nimbin 8 | 704.5 |
| Macro tetrolide 1: nimbin 10 | 610.2 |
| Macro tetrolide 1: nimbin 15 | 235.2 |
| Macro tetrolide | |
| Nimbin |
From table 1 it follows that macro tetrolide and nimbin is compounding, co-toxicity coefficient is far longer than 120, has the highest potentiation, especially macro tetrolide: during nimbin=1:5-10, synergistic effect becomes apparent from.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in detail.
Embodiment 1
44% aqueous emulsion: macro tetrolide and the compositions of nimbin
Macro tetrolide 4%,
Nimbin 40%,
Agriculture breast 600#4%,
Ethyl acetate
6%,
Ethylene glycol
1%,
Mineral oil
1%,
Silicic acid 0.5%,
Surplus is water.
Preparation method is the conventional method of this area.
It is watered 60 kilograms by every mu of medication amount of formulation and carries out even spraying.
This embodiment medicament is applied to prevent and treat the aleyrodid on Cotton Gossypii:
Co-toxicity coefficient is: 610.2；
By 10000 times of dilute sprayings, after medicine, 15 days prevention effects are 97.2%, and 4% macro tetrolide suspending agent dilutes 1000 times and 40% nimbin emulsion dilutes 8000 times, use with same method respectively, after medicine 15 days, prevention effect was respectively 80.1% and 82.5%, significant difference.
Embodiment 2
18% aqueous emulsion: macro tetrolide and the compositions of nimbin
Macro tetrolide 2%,
Nimbin 16%,
Peaceful breast 36# 10%,
Solvent naphtha 2%,
Polyethylene Glycol 3%,
Higher alcohol 1%,
Bentonite 2%,
Surplus is water.
Preparation method is the conventional method of this area.
It is watered 60 kilograms by every mu of medication amount of formulation and carries out even spraying.
This embodiment medicament be applied to prevent and treat leafhopper:
Co-toxicity coefficient is: 705.2；
By the spraying of 4000 times of dilutes, after medicine, 15 days prevention effects are 99.0%, and 2% macro tetrolide suspending agent dilutes 400 times and 16% nimbin emulsion dilutes 3000 times, and respectively with same method use, after medicine 15 days, prevention effect was respectively 82.7% and 73.8%, significant difference.
Embodiment 3
60% wettable powder: macro tetrolide and the compositions of nimbin
Macro tetrolide 10%,
Nimbin 50%,
Attapulgite
5%,
Diffusion agent N O 8%,
Lauryl alcohol polyvinylether sodium sulfate 4%,
Surplus is bentonite.
Preparation method is the conventional method of this area.
It is watered 60 kilograms by every mu of medication amount of formulation and carries out even spraying.
This embodiment medicament is applied to prevent and treat wart demodicid mite:
Co-toxicity coefficient is: 628.3；
By 10000 times of dilute sprayings, after medicine, 15 days prevention effects are 98.4%, and 10% macro tetrolide suspending agent dilutes 1000 times and 50% nimbin emulsion dilutes 8000 times, use with same method respectively, after medicine 15 days, prevention effect was respectively 82.1% and 77.5%, significant difference.
Embodiment 4
20% aqueous emulsion: macro tetrolide and the compositions of nimbin
Macro tetrolide 10%,
Nimbin 10%,
Butanol
3%,
Peaceful breast 36# 5%,
Carbamide 1%,
Mineral oil
2%,
Silicic acid 0.5%,
Surplus is water.
Preparation method is the conventional method of this area.
It is watered 60 kilograms by every mu of medication amount of formulation and carries out even spraying.
This embodiment medicament be applied to prevent and treat unguiculus demodicid mite:
Co-toxicity coefficient is: 226.2；
By 6000 times of dilute sprayings, after medicine, 15 days prevention effects are 93.5%, and 10% macro tetrolide suspending agent dilutes 3000 times and 10% nimbin emulsion dilutes 3000 times, use with same method respectively, after medicine 15 days, prevention effect was respectively 80.5% and 70.2%, significant difference.
Claims (8)
1. macro tetrolide and a compositions for nimbin, effective ingredient is macro tetrolide and nimbin, and wherein the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:1-15.
Macro tetrolide the most according to claim 1 and the compositions of nimbin, it is characterised in that the weight ratio of macro tetrolide and nimbin is, macro tetrolide: nimbin=1:5-10.
Macro tetrolide the most according to claim 1 and 2 and the compositions of nimbin, it is characterised in that the total weight percentage of described effective ingredient is 15～60%.
Macro tetrolide the most according to claim 3 and the compositions of nimbin, it is characterised in that its dosage form includes wettable powder or aqueous emulsion.
Macro tetrolide the most according to claim 4 and the compositions of nimbin, it is characterised in that its dosage form is aqueous emulsion.
Macro tetrolide the most according to claim 5 and the compositions of nimbin, it is characterized in that, consisting of following component by weight percentage: macro tetrolide 2-10%, nimbin 10-50%, emulsifying agent 3-10%, solvent 2-6%, antifreezing agent 1-3%, defoamer 1-3%, thickening agent 0.5-2%, surplus is water.
7. the compositions of macro tetrolide as claimed in claim 1 and nimbin is for preventing and treating the aleyrodid of crop, aphid, unguiculus demodicid mite, leafhopper, the application of wart demodicid mite.
8. the compositions of macro tetrolide as claimed in claim 7 and nimbin is for preventing and treating the application of leafhopper.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410543882.6A CN104273143B (en) | 2014-10-15 | 2014-10-15 | A kind of macro tetrolide and the compositions of nimbin and application |
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|---|---|---|---|
| CN201410543882.6A CN104273143B (en) | 2014-10-15 | 2014-10-15 | A kind of macro tetrolide and the compositions of nimbin and application |
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|---|---|
| CN104273143A CN104273143A (en) | 2015-01-14 |
| CN104273143B true CN104273143B (en) | 2016-08-24 |
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| CN106719730A (en) * | 2016-12-14 | 2017-05-31 | 西安瑞捷生物科技有限公司 | A kind of composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411726A (en) * | 2002-10-09 | 2003-04-23 | 华南农业大学 | Nimbin and antibiotic pesticide mixed pesticide preparation |
| CN1557155A (en) * | 2004-02-09 | 2004-12-29 | 于建垒 | Multiple dispensing acaricide emulsifiable solution |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1411726A (en) * | 2002-10-09 | 2003-04-23 | 华南农业大学 | Nimbin and antibiotic pesticide mixed pesticide preparation |
| CN1557155A (en) * | 2004-02-09 | 2004-12-29 | 于建垒 | Multiple dispensing acaricide emulsifiable solution |
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